Gene Symbol: Cngb1
Description: cyclic nucleotide gated channel beta 1
Alias: Gm1959, cyclic nucleotide-gated cation channel beta-1, cyclic nucleotide-gated channel beta subunit 1
Species: rat
Products:     Cngb1

Top Publications

  1. Lopez Jimenez M, Gonzalez J, Lizasoain I, Sánchez Prieto J, Hernández Guijo J, Torres M. Functional cGMP-gated channels in cerebellar granule cells. J Cell Physiol. 2012;227:2252-63 pubmed publisher
    ..Here, we demonstrate that the CNGC subunits (CNGA1 and CNGB1, presumably the 1b isoform) are expressed in rat cerebellar granule cells and that they combine to form functional ..
  2. Sautter A, Zong X, Hofmann F, Biel M. An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons. Proc Natl Acad Sci U S A. 1998;95:4696-701 pubmed
    ..The expression of various CNG4 isoforms in retina and olfactory epithelium indicates that the CNG4 subunit may be necessary for normal function of both photoreceptor and olfactory CNG channels. ..
  3. Bönigk W, Bradley J, Muller F, Sesti F, Boekhoff I, Ronnett G, et al. The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits. J Neurosci. 1999;19:5332-47 pubmed
    ..Thus, CNG channels in both rod photoreceptors and olfactory sensory neurons result from coassembly of specific alpha subunits with various forms of an alternatively spliced beta subunit. ..
  4. Kaupp U, Seifert R. Cyclic nucleotide-gated ion channels. Physiol Rev. 2002;82:769-824 pubmed
    ..In particular, mutations in the A and B subunits of the CNG channel expressed in human cones cause various forms of complete and incomplete achromatopsia. ..
  5. Hagstrom S, Watson R, Pauer G, Grossman G. Tulp1 is involved in specific photoreceptor protein transport pathways. Adv Exp Med Biol. 2012;723:783-9 pubmed publisher
  6. Meighan S, Meighan P, Rich E, Brown R, Varnum M. Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating. Biochemistry. 2013;52:8352-62 pubmed publisher
    ..of extracellular, Ca(2+)- and Zn(2+)-dependent proteases, enhances the ligand sensitivity of both rod (CNGA1 and CNGB1) and cone (CNGA3 and CNGB3) CNG channels...
  7. Kondo H, Qin M, Mizota A, Kondo M, Hayashi H, Hayashi K, et al. A homozygosity-based search for mutations in patients with autosomal recessive retinitis pigmentosa, using microsatellite markers. Invest Ophthalmol Vis Sci. 2004;45:4433-9 pubmed
    ..Two of them were novel mutations in the genes TULP1 (c.1145T-->C, F382S) and CNGB1 (c.3444 + 1G-->A). The other was a mutation in RPE65 (c...
  8. Michalakis S, Reisert J, Geiger H, Wetzel C, Zong X, Bradley J, et al. Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping. J Biol Chem. 2006;281:35156-66 pubmed
    ..Here, we have analyzed the functional relevance of CNGB1 for olfaction by gene targeting in mice...
  9. Bareil C, Hamel C, Delague V, Arnaud B, Demaille J, Claustres M. Segregation of a mutation in CNGB1 encoding the beta-subunit of the rod cGMP-gated channel in a family with autosomal recessive retinitis pigmentosa. Hum Genet. 2001;108:328-34 pubmed
    ..83 at theta=0 at the D16S3089 locus). Two candidate genes KIFC3 and CNGB1 mapping to this critical interval have been screened for mutations...

More Information


  1. Hüttl S, Michalakis S, Seeliger M, Luo D, Acar N, Geiger H, et al. Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1. J Neurosci. 2005;25:130-8 pubmed
    ..To investigate the importance of the CNGB subunits in vivo, we deleted the CNGB1 gene in mice. In the absence of CNGB1, only trace amounts of the CNGA1 subunit were found on the rod outer segment...
  2. Nache V, Zimmer T, Wongsamitkul N, Schmauder R, Kusch J, Reinhardt L, et al. Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels. Sci Signal. 2012;5:ra48 pubmed publisher
    ..Thus, the modulatory subunits participate actively in translating ligand binding to activation of heterotetrameric olfactory CNG channels and enable the channels to differentiate between cyclic nucleotides. ..
  3. Gilliam J, Chang J, Sandoval I, Zhang Y, Li T, Pittler S, et al. Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration. Cell. 2012;151:1029-41 pubmed publisher
    ..Loss of the proteins encoded by the Cngb1 gene disrupted links between the disk and plasma membranes...
  4. Sautter A, Biel M, Hofmann F. Molecular cloning of cyclic nucleotide-gated cation channel subunits from rat pineal gland. Brain Res Mol Brain Res. 1997;48:171-5 pubmed
    ..In addition, CNG4-specific transcripts were detected in the arcuate, periventricular and supraoptic nuclei of the hypothalamus. ..
  5. Wright A, Chakarova C, Abd El Aziz M, Bhattacharya S. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Nat Rev Genet. 2010;11:273-84 pubmed publisher
    ..Although genetic and mechanistic diversity creates challenges for therapy, some approaches--particularly gene-replacement therapy--are showing considerable promise. ..
  6. Berridge M. Calcium signalling remodelling and disease. Biochem Soc Trans. 2012;40:297-309 pubmed publisher
    ..Such subtle dysregulation of Ca2+ signals have been linked to some of the major diseases in humans such as cardiac disease, schizophrenia, bipolar disorder and Alzheimer's disease. ..
  7. Daiger S, Sullivan L, Bowne S. Genes and mutations causing retinitis pigmentosa. Clin Genet. 2013;84:132-41 pubmed publisher
    ..In this review, we summarize the current approaches to gene discovery and mutation detection for RP, and indicate pitfalls and unsolved problems. Similar considerations apply to other forms of inherited retinal disease. ..