clusterin

Summary

Gene Symbol: clusterin
Description: clusterin
Alias: APOJ, CLI, DAG, RATTRPM2B, SGP-2, SGP2, SP-40, SP40, TRPM-2, TRPM2B, Trpm2, Trpmb, clusterin, dimeric acid glycoprotein, sulfated glycoprotein 2, testosterone repressed prostate message 2, testosterone-repressed prostate message, testostrone-repressed prostate message 2
Species: rat
Products:     clusterin

Top Publications

  1. Zhang H, Kim J, Edwards C, Xu Z, Taichman R, Wang C. Clusterin inhibits apoptosis by interacting with activated Bax. Nat Cell Biol. 2005;7:909-15 pubmed
    b>Clusterin is an enigmatic glycoprotein that is overexpressed in several human cancers such as prostate and breast cancers, and squamous cell carcinoma...
  2. Redondo M, Villar E, Torres Munoz J, Tellez T, Morell M, Petito C. Overexpression of clusterin in human breast carcinoma. Am J Pathol. 2000;157:393-9 pubmed
    b>Clusterin has been implicated in numerous processes including active cell death, immune regulation, cell adhesion and morphological transformation...
  3. Wilson M, Easterbrook Smith S. Clusterin is a secreted mammalian chaperone. Trends Biochem Sci. 2000;25:95-8 pubmed
  4. Nizard P, Tetley S, Le Drean Y, Watrin T, Le Goff P, Wilson M, et al. Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol. Traffic. 2007;8:554-65 pubmed
    b>Clusterin is a usually secreted glycoprotein with chaperone properties...
  5. van Dijk A, Vermond R, Krijnen P, Juffermans L, Hahn N, Makker S, et al. Intravenous clusterin administration reduces myocardial infarct size in rats. Eur J Clin Invest. 2010;40:893-902 pubmed publisher
    b>Clusterin (Apolipoprotein J), a plasma protein with cytoprotective and complement-inhibiting activities, localizes in the infarcted heart during myocardial infarction (MI)...
  6. Zenkel M, Kruse F, Jünemann A, Naumann G, Schlötzer Schrehardt U. Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material. Invest Ophthalmol Vis Sci. 2006;47:1982-90 pubmed
    To determine the role of the extracellular chaperone clusterin in the pathophysiology of pseudoexfoliation (PEX) syndrome/glaucoma, which is characterized by the stable deposition of abnormal extracellular fibrillar material in anterior ..
  7. Yu H, Kuo H, Huang E, Liang C, Hwang K, Lin I, et al. Plasma clusterin levels in predicting the occurrence of coronary artery lesions in patients with Kawasaki disease. Pediatr Cardiol. 2010;31:1151-6 pubmed publisher
    ..A unique proteomic profiling with increased or decreased fibrinogen, alpha-1-antitrypsin, clusterin, and immunoglobulin free light chains were noted in KD in our previous study...
  8. Krijnen P, Cillessen S, Manoe R, Muller A, Visser C, Meijer C, et al. Clusterin: a protective mediator for ischemic cardiomyocytes?. Am J Physiol Heart Circ Physiol. 2005;289:H2193-202 pubmed
    We examined the relationship between clusterin and activated complement in human heart infarction and evaluated the effect of this protein on ischemic rat neonatal cardiomyoblasts (H9c2) and isolated adult ventricular rat cardiomyocytes ..
  9. Fink T, Zimmer M, Tschopp J, Etienne J, Jenne D, Lichter P. Human clusterin (CLI) maps to 8p21 in proximity to the lipoprotein lipase (LPL) gene. Genomics. 1993;16:526-8 pubmed
    b>Clusterin (gene symbol: CLI) is a post-translationally nicked, two-chain plasma and tissue glycoprotein of 80 kDa...
  10. Jung G, Kim M, Jung Y, Kim H, Park I, Min B, et al. Clusterin attenuates the development of renal fibrosis. J Am Soc Nephrol. 2012;23:73-85 pubmed publisher
    Upregulation of clusterin occurs in several renal diseases and models of nephrotoxicity, but whether this promotes injury or is a protective reaction to injury is unknown...

Detail Information

Publications62

  1. Zhang H, Kim J, Edwards C, Xu Z, Taichman R, Wang C. Clusterin inhibits apoptosis by interacting with activated Bax. Nat Cell Biol. 2005;7:909-15 pubmed
    b>Clusterin is an enigmatic glycoprotein that is overexpressed in several human cancers such as prostate and breast cancers, and squamous cell carcinoma...
  2. Redondo M, Villar E, Torres Munoz J, Tellez T, Morell M, Petito C. Overexpression of clusterin in human breast carcinoma. Am J Pathol. 2000;157:393-9 pubmed
    b>Clusterin has been implicated in numerous processes including active cell death, immune regulation, cell adhesion and morphological transformation...
  3. Wilson M, Easterbrook Smith S. Clusterin is a secreted mammalian chaperone. Trends Biochem Sci. 2000;25:95-8 pubmed
  4. Nizard P, Tetley S, Le Drean Y, Watrin T, Le Goff P, Wilson M, et al. Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol. Traffic. 2007;8:554-65 pubmed
    b>Clusterin is a usually secreted glycoprotein with chaperone properties...
  5. van Dijk A, Vermond R, Krijnen P, Juffermans L, Hahn N, Makker S, et al. Intravenous clusterin administration reduces myocardial infarct size in rats. Eur J Clin Invest. 2010;40:893-902 pubmed publisher
    b>Clusterin (Apolipoprotein J), a plasma protein with cytoprotective and complement-inhibiting activities, localizes in the infarcted heart during myocardial infarction (MI)...
  6. Zenkel M, Kruse F, Jünemann A, Naumann G, Schlötzer Schrehardt U. Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material. Invest Ophthalmol Vis Sci. 2006;47:1982-90 pubmed
    To determine the role of the extracellular chaperone clusterin in the pathophysiology of pseudoexfoliation (PEX) syndrome/glaucoma, which is characterized by the stable deposition of abnormal extracellular fibrillar material in anterior ..
  7. Yu H, Kuo H, Huang E, Liang C, Hwang K, Lin I, et al. Plasma clusterin levels in predicting the occurrence of coronary artery lesions in patients with Kawasaki disease. Pediatr Cardiol. 2010;31:1151-6 pubmed publisher
    ..A unique proteomic profiling with increased or decreased fibrinogen, alpha-1-antitrypsin, clusterin, and immunoglobulin free light chains were noted in KD in our previous study...
  8. Krijnen P, Cillessen S, Manoe R, Muller A, Visser C, Meijer C, et al. Clusterin: a protective mediator for ischemic cardiomyocytes?. Am J Physiol Heart Circ Physiol. 2005;289:H2193-202 pubmed
    We examined the relationship between clusterin and activated complement in human heart infarction and evaluated the effect of this protein on ischemic rat neonatal cardiomyoblasts (H9c2) and isolated adult ventricular rat cardiomyocytes ..
  9. Fink T, Zimmer M, Tschopp J, Etienne J, Jenne D, Lichter P. Human clusterin (CLI) maps to 8p21 in proximity to the lipoprotein lipase (LPL) gene. Genomics. 1993;16:526-8 pubmed
    b>Clusterin (gene symbol: CLI) is a post-translationally nicked, two-chain plasma and tissue glycoprotein of 80 kDa...
  10. Jung G, Kim M, Jung Y, Kim H, Park I, Min B, et al. Clusterin attenuates the development of renal fibrosis. J Am Soc Nephrol. 2012;23:73-85 pubmed publisher
    Upregulation of clusterin occurs in several renal diseases and models of nephrotoxicity, but whether this promotes injury or is a protective reaction to injury is unknown...
  11. CARLSON E, Magid R, Petryk A, Georgieff M. Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis. Brain Res. 2008;1237:75-83 pubmed publisher
    ..Our results suggest a role for neonatal iron deficiency in dysregulation of genes that may set the stage for long-term neurodegenerative disease and that this may occur through a histone modification mechanism. ..
  12. Poon S, Easterbrook Smith S, Rybchyn M, Carver J, Wilson M. Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state. Biochemistry. 2000;39:15953-60 pubmed
    We recently reported that the ubiquitous, secreted protein clusterin has chaperone activity in vitro [Humphreys et al. (1999) J. Biol. Chem. 274, 6875-6881]...
  13. Hidaka S, Kränzlin B, Gretz N, Witzgall R. Urinary clusterin levels in the rat correlate with the severity of tubular damage and may help to differentiate between glomerular and tubular injuries. Cell Tissue Res. 2002;310:289-96 pubmed
    b>Clusterin is a secreted glycoprotein that is synthesized after several types of tubular injury. We therefore wondered whether the urinary excretion of clusterin could serve as a parameter to determine the severity of tubular damage...
  14. Kaya Dağistanli F, Ozturk M. The role of clusterin on pancreatic beta cell regeneration after exendin-4 treatment in neonatal streptozotocin administrated rats. Acta Histochem. 2013;115:577-86 pubmed publisher
    We investigated the effects of exendin-4 (Ex4) treatment on expression of clusterin and ? cell regeneration in the endocrine pancreas in neonatal streptozotocin (nSTZ) diabetic rats...
  15. Collard M, Griswold M. Biosynthesis and molecular cloning of sulfated glycoprotein 2 secreted by rat Sertoli cells. Biochemistry. 1987;26:3297-303 pubmed
    b>Sulfated glycoprotein 2 (SGP-2) is the major protein secreted by rat Sertoli cells...
  16. Wong P, Pineault J, Lakins J, Taillefer D, Leger J, Wang C, et al. Genomic organization and expression of the rat TRPM-2 (clusterin) gene, a gene implicated in apoptosis. J Biol Chem. 1993;268:5021-31 pubmed
  17. Kruger S, Ola V, Fischer D, Feller A, Friedrich M. Prognostic significance of clusterin immunoreactivity in breast cancer. Neoplasma. 2007;54:46-50 pubmed
    b>Clusterin (CLU) is involved in a variety of biological processes and has been found to be expressed even in many human malignancies, including breast cancer...
  18. Humphreys D, Carver J, Easterbrook Smith S, Wilson M. Clusterin has chaperone-like activity similar to that of small heat shock proteins. J Biol Chem. 1999;274:6875-81 pubmed
    b>Clusterin is a highly conserved protein which is expressed at increased levels by many cell types in response to a broad variety of stress conditions. A genuine physiological function for clusterin has not yet been established...
  19. Nishida K, Quantock A, Dota A, Choi Miura N, Kinoshita S. Apolipoproteins J and E co-localise with amyloid in gelatinous drop-like and lattice type I corneal dystrophies. Br J Ophthalmol. 1999;83:1178-82 pubmed
    Apolipoprotein J (apoJ) and apolipoprotein E (apoE) are thought to contribute to amyloid formation in patients with Alzheimer's disease...
  20. Ou Yang M, Kuo H, Lin I, Sheen J, Huang F, Chen C, et al. Plasma clusterin concentrations may predict resistance to intravenous immunoglobulin in patients with Kawasaki disease. ScientificWorldJournal. 2013;2013:382523 pubmed publisher
    ..Among the biomarkers, the difference in plasma clusterin concentrations before and after IVIG infusion (CLUSTER 12) was significantly related to IVIG resistance (P = 0...
  21. Garcia Rodriguez S, Arias Santiago S, Perandrés López R, Orgaz Molina J, Castellote L, Buendía Eisman A, et al. Decreased plasma levels of clusterin in patients with psoriasis. Actas Dermosifiliogr. 2013;104:497-503 pubmed publisher
    ..The glycoprotein clusterin (apolipoprotein J) is a component of high-density lipoproteins and has a protective role in atherosclerosis...
  22. Kogel D, Concannon C, Müller T, König H, Bonner C, Poeschel S, et al. The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis. Neurobiol Aging. 2012;33:2200-9 pubmed publisher
    ..that AICD significantly downregulated messenger RNA levels of the Alzheimer's disease susceptibility gene ApoJ/clusterin, indicating transcriptional repression...
  23. Yanaba K, Asano Y, Tada Y, Sugaya M, Kadono T, Sato S. A possible contribution of elevated serum clusterin levels to the inhibition of digital ulcers and pulmonary arterial hypertension in systemic sclerosis. Arch Dermatol Res. 2012;304:459-63 pubmed publisher
    b>Clusterin has been demonstrated to be one of the anti-inflammatory and anti-apoptotic factors, suggesting the potential to be involved in the development of systemic sclerosis (SSc)...
  24. Lam Y, Tam N, Evans J, Green K, Zhang X, Ho S. Differential proteomics in the aging Noble rat ventral prostate. Proteomics. 2008;8:2750-63 pubmed publisher
    ..The expression of GST, ferritin, clusterin, kininogen, oxygen regulated protein 150, spermidine synthase, ADP ribosylation factor, and cyclophilin B was ..
  25. Kim J, Kim J, Yu Y, Min B, Kim K. Protective effect of clusterin on blood-retinal barrier breakdown in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2010;51:1659-65 pubmed publisher
    Purpose. To investigate whether clusterin attenuates blood-retinal barrier (BRB) breakdown in diabetic retinopathy. Methods...
  26. Bettuzzi S, Hiipakka R, Gilna P, Liao S. Identification of an androgen-repressed mRNA in rat ventral prostate as coding for sulphated glycoprotein 2 by cDNA cloning and sequence analysis. Biochem J. 1989;257:293-6 pubmed
    ..By sequence analysis the androgen-repressed mRNA was identified as that coding for sulphated glycoprotein 2. ..
  27. Nakamura T. [Molecular mechanism of pathological keratinization in severe ocular surface diseases]. Nippon Ganka Gakkai Zasshi. 2004;108:654-64 pubmed
    ..We then investigated the expression of epidermal keratinization-related proteins and clusterin, which is the most abundant gene transcript in human corneal epithelium...
  28. Tobisawa S, Honma M, Ishida Yamamoto A, Saijo Y, Iizuka H. Prognostic factors in 105 Japanese cases of mycosis fungoides and Sézary syndrome: clusterin expression as a novel prognostic factor. J Dermatol Sci. 2013;71:160-6 pubmed publisher
    The analysis of prognostic factors in Japanese cases of cutaneous T-cell lymphoma (CTCL) is scarce. Clusterin is a ubiquitous 80kDa heterodimeric glycoprotein expressed on tumor cells of systemic and primary cutaneous anaplastic large ..
  29. Newkirk M, Apostolakos P, Neville C, Fortin P. Systemic lupus erythematosus, a disease associated with low levels of clusterin/apoJ, an antiinflammatory protein. J Rheumatol. 1999;26:597-603 pubmed
    To measure the serum levels of clusterin, an antiinflammatory protein, which binds and inactivates complement, in patients with systemic lupus erythematosus (SLE) to determine whether the levels correlate with disease...
  30. Izawa M. Identification of a transcript predicting an alternative form of sulfated glycoprotein-2 (clusterin) in rat tissues. Biochem Mol Biol Int. 1998;44:9-18 pubmed
    ..study suggested the expression of a transcript predicting an alternative form of Sulfated Glycoprotein-2 (SGP-2)/clusterin. RT-PCR demonstrated the androgen-dependent expression of p116 transcript in the seminal vesicles...
  31. Smith S, Bora N, McCool D, Kutty G, Wong P, Kutty R, et al. Photoreceptor cells in the vitiligo mouse die by apoptosis. TRPM-2/clusterin expression is increased in the neural retina and in the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1995;36:2193-201 pubmed
    ..Additionally, the expression of a gene associated with apoptosis, TRPM-2/clusterin, was examined...
  32. Wyatt A, Yerbury J, Berghofer P, Greguric I, Katsifis A, Dobson C, et al. Clusterin facilitates in vivo clearance of extracellular misfolded proteins. Cell Mol Life Sci. 2011;68:3919-31 pubmed publisher
    ..However, little is known about the specific mechanisms that act to suppress this process in vivo. Clusterin (CLU) is an extracellular chaperone that forms stable and soluble complexes with misfolded client proteins...
  33. Suzuki S, Shiraga K, Sato S, Punfa W, Naiki Ito A, Yamashita Y, et al. Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis. Cancer Sci. 2013;104:1711-7 pubmed publisher
    ..Positivity of Ki67 was significantly reduced by apocynin treatment, and downregulation of clusterin expression, as well as inactivation of the MEK-ERK1/2 pathway, was a feature of the apocynin treated groups...
  34. Zhang Q, Davis K, Hoffmann D, Vaidya V, Brown R, Goering P. Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats. Biomark Med. 2014;8:85-94 pubmed publisher
    ..Urinary albumin, NAG, clusterin, osteopontin, RPA-1 and fibrinogen levels were significantly elevated over time and were closely associated with ..
  35. Flanagan L, Whyte L, Chatterjee N, Tenniswood M. Effects of clusterin over-expression on metastatic progression and therapy in breast cancer. BMC Cancer. 2010;10:107 pubmed publisher
    b>Clusterin is a secreted glycoprotein that is upregulated in a variety of cell lines in response to stress, and enhances cell survival. A second nuclear isoform of clusterin that is associated with cell death has also been identified...
  36. Tian T, Ni H, Sun B. Neurobehavioral Deficits in a Rat Model of Recurrent Neonatal Seizures Are Prevented by a Ketogenic Diet and Correlate with Hippocampal Zinc/Lipid Transporter Signals. Biol Trace Elem Res. 2015;167:251-8 pubmed publisher
    ..any influence in the activity of zinc/lipid transporters such as zinc transporter 3 (ZnT-3), MT-3, ApoE, ApoJ (clusterin), and ACAT-1 activities in neonatal rats submitted to flurothyl-induced recurrent seizures...
  37. Cheng C, Chen C, Feng Z, Marshall A, Bardin C. Rat clusterin isolated from primary Sertoli cell-enriched culture medium is sulfated glycoprotein-2 (SGP-2). Biochem Biophys Res Commun. 1988;155:398-404 pubmed
    b>Clusterin, a glycoprotein originally isolated from ram rete testis fluid, is a dimer composed of monomers with non-identical NH2-terminal amino acid sequences...
  38. Lee K, Lee D, Son H, Kim Y, Park J, Roh G, et al. Clusterin regulates transthyretin amyloidosis. Biochem Biophys Res Commun. 2009;388:256-60 pubmed publisher
    ..b>Clusterin has recently been proposed to play a role as an extracellular molecular chaperone, affecting the fibril ..
  39. Wang Z, Widgren E, Richardson R, O Rand M. Characterization of an eppin protein complex from human semen and spermatozoa. Biol Reprod. 2007;77:476-84 pubmed
    ..and Western blots an eppin protein complex (EPC) containing lactotransferrin (LTF; also known as lactoferrin), clusterin (CLU), and semenogelin (SEMG1)...
  40. Ishii A, Sakai Y, Nakamura A. Molecular pathological evaluation of clusterin in a rat model of unilateral ureteral obstruction as a possible biomarker of nephrotoxicity. Toxicol Pathol. 2007;35:376-82 pubmed
    In the present study, to determine the validity of considering clusterin as a possible biomarker of nephrotoxicity, the expression and distribution of clusterin in the rat UUO kidney were investigated...
  41. DeMattos R, O Dell M, Parsadanian M, Taylor J, Harmony J, Bales K, et al. Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2002;99:10843-8 pubmed
    Studies have shown that clusterin (also called apolipoprotein J) can influence the structure and toxicity of amyloid-beta (Abeta) in vitro...
  42. Navab M, Anantharamaiah G, Reddy S, Van Lenten B, Wagner A, Hama S, et al. An oral apoJ peptide renders HDL antiinflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol. 2005;25:1932-7 pubmed
    ..In contrast to D-4F, D- [113-122]apoJ showed minimal self-association and helicity in the absence of lipids...
  43. Wyatt A, Yerbury J, Poon S, Dabbs R, Wilson M. Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein folding. Adv Cancer Res. 2009;104:89-114 pubmed publisher
    The function(s) of clusterin may depend upon its topological location. A variety of intracellular "isoforms" of clusterin have been reported but further work is required to better define their identity...
  44. Matsushita K, Miyake H, Chiba K, Fujisawa M. Clusterin produced by Sertoli cells inhibits heat stress-induced apoptosis in the rat testis. Andrologia. 2016;48:11-9 pubmed publisher
    The objectives of this study were to determine whether the inhibition of clusterin expression in rat Sertoli cells enhances heat stress-induced apoptosis. The scrotums of rats were immersed in a water bath of 43 °C for 15 min...
  45. Christoffersen C, Nielsen L, Axler O, Andersson A, Johnsen A, Dahlback B. Isolation and characterization of human apolipoprotein M-containing lipoproteins. J Lipid Res. 2006;47:1833-43 pubmed
    ..Mass spectrometry showed that the apoM-containing lipoproteins also contained apoJ, apoA-I, apoA-II, apoC-I, apoC-II, apoC-III, paraoxonase 1, and apoB...
  46. Giannakopoulos P, Kovari E, French L, Viard I, Hof P, Bouras C. Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study. Acta Neuropathol. 1998;95:387-94 pubmed
    b>Clusterin is a secreted glycoprotein that is expressed in response to tissue injury both in peripheral organs and in the brain...
  47. Nuutinen T, Suuronen T, Kyrylenko S, Huuskonen J, Salminen A. Induction of clusterin/apoJ expression by histone deacetylase inhibitors in neural cells. Neurochem Int. 2005;47:528-38 pubmed
    The regulation of clusterin expression is poorly characterized although some regulatory elements have been identified, such as CpG-rich methylation domain...
  48. Narayan P, Orte A, Clarke R, Bolognesi B, HOOK S, Ganzinger K, et al. The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-?(1-40) peptide. Nat Struct Mol Biol. 2011;19:79-83 pubmed publisher
    In recent genome-wide association studies, the extracellular chaperone protein, clusterin, has been identified as a newly-discovered risk factor in Alzheimer's disease...
  49. Matthaei M, Meng H, Meeker A, Eberhart C, Jun A. Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy. Invest Ophthalmol Vis Sci. 2012;53:6718-27 pubmed
    ..upregulation of senescence-associated targets Cdkn1a (p21), Serpine1 (PAI-1), Tagln (Sm22), Fn1 and Clu (ApoJ). Immunofluorescence revealed increased expression of nuclear p53 and p21 in mutant animals...
  50. Nakamura T, Nishida K, Dota A, Kinoshita S. Changes in conjunctival clusterin expression in severe ocular surface disease. Invest Ophthalmol Vis Sci. 2002;43:1702-7 pubmed
    b>Clusterin is a unique gene transcript in the human ocular surface epithelia and is synthesized by and localized in mucosal epithelia in general. It is not present, however, in keratinized epithelia, such as epidermis...
  51. Kim B, Kim S, Lee S, Shin Y, Min B, Bendayan M, et al. Clusterin induces differentiation of pancreatic duct cells into insulin-secreting cells. Diabetologia. 2006;49:311-20 pubmed
    We recently reported that expression of the gene encoding clusterin (Clu) is upregulated in the regenerating pancreas, particularly in tissues undergoing differentiation...
  52. Kim Y, Kim Y, Cheon E, Park J, Yoo J, Kang S, et al. Retinal expression of clusterin in the streptozotocin-induced diabetic rat. Brain Res. 2003;976:53-9 pubmed
    To assess the possible relevance of clusterin in the pathophysiology of retinopathy associated with diabetes mellitus, streptozotocin-induced diabetic rats were studied...
  53. Hammad S, Ranganathan S, Loukinova E, Twal W, Argraves W. Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide. J Biol Chem. 1997;272:18644-9 pubmed
    Apolipoprotein J (apoJ) has been shown to be the predominant amyloid beta-peptide (Abeta)-binding protein in cerebrospinal fluid...
  54. Shin M, Chang H, Namkoong C, Kang G, Kim H, Gil S, et al. Hypothalamic and pituitary clusterin modulates neurohormonal responses to stress. Neuroendocrinology. 2013;98:233-41 pubmed publisher
    b>Clusterin is a sulfated glycoprotein abundantly expressed in the pituitary gland and hypothalamus of mammals. However, its physiological role in neuroendocrine function is largely unknown...
  55. Ni H, Zhao D, Tian T. Ketogenic diet change cPLA2/clusterin and autophagy related gene expression and correlate with cognitive deficits and hippocampal MFs sprouting following neonatal seizures. Epilepsy Res. 2016;120:13-8 pubmed publisher
    ..we tested this hypothesis by examining the long-term expression of lipid membrane peroxidation-related cPLA2 and clusterin, its downstream autophagy marker Beclin-1, LC3 and p62, as well as its execution molecule Cathepsin-E following ..
  56. Gwon J, Kim I, Lee M, Oh S, Chun M. Expression of clusterin in Müller cells of the rat retina after pressure-induced ischemia. Glia. 2004;47:35-45 pubmed
    We have investigated the expression and cellular localization of clusterin in the rat retina following ischemia induced by transiently increasing the intraocular pressure...
  57. Xie Z, Harris White M, Wals P, Frautschy S, Finch C, Morgan T. Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro. J Neurochem. 2005;93:1038-46 pubmed
    Apolipoprotein J (apoJ; also known as clusterin and sulfated glycoprotein (SGP)-2) is associated with senile plaques in degenerating regions of Alzheimer's disease brains, where activated microglia are also prominent...
  58. BRASKIE M, Jahanshad N, Stein J, Barysheva M, McMahon K, de Zubicaray G, et al. Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci. 2011;31:6764-70 pubmed publisher
    ..A newly confirmed genetic risk allele C of the clusterin (CLU) gene variant rs11136000 is carried by ?88% of Caucasians. The C allele confers a 1...
  59. Yerbury J, Poon S, Meehan S, Thompson B, Kumita J, Dobson C, et al. The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures. FASEB J. 2007;21:2312-22 pubmed
    b>Clusterin is an extracellular chaperone present in all disease-associated extracellular amyloid deposits, but its roles in amyloid formation and protein deposition in vivo are poorly understood...
  60. Tunçdemir M, Ozturk M. The effects of ACE inhibitor and angiotensin receptor blocker on clusterin and apoptosis in the kidney tissue of streptozotocin-diabetic rats. J Mol Histol. 2008;39:605-16 pubmed publisher
    Our first aim was to determine the effects of secreted clusterin (sCLU) and nuclear clusterin (nCLU) in diabetic nephropathy...
  61. Niu Z, Li X, Hu B, Li R, Wang L, Wu L, et al. Small interfering RNA targeted to secretory clusterin blocks tumor growth, motility, and invasion in breast cancer. Acta Biochim Biophys Sin (Shanghai). 2012;44:991-8 pubmed publisher
    b>Clusterin/apolipoprotein J (Clu) is a ubiquitously expressed secreted heterodimeric glycoprotein that is implicated in several physiological processes...
  62. Kim J, Yanagihara Y, Kikugawa T, Ji M, Tanji N, Masayoshi Y, et al. A signaling network in phenylephrine-induced benign prostatic hyperplasia. Endocrinology. 2009;150:3576-83 pubmed publisher
    ..The heterodimeric protein clusterin (apolipoprotein J) was also identified as a prominent node in the network...