Gene Symbol: Clec4m
Description: C-type lectin domain family 4 member M
Alias: Cd209b, CD209b antigen
Taylor P, Brown G, Herre J, Williams D, Willment J, Gordon S. The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages. J Immunol. 2004;172:1157-62 pubmed
..These studies have identified SIGNR1 as a major MR for fungal and other pathogens present on specific subsets of Mphi. ..
Powlesland A, Ward E, Sadhu S, Guo Y, Taylor M, Drickamer K. Widely divergent biochemical properties of the complete set of mouse DC-SIGN-related proteins. J Biol Chem. 2006;281:20440-9 pubmed
..The results presented demonstrate that the mouse homologs of DC-SIGN have a diverse set of ligand-binding and intracellular trafficking properties, some of which are distinct from the properties of any of the human receptors. ..
Park J, Choi H, Prabagar M, Choi W, Kim S, Cheong C, et al
. The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumoniae. Neurosci Lett. 2009;450:246-51 pubmed publisher
..Here, we demonstrate that SIGN-R1, as well as the rat SIGN-R1 homologue CD209b are expressed in most regions of mouse or rat brain, respectively...
Lozach P, Lortat Jacob H, de Lacroix de Lavalette A, Staropoli I, Foung S, Amara A, et al
. DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2. J Biol Chem. 2003;278:20358-66 pubmed
..High affinity interaction of viral glycoproteins with oligomeric lectins might represent a strategy by which HCV targets to and concentrates in the liver and infects dendritic cells. ..
Jeffers S, Tusell S, Gillim Ross L, Hemmila E, Achenbach J, Babcock G, et al
. CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci U S A. 2004;101:15748-53 pubmed
..Our data suggest that the large S glycoprotein of SARS-CoV may use both ACE2 and CD209L in virus infection and pathogenesis. ..
Tanne A, Ma B, Boudou F, Tailleux L, Botella H, Badell E, et al
. A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J Exp Med. 2009;206:2205-20 pubmed publisher
..SIGNR3 signaling was dependent on an intracellular tyrosine-based motif and the tyrosine kinase Syk. Thus, the mouse DC-SIGN homologue SIGNR3 makes a unique contribution to protection of the host against a pulmonary bacterial pathogen. ..