claudin 5


Gene Symbol: claudin 5
Description: claudin 5
Alias: claudin-5
Species: rat
Products:     claudin 5

Top Publications

  1. Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, et al. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol. 2003;161:653-60 pubmed
    ..e., the size-selective loosening of the BBB) not only provides new insight into the basic molecular physiology of BBB but also opens a new way to deliver potential drugs across the BBB into the central nervous system. ..
  2. Morita K, Furuse M, Fujimoto K, Tsukita S. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A. 1999;96:511-6 pubmed
    ..These findings indicated that multiple claudin family members are involved in the formation of TJ strands in various tissues. ..
  3. Fontijn R, Volger O, Fledderus J, Reijerkerk A, de Vries H, Horrevoets A. SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function. Am J Physiol Heart Circ Physiol. 2008;294:H891-900 pubmed
  4. Koda R, Zhao L, Yaoita E, Yoshida Y, Tsukita S, Tamura A, et al. Novel expression of claudin-5 in glomerular podocytes. Cell Tissue Res. 2011;343:637-48 pubmed publisher
  5. Wang J, Chen J, Tang Z, Li Y, Hu L, Pan J. The Effects of Copper on Brain Microvascular Endothelial Cells and Claudin Via Apoptosis and Oxidative Stress. Biol Trace Elem Res. 2016;174:132-141 pubmed
    ..Together, our results indicated that copper had dual effects on BMEC growth and intrinsic antioxidant activities played a crucial role in BMEC survival and tight junction. ..
  6. Clark P, Kim R, Pober J, Kluger M. Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases. PLoS ONE. 2015;10:e0120075 pubmed publisher
    ..We conclude that TNF disrupts TJs in HDMECs in two distinct NF-κB-dependent steps, the first involving Rho-associated kinase and the second likely to involve an as yet unidentified but structurally related protein kinase(s). ..
  7. Inamura A, Adachi Y, Inoue T, He Y, Tokuda N, Nawata T, et al. Cooling treatment transiently increases the permeability of brain capillary endothelial cells through translocation of claudin-5. Neurochem Res. 2013;38:1641-7 pubmed publisher
  8. Zhao H, Zhang Q, Xue Y, Chen X, Haun R. Effects of hyperbaric oxygen on the expression of claudins after cerebral ischemia-reperfusion in rats. Exp Brain Res. 2011;212:109-17 pubmed publisher
    ..Our study provides direct evidence that HBO decreases the permeability of the BBB by reducing the enzymatic activity of MMPs and augmenting the expression of claudins at different stages in cerebral IR injury. ..
  9. Helms H, Waagepetersen H, Nielsen C, Brodin B. Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing media buffer capacity during growth. AAPS J. 2010;12:759-70 pubmed publisher
    ..The observations have practical implications for generating tighter BBB cell culture models, and may also have physiological implications, if similar sensitivity to pH-changes can be demonstrated in vivo. ..

More Information


  1. Jin D, Wang F, Qu L, Li Z, Jin L, Liu P, et al. The distribution and expression of claudin-5 and occludin at the rat blood-optic nerve barrier after borneol treatment. Mol Biol Rep. 2011;38:913-20 pubmed publisher
    ..Claudin-5 may play a potential role in permeability of the blood-optic nerve barrier following borneol treatment. ..
  2. Wang L, Zhang X, Liu L, Cui L, Yang R, Li M, et al. Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia. Brain Res. 2010;1321:143-51 pubmed publisher
    ..Tan II A protected the brain from damage caused by pMCAO; this effect may be through down-regulation of HMGB1, RAGE and TLR4, NF-kappaB and up-regulation claudin-5 expression...
  3. Fernandez A, Koval M, Fan X, Guidot D. Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats. Alcohol. 2007;41:371-9 pubmed
    ..Therefore, these findings suggest that changes in claudin expression in the alveolar epithelium produce a "leakier" phenotype that renders the alcoholic lung susceptible to alveolar flooding during acute inflammatory stresses. ..
  4. Ohtsuki S, Sato S, Yamaguchi H, Kamoi M, Asashima T, Terasaki T. Exogenous expression of claudin-5 induces barrier properties in cultured rat brain capillary endothelial cells. J Cell Physiol. 2007;210:81-6 pubmed
    ..These results indicate that claudin-5, but not claudin-12, is predominantly expressed in brain capillaries, and plays a key role in the appearance of barrier properties of brain capillary endothelial cells. ..
  5. Sun Z, Wei J, Xie L, Shen Y, Liu S, Ju G, et al. The CLDN5 locus may be involved in the vulnerability to schizophrenia. Eur Psychiatry. 2004;19:354-7 pubmed
  6. Bulldan A, Dietze R, Shihan M, Scheiner Bobis G. Non-classical testosterone signaling mediated through ZIP9 stimulates claudin expression and tight junction formation in Sertoli cells. Cell Signal. 2016;28:1075-85 pubmed publisher
    ..Further assessment of these interactions will help to supplement our knowledge concerning the mechanism by which testosterone plays a role in male fertility. ..
  7. Kugelmann D, Waschke J, Radeva M. Adducin is involved in endothelial barrier stabilization. PLoS ONE. 2015;10:e0126213 pubmed publisher
    ..Taken together, our results indicate that α-adducin is involved in remodeling of endothelial adhesion junctions and thereby contributes to endothelial barrier regulation. ..
  8. D Agnillo F, Williams M, Moayeri M, Warfel J. Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions. PLoS ONE. 2013;8:e62576 pubmed publisher
    ..Mice challenged with LT also showed significant reduction in claudin-5 expression. Together, these findings support a possible role for LT disruption of endothelial TJs in the vascular leakage pathologies of anthrax. ..
  9. Kluger M, Clark P, Tellides G, Gerke V, Pober J. Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells. Arterioscler Thromb Vasc Biol. 2013;33:489-500 pubmed publisher
    ..Claudin-5 expression and junctional organization control HDMEC and arteriolar-capillary paracellular barriers, whereas HUVEC and venular junctions use vascular endothelial-cadherin. ..
  10. Shen W, Li S, Chung S, Zhu L, Stayt J, Su T, et al. Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-?1-induced permeability of centrally derived vascular endothelium. Eur J Cell Biol. 2011;90:323-32 pubmed publisher
    ..Our results suggest that tyrosine phosphorylation of VE-cadherin and claudin-5 is involved in the increased paracellular permeability of central nervous system-derived vascular endothelium induced by TGF-?1. ..
  11. Jiao H, Wang Z, Liu Y, Wang P, Xue Y. Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult. J Mol Neurosci. 2011;44:130-9 pubmed publisher
  12. Balbuena P, Li W, Ehrich M. Assessments of tight junction proteins occludin, claudin 5 and scaffold proteins ZO1 and ZO2 in endothelial cells of the rat blood-brain barrier: cellular responses to neurotoxicants malathion and lead acetate. Neurotoxicology. 2011;32:58-67 pubmed publisher
    ..Immunoblotting assessments demonstrated that protein levels of tight junction proteins occludin and claudin 5, and scaffold proteins ZO1 and ZO2 were decreased after treatments...
  13. Li Q, Zhang Q, Wang C, Liu X, Qu L, Gu L, et al. Altered distribution of tight junction proteins after intestinal ischaemia/reperfusion injury in rats. J Cell Mol Med. 2009;13:4061-76 pubmed publisher
    ..I/R injury altered distribution of TJ proteins in vivo that was associated with functional TJ deficiencies. ..
  14. Honda M, Nakagawa S, Hayashi K, Kitagawa N, Tsutsumi K, Nagata I, et al. Adrenomedullin improves the blood-brain barrier function through the expression of claudin-5. Cell Mol Neurobiol. 2006;26:109-18 pubmed
    ..Immunoblotting also showed an overexpression of claudin-5 in AM exposure. AM therefore inhibits the paracellular transport in a BBB in vitro model through claudin-5 overexpression. ..
  15. Poliak S, Matlis S, Ullmer C, Scherer S, Peles E. Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells. J Cell Biol. 2002;159:361-72 pubmed
    ..The presence of these different tight junction proteins in regions of noncompact myelin may be required to maintain the intricate cytoarchitecture of myelinating Schwann cells. ..
  16. Yang Y, Rosenberg G. MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia. Methods Mol Biol. 2011;762:333-45 pubmed publisher
  17. Liu J, Jin X, LIU K, Liu W. Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage. J Neurosci. 2012;32:3044-57 pubmed publisher
  18. Guillemot L, Schneider Y, Brun P, Castagliuolo I, Pizzuti D, Martines D, et al. Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. J Cell Sci. 2012;125:5005-14 pubmed publisher
  19. Bai X, Zhang X, Chen L, Zhang J, Zhang L, Zhao X, et al. Protective effect of naringenin in experimental ischemic stroke: down-regulated NOD2, RIP2, NF-?B, MMP-9 and up-regulated claudin-5 expression. Neurochem Res. 2014;39:1405-15 pubmed publisher
    ..05). The results provided a neuroprotective profile of NG in cerebral ischemia, this effect was likely exerted by down-regulated NOD2, RIP2, NF-?B, MMP-9 and up-regulated claudin-5 expression. ..
  20. Uehara K, Uehara A. Localization of claudin-5 and ZO-1 in rat spleen sinus endothelial cells. Histochem Cell Biol. 2008;129:95-103 pubmed
    ..Thus, ZO-1 might play an important role in regulating the cell-cell junctions of sinus endothelial cells for blood-cell passage through splenic cords. ..
  21. Soma T, Chiba H, Kato Mori Y, Wada T, Yamashita T, Kojima T, et al. Thr(207) of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP. Exp Cell Res. 2004;300:202-12 pubmed
    ..cAMP decreased the claudin-5-based endothelial barrier, strongly suggesting that other tight-junction molecule(s) are required to elevate endothelial barrier functions in response to cAMP. ..