class I alcohol dehydrogenase

Summary

Gene Symbol: class I alcohol dehydrogenase
Description: alcohol dehydrogenase 3
Alias: Adh1c, alcohol dehydrogenase 1C, class I alcohol dehydrogenase
Species: rat

Top Publications

  1. doi Glutathione-dependent formaldehyde dehydrogenase (ADH3) and low km mitochondrial aldehyde dehydrogenase (ALDH2). New evidence for differential expression in the rat retina in response to oxidative stress
    C Galbis-Estrada
    Ophthalmic Research Unit Santiago Grisolía, University Hospital Dr Peset, Valencia, Spain
    Free Radic Res 46:77-84. 2012
  2. ncbi Structure and expression of the rat class I alcohol dehydrogenase gene
    D W Crabb
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46223
    Genomics 5:906-14. 1989
  3. ncbi Role of extrahepatic alcohol dehydrogenase in rat ethanol metabolism
    M D Boleda
    Department de Bioquimica i Biologia Molecular, Facultat de Ciencies, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Arch Biochem Biophys 274:74-81. 1989
  4. ncbi Prospective evaluation of the alcohol dehydrogenase gamma1/gamma2 gene polymorphism and risk of stroke
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Stroke 35:e39-42. 2004
  5. ncbi High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease
    Marie Westerlund
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    FEBS J 274:1212-23. 2007

Scientific Experts

  • R Y Zee
  • C Galbis-Estrada
  • Marie Westerlund
  • P Sanz-Solana
  • R Gallego-Pinazo
  • A Lleo-Perez
  • V Vila Bou
  • S Pons-Vazquez
  • J J Garcia-Medina
  • M D Pinazo-Duran
  • Andrea Carmine Belin
  • Dagmar Galter
  • Michael R Felder
  • Lars Olson
  • M D Boleda
  • D W Crabb
  • R Sidhu
  • A Moreno
  • K M Dipple
  • X Pares
  • J B Hittle
  • P M Stein
  • P Julia
  • M Qulali
  • H J Edenberg
  • K Zhang

Detail Information

Publications5

  1. doi Glutathione-dependent formaldehyde dehydrogenase (ADH3) and low km mitochondrial aldehyde dehydrogenase (ALDH2). New evidence for differential expression in the rat retina in response to oxidative stress
    C Galbis-Estrada
    Ophthalmic Research Unit Santiago Grisolía, University Hospital Dr Peset, Valencia, Spain
    Free Radic Res 46:77-84. 2012
    ..In addition to other pathogenic mechanisms not fully understood, the possibility remains that peroxidic aldehydes, acting as cytotoxic chemicals, mediate in the progression of chronic ocular disorders...
  2. ncbi Structure and expression of the rat class I alcohol dehydrogenase gene
    D W Crabb
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46223
    Genomics 5:906-14. 1989
    Clones containing the rat class I alcohol dehydrogenase (ADH) gene were isolated from a Charon 4A genomic library. The gene spans approximately 13 kb and comprises nine exons and eight introns...
  3. ncbi Role of extrahepatic alcohol dehydrogenase in rat ethanol metabolism
    M D Boleda
    Department de Bioquimica i Biologia Molecular, Facultat de Ciencies, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Arch Biochem Biophys 274:74-81. 1989
    ..4 microM) and indicate that at the usual concentration of inhibitor only ADH-3 activity will be effectively suppressed. ADH-1 will be, therefore, responsible in part for the residual ethanol oxidation activity in pyrazole-treated rats...
  4. ncbi Prospective evaluation of the alcohol dehydrogenase gamma1/gamma2 gene polymorphism and risk of stroke
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Stroke 35:e39-42. 2004
    Genetic polymorphism of the alcohol dehydrogenase type 3 gene (ADH1C) has recently been associated with reduced risk of myocardial infarction. However, data on risk of stroke are not available.
  5. ncbi High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease
    Marie Westerlund
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    FEBS J 274:1212-23. 2007
    ..for the possible involvement of alcohol and aldehyde dehydrogenases (ADH; ALDH) by identifying genetic variants in ADH1C and ADH4 that associate with PD...