Gene Symbol: Clasp2
Description: cytoplasmic linker associated protein 2
Alias: CLIP-associating protein 2
Species: rat
Products:     Clasp2

Top Publications

  1. Mimori Kiyosue Y, Grigoriev I, Sasaki H, Matsui C, Akhmanova A, Tsukita S, et al. Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. Genes Cells. 2006;11:845-57 pubmed
    CLASP1 and CLASP2 are homologous mammalian proteins, which associate with the ends of growing microtubules, as well as the cell cortex and the kinetochores of mitotic chromosomes...
  2. Akhmanova A, Hoogenraad C, Drabek K, Stepanova T, Dortland B, Verkerk T, et al. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Cell. 2001;104:923-35 pubmed
    ..Antibody injections suggest that CLASP2 is required for the orientation of stabilized microtubules toward the leading edge...
  3. Drabek K, van Ham M, Stepanova T, Draegestein K, van Horssen R, Sayas C, et al. Role of CLASP2 in microtubule stabilization and the regulation of persistent motility. Curr Biol. 2006;16:2259-64 pubmed
    ..By using mouse embryonic fibroblasts (MEFs) in a wound-healing assay, we show here that CLASP2 is required for the formation of a stable, polarized MT array but that CLIP-170 and an APC-EB1 interaction are not ..
  4. Efimov A, Kharitonov A, Efimova N, Loncarek J, Miller P, Andreyeva N, et al. Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. Dev Cell. 2007;12:917-30 pubmed
    ..We propose that Golgi-emanating microtubules contribute to the asymmetric microtubule networks in polarized cells and support diverse processes including post-Golgi transport to the cell front. ..
  5. Zaoui K, Benseddik K, Daou P, Salaün D, Badache A. ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Proc Natl Acad Sci U S A. 2010;107:18517-22 pubmed publisher
    ..of GSK3 allows the relocalization of APC (adenomatous polyposis coli) and cytoplasmic linker-associated protein 2 (CLASP2), known MT-associated proteins, to the plasma membrane and ruffles...
  6. Maki T, Grimaldi A, Fuchigami S, Kaverina I, Hayashi I. CLASP2 Has Two Distinct TOG Domains That Contribute Differently to Microtubule Dynamics. J Mol Biol. 2015;427:2379-95 pubmed publisher
    ..Here, we report the crystal structures of the two TOG domains of CLASP2. Both domains consist of six HEAT repeats, which are similar to the canonical paddle-like tubulin-binding TOG ..
  7. Langlais P, Dillon J, Mengos A, Baluch D, Ardebili R, Miranda D, et al. Identification of a role for CLASP2 in insulin action. J Biol Chem. 2012;287:39245-53 pubmed publisher
    ..We present evidence that CLIP-associating protein 2 (CLASP2), a protein previously unassociated with insulin action, is responsive to insulin stimulation...
  8. Stehbens S, Paszek M, Pemble H, Ettinger A, Gierke S, Wittmann T. CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover. Nat Cell Biol. 2014;16:561-73 pubmed publisher
    ..We report that clustering of microtubule-associated CLASP1 and CLASP2 proteins around FAs temporally correlates with FA turnover...
  9. Liu J, Zhu B, Zhang G, Wang J, Tian W, Ju G, et al. Electric signals regulate directional migration of ventral midbrain derived dopaminergic neural progenitor cells via Wnt/GSK3β signaling. Exp Neurol. 2015;263:113-21 pubmed publisher
    ..of NPCs(vm), which is associated with the down-regulation of GSK3β phosphorylation, β-catenin activation and CLASP2 expression...

More Information


  1. Nakaya Y, Sukowati E, Sheng G. Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex. J Cell Biol. 2013;202:637-51 pubmed publisher
    ..We propose that epiblast-BM interaction requires CLASP- and Dystroglycan-mediated cortical microtubule anchoring, the disruption of which initiates gastrulation EMT. ..
  2. Ota H, Hikita T, Nishioka T, Matsumoto M, Ito J, Asai N, et al. Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain. Biochem Biophys Res Commun. 2013;442:16-21 pubmed publisher
    ..Our results suggest that Girdin and Girdin-interacting proteins control neuronal migration by regulating actin and/or microtubule dynamics. ..
  3. Efimova N, Grimaldi A, Bachmann A, Frye K, Zhu X, Feoktistov A, et al. Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner. J Cell Sci. 2014;127:5179-88 pubmed publisher
    ..Moreover, chimeric mitochondrially targeted CLASP2 recruits KIF1C, suggesting a transient CLASP-KIF1C association...
  4. Honnappa S, Gouveia S, Weisbrich A, Damberger F, Bhavesh N, Jawhari H, et al. An EB1-binding motif acts as a microtubule tip localization signal. Cell. 2009;138:366-76 pubmed publisher
    ..Our findings establish a general "microtubule tip localization signal" (MtLS) and delineate a unifying mechanism for this subcellular protein targeting process. ..
  5. Engel U, Zhan Y, Long J, Boyle S, Ballif B, Dorey K, et al. Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin. Cytoskeleton (Hoboken). 2014;71:195-209 pubmed publisher
    ..Using purified proteins, we find that Abl phosphorylation modulates direct binding between purified CLASP2 with both MTs and actin...