Gene Symbol: Ckm
Description: creatine kinase, M-type
Alias: CPK-M, Ckmm, creatine kinase M-type, M-CK, creatine kinase M chain, creatine kinase, muscle, creatine phosphokinase M-type
Species: rat
Products:     Ckm

Top Publications

  1. Benfield P, Zivin R, Miller L, Sowder R, Smythers G, Henderson L, et al. Isolation and sequence analysis of cDNA clones coding for rat skeletal muscle creatine kinase. J Biol Chem. 1984;259:14979-84 pubmed
    ..Sequences corresponding to the active site region of the protein, the initiation codon, the termination codon, and poly(A) addition signal have been identified. ..
  2. Park S, Zhang J, Ye Y, Ormaza S, Liang P, Bank A, et al. Myocardial creatine kinase expression after left ventricular assist device support. J Am Coll Cardiol. 2002;39:1773-9 pubmed
    ..The failure of CK-B expression to decrease suggests that abnormalities other than increased loading are responsible for the increase in CK-B expression in the failing heart. ..
  3. Diaz Nido J, Mizuno K, Nawa H, Marshak D. Regulation of protein kinase CK2 isoform expression during rat brain development. Cell Mol Biol Res. 1994;40:581-5 pubmed
    ..These results are consistent with a hypothetical role for CK2 isoforms containing alpha' subunits in the regulation of specific functions in fully differentiated neurons. ..
  4. Nguyen Q, Buskin J, Himeda C, Shield M, Hauschka S. Differences in the function of three conserved E-boxes of the muscle creatine kinase gene in cultured myocytes and in transgenic mouse skeletal and cardiac muscle. J Biol Chem. 2003;278:46494-505 pubmed
  5. Oriyanhan W, Miyamoto T, Yamazaki K, Miwa S, Takaba K, Ikeda T, et al. Regionally perfused taurine. Part I. Minimizes lactic acidosis and preserves CKMB and myocardial contractility after ischemia/reperfusion. Adv Exp Med Biol. 2006;583:271-88 pubmed
  6. Diguet N, Mallat Y, Ladouce R, Clodic G, Prola A, Tritsch E, et al. Muscle creatine kinase deficiency triggers both actin depolymerization and desmin disorganization by advanced glycation end products in dilated cardiomyopathy. J Biol Chem. 2011;286:35007-19 pubmed publisher
    ..Our results suggest that AGE may play an important role in DCM because they alter the organization of desmin filaments that normally support stress response and mitochondrial functions in cardiomyocytes. ..
  7. Fowler E, Benoist D, Drinkhill M, Stones R, Helmes M, Wüst R, et al. Decreased creatine kinase is linked to diastolic dysfunction in rats with right heart failure induced by pulmonary artery hypertension. J Mol Cell Cardiol. 2015;86:1-8 pubmed publisher
    ..Novel therapies for pulmonary artery hypertension are needed. Our data suggest that cardiac energetics would be a potential ventricular therapeutic target. ..
  8. Zhao C, Shang L, Wang W, Jacobs D. Myocellular creatine and creatine transporter serine phosphorylation after starvation. J Surg Res. 2002;105:10-6 pubmed
    ..05) and creatine uptake activity was significantly increased (P < 0.05) in starved animals. Increases in myocellular creatine content after starvation are associated with reduced serine phosphorylation of the creatine transporter. ..
  9. Araya R, Eckardt D, Maxeiner S, Krüger O, Theis M, Willecke K, et al. Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43. J Cell Sci. 2005;118:27-37 pubmed
    ..Thus, the expression of Cx45 and Cx43 is upregulated during skeletal muscle regeneration and Cx43 is required for normal myogenesis in vitro and adult muscle regeneration in vivo. ..

More Information


  1. Bulfield G, Siller W, Wight P, Moore K. X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc Natl Acad Sci U S A. 1984;81:1189-92 pubmed
    ..Linkage analysis with four X chromosome loci indicates that mdx maps in the Hq Bpa region of the mouse X chromosome. This gives a gene order of mdx-Tfm-Pgk-1-Ags, the same as for the equivalent genes on the human X chromosome. ..
  2. Zhao J, Schmieg F, Simmons D, Molloy G. Mouse p53 represses the rat brain creatine kinase gene but activates the rat muscle creatine kinase gene. Mol Cell Biol. 1994;14:8483-92 pubmed
    The creatine kinases (CK) regenerate ATP for cellular reactions with a high energy expenditure. While muscle CK (CKM) is expressed almost exclusively in adult skeletal and cardiac muscle, brain CK (CKB) expression is more widespread and ..
  3. McMullen C, Hayess K, Andrade F. Fatigue resistance of rat extraocular muscles does not depend on creatine kinase activity. BMC Physiol. 2005;5:12 pubmed
    ..Total AK activity was similar in EDL and extraocular muscles. These data indicate that the characteristic fatigue resistance of the extraocular muscles does not depend on CK activity. ..
  4. Callahan L, Supinski G. Diaphragm and cardiac mitochondrial creatine kinases are impaired in sepsis. J Appl Physiol (1985). 2007;102:44-53 pubmed
    ..001 and P = 0.009, respectively, comparing sepsis to control conditions). Our data indicate that endotoxin markedly impairs the MtCK-ATP transporter system; this phenomenon may have significant effects on diaphragm and cardiac function. ..
  5. Sher R, Aoyama C, Huebsch K, Ji S, Kerner J, Yang Y, et al. A rostrocaudal muscular dystrophy caused by a defect in choline kinase beta, the first enzyme in phosphatidylcholine biosynthesis. J Biol Chem. 2006;281:4938-48 pubmed
    ..The rmd mutant mouse offers the first demonstration of a defect in a phospholipid biosynthetic enzyme causing muscular dystrophy, representing a unique model for understanding mechanisms of muscle degeneration. ..