Gene Symbol: Cish
Description: cytokine inducible SH2-containing protein
Alias: Cis, cytokine-inducible SH2-containing protein, CIS-1, SOCS, cytokine inducible SH2-containing protein 1, suppressor of cytokine signaling
Mao Y, Ling P, Fitzgibbons T, McCowen K, Frick G, Bistrian B, et al
. Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo. Endocrinology. 1999;140:5505-15 pubmed
..Rat complementary DNAs for three members of the suppressor of cytokine signaling gene family were cloned [cytokine-inducible sequence (CIS), suppressor of cytokine signaling-2 (SOCS-..
Du L, Frick G, Tai L, Yoshimura A, Goodman H. Interaction of the growth hormone receptor with cytokine-induced Src homology domain 2 protein in rat adipocytes. Endocrinology. 2003;144:868-76 pubmed
..To assess the possible roles of cytokine-induced Src homology domain 2 (SH2) (CIS/SOCS) proteins in these transient responses, we studied the expression and disposition of CIS/SOCS proteins in rat ..
Anderson S, Barclay J, Fanning K, Kusters D, Waters M, Curlewis J. Mechanisms underlying the diminished sensitivity to prolactin negative feedback during lactation: reduced STAT5 signaling and up-regulation of cytokine-inducible SH2 domain-containing protein (CIS) expression in tuberoinfundibular dopaminergic neuron. Endocrinology. 2006;147:1195-202 pubmed
..mechanisms involved in reduced PRL signaling, we examined the expression of suppressors of cytokine signaling (SOCS) proteins...
Piessevaux J, Lavens D, Montoye T, Wauman J, Catteeuw D, Vandekerckhove J, et al
. Functional cross-modulation between SOCS proteins can stimulate cytokine signaling. J Biol Chem. 2006;281:32953-66 pubmed
b>SOCS (suppressors of cytokine signaling) proteins are negative regulators of cytokine signaling that function primarily at the receptor level...
Morales O, Faulds M, Lindgren U, Haldosén L. 1Alpha,25-dihydroxyvitamin D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus kinase (JAK2)/signal transducers and activators of transcription (STAT5) system in osteoblast-like cells. J Biol Chem. 2002;277:34879-84 pubmed
..In UMR 106 cells, GH induced the expression of the JAK/STAT negative regulatory proteins SOCS-3 and CIS. Interestingly, pretreatment with 1,25-(OH)(2)D(3) inhibited GH-induced expression of these proteins...
Chen S, Anderson P, Li L, Sjogren H, Wang P, Li S. Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells. Int Immunol. 2003;15:403-9 pubmed
..We reported recently that TCR stimulation induces the expression of cytokine-induced SH2 protein (CIS). The expression of CIS promotes TCR-mediated activation...
Kasagi Y, Tokita R, Nakata T, Imaki T, Minami S. Human growth hormone induces SOCS3 and CIS mRNA increase in the hypothalamic neurons of hypophysectomized rats. Endocr J. 2004;51:145-54 pubmed
..JAK2-STAT system in peripheral tissues, which in turn induces the expression of suppressors of cytokine signaling (SOCS) and/or cytokine-inducible SH2 protein (CIS) to achieve the attenuation of the signaling...
Ji K, Yang M, Jou I, Shong M, Joe E. Thrombin induces expression of cytokine-induced SH2 protein (CIS) in rat brain astrocytes: involvement of phospholipase A2, cyclooxygenase, and lipoxygenase. Glia. 2004;48:102-11 pubmed
..we found that thrombin induced a negative regulator of a cytokine signaling molecule, cytokine-induced SH2 protein (CIS), in rat brain astrocytes...
Landsman T, Waxman D. Role of the cytokine-induced SH2 domain-containing protein CIS in growth hormone receptor internalization. J Biol Chem. 2005;280:37471-80 pubmed
..specificity of CIS-R107K for blocking the GHR signaling inhibitory actions of CIS, but not those of other SOCS/CIS family members, these findings implicate CIS and the proteasome in the control of GHR internalization following ..