Gene Symbol: Cic
Description: capicua transcriptional repressor
Alias: protein capicua homolog, LOW QUALITY PROTEIN: protein capicua homolog, capicua homolog
Lim J, Crespo Barreto J, Jafar Nejad P, Bowman A, Richman R, Hill D, et al
. Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature. 2008;452:713-8 pubmed publisher
..This model provides mechanistic insight into the molecular pathogenesis of SCA1 as well as other polyglutamine diseases. ..
Lee C, Chan W, Scotting P. CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas. J Neurooncol. 2005;73:101-8 pubmed
..We have recently identified a mammalian gene, capicua (Cic), the ortholog of a Drosophila gene implicated in c-erbB (Egfr) signaling, which is predominantly expressed during ..
Crespo Barreto J, Fryer J, Shaw C, Orr H, Zoghbi H. Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis. PLoS Genet. 2010;6:e1001021 pubmed publisher
..Altogether, these data provide evidence that partial loss of Atxn1 function contributes to SCA1 pathogenesis and raise the possibility that loss-of-function mechanisms contribute to other dominantly inherited neurodegenerative diseases. ..
Lee Y, Fryer J, Kang H, Crespo Barreto J, Bowman A, Gao Y, et al
. ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Dev Cell. 2011;21:746-57 pubmed publisher
..that several Matrix metalloproteinase (Mmp) genes are overexpressed and that the transcriptional repressor Capicua (CIC) is destabilized in Atxn1L(-/-) lungs. Consistent with this, Cic deficiency causes lung alveolarization defect...
Damiano F, Gnoni G, Siculella L. Functional analysis of rat liver citrate carrier promoter: differential responsiveness to polyunsaturated fatty acids. Biochem J. 2009;417:561-71 pubmed publisher
b>CiC (citrate carrier), a mitochondrial membrane protein, plays an important metabolic role by transporting acetyl-CoA into the cytosol for fatty acid and cholesterol synthesis...