Gene Symbol: Chsy1
Description: chondroitin sulfate synthase 1
Alias: chondroitin sulfate synthase 1, carbohydrate (chondroitin) synthase 1
Species: rat
Products:     Chsy1

Top Publications

  1. Wilson D, Phamluong K, Lin W, Barck K, Carano R, Diehl L, et al. Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning. Dev Biol. 2012;363:413-25 pubmed publisher
    ..b>Chondroitin sulfate synthase 1 (Chsy1) is one of a family of enzymes that catalyze the extension of chondroitin and dermatan sulfate ..
  2. Kitagawa H, Uyama T, Sugahara K. Molecular cloning and expression of a human chondroitin synthase. J Biol Chem. 2001;276:38721-6 pubmed
    ..Thus, we demonstrated that analogous to human heparan sulfate polymerases, the single polypeptide chondroitin synthase possesses two glycosyltransferase activities required for chain polymerization. ..
  3. Tian J, Ling L, Shboul M, Lee H, O CONNOR B, Merriman B, et al. Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling. Am J Hum Genet. 2010;87:768-78 pubmed publisher
    ..High-throughput sequencing of all 177 candidate genes detected a truncating frameshift mutation in the gene CHSY1 encoding a chondroitin synthase with a Fringe domain...
  4. Ogawa H, Hatano S, Sugiura N, Nagai N, Sato T, Shimizu K, et al. Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development. PLoS ONE. 2012;7:e43806 pubmed publisher
    ..Our study demonstrates the distinct function of CSS1 and CSS2, providing a clue in the elucidation of the mechanism of CS biosynthesis. ..
  5. Titze J, Shakibaei M, Schafflhuber M, Schulze Tanzil G, Porst M, Schwind K, et al. Glycosaminoglycan polymerization may enable osmotically inactive Na+ storage in the skin. Am J Physiol Heart Circ Physiol. 2004;287:H203-8 pubmed
    ..Inhibition or disinhibition of GAG chain polymerization may regulate osmotically inactive Na(+) storage. ..
  6. Hu B, Shi C, Tian Y, Zhang Y, Xu C, Chen H, et al. TGF-β Induces Up-Regulation of Chondroitin Sulfate Synthase 1 (CHSY1) in Nucleus Pulposus Cells Through MAPK Signaling. Cell Physiol Biochem. 2015;37:793-804 pubmed publisher
    b>Chondroitin sulfate synthase 1 (CHSY1) is a glycosyltransferases involved in the biosynthesis of chondroitin and dermatan sulfate glycosaminoglycan (GAG)...