Gene Symbol: Chrnb3
Description: cholinergic receptor nicotinic beta 3 subunit
Alias: neuronal acetylcholine receptor subunit beta-3, cholinergic receptor, nicotinic beta 3, cholinergic receptor, nicotinic, beta 3 (neuronal), cholinergic receptor, nicotinic, beta polypeptide 3
Deneris E, Boulter J, Swanson L, Patrick J, Heinemann S. Beta 3: a new member of nicotinic acetylcholine receptor gene family is expressed in brain. J Biol Chem. 1989;264:6268-72 pubmed
..The pattern of beta 3 gene expression partially overlaps with that of the neuronal nAChR subunit genes alpha 3, alpha 4, or beta 2. These results lead us to propose that the beta 3 gene encodes a neuronal nAChR subunit. ..
Marritt A, Cox B, Yasuda R, McIntosh J, Xiao Y, Wolfe B, et al
. Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes. Mol Pharmacol. 2005;68:1656-68 pubmed
Cox B, Marritt A, Perry D, Kellar K. Transport of multiple nicotinic acetylcholine receptors in the rat optic nerve: high densities of receptors containing alpha6 and beta3 subunits. J Neurochem. 2008;105:1924-38 pubmed publisher
..Included among these subtypes is the highest percentage and density of alpha6- and beta3-containing nAChRs of any area of the rat CNS that has been reported. ..
Albuquerque E, Pereira E, Alkondon M, Rogers S. Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev. 2009;89:73-120 pubmed publisher
..Despite these numerous developments, our understanding of the contributions of specific neuronal nAChR subtypes to the many facets of physiology throughout the body remains in its infancy. ..
Luo S, Zhangsun D, Schroeder C, Zhu X, Hu Y, Wu Y, et al
. A novel ?4/7-conotoxin LvIA from Conus lividus that selectively blocks ?3?2 vs. ?6/?3?2?3 nicotinic acetylcholine receptors. FASEB J. 2014;28:1842-53 pubmed publisher
..4/7-CTx LvIA is a new, potent, selective ?3?2 nAChR antagonist, which will enable detailed studies of ?3?2 nAChR structure, function, and physiological roles...
Forsayeth J, Kobrin E. Formation of oligomers containing the beta3 and beta4 subunits of the rat nicotinic receptor. J Neurosci. 1997;17:1531-8 pubmed
..In this respect, nicotinic receptors that contain the beta3 subunit are structurally homologous to the muscle nicotinic receptor. ..
Hone A, Ruiz M, Scadden M, Christensen S, Gajewiak J, Azam L, et al
. Positional scanning mutagenesis of ?-conotoxin PeIA identifies critical residues that confer potency and selectivity for ?6/?3?2?3 and ?3?2 nicotinic acetylcholine receptors. J Biol Chem. 2013;288:25428-39 pubmed publisher
..The results of these studies provide molecular insights into designing ligands that selectively target ?6?2* nAChRs. ..