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Genomes and Genes
| Chrna7SummaryGene Symbol: Chrna7 Description: cholinergic receptor, nicotinic, alpha 7 (neuronal) Alias: BTX, NARAD, nAChRa7, C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha), C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha), bungarotoxin alpha, cholinergic receptor, nicotinic, alpha polypeptide 7, neuronal acetylcholine receptor subunit alpha-7, neuronal nicotinic acetycholine receptor alpha 7, nicotinic receptor alpha 7 subunit Species: rat Top Publications
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Publications
Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calciumP Seguela
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
J Neurosci 13:596-604. 1993..These results imply that alpha 7-containing receptors may play a role in activating calcium-dependent mechanisms in specific neuronal populations of the adult rat limbic system...- Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligandRyo Tatsumi
Pharmaceuticals Research Unit, Research and Development Division, Mitsubishi Pharma Corporation, 1000 Kamoshida cho, Aoba ku, Yokohama, Kanagawa 227 0033, Japan
J Med Chem 48:2678-86. 2005.... 
Cellular distribution of the nicotinic acetylcholine receptor alpha7 subunit in rat hippocampusJohn G Mielke
Department of Health Studies and Gerontology, Faculty of Applied Health Sciences, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
Neurosci Res 65:296-306. 2009..The nature of the internal pool of alpha7 subunits remains to be determined, but should have important implications for hippocampal activity...- Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloidSean Shaw
Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912 2500, USA
J Biol Chem 277:44920-4. 2002..These findings identify novel mechanisms of receptor interactions relevant to neuronal viability and suggest novel therapeutic strategies to optimize neuroprotection... 
Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortexRobert B Levy
New York University Center for Neural Science, New York, New York 10003, USA
J Neurosci 22:5001-15. 2002..These observations support the idea that acetylcholine receptors can aid in activating glutamatergic synapses and work together with AMPA receptors to mediate postsynaptic excitation throughout life...- Dendritic nicotinic receptors modulate backpropagating action potentials and long-term plasticity of interneuronsBalazs Rozsa
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
Eur J Neurosci 27:364-77. 2008..Here we provide evidence that long-term potentiation is indeed boosted by stimulation of dendritic alpha7-nAChRs. Our results suggest a new mechanism for a cholinergic switch in memory encoding and retrieval... - beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathologyH Y Wang
R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477 0776, USA
J Biol Chem 275:5626-32. 2000.... - Functional alpha7-containing nicotinic acetylcholine receptors localize to cell bodies and proximal dendrites in the rat substantia nigra pars reticulataOlga V Poisik
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and HumanServices, PO Box 12233, Research Triangle Park, NC 27709, USA
J Physiol 586:1365-78. 2008..Our data are paving the way to a better understanding of the physiological roles of nAChRs in the BG... - Serotoninergic dorsal raphe neurons possess functional postsynaptic nicotinic acetylcholine receptorsLuis Galindo-Charles
Department of Physiology, College of Medicine, Universidad Nacional Autonoma de Mexico, Mexico D F 04510
Synapse 62:601-15. 2008..The possible implications of these newly described nAChRs in various physiological processes and behavioral events, such as the wake-sleep cycle, are discussed... - Nicotinic acetylcholine receptor expression and regulation in the rat kidney after ischemia-reperfusion injuryMichael M Yeboah
The Susan and Herman Merinoff Center for Patient Oriented Research, The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
Am J Physiol Renal Physiol 295:F654-61. 2008..These results suggest that the alpha7nAChR plays an important role in the pathophysiology of renal I/R injury... - Glutamate-dopamine crosstalk in the rat prefrontal cortex is modulated by Alpha7 nicotinic receptors and potentiated by PNU-120596Phil D Livingstone
Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
J Mol Neurosci 40:172-6. 2010.... - Nicotinic acetylcholine receptors and modulation of learning in 4- and 27-month-old rabbitsJian Guo Li
Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19122, USA
Neuropsychopharmacology 33:2820-30. 2008..Results provide evidence for cortical as well as hippocampal nAChR modulation of delay eyeblink conditioning and demonstrate that more sensitive binding assays are required to assess nAChR effects in cerebellum... - Cardiovascular effects of activation of central alpha7 and alpha4beta2 nAChRs: a role for vasopressin in anaesthetized ratsC Moore
Department of Pharmacology, University College London, London, UK
Br J Pharmacol 153:1728-38. 2008..The availability of selective agonists for alpha7 (PSAB-OFP) and alpha4beta2 (TC-2559) nACh receptors allowed their role to be investigated... - Hippocampal interneurons co-express transcripts encoding the alpha7 nicotinic receptor subunit and the cannabinoid receptor 1M Morales
National Institute on Drug Abuse, Intramural Research Program, Cellular Neurophysiology Section, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Neuroscience 152:70-81. 2008.... - Effect of passive cigarette smoking on colonic alpha7-nicotinic acetylcholine receptors in TNBS-induced colitis in ratsYa P Sun
Department of Gastroenterology, Peking University First Hospital, Beijing, PR China
Digestion 76:181-7. 2007..The aim of this study was to investigate the underlying mechanism by examining the effect of cigarette smoking on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats... - Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitizationElaine A Gay
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services PO Box 12233, Research Triangle Park, NC 27709, USA
J Physiol 586:1105-15. 2008..Furthermore, these data suggest that W55 may be a potential target for modulatory agents operating via hydrophobic interactions... - Chronic, intermittent exposure to chlorpyrifos in rats: protracted effects on axonal transport, neurotrophin receptors, cholinergic markers, and information processingAlvin V Terry
Department of Pharmacology and Toxicology, University of Georgia College of Pharmacy, Augusta, Georgia 30912 2300, USA
J Pharmacol Exp Ther 322:1117-28. 2007..Such neurochemical changes may lead to deficits in information processing and cognitive function... - [Expression of alpha7-nAChR on rat hippocampal astrocytes in vivo and in vitro]Yan Wang
Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Nan Fang Yi Ke Da Xue Xue Bao 27:591-4. 2007..To investigate the expression of alpha7-nAChR on rat hippocampal astrocytes in vivo and in vitro... - Dendritic Ca2+ signalling due to activation of alpha 7-containing nicotinic acetylcholine receptors in rat hippocampal neuronsDmitriy Fayuk
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA
J Physiol 582:597-611. 2007..These results may have implications for the role that alpha 7 nAChRs have in regulating various signal transduction cascades, synaptic plasticity, and memory processes, via significant changes in [Ca(2+)]i levels... - Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neuronsGinny G Farías
Centro de Regulación Celular y Patología Joaquín V Luco, Millennium Institute for Fundamental and Applied Biology, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, 8331010 Santiago, Chile
J Neurosci 27:5313-25. 2007..Modulation by Wnt signaling may be essential for alpha7-nAChR expression and function in synapses... - Ethanol consumption produces changes in behavior and on hippocampal alpha7 and alpha4beta2 nicotinic receptorsNoemi Robles
Departament de Bioquimica i Biologia Molecular, Institut de Neurociencies, Facultat de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
J Mol Neurosci 30:119-20. 2006.... - Coexpression and spatial association of nicotinic acetylcholine receptor subunits alpha7 and alpha10 in rat sympathetic neuronsKatrin Susanne Lips
Institute for Anatomy and Cell Biology and University of Giessen Lung Center, Justus Liebig University, 35385 Giessen, Germany
J Mol Neurosci 30:15-6. 2006..1995; Jares-Erijman and Jovin, 2003)... - Endogenous methyl palmitate modulates nicotinic receptor-mediated transmission in the superior cervical ganglionHung Wen Lin
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
Proc Natl Acad Sci U S A 105:19526-31. 2008..Endogenous PAME appears to play a role in modulation of the autonomic ganglionic transmission and to complement the vasodilator effect of NO... - Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: central role for JAK2 activation of STAT3 and NF-kappaBMario B Marrero
Vascular Biology Center, Medical College of Georgia, Augusta, GA, USA
Brain Res 1256:1-7. 2009..Finally, the neuroprotective nicotine-induced production of Bcl-2 appears to fully counteract the Abeta (1-42)-induced apoptosis of PC12 cells by blocking Abeta (1-42)-induced mitochondrial release of cytosolic cytochrome C... - Investigating the role of protein folding and assembly in cell-type dependent expression of alpha7 nicotinic receptors using a green fluorescent protein chimeraH K Lee
Department of Pharmaceutical Science, Northeastern Univ, Boston, MA 02115, USA
Brain Res 1259:7-16. 2009..Further, C-terminal GFP-labeled alpha7 receptors decreased the efficiency of folding/assembly not only of chimeric subunits, but also wild-type subunits, suggesting that the C-terminal is an important domain for alpha7 receptor assembly... - A potential role of alpha-7 nicotinic acetylcholine receptor in cardiac angiogenesis in a pressure-overload rat modelMin Ni
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
J Pharmacol Sci 114:311-9. 2010..We conclude that expression of α7nAChR was increased at 16 weeks after coarctation, and this might be a compensatory response to decreased vagus nerve function and cardiac hypertrophy and may also play a role in cardiac angiogenesis... - Traumatic brain injury elicits similar alterations in α7 nicotinic receptor density in two different experimental modelsPeter Georg Hoffmeister
Institute of Radiopharmacy, Research Site Leipzig, Research Center Dresden Rossendorf, Permoserstraße 15, 04318, Leipzig, Germany
Neuromolecular Med 13:44-53. 2011..The alterations make the α7 nAChR a suitable target for drug development and neuroimaging after TBI... - Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β-sheetThomas J McCormack
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
J Physiol 588:4415-29. 2010..Our results indicate that rapid desensitization of the wild-type rat α7 nAChR is facilitated by the presence of the proline residue within the β9 strand... - Single particle tracking of alpha7 nicotinic AChR in hippocampal neurons reveals regulated confinement at glutamatergic and GABAergic perisynaptic sitesThomas Bürli
Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
PLoS ONE 5:e11507. 2010..Altogether, given their high Ca(2+)-permeability, our results suggest a possible role of alpha7-nAChR on interneurons for activating Ca(2+)-dependent signaling in the vicinity of GABAergic and glutamatergic synapses... - Pre-synaptic nicotinic receptors evoke endogenous glutamate and aspartate release from hippocampal synaptosomes by way of distinct coupling mechanismsS Zappettini
Department of Experimental Medicine, Section of Pharmacology and Toxicology Center of Excellence for Biomedical Research National Institute of Neuroscience, University of Genoa, Viale Cembrano 4, Genoa, Italy
Br J Pharmacol 161:1161-71. 2010..The present work aimed to investigate whether and through which mechanisms selective α7 and α4β2 nicotinic receptor (nAChR) agonists stimulate endogenous glutamate (GLU) and aspartate (ASP) release in rat hippocampus... - The frequency-dependence of the nicotine-induced inhibition of dopamine is controlled by the α7 nicotinic receptorAndrew T Seipel
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
J Neurochem 114:1659-66. 2010..The frequency dependence of the low dose nicotine inhibition therefore requires functional α7 nAChRs, and may arise from differing levels of endogenous acetylcholine evoked by the stimulation... - In vivo modulation of alpha7 nicotinic receptors on striatal glutamate release induced by anatoxin-AF Campos
Department of Functional Biology and Health Sciences, University of Vigo, Vigo, Spain
Neurochem Int 56:850-5. 2010..The increase of glutamate is followed by an increase on dopamine levels. These results represent a clear in vivo evidence of the striatal modulation of dopamine by means of glutamate release through alpha7 nicotinic receptors... - Functional expression of alpha 7 nicotinic acetylcholine receptors in human periodontal ligament fibroblasts and rat periodontal tissuesXiao Jing Wang
Department of Pediatric Dentistry, School of Stomatology, Fourth Military Medical University, Xi an, 710032, Shaanxi, China
Cell Tissue Res 340:347-55. 2010..ligament (PDL) cells were cultured with 10(-12) M of nicotine and/or 10(-9) M of alpha-bungarotoxin (alpha-Btx), a alpha 7 nAChR antagonist... - Alpha7 nAChR-mediated activation of MAP kinase pathways in PC12 cellsEarl J Gubbins
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6125, USA
Brain Res 1328:1-11. 2010..Such mechanisms may endow the alpha7 nAChRs with roles in modulating Ca(2+)-dependent intracellular second messenger events implicated in diverse aspects of cognition... - Distinct neural pathways mediate α7 nicotinic acetylcholine receptor-dependent activation of the forebrainMorten S Thomsen
Neurobiology Research Unit, Copenhagen University Hospital, DK2100 Copenhagen, Denmark
Cereb Cortex 20:2092-102. 2010.... - Second-by-second analysis of alpha 7 nicotine receptor regulation of glutamate release in the prefrontal cortex of awake ratsAsa Konradsson-Geuken
Department of Psychology, The Ohio State University, Columbus, Ohio 43210, USA
Synapse 63:1069-82. 2009..Furthermore, these data may also provide a mechanism underlying the recent focus on alpha 7 full and partial agonists as therapeutic agents in the treatment of cortically mediated cognitive deficits in schizophrenia... - Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitationBolin Cai
Laboratory of Anti inflammatory Signaling and Surgical Immunology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
J Cell Mol Med 13:3774-85. 2009..Our studies suggest that GTS provides significant advantages as compared with non-specific nicotinic agonists, and it could be a promising anti-inflammatory supplement to improve survival during resuscitation... - Inhibitory role of cholinergic system mediated via alpha7 nicotinic acetylcholine receptor in LPS-induced neuro-inflammationEthika Tyagi
Division of Pharmacology, Central Drug Research Institute, Lucknow, India
Innate Immun 16:3-13. 2010..This study suggests that the inhibitory role of the central cholinergic system on neuro-inflammation is mediated via alpha7 nicotinic acetylcholine receptor and muscarinic receptors are not involved... - Choline up-regulates BDNF and down-regulates TrkB neurotrophin receptor in rat cortical cell cultureJan Johansson
Department of Medicine and Public Health, Section of Pharmacology, University of Verona, Piazzale L Scuro, Verona, Italy
Neuroreport 20:828-32. 2009..It is speculated that a choline-induced change of alpha7 nAChRs activity may have resulted in the observed increase of BDNF level and down-regulation of the TrkB receptor... - Spatial and intracellular relationships between the alpha7 nicotinic acetylcholine receptor and the vesicular acetylcholine transporter in the prefrontal cortex of rat and mouseA M Duffy
Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, 407 East Street, New York, NY 10065, USA
Neuroscience 161:1091-103. 2009..These results suggest that in rodent PFC, the alpha7nAChR plays a major role in modulation of the postsynaptic excitation in spiny dendrites in contact with VAChT containing axons... - Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596Bopanna I Kalappa
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
PLoS ONE 5:e13964. 2010.... - Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cellsTsutomu Wada
Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
Endocrinology 148:790-9. 2007.... - Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cellsMark E Williams
Merck Research Laboratories, San Diego, California 92121, USA
J Biol Chem 280:1257-63. 2005..Thus, ric-3 appears to be necessary for proper folding and/or assembly of alpha7 receptors in HEK293 cells... - Paired-pulse potentiation of alpha7-containing nAChRs in rat hippocampal CA1 stratum radiatum interneuronesRebecca C Klein
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, USA
J Physiol 568:881-9. 2005..Thus, rat hippocampal alpha7-containing nAChRs possess a newly described phenomenon of paired-pulse potentiation that may be involved in regulating synaptic plasticity in the hippocampus... - Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathwayWouter J de Jonge
Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
Nat Immunol 6:844-51. 2005..We conclude that the vagal anti-inflammatory pathway acts by alpha7 subunit-mediated Jak2-STAT3 activation... - Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid raftsJin Oshikawa
Department of Physiology and Medicine, Yokohama City University School of Medicine, Yokohama, Japan
Am J Physiol Cell Physiol 285:C567-74. 2003..In addition, nAChR alpha 7 may regulate the AC activity via Ca2+ within lipid rafts... - Volatile organic compounds inhibit human and rat neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytesAmbuja S Bale
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 205:77-88. 2005..This toxicodynamic information will help decrease the uncertainty associated with animal to human extrapolations in the risk assessment of VOCs... - Nicotinic receptor alpha 7-subunits are coupled to the stimulation of nitric oxide synthase in rat dorsal root ganglion neuronsRainer Viktor Haberberger
Institute for Anatomy and Cell Biology, Justus Liebig University, Aulweg 123, 35385 Giessen, Germany
Histochem Cell Biol 120:173-81. 2003..The results show the presence of the alpha 7-nAChR subunit in nociceptive rat DRG neurons and provide evidence for its coupling to NOS activation, indicating a role of this pathway in the intraganglionic communication in sensory ganglia... - Ca2+ permeability of nicotinic acetylcholine receptors from rat dorsal root ganglion neuronesSergio Fucile
Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Roma, Italy
J Physiol 565:219-28. 2005..Finally, we report that Ca2+ influx through nAChRs in adult DRG neurones negatively modulated the TRPV1-mediated responses, representing a possible mechanism underlying the analgesic properties of nicotinic agonists on sensory neurones... - Postsynaptic alpha 4 beta 2 and alpha 7 type nicotinic acetylcholine receptors contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neuronsHiroaki Matsubayashi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami, Hiroshima 734 8551, Japan
Brain Res 1005:1-8. 2004..These results suggest that dopaminergic neurons in the substantia nigra receive excitatory cholinergic inputs that are mediated via at least two types of postsynaptic nicotinic receptors, namely alpha7 and alpha4beta2 subtypes... - Nicotinic acetylcholine receptor subtypes in nociceptive dorsal root ganglion neurons of the adult ratRainer Viktor Haberberger
Institute for Anatomy and Cell Biology Justus Liebig University, Aulweg 123, D 35385 Giessen, Germany
Auton Neurosci 113:32-42. 2004..These findings were corroborated by current recordings and calcium measurements, which revealed excitatory inward currents and calcium responses in capsaicin sensitive neurons... - Involvement of alpha7- and alpha4beta2-type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: a patch clamp and single-cell PCR study using acutely dissociated nigral neuronsHiroaki Matsubayashi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Brain Res Mol Brain Res 129:1-7. 2004..These results suggest that nicotine directly acts on postsynaptic alpha7- and alpha4beta2-type nicotinic acetylcholine receptors and induces inward current, which result in the excitation of dopaminergic neurons in the substantia nigra... - Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cellsJonathan M Beckel
Dept of Pharmacology, Univ of Pittsburgh School of Medicine, A1220 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
Am J Physiol Renal Physiol 290:F103-10. 2006..These results are the first indication that stimulation of nonneuronal nicotinic receptors in the bladder can affect micturition... - An alpha7 nicotinic acetylcholine receptor gain-of-function mutant that retains pharmacological fidelityAndon N Placzek
Department of Pharmacology and Therapeutics, P O Box 100267, University of Florida, Gainesville, Florida 32610 0267, USA
Mol Pharmacol 68:1863-76. 2005.... - Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and beta-amyloid1-42Daniel H S Lee
Biogen Inc, 14 Cambridge Ctr Bio6, 660, Cambridge, Massachusetts 02142, USA
J Neurobiol 55:25-30. 2003..Our data suggest a clear pharmacological distinction between Abeta(1-40) and Abeta(1-42)... - Functional somato-dendritic alpha7-containing nicotinic acetylcholine receptors in the rat basolateral amygdala complexRebecca C Klein
NIEHS, F2 08, PO Box 12233, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
J Physiol 576:865-72. 2006..This is the first report demonstrating the presence of functional nAChR-mediated current responses from rat amygdala slices, where they may be playing a significant role in fear and aversively motivated memory... - The magnitude of alpha7 nicotinic receptor currents in rat hippocampal neurons is dependent upon GABAergic activity and depolarizationHélio R Santos
Departmento de Farmacologia Básica e Clínica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Rio de Janeiro, Brazil
J Pharmacol Exp Ther 319:376-85. 2006..These data indicate that alpha7(*)-gated currents in hippocampal neurons are regulated by GABAergic activity and suggest that depolarization-induced GABA release may underlie the effect of increased extracellular KCl... - Monoamine uptake inhibitors block alpha7-nAChR-mediated cerebral nitrergic neurogenic vasodilationCheng Long
Department of Pharmacology, School of Medicine, Southern Illinois University, Springfield, Illinois, USA
Am J Physiol Heart Circ Physiol 291:H202-9. 2006..These results further support the hypothesis of axo-axonal interaction in nitrergic regulation of cerebral vascular tone... - Nicotinic acetylcholine receptor subtypes in rat superior cervical ganglion neurons as studied by sequential application of two alpha-subunit-specific antibodiesL P Voitenko
Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, 4, Bogomoletz str, 01024 Kiev, Ukraine
Neurosci Lett 303:37-40. 2001.... - Alpha 7 nicotinic receptor subunit is present on serotonin neurons projecting to hippocampus and septumSusana Aznar
Neurobiology Research Unit, Copenhagen University Hospital, 2100 Copenhagen, Denmark
Synapse 55:196-200. 2005..A low degree of colocalization between alpha-bungarotoxin and serotonin-positive neurons suggest that the alpha 7 subunit may be transported anterogradely to the serotonergic axonal terminals... - Role of the large cytoplasmic loop of the alpha 7 neuronal nicotinic acetylcholine receptor subunit in receptor expression and functionLuis M Valor
Instituto de Neurociencias, Universidad Miguel Hernandez CSIC, Campus de San Juan, 03550 San Juan Alicante Spain
Biochemistry 41:7931-8. 2002.... - Involvement of alpha 7 nicotinic acetylcholine receptors in gene expression of dopamine biosynthetic enzymes in rat brainLidia Serova
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
J Pharmacol Exp Ther 303:896-903. 2002..The findings indicate that nicotine may regulate dopamine biosynthesis by alterations in gene expression of TH and its cofactor. The alpha7 nAChRs are involved in mediating these effects of nicotine... - Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channelsSerguei S Khiroug
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
J Physiol 540:425-34. 2002..This co-assembly may help to explain nAChR channel diversity in rat hippocampal interneurons, and perhaps in other areas of the nervous system... - Nicotine induction of theta frequency oscillations in rodent hippocampus in vitroC B Lu
Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
Neuroscience 166:84-93. 2010..In conclusion, theta activity in the hippocampus may be promoted by tonic stimulation of alpha7* nAChRs, possibly via selective stimulation of theta-preferring interneurons in the hippocampus that express post-synaptic alpha7* nAChRs... - Fast synaptic transmission mediated by alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in lamina X neurones of neonatal rat spinal cordA Bradaia
Laboratoire de Neurophysiologie Cellulaire et Intégrée, UMR 7519 CNRS ULP, 21 rue R Descartes, 67084 Strasbourg Cedex, France
J Physiol 544:727-39. 2002..This is the first demonstration in a mammalian spinal cord preparation of a fast cholinergic neurotransmission in which alpha-BgT-sensitive nicotinic receptors are involved... - The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channelsEmily G Severance
Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, MDC 9, Tampa, FL 33612 4799, USA
Mol Pharmacol 66:420-9. 2004..Furthermore, the distribution of the alpha7-2 isoform is not limited to peripheral neurons... - Characterization of a rat neuronal nicotinic acetylcholine receptor alpha7 promoterU Nagavarapu
Department of Neuroscience, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
J Biol Chem 276:16749-57. 2001..Several transcription factors interact in close proximity to control expression of the rat alpha7 nicotinic receptor gene... - Involvement of DDAH/ADMA/NOS pathway in nicotine-induced endothelial dysfunctionDe Jian Jiang
Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, China
Biochem Biophys Res Commun 349:683-93. 2006..In conclusion, nicotine modulates DDAH/ADMA/NOS pathway of endothelial cell via activation of alpha7 nAChR, which may be involved in endothelial dysfunction associated to smoking... - Functional properties of internalization-deficient P2X4 receptors reveal a novel mechanism of ligand-gated channel facilitation by ivermectinEstelle Toulme
Centre National de la Recherche Scientifique Unité Mixte de Recherche 5543, Université Victor Segalen Bordeaux2, France
Mol Pharmacol 69:576-87. 2006.... - Expression of alpha-7 and alpha-4 nicotinic acetylcholine receptors by GABAergic neurons of rostral ventral medulla and caudal ponsOzra Dehkordi
Department of Surgery, Howard University Hospital Washington, DC 20060, USA
Brain Res 1185:95-102. 2007..The expression of alpha-4 and alpha-7 nAChRs by GAD67-ir cells suggests nicotinic cholinergic modulation of GABAergic signaling at these ventrolateral pontomedullary sites... - Expression of nicotinic receptors on primary cultures of rat astrocytes and up-regulation of the alpha7, alpha4 and beta2 subunits in response to nanomolar concentrations of the beta-amyloid peptide(1-42)Jin Xiu
Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, B84, S 14186 Stockholm, Sweden
Neurochem Int 47:281-90. 2005..We propose that the enhanced expression of alpha7, alpha4 and beta2 nAChRs by astrocytes stimulated directly by nanomolar concentrations of Abeta(1-42) might be related to ongoing defensive or compensative mechanisms... - A new model for the study of high-K(+)-induced preconditioning in cultured neurones: role of N-methyl-d-aspartate and alpha7-nicotinic acetylcholine receptorsR van Rensburg
Centre for Integrative Neuroscience CINS, School of Biological and Biomedical Sciences, Science Park, South Road, Durham University, Durham, County Durham DH1 3LE, United Kingdom
J Neurosci Methods 177:311-6. 2009..Finally, preconditioning was shown to be dependent upon N-methyl-d-aspartate (NMDA), CAM-kinase II signalling and alpha7-nicotinic (alpha7 nACh) receptor function, which is analogous to in vivo preconditioning induced by various stimuli... - Alpha-7 and alpha-4 nicotinic receptor subunit immunoreactivity in genioglossus muscle motoneuronsOzra Dehkordi
Department of Surgery, Howard University Hospital, 2041 Georgia Avenue, NW, Washington, DC 20060, USA
Respir Physiol Neurobiol 145:153-61. 2005..90% in rostral areas (P=0.074). These results demonstrate that nAChR immunoreactivity is present in genioglossal motoneurons and suggest a role for alpha-7 and alpha-4 subunits containing nAChRs in the regulation of upper airway patency... - alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate dopamine release in vitro and in vivo in the rat prefrontal cortexPhil D Livingstone
Department of Biology and Biochemistry, University of Bath, Bath, UK
Eur J Neurosci 29:539-50. 2009..Through their distinct actions on dopamine release, these nAChR subtypes could contribute to executive function, making them specific therapeutic targets for conditions such as schizophrenia and attention deficit hyperactivity disorder... - Indirect modulation by alpha7 nicotinic acetylcholine receptors of noradrenaline release in rat hippocampal slices: interaction with glutamate and GABA systems and effect of nicotine withdrawalJacques Barik
Department of Biology and Biochemistry, University of Bath, UK
Mol Pharmacol 69:618-28. 2006..alpha7 nAChR responses were selectively and transiently up-regulated after 3 days of withdrawal. This functional up-regulation could contribute to the withdrawal effects of nicotine... - Excitation of rat hippocampal interneurons via modulation of endogenous agonist activity at the alpha7 nicotinic ACh receptorM H Selina Mok
Schizophrenia and Bipolar Neurophysiology and Pharmacology, Psychiatry CEDD, GlaxoSmithKline, Harlow, Essex CM19 5AW, UK
J Physiol 574:699-710. 2006.... - Desensitization of alpha7 nicotinic receptors potentiated the inhibitory effect on M-current induced by stimulation of muscarinic receptors in rat superior cervical ganglion neuronsX Yin
Beijing Institute of Pharmacology and Toxicology, Beijing, China
J Neural Transm 112:1133-48. 2005..These results indicated that desensitization of alpha7-nAChRs could potentiate the inhibitory effect on M-current by stimulation of mAChRs with their agonist... - Analysis of gene expression profiles in rat hippocampus following treatment with nicotine and an alpha7 nAChR selective agonistJeffrey F Waring
Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
Neurosci Res 60:266-74. 2008..Overall, our results identify gene expression changes that may contribute to further defining the roles of nAChR activation in cognitive function... - Upregulation of neuronal nicotinic receptor subunits alpha4, beta2, and alpha7 in transgenic mice overexpressing human acetylcholinesteraseMarie M Svedberg
Karolinska Institutet, Neurotec, Division of Molecular Neuropharmacology, Huddinge University Hospital, Stockholm, Sweden
J Mol Neurosci 18:211-22. 2002.... - Nicotinic activity stabilizes convergence of nicotinic and GABAergic synapses on filopodia of hippocampal interneuronsWagner M Zago
Neurobiology Section, Division of Biology, 0357, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0357, USA
Mol Cell Neurosci 31:549-59. 2006..The results indicate a convergence of nicotinic and GABAergic input at specific sites on developing hippocampal interneurons and suggest that synaptic activity helps stabilize the nicotinic contribution... - Microglial alpha7 nicotinic acetylcholine receptors drive a phospholipase C/IP3 pathway and modulate the cell activation toward a neuroprotective roleTomohisa Suzuki
Department of Pharmacology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
J Neurosci Res 83:1461-70. 2006..This novel alpha7 nAChR signal may be involved in the nicotine modification of microglia activation towards a neuroprotective role by suppressing the inflammatory state and strengthening the protective function... - Involvement of the alpha 7 subunit of the nicotinic receptor in morphogenic and trophic effects of acetylcholine on embryonic rat spinal motoneurons in cultureChristelle Catone
CNRS Groupe d Etude des Réseaux Moteurs GERM, Marseille, France
J Neurosci Res 72:46-53. 2003..These effects are directly linked to the membrane expression level of alpha7 protein. Indeed, the lower the alpha7 expression, the lower the inhibition of axonal growth (i.e., axonal elongation) and the lower the MN survival... - The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptorMine Sibel Gurun
Department of Pharmacology and Clinical Pharmacology, Uludag University, Gorukle, Bursa, Turkey
Anesth Analg 108:1680-7. 2009..Previous reports also suggest that the peripheral cholinergic system has an antiinflammatory role mediated by alpha7nAChRs on macrophages... - Precise localization of alpha7 nicotinic acetylcholine receptors on glutamatergic axon terminals in the rat ventral tegmental areaIan W Jones
Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
J Neurosci 24:11244-52. 2004..alpha7 nAChRs were not associated with cholinergic synapses, consistent with their activation by a paracrine mode of acetylcholine or choline delivery...
Research Grants
- Carotid Body Chemoreception: Mechanism & DevelopmentDAVID DONNELLY; Fiscal Year: 2006..If supported, the model should lead to a pharmacologic targeting of these processes for the improved treatment of apnea and/or dyspnea. ..
- Mechanism of perinatal-hyperoxic suppression of chemoreceptor functionDAVID DONNELLY; Fiscal Year: 2007..Since hyperoxia is extensively used clinically in newborn and, especially in premature infants, these results are important in understanding physiologic alterations caused by this intervention. ..
- Mechanism of perinatal-hyperoxic suppression of chemoreceptor functionDavid F Donnelly; Fiscal Year: 2010..Since hyperoxia is extensively used clinically in newborn and, especially in premature infants, these results are important in understanding physiologic alterations caused by this intervention. ..