Chrna7

Summary

Gene Symbol: Chrna7
Description: cholinergic receptor, nicotinic, alpha 7 (neuronal)
Alias: BTX, NARAD, nAChRa7, C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha), C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha), bungarotoxin alpha, cholinergic receptor, nicotinic, alpha polypeptide 7, neuronal acetylcholine receptor subunit alpha-7, neuronal nicotinic acetycholine receptor alpha 7, nicotinic receptor alpha 7 subunit
Species: rat

Top Publications

  1. pmc Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596
    Bopanna I Kalappa
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 5:e13964. 2010
  2. pmc Pre-synaptic nicotinic receptors evoke endogenous glutamate and aspartate release from hippocampal synaptosomes by way of distinct coupling mechanisms
    S Zappettini
    Department of Experimental Medicine, Section of Pharmacology and Toxicology Center of Excellence for Biomedical Research National Institute of Neuroscience, University of Genoa, Viale Cembrano 4, Genoa, Italy
    Br J Pharmacol 161:1161-71. 2010
  3. pmc Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels
    Serguei S Khiroug
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 540:425-34. 2002
  4. ncbi Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and beta-amyloid1-42
    Daniel H S Lee
    Biogen Inc, 14 Cambridge Ctr Bio6, 660, Cambridge, Massachusetts 02142, USA
    J Neurobiol 55:25-30. 2003
  5. ncbi Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium
    P Seguela
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
    J Neurosci 13:596-604. 1993
  6. doi Cellular distribution of the nicotinic acetylcholine receptor alpha7 subunit in rat hippocampus
    John G Mielke
    Department of Health Studies and Gerontology, Faculty of Applied Health Sciences, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
    Neurosci Res 65:296-306. 2009
  7. ncbi Expression of alpha-7 and alpha-4 nicotinic acetylcholine receptors by GABAergic neurons of rostral ventral medulla and caudal pons
    Ozra Dehkordi
    Department of Surgery, Howard University Hospital Washington, DC 20060, USA
    Brain Res 1185:95-102. 2007
  8. pmc Presynaptic nicotinic α7 and non-α7 receptors stimulate endogenous GABA release from rat hippocampal synaptosomes through two mechanisms of action
    Stefania Zappettini
    Section of Pharmacology and Toxicology, Department of Experimental Medicine, University of Genoa, Genoa, Italy
    PLoS ONE 6:e16911. 2011
  9. pmc Dual effect of beta-amyloid on α7 and α4β2 nicotinic receptors controlling the release of glutamate, aspartate and GABA in rat hippocampus
    Elisa Mura
    Department of Drug Sciences, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    PLoS ONE 7:e29661. 2012
  10. doi Nicotinic acetylcholine receptors and modulation of learning in 4- and 27-month-old rabbits
    Jian Guo Li
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19122, USA
    Neuropsychopharmacology 33:2820-30. 2008

Scientific Experts

Detail Information

Publications93

  1. pmc Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596
    Bopanna I Kalappa
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 5:e13964. 2010
    ....
  2. pmc Pre-synaptic nicotinic receptors evoke endogenous glutamate and aspartate release from hippocampal synaptosomes by way of distinct coupling mechanisms
    S Zappettini
    Department of Experimental Medicine, Section of Pharmacology and Toxicology Center of Excellence for Biomedical Research National Institute of Neuroscience, University of Genoa, Viale Cembrano 4, Genoa, Italy
    Br J Pharmacol 161:1161-71. 2010
    ..The present work aimed to investigate whether and through which mechanisms selective α7 and α4β2 nicotinic receptor (nAChR) agonists stimulate endogenous glutamate (GLU) and aspartate (ASP) release in rat hippocampus...
  3. pmc Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels
    Serguei S Khiroug
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 540:425-34. 2002
    ..This co-assembly may help to explain nAChR channel diversity in rat hippocampal interneurons, and perhaps in other areas of the nervous system...
  4. ncbi Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and beta-amyloid1-42
    Daniel H S Lee
    Biogen Inc, 14 Cambridge Ctr Bio6, 660, Cambridge, Massachusetts 02142, USA
    J Neurobiol 55:25-30. 2003
    ..Our data suggest a clear pharmacological distinction between Abeta(1-40) and Abeta(1-42)...
  5. ncbi Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium
    P Seguela
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
    J Neurosci 13:596-604. 1993
    ..These results imply that alpha 7-containing receptors may play a role in activating calcium-dependent mechanisms in specific neuronal populations of the adult rat limbic system...
  6. doi Cellular distribution of the nicotinic acetylcholine receptor alpha7 subunit in rat hippocampus
    John G Mielke
    Department of Health Studies and Gerontology, Faculty of Applied Health Sciences, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
    Neurosci Res 65:296-306. 2009
    ..The nature of the internal pool of alpha7 subunits remains to be determined, but should have important implications for hippocampal activity...
  7. ncbi Expression of alpha-7 and alpha-4 nicotinic acetylcholine receptors by GABAergic neurons of rostral ventral medulla and caudal pons
    Ozra Dehkordi
    Department of Surgery, Howard University Hospital Washington, DC 20060, USA
    Brain Res 1185:95-102. 2007
    ..The expression of alpha-4 and alpha-7 nAChRs by GAD67-ir cells suggests nicotinic cholinergic modulation of GABAergic signaling at these ventrolateral pontomedullary sites...
  8. pmc Presynaptic nicotinic α7 and non-α7 receptors stimulate endogenous GABA release from rat hippocampal synaptosomes through two mechanisms of action
    Stefania Zappettini
    Section of Pharmacology and Toxicology, Department of Experimental Medicine, University of Genoa, Genoa, Italy
    PLoS ONE 6:e16911. 2011
    ....
  9. pmc Dual effect of beta-amyloid on α7 and α4β2 nicotinic receptors controlling the release of glutamate, aspartate and GABA in rat hippocampus
    Elisa Mura
    Department of Drug Sciences, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    PLoS ONE 7:e29661. 2012
    ..Particularly, we focused on some neurotransmitters that are usually involved in learning and memory: glutamate, aspartate and GABA...
  10. doi Nicotinic acetylcholine receptors and modulation of learning in 4- and 27-month-old rabbits
    Jian Guo Li
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19122, USA
    Neuropsychopharmacology 33:2820-30. 2008
    ..Results provide evidence for cortical as well as hippocampal nAChR modulation of delay eyeblink conditioning and demonstrate that more sensitive binding assays are required to assess nAChR effects in cerebellum...
  11. pmc Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex
    Robert B Levy
    New York University Center for Neural Science, New York, New York 10003, USA
    J Neurosci 22:5001-15. 2002
    ..These observations support the idea that acetylcholine receptors can aid in activating glutamatergic synapses and work together with AMPA receptors to mediate postsynaptic excitation throughout life...
  12. ncbi Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid
    Sean Shaw
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912 2500, USA
    J Biol Chem 277:44920-4. 2002
    ..These findings identify novel mechanisms of receptor interactions relevant to neuronal viability and suggest novel therapeutic strategies to optimize neuroprotection...
  13. doi Dendritic nicotinic receptors modulate backpropagating action potentials and long-term plasticity of interneurons
    Balazs Rozsa
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Eur J Neurosci 27:364-77. 2008
    ..Here we provide evidence that long-term potentiation is indeed boosted by stimulation of dendritic alpha7-nAChRs. Our results suggest a new mechanism for a cholinergic switch in memory encoding and retrieval...
  14. doi Functional expression of the α7 and α4-containing nicotinic acetylcholine receptors on the neonatal rat carotid body
    Rodrigo C Meza
    Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Neurochem Int 60:115-24. 2012
    ..Therefore, our results suggest that both nAChR subtypes contribute to the cholinergic nicotinic regulation of catecholamine signaling in the carotid body system...
  15. pmc The α7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membrane
    José O Colón-Sáez
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    J Physiol 589:3163-74. 2011
    ..These data provide new insights into themechanism of desensitization of α7 nAChRs by providing evidence that the lipid composition of the plasma membrane can modulate the activity of the α7 nAChRs...
  16. ncbi Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand
    Ryo Tatsumi
    Pharmaceuticals Research Unit, Research and Development Division, Mitsubishi Pharma Corporation, 1000 Kamoshida cho, Aoba ku, Yokohama, Kanagawa 227 0033, Japan
    J Med Chem 48:2678-86. 2005
    ....
  17. pmc Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596
    Victor V Uteshev
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 7:e32951. 2012
    ..01 mV/µm). These research efforts could benefit optimization of potential α7-PAM-based therapies...
  18. pmc Nicotinic agonist-induced improvement of vigilance in mice in the 5-choice continuous performance test
    Jared W Young
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA 92093 0804, United States
    Behav Brain Res 240:119-33. 2013
    ..Future studies using more selective agonists may result in more robust improvements in performance...
  19. ncbi beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology
    H Y Wang
    R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477 0776, USA
    J Biol Chem 275:5626-32. 2000
    ....
  20. pmc Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors
    Gracia X J Quek
    Faculty of Pharmacy, The University of Sydney, Australia
    ACS Chem Neurosci 1:796-809. 2010
    ..Thus our data reveal distinct pharmacological differences between different nAChR subtypes and also identify a specific binding site for a noncompetitive channel blocker...
  21. doi Cell-specific effects on surface α7 nicotinic receptor expression revealed by over-expression and knockdown of rat RIC3 protein
    Thomas M Koperniak
    Department of Pharmaceutical Science, Northeastern University, Boston, MA 02115, USA
    J Neurochem 124:300-9. 2013
    ..These results suggest GH4C1 cells may possess unknown chaperone(s) allowing high surface α7 expression in the absence of known RIC3 splice variants...
  22. pmc Atomic force microscopy to characterize binding properties of α7-containing nicotinic acetylcholine receptors on neurokinin-1 receptor-expressing medullary respiratory neurons
    Catharine G Clark
    Dalton Cardiovascular Research Center and Departments of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Exp Physiol 98:415-24. 2013
    ..Moreover, these data demonstrate that nicotine exposure decreases the binding probability of α7 subunit-containing nAChRs...
  23. doi Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: central role for JAK2 activation of STAT3 and NF-kappaB
    Mario B Marrero
    Vascular Biology Center, Medical College of Georgia, Augusta, GA, USA
    Brain Res 1256:1-7. 2009
    ..Finally, the neuroprotective nicotine-induced production of Bcl-2 appears to fully counteract the Abeta (1-42)-induced apoptosis of PC12 cells by blocking Abeta (1-42)-induced mitochondrial release of cytosolic cytochrome C...
  24. doi Investigating the role of protein folding and assembly in cell-type dependent expression of alpha7 nicotinic receptors using a green fluorescent protein chimera
    H K Lee
    Department of Pharmaceutical Science, Northeastern Univ, Boston, MA 02115, USA
    Brain Res 1259:7-16. 2009
    ..Further, C-terminal GFP-labeled alpha7 receptors decreased the efficiency of folding/assembly not only of chimeric subunits, but also wild-type subunits, suggesting that the C-terminal is an important domain for alpha7 receptor assembly...
  25. pmc Spatial and intracellular relationships between the alpha7 nicotinic acetylcholine receptor and the vesicular acetylcholine transporter in the prefrontal cortex of rat and mouse
    A M Duffy
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, 407 East Street, New York, NY 10065, USA
    Neuroscience 161:1091-103. 2009
    ..These results suggest that in rodent PFC, the alpha7nAChR plays a major role in modulation of the postsynaptic excitation in spiny dendrites in contact with VAChT containing axons...
  26. doi Choline up-regulates BDNF and down-regulates TrkB neurotrophin receptor in rat cortical cell culture
    Jan Johansson
    Department of Medicine and Public Health, Section of Pharmacology, University of Verona, Piazzale L Scuro, Verona, Italy
    Neuroreport 20:828-32. 2009
    ..It is speculated that a choline-induced change of alpha7 nAChRs activity may have resulted in the observed increase of BDNF level and down-regulation of the TrkB receptor...
  27. doi Inhibitory role of cholinergic system mediated via alpha7 nicotinic acetylcholine receptor in LPS-induced neuro-inflammation
    Ethika Tyagi
    Division of Pharmacology, Central Drug Research Institute, Lucknow, India
    Innate Immun 16:3-13. 2010
    ..This study suggests that the inhibitory role of the central cholinergic system on neuro-inflammation is mediated via alpha7 nicotinic acetylcholine receptor and muscarinic receptors are not involved...
  28. pmc Endogenous methyl palmitate modulates nicotinic receptor-mediated transmission in the superior cervical ganglion
    Hung Wen Lin
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
    Proc Natl Acad Sci U S A 105:19526-31. 2008
    ..Endogenous PAME appears to play a role in modulation of the autonomic ganglionic transmission and to complement the vasodilator effect of NO...
  29. pmc Nicotinic acetylcholine receptor expression and regulation in the rat kidney after ischemia-reperfusion injury
    Michael M Yeboah
    The Susan and Herman Merinoff Center for Patient Oriented Research, The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Am J Physiol Renal Physiol 295:F654-61. 2008
    ..These results suggest that the alpha7nAChR plays an important role in the pathophysiology of renal I/R injury...
  30. pmc Functional alpha7-containing nicotinic acetylcholine receptors localize to cell bodies and proximal dendrites in the rat substantia nigra pars reticulata
    Olga V Poisik
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and HumanServices, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 586:1365-78. 2008
    ..Our data are paving the way to a better understanding of the physiological roles of nAChRs in the BG...
  31. pmc Cardiovascular effects of activation of central alpha7 and alpha4beta2 nAChRs: a role for vasopressin in anaesthetized rats
    C Moore
    Department of Pharmacology, University College London, London, UK
    Br J Pharmacol 153:1728-38. 2008
    ..The availability of selective agonists for alpha7 (PSAB-OFP) and alpha4beta2 (TC-2559) nACh receptors allowed their role to be investigated...
  32. ncbi Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts
    Jin Oshikawa
    Department of Physiology and Medicine, Yokohama City University School of Medicine, Yokohama, Japan
    Am J Physiol Cell Physiol 285:C567-74. 2003
    ..In addition, nAChR alpha 7 may regulate the AC activity via Ca2+ within lipid rafts...
  33. pmc Hippocampal interneurons co-express transcripts encoding the alpha7 nicotinic receptor subunit and the cannabinoid receptor 1
    M Morales
    National Institute on Drug Abuse, Intramural Research Program, Cellular Neurophysiology Section, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 152:70-81. 2008
    ....
  34. ncbi Nicotinic receptor alpha 7-subunits are coupled to the stimulation of nitric oxide synthase in rat dorsal root ganglion neurons
    Rainer Viktor Haberberger
    Institute for Anatomy and Cell Biology, Justus Liebig University, Aulweg 123, 35385 Giessen, Germany
    Histochem Cell Biol 120:173-81. 2003
    ..The results show the presence of the alpha 7-nAChR subunit in nociceptive rat DRG neurons and provide evidence for its coupling to NOS activation, indicating a role of this pathway in the intraganglionic communication in sensory ganglia...
  35. pmc Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation
    Bolin Cai
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Cell Mol Med 13:3774-85. 2009
    ..Our studies suggest that GTS provides significant advantages as compared with non-specific nicotinic agonists, and it could be a promising anti-inflammatory supplement to improve survival during resuscitation...
  36. pmc Second-by-second analysis of alpha 7 nicotine receptor regulation of glutamate release in the prefrontal cortex of awake rats
    Asa Konradsson-Geuken
    Department of Psychology, The Ohio State University, Columbus, Ohio 43210, USA
    Synapse 63:1069-82. 2009
    ..Furthermore, these data may also provide a mechanism underlying the recent focus on alpha 7 full and partial agonists as therapeutic agents in the treatment of cortically mediated cognitive deficits in schizophrenia...
  37. doi Glutamate-dopamine crosstalk in the rat prefrontal cortex is modulated by Alpha7 nicotinic receptors and potentiated by PNU-120596
    Phil D Livingstone
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    J Mol Neurosci 40:172-6. 2010
    ....
  38. ncbi Nicotinic acetylcholine receptor subtypes in rat superior cervical ganglion neurons as studied by sequential application of two alpha-subunit-specific antibodies
    L P Voitenko
    Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, 4, Bogomoletz str, 01024 Kiev, Ukraine
    Neurosci Lett 303:37-40. 2001
    ....
  39. ncbi Role of the large cytoplasmic loop of the alpha 7 neuronal nicotinic acetylcholine receptor subunit in receptor expression and function
    Luis M Valor
    Instituto de Neurociencias, Universidad Miguel Hernandez CSIC, Campus de San Juan, 03550 San Juan Alicante Spain
    Biochemistry 41:7931-8. 2002
    ....
  40. ncbi A potential role of alpha-7 nicotinic acetylcholine receptor in cardiac angiogenesis in a pressure-overload rat model
    Min Ni
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
    J Pharmacol Sci 114:311-9. 2010
    ..We conclude that expression of α7nAChR was increased at 16 weeks after coarctation, and this might be a compensatory response to decreased vagus nerve function and cardiac hypertrophy and may also play a role in cardiac angiogenesis...
  41. ncbi [Expression of alpha7-nAChR on rat hippocampal astrocytes in vivo and in vitro]
    Yan Wang
    Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:591-4. 2007
    ..To investigate the expression of alpha7-nAChR on rat hippocampal astrocytes in vivo and in vitro...
  42. pmc Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β-sheet
    Thomas J McCormack
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    J Physiol 588:4415-29. 2010
    ..Our results indicate that rapid desensitization of the wild-type rat α7 nAChR is facilitated by the presence of the proline residue within the β9 strand...
  43. pmc Single particle tracking of alpha7 nicotinic AChR in hippocampal neurons reveals regulated confinement at glutamatergic and GABAergic perisynaptic sites
    Thomas Bürli
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    PLoS ONE 5:e11507. 2010
    ..Altogether, given their high Ca(2+)-permeability, our results suggest a possible role of alpha7-nAChR on interneurons for activating Ca(2+)-dependent signaling in the vicinity of GABAergic and glutamatergic synapses...
  44. ncbi Involvement of alpha 7 nicotinic acetylcholine receptors in gene expression of dopamine biosynthetic enzymes in rat brain
    Lidia Serova
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    J Pharmacol Exp Ther 303:896-903. 2002
    ..The findings indicate that nicotine may regulate dopamine biosynthesis by alterations in gene expression of TH and its cofactor. The alpha7 nAChRs are involved in mediating these effects of nicotine...
  45. pmc The frequency-dependence of the nicotine-induced inhibition of dopamine is controlled by the α7 nicotinic receptor
    Andrew T Seipel
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    J Neurochem 114:1659-66. 2010
    ..The frequency dependence of the low dose nicotine inhibition therefore requires functional α7 nAChRs, and may arise from differing levels of endogenous acetylcholine evoked by the stimulation...
  46. doi In vivo modulation of alpha7 nicotinic receptors on striatal glutamate release induced by anatoxin-A
    F Campos
    Department of Functional Biology and Health Sciences, University of Vigo, Vigo, Spain
    Neurochem Int 56:850-5. 2010
    ..The increase of glutamate is followed by an increase on dopamine levels. These results represent a clear in vivo evidence of the striatal modulation of dopamine by means of glutamate release through alpha7 nicotinic receptors...
  47. doi Functional expression of alpha 7 nicotinic acetylcholine receptors in human periodontal ligament fibroblasts and rat periodontal tissues
    Xiao Jing Wang
    Department of Pediatric Dentistry, School of Stomatology, Fourth Military Medical University, Xi an, 710032, Shaanxi, China
    Cell Tissue Res 340:347-55. 2010
    ..ligament (PDL) cells were cultured with 10(-12) M of nicotine and/or 10(-9) M of alpha-bungarotoxin (alpha-Btx), a alpha 7 nAChR antagonist...
  48. doi Alpha7 nAChR-mediated activation of MAP kinase pathways in PC12 cells
    Earl J Gubbins
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6125, USA
    Brain Res 1328:1-11. 2010
    ..Such mechanisms may endow the alpha7 nAChRs with roles in modulating Ca(2+)-dependent intracellular second messenger events implicated in diverse aspects of cognition...
  49. doi Distinct neural pathways mediate α7 nicotinic acetylcholine receptor-dependent activation of the forebrain
    Morten S Thomsen
    Neurobiology Research Unit, Copenhagen University Hospital, DK2100 Copenhagen, Denmark
    Cereb Cortex 20:2092-102. 2010
    ....
  50. doi Effect of passive cigarette smoking on colonic alpha7-nicotinic acetylcholine receptors in TNBS-induced colitis in rats
    Ya P Sun
    Department of Gastroenterology, Peking University First Hospital, Beijing, PR China
    Digestion 76:181-7. 2007
    ..The aim of this study was to investigate the underlying mechanism by examining the effect of cigarette smoking on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats...
  51. ncbi Involvement of alpha7- and alpha4beta2-type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: a patch clamp and single-cell PCR study using acutely dissociated nigral neurons
    Hiroaki Matsubayashi
    Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Brain Res Mol Brain Res 129:1-7. 2004
    ..These results suggest that nicotine directly acts on postsynaptic alpha7- and alpha4beta2-type nicotinic acetylcholine receptors and induces inward current, which result in the excitation of dopaminergic neurons in the substantia nigra...
  52. ncbi The magnitude of alpha7 nicotinic receptor currents in rat hippocampal neurons is dependent upon GABAergic activity and depolarization
    Hélio R Santos
    Departmento de Farmacologia Básica e Clínica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Rio de Janeiro, Brazil
    J Pharmacol Exp Ther 319:376-85. 2006
    ..These data indicate that alpha7(*)-gated currents in hippocampal neurons are regulated by GABAergic activity and suggest that depolarization-induced GABA release may underlie the effect of increased extracellular KCl...
  53. ncbi Monoamine uptake inhibitors block alpha7-nAChR-mediated cerebral nitrergic neurogenic vasodilation
    Cheng Long
    Department of Pharmacology, School of Medicine, Southern Illinois University, Springfield, Illinois, USA
    Am J Physiol Heart Circ Physiol 291:H202-9. 2006
    ..These results further support the hypothesis of axo-axonal interaction in nitrergic regulation of cerebral vascular tone...
  54. doi Serotoninergic dorsal raphe neurons possess functional postsynaptic nicotinic acetylcholine receptors
    Luis Galindo-Charles
    Department of Physiology, College of Medicine, Universidad Nacional Autonoma de Mexico, Mexico D F 04510
    Synapse 62:601-15. 2008
    ..The possible implications of these newly described nAChRs in various physiological processes and behavioral events, such as the wake-sleep cycle, are discussed...
  55. pmc Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells
    Jonathan M Beckel
    Dept of Pharmacology, Univ of Pittsburgh School of Medicine, A1220 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 290:F103-10. 2006
    ..These results are the first indication that stimulation of nonneuronal nicotinic receptors in the bladder can affect micturition...
  56. ncbi An alpha7 nicotinic acetylcholine receptor gain-of-function mutant that retains pharmacological fidelity
    Andon N Placzek
    Department of Pharmacology and Therapeutics, P O Box 100267, University of Florida, Gainesville, Florida 32610 0267, USA
    Mol Pharmacol 68:1863-76. 2005
    ....
  57. pmc Paired-pulse potentiation of alpha7-containing nAChRs in rat hippocampal CA1 stratum radiatum interneurones
    Rebecca C Klein
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 568:881-9. 2005
    ..Thus, rat hippocampal alpha7-containing nAChRs possess a newly described phenomenon of paired-pulse potentiation that may be involved in regulating synaptic plasticity in the hippocampus...
  58. ncbi Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
    Wouter J de Jonge
    Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Nat Immunol 6:844-51. 2005
    ..We conclude that the vagal anti-inflammatory pathway acts by alpha7 subunit-mediated Jak2-STAT3 activation...
  59. doi Traumatic brain injury elicits similar alterations in α7 nicotinic receptor density in two different experimental models
    Peter Georg Hoffmeister
    Institute of Radiopharmacy, Research Site Leipzig, Research Center Dresden Rossendorf, Permoserstraße 15, 04318, Leipzig, Germany
    Neuromolecular Med 13:44-53. 2011
    ..The alterations make the α7 nAChR a suitable target for drug development and neuroimaging after TBI...
  60. ncbi Volatile organic compounds inhibit human and rat neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes
    Ambuja S Bale
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 205:77-88. 2005
    ..This toxicodynamic information will help decrease the uncertainty associated with animal to human extrapolations in the risk assessment of VOCs...
  61. pmc Ca2+ permeability of nicotinic acetylcholine receptors from rat dorsal root ganglion neurones
    Sergio Fucile
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Roma, Italy
    J Physiol 565:219-28. 2005
    ..Finally, we report that Ca2+ influx through nAChRs in adult DRG neurones negatively modulated the TRPV1-mediated responses, representing a possible mechanism underlying the analgesic properties of nicotinic agonists on sensory neurones...
  62. ncbi Alpha 7 nicotinic receptor subunit is present on serotonin neurons projecting to hippocampus and septum
    Susana Aznar
    Neurobiology Research Unit, Copenhagen University Hospital, 2100 Copenhagen, Denmark
    Synapse 55:196-200. 2005
    ..A low degree of colocalization between alpha-bungarotoxin and serotonin-positive neurons suggest that the alpha 7 subunit may be transported anterogradely to the serotonergic axonal terminals...
  63. ncbi Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells
    Mark E Williams
    Merck Research Laboratories, San Diego, California 92121, USA
    J Biol Chem 280:1257-63. 2005
    ..Thus, ric-3 appears to be necessary for proper folding and/or assembly of alpha7 receptors in HEK293 cells...
  64. pmc Functional somato-dendritic alpha7-containing nicotinic acetylcholine receptors in the rat basolateral amygdala complex
    Rebecca C Klein
    NIEHS, F2 08, PO Box 12233, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    J Physiol 576:865-72. 2006
    ..This is the first report demonstrating the presence of functional nAChR-mediated current responses from rat amygdala slices, where they may be playing a significant role in fear and aversively motivated memory...
  65. ncbi Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons
    Ginny G Farías
    Centro de Regulación Celular y Patología Joaquín V Luco, Millennium Institute for Fundamental and Applied Biology, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, 8331010 Santiago, Chile
    J Neurosci 27:5313-25. 2007
    ..Modulation by Wnt signaling may be essential for alpha7-nAChR expression and function in synapses...
  66. ncbi Nicotinic acetylcholine receptor subtypes in nociceptive dorsal root ganglion neurons of the adult rat
    Rainer Viktor Haberberger
    Institute for Anatomy and Cell Biology Justus Liebig University, Aulweg 123, D 35385 Giessen, Germany
    Auton Neurosci 113:32-42. 2004
    ..These findings were corroborated by current recordings and calcium measurements, which revealed excitatory inward currents and calcium responses in capsaicin sensitive neurons...
  67. ncbi Ethanol consumption produces changes in behavior and on hippocampal alpha7 and alpha4beta2 nicotinic receptors
    Noemi Robles
    Departament de Bioquimica i Biologia Molecular, Institut de Neurociencies, Facultat de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    J Mol Neurosci 30:119-20. 2006
    ....
  68. ncbi Chronic, intermittent exposure to chlorpyrifos in rats: protracted effects on axonal transport, neurotrophin receptors, cholinergic markers, and information processing
    Alvin V Terry
    Department of Pharmacology and Toxicology, University of Georgia College of Pharmacy, Augusta, Georgia 30912 2300, USA
    J Pharmacol Exp Ther 322:1117-28. 2007
    ..Such neurochemical changes may lead to deficits in information processing and cognitive function...
  69. pmc Dendritic Ca2+ signalling due to activation of alpha 7-containing nicotinic acetylcholine receptors in rat hippocampal neurons
    Dmitriy Fayuk
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 582:597-611. 2007
    ..These results may have implications for the role that alpha 7 nAChRs have in regulating various signal transduction cascades, synaptic plasticity, and memory processes, via significant changes in [Ca(2+)]i levels...
  70. ncbi Postsynaptic alpha 4 beta 2 and alpha 7 type nicotinic acetylcholine receptors contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons
    Hiroaki Matsubayashi
    Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami, Hiroshima 734 8551, Japan
    Brain Res 1005:1-8. 2004
    ..These results suggest that dopaminergic neurons in the substantia nigra receive excitatory cholinergic inputs that are mediated via at least two types of postsynaptic nicotinic receptors, namely alpha7 and alpha4beta2 subtypes...
  71. ncbi Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells
    Tsutomu Wada
    Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Endocrinology 148:790-9. 2007
    ....
  72. pmc Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization
    Elaine A Gay
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 586:1105-15. 2008
    ..Furthermore, these data suggest that W55 may be a potential target for modulatory agents operating via hydrophobic interactions...
  73. ncbi Coexpression and spatial association of nicotinic acetylcholine receptor subunits alpha7 and alpha10 in rat sympathetic neurons
    Katrin Susanne Lips
    Institute for Anatomy and Cell Biology and University of Giessen Lung Center, Justus Liebig University, 35385 Giessen, Germany
    J Mol Neurosci 30:15-6. 2006
    ..1995; Jares-Erijman and Jovin, 2003)...
  74. ncbi Characterization of a rat neuronal nicotinic acetylcholine receptor alpha7 promoter
    U Nagavarapu
    Department of Neuroscience, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
    J Biol Chem 276:16749-57. 2001
    ..Several transcription factors interact in close proximity to control expression of the rat alpha7 nicotinic receptor gene...
  75. ncbi Desensitization of alpha7 nicotinic receptors potentiated the inhibitory effect on M-current induced by stimulation of muscarinic receptors in rat superior cervical ganglion neurons
    X Yin
    Beijing Institute of Pharmacology and Toxicology, Beijing, China
    J Neural Transm 112:1133-48. 2005
    ..These results indicated that desensitization of alpha7-nAChRs could potentiate the inhibitory effect on M-current by stimulation of mAChRs with their agonist...
  76. ncbi Expression of nicotinic receptors on primary cultures of rat astrocytes and up-regulation of the alpha7, alpha4 and beta2 subunits in response to nanomolar concentrations of the beta-amyloid peptide(1-42)
    Jin Xiu
    Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, B84, S 14186 Stockholm, Sweden
    Neurochem Int 47:281-90. 2005
    ..We propose that the enhanced expression of alpha7, alpha4 and beta2 nAChRs by astrocytes stimulated directly by nanomolar concentrations of Abeta(1-42) might be related to ongoing defensive or compensative mechanisms...
  77. ncbi The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channels
    Emily G Severance
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, MDC 9, Tampa, FL 33612 4799, USA
    Mol Pharmacol 66:420-9. 2004
    ..Furthermore, the distribution of the alpha7-2 isoform is not limited to peripheral neurons...
  78. ncbi Alpha-7 and alpha-4 nicotinic receptor subunit immunoreactivity in genioglossus muscle motoneurons
    Ozra Dehkordi
    Department of Surgery, Howard University Hospital, 2041 Georgia Avenue, NW, Washington, DC 20060, USA
    Respir Physiol Neurobiol 145:153-61. 2005
    ..90% in rostral areas (P=0.074). These results demonstrate that nAChR immunoreactivity is present in genioglossal motoneurons and suggest a role for alpha-7 and alpha-4 subunits containing nAChRs in the regulation of upper airway patency...
  79. pmc Fast synaptic transmission mediated by alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in lamina X neurones of neonatal rat spinal cord
    A Bradaia
    Laboratoire de Neurophysiologie Cellulaire et Intégrée, UMR 7519 CNRS ULP, 21 rue R Descartes, 67084 Strasbourg Cedex, France
    J Physiol 544:727-39. 2002
    ..This is the first demonstration in a mammalian spinal cord preparation of a fast cholinergic neurotransmission in which alpha-BgT-sensitive nicotinic receptors are involved...
  80. pmc Excitation of rat hippocampal interneurons via modulation of endogenous agonist activity at the alpha7 nicotinic ACh receptor
    M H Selina Mok
    Schizophrenia and Bipolar Neurophysiology and Pharmacology, Psychiatry CEDD, GlaxoSmithKline, Harlow, Essex CM19 5AW, UK
    J Physiol 574:699-710. 2006
    ....
  81. doi Analysis of gene expression profiles in rat hippocampus following treatment with nicotine and an alpha7 nAChR selective agonist
    Jeffrey F Waring
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Neurosci Res 60:266-74. 2008
    ..Overall, our results identify gene expression changes that may contribute to further defining the roles of nAChR activation in cognitive function...
  82. doi alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate dopamine release in vitro and in vivo in the rat prefrontal cortex
    Phil D Livingstone
    Department of Biology and Biochemistry, University of Bath, Bath, UK
    Eur J Neurosci 29:539-50. 2009
    ..Through their distinct actions on dopamine release, these nAChR subtypes could contribute to executive function, making them specific therapeutic targets for conditions such as schizophrenia and attention deficit hyperactivity disorder...
  83. doi A new model for the study of high-K(+)-induced preconditioning in cultured neurones: role of N-methyl-d-aspartate and alpha7-nicotinic acetylcholine receptors
    R van Rensburg
    Centre for Integrative Neuroscience CINS, School of Biological and Biomedical Sciences, Science Park, South Road, Durham University, Durham, County Durham DH1 3LE, United Kingdom
    J Neurosci Methods 177:311-6. 2009
    ..Finally, preconditioning was shown to be dependent upon N-methyl-d-aspartate (NMDA), CAM-kinase II signalling and alpha7-nicotinic (alpha7 nACh) receptor function, which is analogous to in vivo preconditioning induced by various stimuli...
  84. doi Nicotine induction of theta frequency oscillations in rodent hippocampus in vitro
    C B Lu
    Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Neuroscience 166:84-93. 2010
    ..In conclusion, theta activity in the hippocampus may be promoted by tonic stimulation of alpha7* nAChRs, possibly via selective stimulation of theta-preferring interneurons in the hippocampus that express post-synaptic alpha7* nAChRs...
  85. ncbi Functional properties of internalization-deficient P2X4 receptors reveal a novel mechanism of ligand-gated channel facilitation by ivermectin
    Estelle Toulme
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 5543, Université Victor Segalen Bordeaux2, France
    Mol Pharmacol 69:576-87. 2006
    ....
  86. ncbi Indirect modulation by alpha7 nicotinic acetylcholine receptors of noradrenaline release in rat hippocampal slices: interaction with glutamate and GABA systems and effect of nicotine withdrawal
    Jacques Barik
    Department of Biology and Biochemistry, University of Bath, UK
    Mol Pharmacol 69:618-28. 2006
    ..alpha7 nAChR responses were selectively and transiently up-regulated after 3 days of withdrawal. This functional up-regulation could contribute to the withdrawal effects of nicotine...
  87. ncbi Involvement of DDAH/ADMA/NOS pathway in nicotine-induced endothelial dysfunction
    De Jian Jiang
    Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, China
    Biochem Biophys Res Commun 349:683-93. 2006
    ..In conclusion, nicotine modulates DDAH/ADMA/NOS pathway of endothelial cell via activation of alpha7 nAChR, which may be involved in endothelial dysfunction associated to smoking...
  88. ncbi Precise localization of alpha7 nicotinic acetylcholine receptors on glutamatergic axon terminals in the rat ventral tegmental area
    Ian W Jones
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    J Neurosci 24:11244-52. 2004
    ..alpha7 nAChRs were not associated with cholinergic synapses, consistent with their activation by a paracrine mode of acetylcholine or choline delivery...
  89. ncbi Microglial alpha7 nicotinic acetylcholine receptors drive a phospholipase C/IP3 pathway and modulate the cell activation toward a neuroprotective role
    Tomohisa Suzuki
    Department of Pharmacology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Neurosci Res 83:1461-70. 2006
    ..This novel alpha7 nAChR signal may be involved in the nicotine modification of microglia activation towards a neuroprotective role by suppressing the inflammatory state and strengthening the protective function...
  90. ncbi Involvement of the alpha 7 subunit of the nicotinic receptor in morphogenic and trophic effects of acetylcholine on embryonic rat spinal motoneurons in culture
    Christelle Catone
    CNRS Groupe d Etude des Réseaux Moteurs GERM, Marseille, France
    J Neurosci Res 72:46-53. 2003
    ..These effects are directly linked to the membrane expression level of alpha7 protein. Indeed, the lower the alpha7 expression, the lower the inhibition of axonal growth (i.e., axonal elongation) and the lower the MN survival...
  91. ncbi Upregulation of neuronal nicotinic receptor subunits alpha4, beta2, and alpha7 in transgenic mice overexpressing human acetylcholinesterase
    Marie M Svedberg
    Karolinska Institutet, Neurotec, Division of Molecular Neuropharmacology, Huddinge University Hospital, Stockholm, Sweden
    J Mol Neurosci 18:211-22. 2002
    ....
  92. ncbi Nicotinic activity stabilizes convergence of nicotinic and GABAergic synapses on filopodia of hippocampal interneurons
    Wagner M Zago
    Neurobiology Section, Division of Biology, 0357, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0357, USA
    Mol Cell Neurosci 31:549-59. 2006
    ..The results indicate a convergence of nicotinic and GABAergic input at specific sites on developing hippocampal interneurons and suggest that synaptic activity helps stabilize the nicotinic contribution...
  93. doi The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor
    Mine Sibel Gurun
    Department of Pharmacology and Clinical Pharmacology, Uludag University, Gorukle, Bursa, Turkey
    Anesth Analg 108:1680-7. 2009
    ..Previous reports also suggest that the peripheral cholinergic system has an antiinflammatory role mediated by alpha7nAChRs on macrophages...

Research Grants9

  1. Carotid Body Chemoreception: Mechanism & Development
    DAVID DONNELLY; Fiscal Year: 2006
    ..If supported, the model should lead to a pharmacologic targeting of these processes for the improved treatment of apnea and/or dyspnea. ..
  2. Mechanism of perinatal-hyperoxic suppression of chemoreceptor function
    DAVID DONNELLY; Fiscal Year: 2007
    ..Since hyperoxia is extensively used clinically in newborn and, especially in premature infants, these results are important in understanding physiologic alterations caused by this intervention. ..
  3. Mechanism of perinatal-hyperoxic suppression of chemoreceptor function
    David F Donnelly; Fiscal Year: 2010
    ..Since hyperoxia is extensively used clinically in newborn and, especially in premature infants, these results are important in understanding physiologic alterations caused by this intervention. ..