Chrna6

Summary

Gene Symbol: Chrna6
Description: cholinergic receptor nicotinic alpha 6 subunit
Alias: neuronal acetylcholine receptor subunit alpha-6, cholinergic receptor, nicotinic, alpha 6 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 6
Species: rat
Products:     Chrna6

Top Publications

  1. Cox B, Marritt A, Perry D, Kellar K. Transport of multiple nicotinic acetylcholine receptors in the rat optic nerve: high densities of receptors containing alpha6 and beta3 subunits. J Neurochem. 2008;105:1924-38 pubmed publisher
    ..Included among these subtypes is the highest percentage and density of alpha6- and beta3-containing nAChRs of any area of the rat CNS that has been reported. ..
  2. Hone A, Meyer E, McIntyre M, McIntosh J. Nicotinic acetylcholine receptors in dorsal root ganglion neurons include the ?6?4* subtype. FASEB J. 2012;26:917-26 pubmed publisher
    ..We conclude that ?6?4* nAChRs are among the subtypes expressed by DRG, and to our knowledge, this is the first demonstration of ?6?4* in neurons outside the CNS. ..
  3. Champtiaux N, Han Z, Bessis A, Rossi F, Zoli M, Marubio L, et al. Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice. J Neurosci. 2002;22:1208-17 pubmed
    ..They further show that alpha6-/- mice might be useful tools to understand the mechanisms of nicotine addiction, although some developmental compensation might occur in these mice. ..
  4. Ebihara M, Ohba H, Ohno S, Yoshikawa T. Genomic organization and promoter analysis of the human nicotinic acetylcholine receptor alpha6 subunit (CHNRA6) gene: Alu and other elements direct transcriptional repression. Gene. 2002;298:101-8 pubmed
    ..We performed molecular analysis on the human neuronal nAChR alpha6 subunit (CHRNA6) gene, a member of nAChR gene family, to understand its role in disease...
  5. Azam L, Yoshikami D, McIntosh J. Amino acid residues that confer high selectivity of the alpha6 nicotinic acetylcholine receptor subunit to alpha-conotoxin MII[S4A,E11A,L15A]. J Biol Chem. 2008;283:11625-32 pubmed publisher
    ..Similar effects were seen with other alpha6-selective conotoxins, suggesting the general importance of thesealpha6 residues in conferring selective binding. ..
  6. Albuquerque E, Pereira E, Alkondon M, Rogers S. Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev. 2009;89:73-120 pubmed publisher
    ..Despite these numerous developments, our understanding of the contributions of specific neuronal nAChR subtypes to the many facets of physiology throughout the body remains in its infancy. ..
  7. Luo S, Zhangsun D, Schroeder C, Zhu X, Hu Y, Wu Y, et al. A novel ?4/7-conotoxin LvIA from Conus lividus that selectively blocks ?3?2 vs. ?6/?3?2?3 nicotinic acetylcholine receptors. FASEB J. 2014;28:1842-53 pubmed publisher
    ..4/7-CTx LvIA is a new, potent, selective ?3?2 nAChR antagonist, which will enable detailed studies of ?3?2 nAChR structure, function, and physiological roles...
  8. Champtiaux N, Gotti C, Cordero Erausquin M, David D, Przybylski C, Léna C, et al. Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J Neurosci. 2003;23:7820-9 pubmed
  9. Marritt A, Cox B, Yasuda R, McIntosh J, Xiao Y, Wolfe B, et al. Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes. Mol Pharmacol. 2005;68:1656-68 pubmed

More Information

Publications13

  1. Perez X, Bordia T, McIntosh J, Grady S, Quik M. Long-term nicotine treatment differentially regulates striatal alpha6alpha4beta2* and alpha6(nonalpha4)beta2* nAChR expression and function. Mol Pharmacol. 2008;74:844-53 pubmed publisher
    ..Thus, alpha6beta2(*) nAChR subtypes may represent important targets for smoking cessation therapies and neurological disorders involving these receptors such as Parkinson's disease. ..
  2. Bordia T, Hrachova M, Chin M, McIntosh J, Quik M. Varenicline is a potent partial agonist at ?6?2* nicotinic acetylcholine receptors in rat and monkey striatum. J Pharmacol Exp Ther. 2012;342:327-34 pubmed publisher
    ..These data suggest that the ability of varenicline to interact at ?6?2* nAChRs may contribute to its efficacy as a smoking cessation aid. ..
  3. Wickham R, Solecki W, Rathbun L, McIntosh J, Addy N. Ventral tegmental area ?6?2 nicotinic acetylcholine receptors modulate phasic dopamine release in the nucleus accumbens core. Psychopharmacology (Berl). 2013;229:73-82 pubmed publisher
    ..The results suggest that VTA ?6?2 nAChRs, but not ?4?2 or ?7 nAChRs, regulate phasic DA release in the NAc core and that VTA ?6?2 nAChRs and NMDA receptors act at a common site or target to regulate NAc phasic DA signaling. ..
  4. Hone A, Ruiz M, Scadden M, Christensen S, Gajewiak J, Azam L, et al. Positional scanning mutagenesis of ?-conotoxin PeIA identifies critical residues that confer potency and selectivity for ?6/?3?2?3 and ?3?2 nicotinic acetylcholine receptors. J Biol Chem. 2013;288:25428-39 pubmed publisher
    ..The results of these studies provide molecular insights into designing ligands that selectively target ?6?2* nAChRs. ..