Genomes and Genes
Gene Symbol: Chrna6
Description: cholinergic receptor nicotinic alpha 6 subunit
Alias: neuronal acetylcholine receptor subunit alpha-6, cholinergic receptor, nicotinic, alpha 6 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 6
- Perez X, Bordia T, McIntosh J, Grady S, Quik M. Long-term nicotine treatment differentially regulates striatal alpha6alpha4beta2* and alpha6(nonalpha4)beta2* nAChR expression and function. Mol Pharmacol. 2008;74:844-53 pubmed publisher..Thus, alpha6beta2(*) nAChR subtypes may represent important targets for smoking cessation therapies and neurological disorders involving these receptors such as Parkinson's disease. ..
- Bordia T, Hrachova M, Chin M, McIntosh J, Quik M. Varenicline is a potent partial agonist at ?6?2* nicotinic acetylcholine receptors in rat and monkey striatum. J Pharmacol Exp Ther. 2012;342:327-34 pubmed publisher..These data suggest that the ability of varenicline to interact at ?6?2* nAChRs may contribute to its efficacy as a smoking cessation aid. ..
- Wickham R, Solecki W, Rathbun L, McIntosh J, Addy N. Ventral tegmental area ?6?2 nicotinic acetylcholine receptors modulate phasic dopamine release in the nucleus accumbens core. Psychopharmacology (Berl). 2013;229:73-82 pubmed publisher..The results suggest that VTA ?6?2 nAChRs, but not ?4?2 or ?7 nAChRs, regulate phasic DA release in the NAc core and that VTA ?6?2 nAChRs and NMDA receptors act at a common site or target to regulate NAc phasic DA signaling. ..
- Hone A, Ruiz M, Scadden M, Christensen S, Gajewiak J, Azam L, et al. Positional scanning mutagenesis of ?-conotoxin PeIA identifies critical residues that confer potency and selectivity for ?6/?3?2?3 and ?3?2 nicotinic acetylcholine receptors. J Biol Chem. 2013;288:25428-39 pubmed publisher..The results of these studies provide molecular insights into designing ligands that selectively target ?6?2* nAChRs. ..