Gene Symbol: Chrna5
Description: cholinergic receptor nicotinic alpha 5 subunit
Alias: neuronal acetylcholine receptor subunit alpha-5, acetylcholine receptor alpha 5, cholinergic receptor, nicotinic, alpha 5 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 5
Species: rat
Products:     Chrna5

Top Publications

  1. Fowler C, Lu Q, Johnson P, Marks M, Kenny P. Habenular ?5 nicotinic receptor subunit signalling controls nicotine intake. Nature. 2011;471:597-601 pubmed publisher
    Genetic variation in CHRNA5, the gene encoding the ?5 nicotinic acetylcholine receptor subunit, increases vulnerability to tobacco addiction and lung cancer, but the underlying mechanisms are unknown...
  2. Berrettini W, Yuan X, Tozzi F, Song K, Francks C, Chilcoat H, et al. Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. Mol Psychiatry. 2008;13:368-73 pubmed publisher
    ..In these approximately 7500 persons, a common haplotype in the CHRNA3-CHRNA5 nicotinic receptor subunit gene cluster was associated with CPD (nominal P=6.9 x 10(-5))...
  3. Boulter J, O Shea Greenfield A, Duvoisin R, Connolly J, Wada E, Jensen A, et al. Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster. J Biol Chem. 1990;265:4472-82 pubmed
    ..Finally, the genes that encode the beta 4, alpha 3, and alpha 5 proteins are transcribed with convergent polarities and form a tightly linked gene cluster spanning approximately 60 kilobase pairs. ..
  4. Nuutinen S, Panula P, Salminen O. Different Hypothalamic Nicotinic α7 Receptor Expression and Response to Low Nicotine Dose in Alcohol-Preferring and Alcohol-Avoiding Rats. Alcohol Clin Exp Res. 2016;40:329-34 pubmed publisher
    ..Stronger nicotine-induced locomotor response, mediated partially via α7 receptors, and previously described high alcohol consumption in AA rats could be explained by the found difference in tuberomamillary α7 receptor levels. ..
  5. Scholze P, Koth G, Orr Urtreger A, Huck S. Subunit composition of ?5-containing nicotinic receptors in the rodent habenula. J Neurochem. 2012;121:551-60 pubmed publisher
    Gene association studies in humans have linked the ?5 subunit gene CHRNA5 to an increased risk for nicotine dependence...
  6. Lomazzo E, MacArthur L, Yasuda R, Wolfe B, Kellar K. Quantitative analysis of the heteromeric neuronal nicotinic receptors in the rat hippocampus. J Neurochem. 2010;115:625-34 pubmed publisher
    ..Results suggested these subtypes have comparable binding affinities for the nicotinic ligands used here. ..
  7. Albuquerque E, Pereira E, Alkondon M, Rogers S. Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev. 2009;89:73-120 pubmed publisher
    ..Despite these numerous developments, our understanding of the contributions of specific neuronal nAChR subtypes to the many facets of physiology throughout the body remains in its infancy. ..
  8. Vincler M, Eisenach J. Knock down of the alpha 5 nicotinic acetylcholine receptor in spinal nerve-ligated rats alleviates mechanical allodynia. Pharmacol Biochem Behav. 2005;80:135-43 pubmed
    ..These results suggest that the increased expression of the alpha5 nAChR subunit following SNL contributes to spinal CREB phosphorylation and the maintenance of mechanical allodynia. ..
  9. Winzer Serhan U, Leslie F. Expression of alpha5 nicotinic acetylcholine receptor subunit mRNA during hippocampal and cortical development. J Comp Neurol. 2005;481:19-30 pubmed
    ..This expression pattern places nicotinic receptors containing the alpha5 subunit in a position to regulate glutamatergic and GABAergic transmission during the postnatal period. ..

More Information


  1. Vincler M, Eisenach J. Plasticity of spinal nicotinic acetylcholine receptors following spinal nerve ligation. Neurosci Res. 2004;48:139-45 pubmed
    ..We propose that the increased expression of the alpha3 and alpha5 nicotinic subunits may contribute to the mechanical hypersensitivity observed following spinal nerve ligation. ..
  2. Di Angelantonio S, Matteoni C, Fabbretti E, Nistri A. Molecular biology and electrophysiology of neuronal nicotinic receptors of rat chromaffin cells. Eur J Neurosci. 2003;17:2313-22 pubmed
  3. Oshikawa J, Toya Y, Fujita T, Egawa M, Kawabe J, Umemura S, et al. Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts. Am J Physiol Cell Physiol. 2003;285:C567-74 pubmed
    ..In addition, nAChR alpha 7 may regulate the AC activity via Ca2+ within lipid rafts. ..
  4. Chini B, Clementi F, Hukovic N, Sher E. Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines. Proc Natl Acad Sci U S A. 1992;89:1572-6 pubmed
    ..We conclude that both alpha Bgtx receptors and the alpha 5-nicotinic subunit gene are not neuron-specific, as previously thought, but are expressed in a number of human cell lines of various origin. ..
  5. Spies M, Lips K, Kurzen H, Kummer W, Haberberger R. Nicotinic acetylcholine receptors containing subunits alpha3 and alpha5 in rat nociceptive dorsal root ganglion neurons. J Mol Neurosci. 2006;30:55-6 pubmed
    ..2004; Papadopolou et al., 2004). To this end, calcium-imaging and double-labeling immunofluorescence with nAChR alpha-subunit-specific antibodies, in combination with markers for nociceptive neurons (TRPV1, I-B4), were applied. ..
  6. Yu W, Guan Z, Nordberg A. Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice. Neuroscience. 2007;146:1618-28 pubmed
    ..These data suggest that increased levels of alpha4, alpha3-containing nAChRs, co-assembled with the alpha5 nAChR subunit, may contribute to the normal brain development of alpha7 -/- and alpha7 +/- mice. ..
  7. Gahring L, Rogers S. Nicotinic receptor subunit alpha5 modifies assembly, up-regulation, and response to pro-inflammatory cytokines. J Biol Chem. 2010;285:26049-57 pubmed publisher
    ..These findings suggest that alpha5 is an influential modulator of alpha4+beta2 nicotinic acetylcholine receptor assembly and stabilizes their expression in response to fluctuations in external conditions. ..
  8. Voitenko L, Voitenko S, Skok M, Purnyn H, Skok V. Nicotinic acetylcholine receptor subtypes in rat superior cervical ganglion neurons as studied by sequential application of two alpha-subunit-specific antibodies. Neurosci Lett. 2001;303:37-40 pubmed
  9. Stitzel J, Blanchette J, Collins A. Sensitivity to the seizure-inducing effects of nicotine is associated with strain-specific variants of the alpha 5 and alpha 7 nicotinic receptor subunit genes. J Pharmacol Exp Ther. 1998;284:1104-11 pubmed
    ..Levels of alpha-BTX binding did not correlate with nicotine-induced seizure sensitivity or overall nicotine sensitivity score in any of the four brain regions examined. ..