choline kinase R
Gene Symbol: choline kinase R
Description: choline kinase alpha
Alias: CK-R, Chk, choline kinase alpha, CHETK-alpha, choline kinase R, ethanolamine kinase
Aoyama C, Ohtani A, Ishidate K. Expression and characterization of the active molecular forms of choline/ethanolamine kinase-alpha and -beta in mouse tissues, including carbon tetrachloride-induced liver. Biochem J. 2002;363:777-84 pubmed
Choline/ethanolamine kinase (ChoK/EtnK) exists as at least three isoforms (alpha1, alpha2 and beta) in mammalian cells...
Sher R, Aoyama C, Huebsch K, Ji S, Kerner J, Yang Y, et al
. A rostrocaudal muscular dystrophy caused by a defect in choline kinase beta, the first enzyme in phosphatidylcholine biosynthesis. J Biol Chem. 2006;281:4938-48 pubmed
..CHKB is one of two mammalian choline kinase (CHK) enzymes (alpha and beta) that catalyze the phosphorylation of choline to phosphocholine in the biosynthesis of the ..
Uchida T, Yamashita S. Molecular cloning, characterization, and expression in Escherichia coli of a cDNA encoding mammalian choline kinase. J Biol Chem. 1992;267:10156-62 pubmed
..These results show that the cloned cDNA encodes one of the choline kinase isoforms present in mammalian tissues. ..
Uchida T. Regulation of choline kinase R: analyses of alternatively spliced choline kinases and the promoter region. J Biochem. 1994;116:508-18 pubmed
..Southern blot analysis demonstrated a single copy of choline kinase R gene...
Nakagami K, Uchida T, Ohwada S, Koibuchi Y, Morishita Y. Increased choline kinase activity in 1,2-dimethylhydrazine-induced rat colon cancer. Jpn J Cancer Res. 1999;90:1212-7 pubmed
..The elevated phosphocholine levels were in part due to both activation of choline kinase and increased choline kinase alpha protein levels...
Liu Y, Blum P, Pabst D, Chakrabarti I, Jernigan H. Effects of cataractogenesis on the CDP-choline pathway: changes in ATP concentration and phosphocholine synthesis during and after exposure of rat lenses to sugars in vitro and in vivo. Ophthalmic Res. 2003;35:185-91 pubmed
..Neither model caused a substantial change in the choline kinase activity (as measured in cell-free assays). The data did not generally support the hypothesis that decreased [ATP] causes decreased P-Cho synthesis. ..
Tian Y, Jackson P, Gunter C, Wang J, Rock C, Jackowski S. Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2. J Biol Chem. 2006;281:28438-49 pubmed
b>Ethanolamine kinase catalyzes the first step in the CDP-ethanolamine pathway for the formation of the major membrane phospholipid phosphatidylethanolamine (PtdEtn)...
Gallego Ortega D, Ramirez de Molina A, Ramos M, Valdes Mora F, Barderas M, Sarmentero Estrada J, et al
. Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. PLoS ONE. 2009;4:e7819 pubmed publisher
..Both ChoKalpha1 and ChoKbeta showed choline and ethanolamine kinase activities when assayed in cell extracts, though with different affinity for their substrates...
Nakagami K, Uchida T, Ohwada S, Koibuchi Y, Suda Y, Sekine T, et al
. Increased choline kinase activity and elevated phosphocholine levels in human colon cancer. Jpn J Cancer Res. 1999;90:419-24 pubmed
..The activation of choline kinase and the increased levels of choline kinase alpha were partly responsible for the elevated phosphocholine levels...