Gene Symbol: Chmp4c
Description: charged multivesicular body protein 4C
Alias: charged multivesicular body protein 4c, Snf7 homologue associated with Alix 3, chromatin modifying protein 4C, chromatin-modifying protein 4c
Carlton J, Caballe A, Agromayor M, Kloc M, Martin Serrano J. ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. Science. 2012;336:220-5 pubmed publisher
..Here, we show that charged multivesicular body (MVB) protein 4C (CHMP4C), a human ESCRT-III subunit, is involved in abscission timing...
Dores M, Chen B, Lin H, Soh U, Paing M, Montagne W, et al
. ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. J Cell Biol. 2012;197:407-19 pubmed publisher
..This study reveals a novel MVB/lysosomal sorting pathway for signaling receptors that bypasses the requirement for ubiquitination and ubiquitin-binding ESCRTs and may be applicable to a subset of GPCRs containing YPX(n)L motifs. ..
Capalbo L, Montembault E, Takeda T, Bassi Z, Glover D, D Avino P. The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis. Open Biol. 2012;2:120070 pubmed publisher
..we find that the CPC's catalytic subunit, Aurora B kinase, phosphorylates one of the three human Snf7 paralogues-CHMP4C-in its C-terminal tail, a region known to regulate its ability to form polymers and associate with membranes...
Thoresen S, Campsteijn C, Vietri M, Schink K, Liestøl K, Andersen J, et al
. ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4. Nat Cell Biol. 2014;16:550-60 pubmed publisher
..This arrest depends on Aurora-B-mediated phosphorylation of CHMP4C, a component of the endosomal sorting complex required for transport (ESCRT) machinery that mediates abscission, ..