Gene Symbol: Chmp3
Description: charged multivesicular body protein 3
Alias: Vps24, charged multivesicular body protein 3, Vps24p protein, chromatin-modifying protein 3, rVps24p, vacuolar protein sorting 24 homolog, vacuolar protein sorting-associated protein 24
Zamborlini A, Usami Y, Radoshitzky S, Popova E, Palu G, Gottlinger H. Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding. Proc Natl Acad Sci U S A. 2006;103:19140-5 pubmed
..Together with biochemical evidence for specific intramolecular interactions between the basic and acidic halves of CHMP3 and CHMP4B, these results suggest that the acidic domains are autoinhibitory...
Effantin G, Dordor A, Sandrin V, Martinelli N, Sundquist W, Schoehn G, et al
. ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding. Cell Microbiol. 2013;15:213-26 pubmed publisher
..We have used electron cryomicroscopy to determine the molecular organization of pleiomorphic ESCRT-III CHMP2A-CHMP3 polymers...
Muzioł T, Pineda Molina E, Ravelli R, Zamborlini A, Usami Y, Gottlinger H, et al
. Structural basis for budding by the ESCRT-III factor CHMP3. Dev Cell. 2006;10:821-30 pubmed
..Here we report the crystal structure of the human ESCRT-III protein CHMP3 at 2.8 A resolution...
Lata S, Schoehn G, Jain A, Pires R, Piehler J, Gottlinger H, et al
. Helical structures of ESCRT-III are disassembled by VPS4. Science. 2008;321:1354-7 pubmed publisher
..We found that the ESCRT-III proteins CHMP2A and CHMP3 (charged multivesicular body proteins 2A and 3) could assemble in vitro into helical tubular structures that ..
Bache K, Stuffers S, Malerød L, Slagsvold T, Raiborg C, Lechardeur D, et al
. The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Mol Biol Cell. 2006;17:2513-23 pubmed
..the importance of the ESCRT-I subunit tumor susceptibility gene 101 (Tsg101) and the ESCRT-III subunit hVps24/CHMP3 for endosomal functions and receptor signaling. Like Tsg101, endogenous hVps24 localized mainly to late endosomes...
Whitley P, Reaves B, Hashimoto M, Riley A, Potter B, Holman G. Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization. J Biol Chem. 2003;278:38786-95 pubmed publisher
..We hypothesize that accumulation of Vps24 on membranes occurs when membrane association (dependent on interaction of phosphatidylinositol 3,5-bisphosphate ..
Dukes J, Richardson J, Simmons R, Whitley P. A dominant-negative ESCRT-III protein perturbs cytokinesis and trafficking to lysosomes. Biochem J. 2008;411:233-9 pubmed
..Here, we report that a subunit, CHMP3 (charged multivesicular body protein-3), of ESCRT-III localizes at the midbody...
Lata S, Roessle M, Solomons J, Jamin M, Gottlinger H, Svergun D, et al
. Structural basis for autoinhibition of ESCRT-III CHMP3. J Mol Biol. 2008;378:818-27 pubmed publisher
..Here we provide structural evidence based on small-angle X-ray scattering data that ESCRT-III CHMP3 can adopt two conformations in solution: a closed globular form that most likely represents the cytosolic ..
Rusten T, Stenmark H. How do ESCRT proteins control autophagy?. J Cell Sci. 2009;122:2179-83 pubmed publisher
..We propose that the involvement of ESCRT proteins in the fusion of autophagosomes with the endolysosomal system is the most plausible model. ..