Gene Symbol: Chmp2b
Description: charged multivesicular body protein 2B
Alias: RGD1306781, charged multivesicular body protein 2b, chromatin modifying protein 2B
Species: rat
Products:     Chmp2b

Top Publications

  1. Stuchell Brereton M, Skalicky J, Kieffer C, Karren M, Ghaffarian S, Sundquist W. ESCRT-III recognition by VPS4 ATPases. Nature. 2007;449:740-4 pubmed
    ..Structures of VPS4A MIT-CHMP1A and VPS4B MIT-CHMP2B complexes reveal that the C-terminal CHMP motif forms an amphipathic helix that binds in a groove between the last ..
  2. Effantin G, Dordor A, Sandrin V, Martinelli N, Sundquist W, Schoehn G, et al. ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding. Cell Microbiol. 2013;15:213-26 pubmed publisher HIV-1 budding, and the CHMP3 contribution is ~ 10-fold more pronounced in concert with CHMP2A than with CHMP2B. This is consistent with surface plasmon resonance affinity measurements that suggest sequential CHMP4B-CHMP3-..
  3. Parkinson N, Ince P, Smith M, Highley R, Skibinski G, Andersen P, et al. ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B). Neurology. 2006;67:1074-7 pubmed
    Mutation in the CHMP2B gene has been implicated in frontotemporal dementia. The authors screened CHMP2B in patients with ALS and several cohorts of control samples. They identified mutations (Q206H; I29V) in two patients with non-SOD1 ALS...
  4. Schumacher A, Friedrich P, Diehl Schmid J, Ibach B, Eisele T, Laws S, et al. No association of chromatin-modifying protein 2B with sporadic frontotemporal dementia. Neurobiol Aging. 2007;28:1789-90 pubmed
    Mutations of the chromatin modifying protein 2B gene (CHMP2B) were identified, in a Danish pedigree, to cause familial frontotemporal dementia (FTD)...
  5. Rohrer J, Ahsan R, Isaacs A, Nielsen J, Ostergaard L, Scahill R, et al. Presymptomatic generalized brain atrophy in frontotemporal dementia caused by CHMP2B mutation. Dement Geriatr Cogn Disord. 2009;27:182-6 pubmed publisher
    b>CHMP2B mutations are a rare cause of familial frontotemporal dementia (FTD)...
  6. Kaivorinne A, Kruger J, Udd B, Majamaa K, Remes A. Mutations in CHMP2B are not a cause of frontotemporal lobar degeneration in Finnish patients. Eur J Neurol. 2010;17:1393-5 pubmed publisher
    ..Mutations in the chromatin-modifying protein 2B gene (CHMP2B) have been identified in a few families. However, CHMP2B has been showed to be a rare cause of FTLD...
  7. Ghazi Noori S, Froud K, Mizielinska S, Powell C, Smidak M, Fernández de Marco M, et al. Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice. Brain. 2012;135:819-32 pubmed publisher
    Mutations in the charged multivesicular body protein 2B (CHMP2B) gene cause frontotemporal lobar degeneration. The mutations lead to C-terminal truncation of the CHMP2B protein...
  8. Sandrin V, Sundquist W. ESCRT requirements for EIAV budding. Retrovirology. 2013;10:104 pubmed publisher
    ..These studies help establish EIAV as a streamlined model system for dissecting the stepwise processes of lentivirus assembly and ESCRT-mediated budding. ..
  9. Cashikar A, Shim S, Roth R, Maldazys M, Heuser J, Hanson P. Structure of cellular ESCRT-III spirals and their relationship to HIV budding. elife. 2014;3: pubmed publisher
    ..Interpolating between the observed structures suggests a new role for Vps4 in separating ESCRT-III from Gag or other cargo to allow centripetal growth of a neck constricting ESCRT-III spiral...

More Information


  1. Skibinski G, Parkinson N, Brown J, Chakrabarti L, Lloyd S, Hummerich H, et al. Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia. Nat Genet. 2005;37:806-8 pubmed
    ..Here we identify a mutation in CHMP2B, encoding a component of the endosomal ESCRTIII complex, and show that it results in aberrant mRNA splicing in ..
  2. Rusten T, Stenmark H. How do ESCRT proteins control autophagy?. J Cell Sci. 2009;122:2179-83 pubmed publisher
    ..We propose that the involvement of ESCRT proteins in the fusion of autophagosomes with the endolysosomal system is the most plausible model. ..