Gene Symbol: Chmp2b
Description: charged multivesicular body protein 2B
Alias: RGD1306781, charged multivesicular body protein 2b, chromatin modifying protein 2B
Stuchell Brereton M, Skalicky J, Kieffer C, Karren M, Ghaffarian S, Sundquist W. ESCRT-III recognition by VPS4 ATPases. Nature. 2007;449:740-4 pubmed
..Structures of VPS4A MIT-CHMP1A and VPS4B MIT-CHMP2B complexes reveal that the C-terminal CHMP motif forms an amphipathic helix that binds in a groove between the last ..
Effantin G, Dordor A, Sandrin V, Martinelli N, Sundquist W, Schoehn G, et al
. ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding. Cell Microbiol. 2013;15:213-26 pubmed publisher
..to HIV-1 budding, and the CHMP3 contribution is ~ 10-fold more pronounced in concert with CHMP2A than with CHMP2B. This is consistent with surface plasmon resonance affinity measurements that suggest sequential CHMP4B-CHMP3-..
Parkinson N, Ince P, Smith M, Highley R, Skibinski G, Andersen P, et al
. ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B). Neurology. 2006;67:1074-7 pubmed
Mutation in the CHMP2B gene has been implicated in frontotemporal dementia. The authors screened CHMP2B in patients with ALS and several cohorts of control samples. They identified mutations (Q206H; I29V) in two patients with non-SOD1 ALS...
Schumacher A, Friedrich P, Diehl Schmid J, Ibach B, Eisele T, Laws S, et al
. No association of chromatin-modifying protein 2B with sporadic frontotemporal dementia. Neurobiol Aging. 2007;28:1789-90 pubmed
Mutations of the chromatin modifying protein 2B gene (CHMP2B) were identified, in a Danish pedigree, to cause familial frontotemporal dementia (FTD)...
Rohrer J, Ahsan R, Isaacs A, Nielsen J, Ostergaard L, Scahill R, et al
. Presymptomatic generalized brain atrophy in frontotemporal dementia caused by CHMP2B mutation. Dement Geriatr Cogn Disord. 2009;27:182-6 pubmed publisher
b>CHMP2B mutations are a rare cause of familial frontotemporal dementia (FTD)...
Kaivorinne A, Kruger J, Udd B, Majamaa K, Remes A. Mutations in CHMP2B are not a cause of frontotemporal lobar degeneration in Finnish patients. Eur J Neurol. 2010;17:1393-5 pubmed publisher
..Mutations in the chromatin-modifying protein 2B gene (CHMP2B) have been identified in a few families. However, CHMP2B has been showed to be a rare cause of FTLD...
Ghazi Noori S, Froud K, Mizielinska S, Powell C, Smidak M, Fernández de Marco M, et al
. Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice. Brain. 2012;135:819-32 pubmed publisher
Mutations in the charged multivesicular body protein 2B (CHMP2B) gene cause frontotemporal lobar degeneration. The mutations lead to C-terminal truncation of the CHMP2B protein...
Sandrin V, Sundquist W. ESCRT requirements for EIAV budding. Retrovirology. 2013;10:104 pubmed publisher
..These studies help establish EIAV as a streamlined model system for dissecting the stepwise processes of lentivirus assembly and ESCRT-mediated budding. ..
Cashikar A, Shim S, Roth R, Maldazys M, Heuser J, Hanson P. Structure of cellular ESCRT-III spirals and their relationship to HIV budding. elife. 2014;3: pubmed publisher
..Interpolating between the observed structures suggests a new role for Vps4 in separating ESCRT-III from Gag or other cargo to allow centripetal growth of a neck constricting ESCRT-III spiral...