Gene Symbol: Chchd3
Description: coiled-coil-helix-coiled-coil-helix domain containing 3
Alias: MICOS complex subunit MIC19, coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial
Darshi M, Mendiola V, Mackey M, Murphy A, Koller A, Perkins G, et al
. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem. 2011;286:2918-32 pubmed publisher
..Here, we characterize ChChd3, a previously identified PKA substrate of unknown function (Schauble, S., King, C. C., Darshi, M., Koller, A...
Liu H, Li Y, Li Y, Liu B, Wu H, Wang J, et al
. Cloning and functional analysis of FLJ20420: a novel transcription factor for the BAG-1 promoter. PLoS ONE. 2012;7:e34832 pubmed publisher
..0001). Taken together, our experiments suggest that FLJ20420 functions as a down-regulator of BAG-1 expression. Its abnormal expression may be involved in the oncogenesis of human malignancies such as lung cancer. ..
Zerbes R, van der Klei I, Veenhuis M, Pfanner N, van der Laan M, Bohnert M. Mitofilin complexes: conserved organizers of mitochondrial membrane architecture. Biol Chem. 2012;393:1247-61 pubmed publisher
..MINOS has been conserved in evolution from unicellular eukaryotes to humans, where alterations of MINOS subunits are associated with multiple pathological conditions. ..
Ott C, Dorsch E, Fraunholz M, Straub S, Kozjak Pavlovic V. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. PLoS ONE. 2015;10:e0120213 pubmed publisher
..We show that the most important subunits of the MIB complex in human mitochondria are Mic60/Mitofilin, Mic19/CHCHD3 and an outer membrane component Sam50...
Guarani V, McNeill E, Paulo J, Huttlin E, FrÃ¶hlich F, Gygi S, et al
. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. elife. 2015;4: pubmed publisher
..Collectively, our work uncovers a previously unrecognized subunit of the MICOS complex, necessary for CJ integrity, cristae morphology, and mitochondrial function and provides a resource for further analysis of MICOS architecture. ..