Cebpb

Summary

Gene Symbol: Cebpb
Description: CCAAT/enhancer binding protein beta
Alias: Il6dbp, NF-IL6, TCF5, CCAAT/enhancer-binding protein beta, C/EBP beta, CCAAT/enhancer binding protein (C/EBP), beta, IL-6DBP, SF-B, interleukin-6-dependent-binding protein, nuclear factor-IL6, silencer factor B
Species: rat
Products:     Cebpb

Top Publications

  1. Villagra A, Cruzat F, Carvallo L, Paredes R, Olate J, Van Wijnen A, et al. Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT/enhancer-binding protein beta-dependent recruitment of SWI/SNF activity. J Biol Chem. 2006;281:22695-706 pubmed
    ..Together, our results indicate that the SWI/SNF complex is a key regulator of the chromatin-remodeling events that promote tissue-specific transcription in osteoblasts. ..
  2. Wang K, Brems J, Gamelli R, Holterman A. C/EBP? and C/EBP? binding proteins modulate hepatocyte apoptosis through iNOS signaling pathway. Biochim Biophys Acta. 2011;1813:1395-403 pubmed publisher
    ..These findings indicate that C/EBP? and C/EBP? regulate the iNOS expression, which may further modify cell responses such as apoptosis and cell survival. ..
  3. Uematsu S, Kaisho T, Tanaka T, Matsumoto M, Yamakami M, Omori H, et al. The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing. J Immunol. 2007;179:5378-86 pubmed
    ..Collectively, we demonstrated that 34-kDa LAP is responsible for NF-IL6-mediated gene induction, but not essential for intracellular bacteria killing in activated macrophages. ..
  4. Sterneck E, Tessarollo L, Johnson P. An essential role for C/EBPbeta in female reproduction. Genes Dev. 1997;11:2153-62 pubmed
  5. Begay V, Smink J, Leutz A. Essential requirement of CCAAT/enhancer binding proteins in embryogenesis. Mol Cell Biol. 2004;24:9744-51 pubmed
    ..Our data thus reveal novel essential, redundant, and dosage dependent functions of C/EBPs. ..
  6. Descombes P, Schibler U. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell. 1991;67:569-79 pubmed
    ..The LAP/LIP ratio increases about 5-fold during terminal rat liver differentiation and is thus likely to modulate the activity of LAP in the intact animal. ..
  7. Calkhoven C, Muller C, Leutz A. Translational control of C/EBPalpha and C/EBPbeta isoform expression. Genes Dev. 2000;14:1920-32 pubmed
    ..Our results demonstrate that the translational controlled ratio of C/EBPalpha and C/EBPbeta isoform expression determines cell fate. ..
  8. Ohoka N, Yoshii S, Hattori T, Onozaki K, Hayashi H. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 2005;24:1243-55 pubmed
    ..These results indicate that TRB3 is a novel target of CHOP/ATF4 and downregulates its own induction by repression of CHOP/ATF4 functions, and that it is involved in CHOP-dependent cell death during ER stress. ..
  9. Ubeda M, Wang X, Zinszner H, Wu I, Habener J, Ron D. Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Mol Cell Biol. 1996;16:1479-89 pubmed
    ..We conclude that CHOP may serve a dual role both as an inhibitor of the ability of C/EBP proteins to activate some target genes and as a direct activator of others. ..

More Information

Publications62

  1. Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot R, Remotti H, et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 1998;12:982-95 pubmed
    ..CHOP therefore has a role in the induction of cell death under conditions associated with malfunction of the ER and may also have a role in cellular regeneration under such circumstances. ..
  2. Lee K, Kwak S, Ahn B, Lee H, Jung H, Cho Y, et al. F-box only protein 9 is required for adipocyte differentiation. Biochem Biophys Res Commun. 2013;435:239-43 pubmed publisher
    ..These results suggest that FBXO9 is required for adipocyte differentiation, and C/EBP? plays a role in the effect of FBXO9 on adipogenesis. ..
  3. Rochford J, Semple R, Laudes M, Boyle K, Christodoulides C, Mulligan C, et al. ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis. Mol Cell Biol. 2004;24:9863-72 pubmed
    ..These findings define, for the first time, a molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta and a novel regulator of early adipogenesis. ..
  4. Lee S, Miller M, Shuman J, Johnson P. CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein (CBP). J Biol Chem. 2010;285:21399-410 pubmed publisher
    ..Thus, the N-terminal regulatory elements have dual roles in auto-inhibition and coactivator binding. ..
  5. Descombes P, Chojkier M, Lichtsteiner S, Falvey E, Schibler U. LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev. 1990;4:1541-51 pubmed
    ..Thus, the preferential accumulation of LAP protein in liver appears to be regulated post-transcriptionally. ..
  6. Kolyada A, Johns C, Madias N. Role of C/EBP proteins in hepatic and vascular smooth muscle transcription of human NHE1 gene. Am J Physiol. 1995;269:C1408-16 pubmed
    ..These results indicate that members of the C/EBP family of transcription factors are involved in the regulation of hepatic and vascular smooth muscle transcription of the human NHE1 gene...
  7. Oh Y, Lee Y, Kang Y, Han J, Lim O, Jun H. Exendin-4 inhibits glucolipotoxic ER stress in pancreatic ? cells via regulation of SREBP1c and C/EBP? transcription factors. J Endocrinol. 2013;216:343-52 pubmed publisher
    ..cells increased SREBP1 (SREBF1) protein and induced its nuclear translocation and subsequently increased C/EBP? (CEBPB) protein and its nuclear translocation. Exendin-4 treatment attenuated this increase...
  8. Pan H, Yang C, Hung Y, Lee W, Tien H, Shen C, et al. Reciprocal modulation of C/EBP-? and C/EBP-? by IL-13 in activated microglia prevents neuronal death. Eur J Immunol. 2013;43:2854-65 pubmed publisher
    ..In parallel, ER stress-related calpain downregulates the PPAR-?/HO-1 pathway via C/EBP-? and leads to aggravated death of activated microglia via IL-13, thereby preventing cerebral inflammation and neuronal injury. ..
  9. Bambah Mukku D, Travaglia A, Chen D, Pollonini G, Alberini C. A positive autoregulatory BDNF feedback loop via C/EBPβ mediates hippocampal memory consolidation. J Neurosci. 2014;34:12547-59 pubmed publisher
    ..The autoregulatory loop terminates by 48 h after training with decreased C/EBPβ and pCREB and increased methyl-CpG binding protein-2, histone-deacetylase-2, and switch-independent-3a binding at the bdnf exon IV promoter. ..
  10. Bunker S, Dandapat J, Sahoo S, Roy A, Chainy G. Neonatal Persistent Exposure to 6-Propyl-2-thiouracil, a Thyroid-Disrupting Chemical, Differentially Modulates Expression of Hepatic Catalase and C/EBP-β in Adult Rats. J Biochem Mol Toxicol. 2016;30:80-90 pubmed publisher
    ..It is possible that besides thyroid-disrupting behavior, PTU may impair expression of hepatic catalase by altering methylation pattern of its promoter. ..
  11. Thomassin H, Hamel D, Bernier D, Guertin M, Belanger L. Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma. Nucleic Acids Res. 1992;20:3091-8 pubmed
    ..The high levels of C/EBP beta and gamma mRNAs in rat yolk sac and fetal liver, where C/EBP alpha is poorly expressed, suggest that C/EBP beta and/or gamma could be preponderant or early regulators of the AFP gene in these tissues. ..
  12. Isoda K, Koide H, Kojima M, Arita E, Ikkaku M, Higashiyama S, et al. Stimulation of hepatocyte survival and suppression of CCl4-induced liver injury by the adenovirally introduced C/EBPbeta gene. Biochem Biophys Res Commun. 2005;329:182-7 pubmed
    ..These results indicate that C/EBPbeta appears to be a survival factor under stressful conditions, and the introduction of the gene has therapeutic function against liver injury. ..
  13. Merhav M, Kuulmann Vander S, Elkobi A, Jacobson Pick S, Karni A, Rosenblum K. Behavioral interference and C/EBPbeta expression in the insular-cortex reveal a prolonged time period for taste memory consolidation. Learn Mem. 2006;13:571-4 pubmed
    ..This modulation was attenuated by a subsequent novel taste. Our findings reveal temporal constraints and a lingering nature of taste memory consolidation. ..
  14. Yang H, Mammen J, Wei W, Menconi M, Evenson A, Fareed M, et al. Expression and activity of C/EBPbeta and delta are upregulated by dexamethasone in skeletal muscle. J Cell Physiol. 2005;204:219-26 pubmed
    ..The results suggest that glucocorticoids increase C/EBPbeta and delta activity and expression through a direct effect in skeletal muscle. ..
  15. Liu M, Yuan T, Liu H, Chen P. CCAAT/enhancer-binding protein β regulates interleukin-6-induced transmembrane and ubiquitin-like domain containing 1 gene expression in hepatocytes. Mol Med Rep. 2014;10:2177-83 pubmed publisher
    ..The present study demonstrated that C/EBPβ is a key transcription factor, which can positively regulate the expression of Tmub1 during liver cell proliferation through a possible association with IL-6. ..
  16. Cho I, Sung D, Kang K, Kim S. Oltipraz promotion of liver regeneration after partial hepatectomy: The role of PI3-kinase-dependent C/EBPbeta and cyclin E regulation. Arch Pharm Res. 2009;32:625-35 pubmed publisher
    ..The results of this study demonstrate that oltipraz treatment enhances liver regeneration after PH, which involves activation of C/EBPbeta and C/EBPbeta-dependent cyclin E expression via the PI3K-p70S6 kinase pathway. ..
  17. Penner G, Gang G, Sun X, Wray C, Hasselgren P. C/EBP DNA-binding activity is upregulated by a glucocorticoid-dependent mechanism in septic muscle. Am J Physiol Regul Integr Comp Physiol. 2002;282:R439-44 pubmed
    ..The present results suggest that C/EBP-beta and -delta are activated in skeletal muscle during sepsis and that this response is, at least in part, regulated by glucocorticoids. ..
  18. Sandhir R, Berman N. Age-dependent response of CCAAT/enhancer binding proteins following traumatic brain injury in mice. Neurochem Int. 2010;56:188-93 pubmed publisher
    ..In addition elevated C/EBPdelta levels following TBI in the aged brain may play a role in the link between TBI and Alzheimer's disease. ..
  19. Williams S, Cantwell C, Johnson P. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev. 1991;5:1553-67 pubmed
    ..Our findings indicate that a set of potentially interacting C/EBP-like proteins exists, whose complexity is comparable to that of other bZIP protein subfamilies such as Jun, Fos, and ATF/CREB. ..
  20. Ichida F, Nishimura R, Hata K, Matsubara T, Ikeda F, Hisada K, et al. Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem. 2004;279:34015-22 pubmed
    ..These data indicate that Msx2 promotes osteoblast differentiation independently of Runx2 and negatively regulates adipocyte differentiation through inhibition of PPARgamma and the C/EBP family. ..
  21. Antes T, Goodart S, Huynh C, Sullivan M, Young S, Levy Wilson B. Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine. J Biol Chem. 2000;275:26637-48 pubmed
    ..In transgenic mouse expression studies, the 315-bp enhancer conferred intestinal expression to human apoB transgenes. ..
  22. Vasseur S, Mallo G, Garcia Montero A, Ortiz E, Fiedler F, Canepa E, et al. Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promot. Biochem J. 1999;343 Pt 2:377-83 pubmed
  23. Zou J, Gan X, Zhou H, Chen X, Guo Y, Chen J, et al. Alpha-lipoic acid attenuates cardiac hypertrophy via inhibition of C/EBPβ activation. Mol Cell Endocrinol. 2015;399:321-9 pubmed publisher
    ..Taken together, our results revealed a robust anti-hypertrophic and anti-remodeling effect of ALA, which is mediated by inhibition of C/EBPβ activation. ..
  24. Lincoln A, Monczak Y, Williams S, Johnson P. Inhibition of CCAAT/enhancer-binding protein alpha and beta translation by upstream open reading frames. J Biol Chem. 1998;273:9552-60 pubmed
    ..Our data indicate that the uORFs regulate translation of full-length C/EBPalpha and C/EBPbeta and do not play a role in generating truncated forms of these proteins, as has been suggested by start site multiplicity models. ..
  25. Gong B, Pan Y, Zhao W, Knable L, Vempati P, Begum S, et al. IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway. Mol Immunol. 2013;56:619-29 pubmed publisher
    ..IVIG may systematically improve cognitive function in AD brain by passing A? toxicity. ..
  26. Wang L, Shao J, Muhlenkamp P, Liu S, Klepcyk P, Ren J, et al. Increased insulin receptor substrate-1 and enhanced skeletal muscle insulin sensitivity in mice lacking CCAAT/enhancer-binding protein beta. J Biol Chem. 2000;275:14173-81 pubmed
    ..These results demonstrate that C/EBPbeta deletion decreases plasma FFA levels and increases insulin signal transduction specifically in skeletal muscle, and both contribute to increased whole-body insulin sensitivity. ..
  27. Imamura T, Imamura C, Iwamoto Y, Sandell L. Transcriptional Co-activators CREB-binding protein/p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding protein. J Biol Chem. 2005;280:16625-34 pubmed
    ..This new paradigm is likely generally applicable to cartilage genes as Col2a1 cartilage collagen gene responds similarly. ..
  28. Attia R, Sharma P, Janssen R, Friedman J, Deng X, Lee J, et al. Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by CCAAT/enhancer-binding protein beta (C/EBPbeta). J Biol Chem. 2011;286:23799-807 pubmed publisher
    ..CPT1a is an initiating step in the mitochondrial oxidation of long chain fatty acids. Our results indicate that C/EBP? stimulates Pdk4 expression and participates in the T(3) induction of the Cpt1a and Pdk4 genes. ..
  29. Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, et al. C/EBP? and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2? as the inducer in chondrocytes. Hum Mol Genet. 2012;21:1111-23 pubmed publisher
    ..OA) development, we examined the signal network around CCAAT/enhancer-binding protein-? (C/EBP?, encoded by CEBPB), a potent regulator of this process...
  30. Zou J, Li H, Chen X, Zeng S, Ye J, Zhou C, et al. C/EBP? knockdown protects cardiomyocytes from hypertrophy via inhibition of p65-NF?B. Mol Cell Endocrinol. 2014;390:18-25 pubmed publisher
    ..These findings shed new light on the understanding of C/EBP?-related cardiomyopathy, and suggest the potential application of C/EBP? inhibitors in cardiac hypertrophy. ..
  31. Miau L, Chang C, Tsai W, Lee S. Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor. Mol Cell Biol. 1997;17:230-9 pubmed
    ..Thus, the molecular mechanism for agp gene activation may involve the interaction of AGP/EBP and TFIIB mediated by coactivator Nopp140. ..
  32. Qiang L, Lin H, Kim Muller J, Welch C, Gu W, Accili D. Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. Cell Metab. 2011;14:758-67 pubmed publisher
    ..We propose that SirT1-dependent Creb deacetylation regulates the balance between glucose and lipid metabolism, integrating fasting signals. ..
  33. Shimizu H, Yamamoto K. NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines. Gene. 1994;149:305-10 pubmed
  34. Choudhury M, Qadri I, Rahman S, Schroeder Gloeckler J, Janssen R, Friedman J. C/EBP? is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells. Mol Cell Endocrinol. 2011;331:102-8 pubmed publisher
    ..Understanding how ER stress suppresses AMPK activation and increases C/EBP? expression could lead to a potentially novel pathway for treatment of diabetes. ..
  35. Zheng S, Rollet M, Pan Y. Maternal protein restriction during pregnancy induces CCAAT/enhancer-binding protein (C/EBP?) expression through the regulation of histone modification at its promoter region in female offspring rat skeletal muscle. Epigenetics. 2011;6:161-70 pubmed publisher
    ..The induction of C/EBP? expression in female offspring skeletal muscle by maternal protein restriction during pregnancy may indicate C/EBP? involvement in signaling response in energy metabolism to a low maternal protein diet. ..
  36. Susperreguy S, Prendes L, Desbats M, Charó N, Brown K, MacDougald O, et al. Visualization by BiFC of different C/EBP? dimers and their interaction with HP1? reveals a differential subnuclear distribution of complexes in living cells. Exp Cell Res. 2011;317:706-23 pubmed publisher
    ..Thus, the equilibrium among different pools of C/EBP? associated with chromatin or nucleoskeleton, and dynamic changes in their interaction with HP1?, play key roles in the regulation of C/EBP target genes during adipogenesis. ..
  37. Poli V, Mancini F, Cortese R. IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell. 1990;63:643-53 pubmed
  38. Jana M, Dasgupta S, Saha R, Liu X, Pahan K. Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages. J Neurochem. 2003;86:519-28 pubmed
    ..This study delineates a novel biological function of p40 in inducing TNF-alpha in microglia and macrophages. ..
  39. Sato Y, Nishio Y, Sekine O, Kodama K, Nagai Y, Nakamura T, et al. Increased expression of CCAAT/enhancer binding protein-beta and -delta and monocyte chemoattractant protein-1 genes in aortas from hyperinsulinaemic rats. Diabetologia. 2007;50:481-9 pubmed
    ..CCL2 production was analysed by ELISA. The expression of Ccl2, Cebpb and Cebpd mRNAs was investigated by quantitative RT-PCR...
  40. Pauleau A, Rutschman R, Lang R, Pernis A, Watowich S, Murray P. Enhancer-mediated control of macrophage-specific arginase I expression. J Immunol. 2004;172:7565-73 pubmed
    ..Identification of a powerful extrahepatic regulatory enhancer for arginase I provides potential to manipulate arginase I activity in immune cells while sparing liver urea cycle function. ..
  41. Boström P, Mann N, Wu J, Quintero P, Plovie E, Panàkovà D, et al. C/EBP? controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell. 2010;143:1072-83 pubmed publisher
    ..These data indicate that C/EBP? represses cardiomyocyte growth and proliferation in the adult mammalian heart and that reduction in C/EBP? is a central signal in physiologic hypertrophy and proliferation. ..
  42. Miau L, Chang C, Shen B, Tsai W, Lee S. Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation. J Biol Chem. 1998;273:10784-91 pubmed
    ..The kinetics of appearance of C/EBPbeta-hnRNP K complex in the nuclear extract after initiation of acute-phase reaction indicates that hnRNP K functions as a negative regulator of C/EBPbeta-mediated activation of agp gene. ..
  43. Berberich Siebelt F, Berberich I, Andrulis M, Santner Nanan B, Jha M, Klein Hessling S, et al. SUMOylation interferes with CCAAT/enhancer-binding protein beta-mediated c-myc repression, but not IL-4 activation in T cells. J Immunol. 2006;176:4843-51 pubmed
    ..These results suggest an important role of sumoylation in adjusting the finely tuned balance between proliferation and differentiation in peripheral T cells which is controlled by C/EBPbeta. ..
  44. Gao H, Parkin S, Johnson P, Schwartz R. C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters. J Biol Chem. 2002;277:38827-37 pubmed
  45. Ossipow V, Descombes P, Schibler U. CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials. Proc Natl Acad Sci U S A. 1993;90:8219-23 pubmed
    ..The production of multiple proteins from a single mRNA is not only shared between different C/EBP family members but also appears to be conserved in vertebrate evolution. ..
  46. Jia Y, Yao H, Zhou J, Chen L, Zeng Q, Yuan H, et al. Role of epimorphin in bile duct formation of rat liver epithelial stem-like cells: involvement of small G protein RhoA and C/EBP?. J Cell Physiol. 2011;226:2807-16 pubmed publisher
    ..Taken together, these data demonstrated that EPM regulates bile duct formation of WB-F344 cells through effects on RhoA and C/EBP?, implicating a dual aspect of this morphoregulator in bile duct epithelial morphogenesis. ..
  47. Wang F, Demura M, Cheng Y, Zhu A, Karashima S, Yoneda T, et al. Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene. Hypertension. 2014;63:281-8 pubmed publisher
    ..Decreased DNA methylation activity in the nucleus may play a role in DNA demethylation. DNA demethylation switches the phenotype of AGT expression from an inactive to an active state. ..
  48. Sasaki M, Hashimoto S, Sawa T, Amaya F. Tumor necrosis factor-alpha induces expression of C/EBP-beta in primary afferent neurons following nerve injury. Neuroscience. 2014;279:1-9 pubmed publisher
    ..These results demonstrate that C/EBP-beta is activated in the DRG neurons by a TNF-alpha-dependent manner and might be involved in the activation of primary afferent neurons after nerve injury. ..
  49. Obrietan K, Hoyt K. CRE-mediated transcription is increased in Huntington's disease transgenic mice. J Neurosci. 2004;24:791-6 pubmed
    ..Thus, rather than repressing CRE-mediated transcription, mutant huntingtin appears to facilitate transcription via a CRE-dependent mechanism in vivo. ..
  50. Trautwein C, van der Geer P, Karin M, Hunter T, Chojkier M. Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements. J Clin Invest. 1994;93:2554-61 pubmed
    ..These results suggest that site-specific phosphorylations of LAP modulate transactivation of its target genes. ..
  51. Zhao G, Nakano K, Chijiiwa K, Ueda J, Tanaka M. Inhibited activities in CCAAT/enhancer-binding protein, activating protein-1 and cyclins after hepatectomy in rats with thioacetamide-induced liver cirrhosis. Biochem Biophys Res Commun. 2002;292:474-81 pubmed
    ..In conclusion, downregulation of cyclin -D1, -E, and -A expression, which may be induced by impaired activities of C/EBP and AP-1, is responsible for the decreased regenerative capacity of cirrhotic liver after partial hepatectomy. ..
  52. Rosenberg E, Li F, Reisher S, Wang M, Gonzales L, Ewing J, et al. Members of the C/EBP transcription factor family stimulate expression of the human and rat surfactant protein A (SP-A) genes. Biochim Biophys Acta. 2002;1575:82-90 pubmed
    ..The data indicate that C/EBPs facilitate SP-A gene expression, possibly by overcoming transcriptional silencing. ..
  53. Ron D, Habener J. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992;6:439-53 pubmed