Cdkn1b

Summary

Gene Symbol: Cdkn1b
Description: cyclin-dependent kinase inhibitor 1B
Alias: CDKN4, Cdki1b, Kip1, P27KIP1, p27, cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor 1B (p27, Kip1), cyclin-dependent kinase inhibitor p27, cyclin-dependent kinase inhibitor p27/Kip1
Species: rat
Products:     Cdkn1b

Top Publications

  1. Toyoshima H, Hunter T. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell. 1994;78:67-74 pubmed
    ..p27 is identical to p27Kip1, a cyclin-Cdk inhibitor present in TGF beta-treated cells...
  2. Karnik S, Hughes C, Gu X, Rozenblatt Rosen O, McLean G, Xiong Y, et al. Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc Natl Acad Sci U S A. 2005;102:14659-64 pubmed
    ..In vivo expression of CDK inhibitors, including p27 and p18, and other cell cycle regulators is disrupted in mouse islet tumors lacking menin...
  3. Kawada M, Yamagoe S, Murakami Y, Suzuki K, Mizuno S, Uehara Y. Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway. Oncogene. 1997;15:629-37 pubmed
    ..without substrate attachment, the cell cycle arrested in G1 phase and the cyclin-dependent kinase inhibitor p27Kip1 protein and its mRNA accumulated...
  4. Pellegata N, Quintanilla Martinez L, Siggelkow H, Samson E, Bink K, Hofler H, et al. Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Proc Natl Acad Sci U S A. 2006;103:15558-63 pubmed
    ..We report the fine mapping of the disease locus and the identification of a homozygous frameshift mutation in Cdkn1b, encoding the cyclin-dependent kinase inhibitor p27(Kip1)...
  5. Rodier G, Montagnoli A, Di Marcotullio L, Coulombe P, Draetta G, Pagano M, et al. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J. 2001;20:6672-82 pubmed
    The activity of the cyclin-dependent kinase inhibitor p27 is controlled by its concentration and subcellular localization. However, the mechanisms that regulate its intracellular transport are poorly understood...
  6. Schreiber M, Muller W, Singh G, Graham F. Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. Oncogene. 1999;18:1663-76 pubmed
    ..vectors were constructed to overexpress cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 under the control of the murine cytomegalovirus immediate early gene promoter...
  7. Aravindan N, Williams M, Riedel B, Shaw A. Transcriptional responses of rat skeletal muscle following hypoxia-reoxygenation and near ischaemia-reperfusion. Acta Physiol Scand. 2005;183:367-77 pubmed
    ..Several genes, including insulin-like growth factor 1 (IGF-1) and cyclin-dependent kinase inhibitor (p27(Kip1)) were induced by both injury types and these may have potential clinical application as markers of tissue damage...
  8. Kumar S, Vaidya M. Hypoxia inhibits mesenchymal stem cell proliferation through HIF1α-dependent regulation of P27. Mol Cell Biochem. 2016;415:29-38 pubmed publisher
    ..Cyclin-dependent kinase inhibitor (CDKI), p27 was significantly increased, in concordance with the findings, cyclin D1 was also reduced under hypoxia and ..
  9. Wu S, Liao P, Dong L, Jiang X. [Protective effects of 15-methyl-lipoxin A4 on mesangioproliferative nephritis in rats]. Zhongguo Dang Dai Er Ke Za Zhi. 2006;8:225-30 pubmed
    ..Phosphorylated phosphoinositide 3-kinase (PI3-K), Akt1 and p27(kip1) in glomeruli were analyzed by Western Blot...

More Information

Publications94

  1. Zhang P, Wong C, DePinho R, Harper J, Elledge S. Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. Genes Dev. 1998;12:3162-7 pubmed
    ..In this study, using multiple mutant mice, we show that the Cdk inhibitors p27(KIP1) and p57(KIP2) function redundantly to control cell cycle exit and differentiation of lens fiber cells and ..
  2. Tsutsui S, Yasuda K, Suzuki K, Takeuchi H, Nishizaki T, Higashi H, et al. Bcl-2 protein expression is associated with p27 and p53 protein expressions and MIB-1 counts in breast cancer. BMC Cancer. 2006;6:187 pubmed
    ..The aim of this study was to investigate the relationship between Bcl-2 and p27 protein expression, p53 protein expression and the proliferation activity as defined by the MIB-1 counts...
  3. Mao X, Zhang D, Tao T, Liu X, Sun X, Wang Y, et al. O-GlcNAc glycosylation of p27(kip1) promotes astrocyte migration and functional recovery after spinal cord contusion. Exp Cell Res. 2015;339:197-205 pubmed publisher
    ..Cyclin-dependent kinase inhibitor p27(kip1), whose activity is closely related to its phosphorylation state, reportedly regulates astrocyte proliferation and ..
  4. Hikosaka A, Ogawa K, Sugiura S, Asamoto M, Takeshita F, Sato S, et al. Susceptibility of p27 kip1 knockout mice to urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine may not simply be due to enhanced proliferation. Int J Cancer. 2008;122:1222-8 pubmed
    Deregulated proliferation is one of the fundamental characteristics of carcinogenesis. p27 is one of the most well characterized negative cell cycle regulator...
  5. Mitra P, Ghule P, van der Deen M, Medina R, Xie R, Holmes W, et al. CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P. J Cell Physiol. 2009;219:438-48 pubmed publisher
    ..The three CDK inhibitors (CKIs) p21(CIP1/WAF1), p27(KIP1), and p57(KIP2) attenuate CDK2 activity...
  6. Er H, Acar N, Kipmen Korgun D, Celik Ozenci C, Ustunel I, Asar M, et al. Determination of PCNA, cyclin D3, p27, p57 and apoptosis rate in normal and dexamethasone-induced intrauterine growth restricted rat placentas. Acta Histochem. 2015;117:137-47 pubmed publisher
    ..the immunolocalization, mRNA and protein levels of proliferating cell nuclear antigen (PCNA), cyclin D3, p27 and p57 in normal and dexamethasone-induced IUGR Wistar rat placentas by reverse transcriptase polymerase chain ..
  7. Andreasson P, Johansson B, Arheden K, Billström R, Mitelman F, Hoglund M. Deletions of CDKN1B and ETV6 in acute myeloid leukemia and myelodysplastic syndromes without cytogenetic evidence of 12p abnormalities. Genes Chromosomes Cancer. 1997;19:77-83 pubmed
    ..evidence of 12p aberrations were investigated by fluorescence in situ hybridization with probes for ETV6 and CDKN1B (previously called TEL and KIP1, respectively) to ascertain whether abnormalities of these genes are frequently ..
  8. Marinoni I, Lee M, Mountford S, Perren A, Bravi I, Jennen L, et al. Characterization of MENX-associated pituitary tumours. Neuropathol Appl Neurobiol. 2013;39:256-69 pubmed publisher
    ..MENX is multiple endocrine neoplasia syndrome caused by a germline mutation in the cell cycle inhibitor p27. Characterization of MENX adenomas is a prerequisite to exploit this animal model for molecular and translational ..
  9. Zheng T, Lu Y. Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans. Curr Eye Res. 2011;36:449-55 pubmed publisher
    ..SIRT1 mRNA; Western blot analysis by anti-SIRT1, anti-p53, anti-p53 (acetyl K379), anti-FOXO3a, anti-FOXO4, anti-p27kip1, anti-p130, and anti-Bim; immunofluorescence of SIRT1; and TUNEL assay were performed in each group...
  10. Hauck L, Harms C, An J, Rohne J, Gertz K, Dietz R, et al. Protein kinase CK2 links extracellular growth factor signaling with the control of p27(Kip1) stability in the heart. Nat Med. 2008;14:315-24 pubmed publisher
    p27(Kip1) (p27) blocks cell proliferation through the inhibition of cyclin-dependent kinase-2 (Cdk2)...
  11. Machida S, Spangenburg E, Booth F. Forkhead transcription factor FoxO1 transduces insulin-like growth factor's signal to p27Kip1 in primary skeletal muscle satellite cells. J Cell Physiol. 2003;196:523-31 pubmed
    ..with the activation of phosphatidylinositol 3'-kinase (PI3K)/Akt and the downregulation of a cell-cycle inhibitor p27Kip1. To understand mechanisms by which IGF-I signals the downregulation of p27Kip1 in rat skeletal satellite cells, ..
  12. Mielke K. Growth-arrest-dependent expression and phosphorylation of p27kip at serine10 is mediated by the JNK pathway in C6 glioma cells. Mol Cell Neurosci. 2008;38:301-11 pubmed publisher
  13. Del Debbio C, Mir Q, Parameswaran S, Mathews S, Xia X, Zheng L, et al. Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27Kip1. PLoS ONE. 2016;11:e0152025 pubmed publisher
    ..We demonstrate that one of the targets of Notch signaling is the cyclin-dependent kinase inhibitor (CKI), p27Kip1, which is highly expressed in quiescent MG...
  14. Lees S, Childs T, Booth F. Age-dependent FOXO regulation of p27Kip1 expression via a conserved binding motif in rat muscle precursor cells. Am J Physiol Cell Physiol. 2008;295:C1238-46 pubmed publisher
    Previously, we have demonstrated that forkhead box O3a (FOXO3a) overexpression increased p27(Kip1) promoter activity and protein expression, whereas it decreased proliferation in muscle precursor cells (MPCs)...
  15. Wang H, Lee W. Progesterone-induced migration inhibition in male rat aortic smooth muscle cells through the cSrc/AKT/ERK 2/p38 pathway-mediated up-regulation of p27. Endocrinology. 2014;155:1428-35 pubmed publisher
    ..We also observed that P4 increased the formation of p27-RhoA complex in RASMCs...
  16. Braun K, Hölzl G, Soucek T, Geisen C, Moroy T, Hengstschlager M. Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. Oncogene. 1998;17:2259-69 pubmed
    ..affected by p16 (in contrast to cdk4/6) nor by E2F-1 (in contrast to cdk2), but is downregulated upon transient p27 expression. We found cdk3 to bind to p21 and p27...
  17. Rizk D, Hassan H, Al Marzouqi A, Shafiullah M, Fahim M. Combined estrogen and ghrelin administration decreases expression of p27(kip1) and proportion of isomyosin type I in the striated urethral and anal sphincters and levator ani of old ovariectomized rats. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19:1363-9 pubmed publisher
    ..Cytoplasmic p27(kip1) expression and isomyosin I proportion in striated urethral and anal sphincters and levator ani were measured, ..
  18. Tokumoto Y, Apperly J, Gao F, Raff M. Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation. Dev Biol. 2002;245:224-34 pubmed
    ..There is evidence that the cyclin-dependent kinase inhibitor (CKI) p27/Kip1 (p27) is a component of this TH-regulated timer, as it increases as OPCs proliferate and is required for the timer ..
  19. Sherr C. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res. 2000;60:3689-95 pubmed
    ..Reduction in levels of p27(Kip1) and increased expression of cyclin E also occur and carry a poor prognostic significance in many common forms of ..
  20. Zhang S, Huan W, Wei H, Shi J, Fan J, Zhao J, et al. FOXO3a/p27kip1 expression and essential role after acute spinal cord injury in adult rat. J Cell Biochem. 2013;114:354-65 pubmed publisher
    ..progression at the G1/S transition by controlling transcription of the cyclin-dependent kinase inhibitor p27(kip1) , which is also a key regulator of the mammalian neurogenesis...
  21. Ge J, Ren G, Yao H. [Expression of cyclin D1 and p27kip1 in renal cell carcinoma and its significance]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007;36:483-7 pubmed
    To investigate the role of cyclin D1 and p27(kip1) in the occurrence and development of conventional renal cell carcinoma(CRCC)...
  22. Messina G, Blasi C, La Rocca S, Pompili M, Calconi A, Grossi M. p27Kip1 acts downstream of N-cadherin-mediated cell adhesion to promote myogenesis beyond cell cycle regulation. Mol Biol Cell. 2005;16:1469-80 pubmed
    ..failure to undergo terminal differentiation is independent from cell cycle control and reflects the lack of p27Kip1 and MyoD in proliferating myoblasts...
  23. Shen A, Shi S, Chen M, Qin J, Gao S, Cheng C. Dynamic changes of p27(kip1) and Skp2 expression in injured rat sciatic nerve. Cell Mol Neurobiol. 2008;28:713-25 pubmed
    ..protein 2 (Skp2), an F-box protein, is required for the ubiquitination and consequent degradation of p27(kip1)...
  24. Yao L, Cao J, Sun H, Guo A, Li A, Ben Z, et al. FBP1 and p27kip1 expression after sciatic nerve injury: implications for Schwann cells proliferation and differentiation. J Cell Biochem. 2014;115:130-40 pubmed publisher
    ..Typically, FBP1 could active the translation of p27kip1 (p27) and participate in tumor growth...
  25. Wang H, Hsu S, Lee W. Extra-Nuclear Signaling Pathway Involved in Progesterone-Induced Up-Regulations of p21cip1 and p27kip1 in Male Rat Aortic Smooth Muscle Cells. PLoS ONE. 2015;10:e0125903 pubmed publisher
    ..that P4-induced cell cycle arrest in RASMCs occurs when the cyclin-CDK2 system is inhibited just as p21cip1 and p27kip1 protein levels are augmented...
  26. Shen A, Liu Y, Zhao J, Qin J, Shi S, Chen M, et al. Temporal-spatial expressions of p27kip1 and its phosphorylation on Serine-10 after acute spinal cord injury in adult rat: Implications for post-traumatic glial proliferation. Neurochem Int. 2008;52:1266-75 pubmed publisher
    b>P27kip1, as a member of Cip/Kip family of cyclin-dependent kinase inhibitors, plays important roles in cell cycle regulation and neurogenesis in the developing central nervous system...
  27. Nowee M, Dorsman J, Piek J, Kosma V, Hamalainen K, Verheijen R, et al. HER-2/neu and p27Kip1 in progression of Fallopian tube carcinoma: an immunohistochemical and array comparative genomic hybridization study. Histopathology. 2007;51:666-73 pubmed
    ..tube carcinoma (FTC) in relation to stage and grade, and to investigate DNA copy number changes of HER-2 and P27KIP1 as a potential mechanism of altered expression status...
  28. Larocque D, Galarneau A, Liu H, Scott M, Almazan G, Richard S. Protection of p27(Kip1) mRNA by quaking RNA binding proteins promotes oligodendrocyte differentiation. Nat Neurosci. 2005;8:27-33 pubmed
    ..The mRNA encoding the cyclin-dependent kinase (CDK)-inhibitor p27(Kip1) was bound and stabilized by QKI, leading to an increased accumulation of p27(Kip1) protein in oligodendrocytes...
  29. Murray S, Yang S, Demicco E, Ying H, Sherr D, Hafer L, et al. Increased expression of MDM2, cyclin D1, and p27Kip1 in carcinogen-induced rat mammary tumors. J Cell Biochem. 2005;95:875-84 pubmed
    ..Expression of p27Kip1 protein was also elevated in the tumors with increased cytoplasmic localization...
  30. Brunner A, Verdorfer I, Prelog M, Mayerl C, Mikuz G, Tzankov A. Large-scale analysis of cell cycle regulators in urothelial bladder cancer identifies p16 and p27 as potentially useful prognostic markers. Pathobiology. 2008;75:25-33 pubmed publisher
    ..A tissue microarray consisting of 99 UCs was evaluated for the expression of p53, p16, p21, p27, cyclin D1, cyclin E , Bcl-2, Ki-67 and PCNA...
  31. Chiappini F, Pontillo C, Randi A, Alvarez L, Kleiman de Pisarev D. Hexachlorobenzene induces TGF-?1 expression, which is a regulator of p27 and cyclin D1 modifications. Toxicol Lett. 2014;230:1-9 pubmed publisher
    ..Time-dependent studies showed that both cytosolic and nuclear p27 protein levels were increased by 5 ?M HCB. After 24 h of treatment, total p27 in whole cells lysate was increased...
  32. Unahara Y, Kojima Yuasa A, Higashida M, Kennedy D, Murakami A, Ohigashi H, et al. Cellular thiol status-dependent inhibition of tumor cell growth via modulation of p27(kip1) translocation and retinoblastoma protein phosphorylation by 1'-acetoxychavicol acetate. Amino Acids. 2007;33:469-76 pubmed
    ..As Rb phosphorylation is regulated by G1 cyclin dependent kinase and CDK inhibitor p27(kip1), which is an important regulator of the mammalian cell cycle, we estimated the amount of p27(kip1) levels by ..
  33. McCampbell A, Mittelstadt M, Dere R, Kim S, Zhou L, Djordjevic B, et al. Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity. Curr Mol Med. 2016;16:252-65 pubmed
    ..by PI3K/AKT activation, and opposed by tumor suppressors, including the tuberous sclerosis complex 2 (TSC-2) and p27, with inactivation of TSC2 and loss or cytoplasmic mislocalization of p27 both being linked to PI3K/AKT activation...
  34. Zeng L, Xu H, Chew T, Chisholm R, Sadeghi M, Kanwar Y, et al. Simvastatin modulates angiotensin II signaling pathway by preventing Rac1-mediated upregulation of p27. J Am Soc Nephrol. 2004;15:1711-20 pubmed
    ..SMV) on the angiotensin II (Ang II)-induced Rac1-mediated, upregulation of cyclin-dependent kinase inhibitor p27. Ang II (100 nM) stimulation of rat mesangial cells induced a significant increase in p27 protein expression...
  35. Wang Y, Zheng H, Liu S. Effects of ATP-sensitive potassium channels on the expression of P21, P27 and leptin. J Huazhong Univ Sci Technolog Med Sci. 2009;29:8-11 pubmed publisher
    This study investigated the effects of ATP-sensitive potassium channels on the expression of P21, P27 and leptin...
  36. Wu X, Shi W, Zhao W, Shao B, Yuan Q, Li C, et al. Changes in Pirh2 and p27kip1 expression following traumatic brain injury in adult rats. J Mol Neurosci. 2012;46:184-91 pubmed publisher
    Pirh2, a p53-induced ubiquitin-protein ligase, has been reported to promote ubiquitin-dependent degradation of p27(kip1), which plays an essential role in mammalian cell cycle regulation and neurogenesis in the developing central nervous ..
  37. Yu J, Lee J, Lim Y, Kim T, Jin Y, Sheen Y, et al. Genistein inhibits rat aortic smooth muscle cell proliferation through the induction of p27kip1. J Pharmacol Sci. 2008;107:90-8 pubmed
    ..cell nuclear antigen (PCNA) protein, but also inhibited downregulation of cyclin-dependent kinase inhibitor (CKI) p27kip1. However, genistein did not affect p21cip1, CDK4, and cyclin D1 expression or early signal transduction through ..
  38. Kouvaraki M, Gorgoulis V, Rassidakis G, Liodis P, Markopoulos C, Gogas J, et al. High expression levels of p27 correlate with lymph node status in a subset of advanced invasive breast carcinomas: relation to E-cadherin alterations, proliferative activity, and ploidy of the tumors. Cancer. 2002;94:2454-65 pubmed
    The cyclin-dependent kinase inhibitor p27 plays a central role in cell cycle progression and is deregulated in breast carcinomas...
  39. Lee M, Pellegata N. Multiple endocrine neoplasia syndromes associated with mutation of p27. J Endocrinol Invest. 2013;36:781-7 pubmed publisher
    ..Genetic studies identified a germline mutation in the Cdkn1b gene, encoding the p27 cell cycle inhibitor, as the causative mutation for MENX...
  40. Nakamura S, Tatuno I, Noguchi Y, Kitagawa M, Kohn L, Saito Y, et al. 73-kDa heat shock cognate protein interacts directly with P27Kip1, a cyclin-dependent kinase inhibitor, during G1/S transition. Biochem Biophys Res Commun. 1999;257:340-3 pubmed
    ..73hsc (heat shock cognate protein), which belongs to the HSP70 family of molecular chaperones, interacts with P27Kip1, an inhibitor of cyclin-dependent kinase, during G1/S transition...
  41. Hong M, Turner N, Murphy M, Carroll R, Chapkin R, Lupton J. In vivo regulation of colonic cell proliferation, differentiation, apoptosis, and P27Kip1 by dietary fish oil and butyrate in rats. Cancer Prev Res (Phila). 2015;8:1076-83 pubmed publisher
    ..colon cancer initiation by decreasing cell proliferation and increasing differentiation and apoptosis through a p27(Kip1)-mediated mechanism...
  42. Rosner M, Hengstschlager M. Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2. J Biol Chem. 2004;279:48707-15 pubmed
    ..regulate cell cycle progression, the activity of cdk2, and the degradation of the cyclin-dependent kinase inhibitor p27. To date, the underlying molecular mechanism remains elusive. Here, we show that tuberin binds to p27...
  43. Mohanty A, Kan Q, Srivastava S, Uranbileg B, Arakawa Takeuchi S, Fujita N, et al. Successive phosphorylation of p27(KIP1) protein at serine-10 and C terminus crucially controls its potency to inactivate Cdk2. J Biol Chem. 2012;287:21757-64 pubmed publisher
    During the G(1)-S transition, the activity of Cdk2 is regulated by its association with p27(KIP1), which in rodent fibroblasts undergoes phosphorylation mainly at serine 10, threonine 187, and C-terminal threonine 197 by KIS, Cdk2, and ..
  44. Molatore S, Kiermaier E, Jung C, Lee M, Pulz E, Hofler H, et al. Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors. Mol Cancer. 2010;9:116 pubmed publisher
    b>p27Kip1 (p27) is an important negative regulator of the cell cycle and a putative tumor suppressor...
  45. Crean J, Furlong F, Mitchell D, McArdle E, Godson C, Martin F. Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1). FASEB J. 2006;20:1712-4 pubmed
    ..Two of these substrates were identified as FKHR and p27(Kip-1). CTGF stimulated the phosphorylation and cytoplasmic translocation of p27(Kip-1) on serine 10...
  46. Shaughnessy J. Amplification and overexpression of CKS1B at chromosome band 1q21 is associated with reduced levels of p27Kip1 and an aggressive clinical course in multiple myeloma. Hematology. 2005;10 Suppl 1:117-26 pubmed
    ..myeloma and regulates SCF(Skp2)-mediated ubquitination and proteolysis of the cyclin dependent kinase inhibitor p27Kip1 was significantly over-expressed in patients with poor survival...
  47. Davis B, Hilyard A, Nguyen P, Lagna G, Hata A. Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J Biol Chem. 2009;284:3728-38 pubmed publisher
    ..induced upon PDGF treatment in primary vSMCs, leading to down-regulation of the targets c-Kit and p27Kip1. Down-regulation of p27Kip1 by miR-221 is critical for PDGF-mediated induction of cell proliferation...
  48. Han J, Zhao J, Jiang J, Ma X, Liu X, Wang C, et al. Zinc deficiency impairs the renewal of hippocampal neural stem cells in adult rats: involvement of FoxO3a activation and downstream p27(kip1) expression. J Neurochem. 2015;134:879-91 pubmed publisher
    ..rat model, and, using western blot and immunohistochemical analyses, found that the expression of FoxO3a and p27(kip1) was remarkably up-regulated in the rat brain hippocampus...
  49. Kwon Y, Jovanovic A, Serfas M, Tyner A. The Cdk inhibitor p21 is required for necrosis, but it inhibits apoptosis following toxin-induced liver injury. J Biol Chem. 2003;278:30348-55 pubmed
    Liver injury and repair were examined in wild type, p21Waf1/Cip1, and p27Kip1-deficient mice following carbon tetrachloride (CCl4) administration...
  50. Russo A, Jeffrey P, Patten A, Massague J, Pavletich N. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature. 1996;382:325-31 pubmed
    The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom...
  51. Akashiba H, Ikegaya Y, Nishiyama N, Matsuki N. Differential involvement of cell cycle reactivation between striatal and cortical neurons in cell death induced by 3-nitropropionic acid. J Biol Chem. 2008;283:6594-606 pubmed publisher
    ..3-NP reduced the level of cyclin-dependent kinase inhibitor p27 in striatum but not in cerebral cortex...
  52. Hennenlotter J, Ohneseit P, Simon P, Merseburger A, Serth J, Kuehs U, et al. PTEN and p27Kip1 are not downregulated in the majority of renal cell carcinomas--implications for Akt activation. Oncol Rep. 2008;19:1141-7 pubmed
    ..The present study aimed at determining the occurrence of an impaired PTEN and p27Kip1 expression alone or in combination in a renal cell carcinoma to further clarify the role of Akt-pathway-..
  53. Li H, Yang H, Liu Y, Huan W, Zhang S, Wu G, et al. The cyclin-dependent kinase inhibitor p27(Kip1) is a positive regulator of Schwann cell differentiation in vitro. J Mol Neurosci. 2011;45:277-83 pubmed publisher
    ..Western blot analysis showed that p27(Kip1) expression was upregulated during the differentiation of Schwann cell, while the inhibition of p27(Kip1) ..
  54. Szentmary N, Stündl A, Szende B, Suveges I. P21, p27, bax, cathepsin and survivin pathways in macular dystrophy corneas. Histol Histopathol. 2010;25:287-90 pubmed publisher
    ..Immunohistochemical analysis was performed to investigate the presence of p21, p27, bax, cathepsin and survivin proteins...
  55. Romics I, Bánfi G, Szekely E, Krenacs T, Szende B. Expression of p21(waf1/cip1), p27 (kip1), p63 and androgen receptor in low and high Gleason score prostate cancer. Pathol Oncol Res. 2008;14:307-11 pubmed publisher
    The aim of this study was to investigate the expression of p21(waf1/cip1), p27(kip1), p63 and androgen receptor proteins in relation to serum prostate specific antigen levels in low and high Gleason score prostate cancers...
  56. Havrda M, Johnson M, O Neill C, Liaw L. A novel mechanism of transcriptional repression of p27kip1 through Notch/HRT2 signaling in vascular smooth muscle cells. Thromb Haemost. 2006;96:361-70 pubmed
    ..This was associated with a reduction in levels of the cyclin-dependent kinase inhibitor (cdk) p27(kip1)...
  57. Sue Y, Chung C, Lin H, Chou Y, Jen C, Li H, et al. PPARdelta-mediated p21/p27 induction via increased CREB-binding protein nuclear translocation in beraprost-induced antiproliferation of murine aortic smooth muscle cells. Am J Physiol Cell Physiol. 2009;297:C321-9 pubmed publisher
    ..Herein, we delineated the mechanisms of the antiproliferative effects of BPS through the induction of p21/p27. BPS concentration dependently induced the p21/p27 promoter- and consensus cAMP-responsive element (CRE)-driven ..
  58. Raina K, Blouin M, Singh R, Majeed N, Deep G, Varghese L, et al. Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 2007;67:11083-91 pubmed
    ..001) with a concomitant increase in Cdk inhibitors, Cip1/p21 and Kip1/p27 (P < 0.05, for both)...
  59. Jiang W, Zhu Z, McGinley J, El Bayoumy K, Manni A, Thompson H. Identification of a molecular signature underlying inhibition of mammary carcinoma growth by dietary N-3 fatty acids. Cancer Res. 2012;72:3795-806 pubmed publisher
    ..protein expression and increased levels of cyclin-dependent kinase inhibitors, CIP1 (p21) and KIP1 (p27)...
  60. Li J, Brooks G. Downregulation of cyclin-dependent kinase inhibitors p21 and p27 in pressure-overload hypertrophy. Am J Physiol. 1997;273:H1358-67 pubmed
    We postulated that the cyclin-dependent kinase inhibitors p21 and p27 could regulate the alterations in growth potential of cardiomyocytes during left ventricular hypertrophy (LVH)...
  61. Nomura H, Sawada Y, Ohtaki S. Interaction of p27 with E1A and its effect on CDK kinase activity. Biochem Biophys Res Commun. 1998;248:228-34 pubmed
    The interaction of p27 with adenovirus (Ad) E1A was investigated to study its possible role in cell-cycle regulation and transformation by E1A...
  62. Nomura H, Sawada Y, Fujinaga K, Ohtaki S. Cloning and characterization of rat p27Kip1, a cyclin-dependent kinase inhibitor. Gene. 1997;191:211-8 pubmed
    ..To characterize the role of Cdk inhibitors in rat cells, we isolated a cDNA encoding rat p27Kip1, a 27-kDa Cdk inhibitor. The 1...
  63. Sun J, Tao L, Ning W, Jin O, Liu J. [Expression of p27 and TGF-beta in rat kidney with unilateral ureteral obstruction and the relationship between TGF-beta and p27]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008;24:808-10 pubmed
    To explore the expression of p27 and the changes of TGF-beta in the renal tubule on the process of renal interstitial fibrosis caused by unilateral ureteral obstruction (UUO) in rats and to investigate the relationship between TGF-beta ..
  64. Xu Z, Yoo T, Ryu D, Cheon Park H, Ha S, Han D, et al. Angiotensin II receptor blocker inhibits p27Kip1 expression in glucose-stimulated podocytes and in diabetic glomeruli. Kidney Int. 2005;67:944-52 pubmed
    ..To determine the effect of ARB on podocyte p27(Kip1) mRNA and protein expression, podocytes were exposed to 5...
  65. Zlobec I, Minoo P, Baumhoer D, Baker K, Terracciano L, Jass J, et al. Multimarker phenotype predicts adverse survival in patients with lymph node-negative colorectal cancer. Cancer. 2008;112:495-502 pubmed
    ..In univariate analysis, the absence of CD8+ tumor infiltrating lymphocytes (TILs) (P < .001), loss of p27 (P = .006), positive urokinase-type plasminogen activator (uPA) expression (P = ...
  66. Mahimainathan L, Ghosh Choudhury N, Venkatesan B, Danda R, Choudhury G. EGF stimulates mesangial cell mitogenesis via PI3-kinase-mediated MAPK-dependent and AKT kinase-independent manner: involvement of c-fos and p27Kip1. Am J Physiol Renal Physiol. 2005;289:F72-82 pubmed
    ..of EGF-induced DNA synthesis, we investigated the effect of EGF on the cyclin-dependent kinase inhibitor p27(Kip1). EGF reduced the expression of p27(Kip1)...
  67. Iwanaga R, Komori H, Ishida S, Okamura N, Nakayama K, Nakayama K, et al. Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners. Oncogene. 2006;25:1786-98 pubmed
    ..The other was the cyclin-dependent kinase inhibitor p27(Kip1), which was involved in suppression of inappropriate cell cycle progression induced by deregulated E2F...
  68. Kamai T, Takagi K, Asami H, Ito Y, Arai K, Yoshida K. Prognostic significance of p27Kip1 and Ki-67 expression in carcinoma of the renal pelvis and ureter. BJU Int. 2000;86:14-9 pubmed
    To determine the significance of p27(Kip1) (p27) for tumour behaviour and prognosis of patients with transitional cell carcinoma (TCC) of the renal pelvis and ureter...
  69. Cipriano S, Chen L, Burns K, Koff A, Matzuk M. Inhibin and p27 interact to regulate gonadal tumorigenesis. Mol Endocrinol. 2001;15:985-96 pubmed
    ..For example, absence of the tumor suppressor p27(Kip1), a cyclin-dependent kinase inhibitor (CKI), results in increased body size, hyperplasia of several organs ..
  70. Lahav Baratz S, Ben Izhak O, Sabo E, Ben Eliezer S, Lavie O, Ishai D, et al. Decreased level of the cell cycle regulator p27 and increased level of its ubiquitin ligase Skp2 in endometrial carcinoma but not in normal secretory or in hyperstimulated endometrium. Mol Hum Reprod. 2004;10:567-72 pubmed
    b>p27 is a cyclin-dependent kinase (CDK) inhibitor whose specific late G(1) destruction allows progression of the cell across the G(1)/S boundary...
  71. Hussein N, Lu J, Casse H, Fontanière S, Morera A, Guittot S, et al. Deregulation of anti-Mullerian hormone/BMP and transforming growth factor-beta pathways in Leydig cell lesions developed in male heterozygous multiple endocrine neoplasia type 1 mutant mice. Endocr Relat Cancer. 2008;15:217-27 pubmed publisher
    ..Furthermore, we found that the expression of p18, p27 and cyclin dependant kinase 4 (Cdk4), targets of TGF-beta pathways, is altered in the Leydig cell lesions...
  72. Cohen J, Tham K, Mastrandrea N, Gallegos A, Monks T, Lau S. cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinoma. Toxicol Sci. 2011;122:361-71 pubmed publisher
    ..The loss of tuberin, the tuberous sclerosis-2 (Tsc-2) gene product, is associated with cytoplasmic mislocalization of p27 in uterine leiomyomas derived from Eker rats (Tsc-2(EK/+)) and in human metastatic renal cell carcinoma tissue...
  73. Reuveni H, Klein S, Levitzki A. The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest. Eur J Biochem. 2003;270:2759-72 pubmed
    ..that HR12 treatment of Rat1/ras cells led to elevated cellular levels of the cyclin-dependent kinase inhibitor p27Kip1 and inhibition of the kinase activity of the cyclin E/Cdk2 complex...
  74. Jansen L, Uhlmann E, Crino P, Gutmann D, Wong M. Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes. Epilepsia. 2005;46:1871-80 pubmed
    ..Impaired extracellular potassium uptake by astrocytes through Kir channels may contribute to neuronal hyperexcitability and epileptogenesis in a mouse model of TSC. ..
  75. Osaki L, Gama P. MAPK signaling pathway regulates p27 phosphorylation at threonin 187 as part of the mechanism triggered by early-weaning to induce cell proliferation in rat gastric mucosa. PLoS ONE. 2013;8:e66651 pubmed publisher
    ..of ERK pathway in the control of cell cycle progression during early weaning, and studied the specific role of p27. At 15 days, Wistar rats were separated from dams, fed with powdered chow and daily injected with PD98059 (MEK ..
  76. Maass J, Berndt F, Cánovas J, Kukuljan M. p27Kip1 knockdown induces proliferation in the organ of Corti in culture after efficient shRNA lentiviral transduction. J Assoc Res Otolaryngol. 2013;14:495-508 pubmed publisher
    ..The loss of p27Kip1 function induces proliferation in the organ of Corti, which raises the possibility to integrate it to the ..
  77. Su B, Chen X, Zhong C, Guo N, He J, Fan Y. All-trans retinoic acid inhibits mesangial cell proliferation by up-regulating p21Waf1/Cip1 and p27Kip1 and down-regulating Skp2. J Nephrol. 2012;25:1031-40 pubmed publisher
    ..After treatments, the cells were studied by CCK-8 assay, cell cycle assay and TUNEL staining. p21(Waf1/Cip1), p27(Kip1) and Skp2 mRNA levels were measured by real-time PCR...
  78. Corroyer S, Schittny J, Djonov V, Burri P, Clement A. Impairment of rat postnatal lung alveolar development by glucocorticoids: involvement of the p21CIP1 and p27KIP1 cyclin-dependent kinase inhibitors. Pediatr Res. 2002;51:169-76 pubmed
    ..Analysis of the mechanisms involved suggested a role for the CKIs p21CIP1 and p27KIP1. Indeed, we observed an increase in p21CIP1 and p27KIP1 protein levels on d 4 in the dexamethasone-treated ..
  79. Xu D, Luo Y, Liu Y, Wang J, Zhang B, Xu M, et al. Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats. Respir Res. 2010;11:182 pubmed publisher
    Pulmonary vascular structure remodeling (PVSR) is a hallmark of pulmonary hypertension. P27(kip1), one of critical cyclin-dependent kinase inhibitors, has been shown to mediate anti-proliferation effects on various vascular cells...
  80. Kwon T, Nagel J, Buchholz M, Nordin A. Characterization of the murine cyclin-dependent kinase inhibitor gene p27Kip1. Gene. 1996;180:113-20 pubmed
    The cyclin-dependent kinase inhibitor p27Kip1 plays an important role in regulating cell-cycle progression...
  81. Clurman B, Porter P. New insights into the tumor suppression function of P27(kip1). Proc Natl Acad Sci U S A. 1998;95:15158-60 pubmed
  82. Ozkara S, Corakci A. Significantly decreased P27 expression in endometrial carcinoma compared to complex hyperplasia with atypia (correlation with p53 expression). Pathol Oncol Res. 2004;10:89-97 pubmed
    b>P27 expression was examined on paraffin-embedded specimens in proliferative, secretory, hyperplastic and neoplastic human endometrium by immunohistochemistry...
  83. Akashiba H, Matsuki N, Nishiyama N. p27 small interfering RNA induces cell death through elevating cell cycle activity in cultured cortical neurons: a proof-of-concept study. Cell Mol Life Sci. 2006;63:2397-404 pubmed
    ..Here we transfected small interfering RNA (siRNA) targeting cyclin-dependent kinase (CDK) inhibitor p27, which plays an important role in cell cycle arrest at G1-S phase, into cultured cortical neurons...
  84. Obaya A, Kotenko I, Cole M, Sedivy J. The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progression. J Biol Chem. 2002;277:31263-9 pubmed
    ..c-myc(-/-) cells express elevated levels of the Cdk inhibitor p27(Kip1) and reduced levels of Cdk7, the catalytic subunit of Cdk-activating kinase...
  85. Majumder P, Grisanzio C, O Connell F, Barry M, Brito J, Xu Q, et al. A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression. Cancer Cell. 2008;14:146-55 pubmed publisher
    ..In luminal epithelial cells of Akt-driven PIN, we show the concomitant induction of p27(Kip1) and senescence...