Cdk5

Summary

Gene Symbol: Cdk5
Description: cyclin-dependent kinase 5
Alias: cyclin-dependent-like kinase 5, TPKII catalytic subunit, cell division protein kinase 5, serine/threonine-protein kinase PSSALRE, tau protein kinase II catalytic subunit
Species: rat
Products:     Cdk5

Top Publications

  1. Maestre C, Delgado Esteban M, Gomez Sanchez J, Bolanos J, Almeida A. Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity. EMBO J. 2008;27:2736-45 pubmed publisher
    ..we found that the Ser-40, Thr-121 and Ser-163 triple phosphorylation of Cdh1 by the cyclin-dependent kinase-5 (Cdk5)-p25 complex was necessary and sufficient for cyclin B1 stabilization and apoptotic death after NMDAR stimulation...
  2. Sharma M, Hanchate N, Tyagi R, Sharma P. Cyclin dependent kinase 5 (Cdk5) mediated inhibition of the MAP kinase pathway results in CREB down regulation and apoptosis in PC12 cells. Biochem Biophys Res Commun. 2007;358:379-84 pubmed
    Cyclin dependent kinase 5 (cdk5) is active mainly in postmitotic cells like neurons and regulates important cellular functions by phosphorylating a wide variety of targets...
  3. Tan T, Valova V, Malladi C, Graham M, Berven L, Jupp O, et al. Cdk5 is essential for synaptic vesicle endocytosis. Nat Cell Biol. 2003;5:701-10 pubmed
    ..Here, we show that cyclin-dependent kinase 5 (Cdk5) phosphorylates dynamin I on Ser 774 and Ser 778 in vitro, which are identical to its endogenous phosphorylation ..
  4. Xiong Y, Zhang H, Beach D. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell. 1992;71:505-14 pubmed
    ..Among them are protein kinase catalytic subunits CDK2, CDK4 (previously called PSK-J3), and CDK5 (also called PSSALRE). In addition, polypeptides of 21 kd and 36 kd are identified in association with cyclin D1...
  5. Gong X, Tang X, Wiedmann M, Wang X, Peng J, Zheng D, et al. Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Neuron. 2003;38:33-46 pubmed
    Neurotoxic insults deregulate Cdk5 activity, which leads to neuronal apoptosis and may contribute to neurodegeneration. The biological activity of Cdk5 has been ascribed to its phosphorylation of cytoplasmic substrates...
  6. Ino H, Chiba T. Intracellular localization of cyclin-dependent kinase 5 (CDK5) in mouse neuron: CDK5 is located in both nucleus and cytoplasm. Brain Res. 1996;732:179-85 pubmed
    Cyclin-dependent kinase 5 (CDK5) is one of the cyclin-dependent kinases, and is expressed in mature neurons...
  7. Nikolic M, Dudek H, Kwon Y, Ramos Y, Tsai L. The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Genes Dev. 1996;10:816-25 pubmed
    Cyclin-dependent kinase 5(cdk5) is highly homologous to other members of the cdk family that are known to function in proliferating cells...
  8. Xing B, Yang Y, Du J, Chen H, Qi C, Huang Z, et al. Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B. J Neurosci. 2012;32:14709-21 pubmed publisher
    ..Here, we show that cyclin-dependent kinase 5 (Cdk5), a new player in thermal pain sensation, positively regulates TRPV1 surface localization...
  9. Meyerson M, Enders G, Wu C, Su L, Gorka C, Nelson C, et al. A family of human cdc2-related protein kinases. EMBO J. 1992;11:2909-17 pubmed
    ..The identification of a large family of cdc2-related kinases opens the possibility of combinatorial regulation of the cell cycle together with the emerging large family of cyclins. ..

More Information

Publications72

  1. Pareek T, Keller J, Kesavapany S, Agarwal N, Kuner R, Pant H, et al. Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci U S A. 2007;104:660-5 pubmed
    ..We have previously reported that cyclin-dependent kinase 5 (Cdk5) activity regulates nociceptive signaling...
  2. Zheng Y, Li B, Kanungo J, Kesavapany S, Amin N, Grant P, et al. Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival. Mol Biol Cell. 2007;18:404-13 pubmed
    b>Cdk5, a cyclin-dependent kinase, is critical for neuronal development, neuronal migration, cortical lamination, and survival...
  3. Ohshima T, Ward J, Huh C, Longenecker G, Veeranna -, Pant H, et al. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci U S A. 1996;93:11173-8 pubmed
    Although cyclin-dependent kinase 5 (Cdk5) is closely related to other cyclin-dependent kinases, its kinase activity is detected only in the postmitotic neurons...
  4. Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttila T. Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35. Brain Res Mol Brain Res. 2002;106:50-6 pubmed
    Cyclin-dependent kinase 5 (cdk5) is involved in the development of the nervous system and neuronal process outgrowth, and it regulates several intracellular processes including cytoskeletal dynamics...
  5. Sun K, de Pablo Y, Vincent F, Johnson E, Chavers A, Shah K. Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease. Mol Biol Cell. 2008;19:3052-69 pubmed publisher
    ..A potential link between Cdk5 and Golgi fragmentation in Alzheimer's disease (AD) was investigated in this study...
  6. Bhaskar K, Shareef M, Sharma V, Shetty A, Ramamohan Y, Pant H, et al. Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins. Neurochem Int. 2004;44:35-44 pubmed
    ..protein, and as a component that co-purifies with, and regulates the kinase activity of cyclin dependent kinase (Cdk5)...
  7. Lee S, Wenk M, Kim Y, Nairn A, De Camilli P. Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses. Proc Natl Acad Sci U S A. 2004;101:546-51 pubmed
    ..Here, we show that cyclin-dependent kinase 5 (Cdk5) phosphorylates synaptojanin 1 and regulates its function both in vitro and in intact synaptosomes...
  8. Kim S, Ryan T. CDK5 serves as a major control point in neurotransmitter release. Neuron. 2010;67:797-809 pubmed publisher
    b>CDK5 is an important kinase in nervous system function, controlling neural development and postsynaptic signal integration. Here we show that CDK5 plays a major role in controlling neurotransmitter release...
  9. Lilja L, Johansson J, Gromada J, Mandic S, Fried G, Berggren P, et al. Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis. J Biol Chem. 2004;279:29534-41 pubmed
    Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine protein kinase that requires association with a regulatory protein, p35 or p39, to form an active enzyme...
  10. Chen J, Miao Y, Wang X, Wang Z. Elevation of p-NR2A(S1232) by Cdk5/p35 contributes to retinal ganglion cell apoptosis in a rat experimental glaucoma model. Neurobiol Dis. 2011;43:455-64 pubmed publisher
    ..We investigated the possible involvement of cyclin-dependent kinase 5 (Cdk5) and its activator p35, which have been implicated in a variety of neurological disorders, in RGC apoptosis in a ..
  11. Cheng K, Li Z, Fu W, Wang J, Fu A, Ip N. Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35. J Biol Chem. 2002;277:31988-93 pubmed
    Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that plays important roles during central nervous system development...
  12. Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, et al. Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron. 2002;35:907-20 pubmed
    ..We observed that in fyn- and cdk5-deficient mice, Sema3A-induced growth cone collapse responses were attenuated compared to their heterologous ..
  13. Fu A, Fu W, Cheung J, Tsim K, Ip F, Wang J, et al. Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Nat Neurosci. 2001;4:374-81 pubmed
    Here we describe an important involvement of Cdk5/p35 in regulating the gene expression of acetylcholine receptor (AChR) at the neuromuscular synapse...
  14. Cicero S, Herrup K. Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation. J Neurosci. 2005;25:9658-68 pubmed
    Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase with significant homology to cell cycle-related Cdks but is not believed to be active in a typical cell cycle...
  15. Yang Y, He Y, Zhang Y, Li Y, Li Y, Han Y, et al. Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia. Pain. 2007;127:109-20 pubmed
    Cyclin-dependent kinase 5 (Cdk5) is a unique member of the CDK family. It is predominantly expressed in postmitotic neurons and has been implicated in neuronal plasticity...
  16. Czapski G, Gassowska M, Songin M, Radecka U, Strosznajder J. Alterations of cyclin dependent kinase 5 expression and phosphorylation in amyloid precursor protein (APP)-transfected PC12 cells. FEBS Lett. 2011;585:1243-8 pubmed publisher
    The aim of the present study was to analyse the alterations of cyclin dependent kinase 5 (Cdk5) expression and phosphorylation in PC12 cells overexpressing amyloid precursor protein (APP)...
  17. Li B, Sun M, Zhang L, Takahashi S, Ma W, Vinade L, et al. Regulation of NMDA receptors by cyclin-dependent kinase-5. Proc Natl Acad Sci U S A. 2001;98:12742-7 pubmed
    ..Here, we demonstrate that cyclin dependent kinase-5 (Cdk5) associates with and phosphorylates NR2A subunits at Ser-1232 in vitro and in intact cells...
  18. Peng H, Chen G, Tung K, Chien Y, Lai C, Hsieh M, et al. Estrogen-dependent facilitation on spinal reflex potentiation involves the Cdk5/ERK1/2/NR2B cascade in anesthetized rats. Am J Physiol Endocrinol Metab. 2009;297:E416-26 pubmed publisher
    Cyclin-dependent kinase-5 (Cdk5), a proline-directed serine/threonine kinase, may alter pain-related neuronal plasticity by regulating extracellular signal-related kinase-1/2 (ERK1/2) activation...
  19. Gilmore E, Ohshima T, Goffinet A, Kulkarni A, Herrup K. Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex. J Neurosci. 1998;18:6370-7 pubmed
    The cerebral cortex of mice with a targeted disruption in the gene for cyclin-dependent kinase 5 (cdk5) is abnormal in its structure...
  20. Sahlgren C, Pallari H, He T, Chou Y, Goldman R, Eriksson J. A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. EMBO J. 2006;25:4808-19 pubmed
    ..neuronal precursor cells led to downregulation of nestin with subsequent activation of cyclin-dependent kinase 5 (Cdk5), a crucial kinase in the nervous system...
  21. Utreras E, Futatsugi A, Rudrabhatla P, Keller J, Iadarola M, Pant H, et al. Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35. J Biol Chem. 2009;284:2275-84 pubmed publisher
    Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase...
  22. Zhang Q, Ahuja H, Zakeri Z, Wolgemuth D. Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling. Dev Biol. 1997;183:222-33 pubmed
    ..of the cyclin-dependent kinase (Cdk) family members in reproductive organs, we observed a striking expression of Cdk5 in atretic follicles in the ovary, particularly in granulosa cells that appeared to be dying...
  23. Xie Z, Sanada K, Samuels B, Shih H, Tsai L. Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. Cell. 2003;114:469-82 pubmed
    The serine/threonine kinase Cdk5 plays an essential role in neuronal positioning during corticogenesis, but the underlying mechanisms are unknown...
  24. Fu W, Chen Y, Sahin M, Zhao X, Shi L, Bikoff J, et al. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci. 2007;10:67-76 pubmed
    ..Here we report an important function of cyclin-dependent kinase 5 (Cdk5) in EphA4-dependent spine retraction in mice...
  25. Bibb J, Chen J, Taylor J, Svenningsson P, Nishi A, Snyder G, et al. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature. 2001;410:376-80 pubmed
    ..Here we identify cyclin-dependent kinase 5 (Cdk5) as a downstream target gene of DeltaFosB by use of DNA array analysis of striatal material from inducible ..
  26. Zhang H, Zhang X, Wang W, Xue Q, Lu H, Huang J, et al. Increased synaptophysin is involved in inflammation-induced heat hyperalgesia mediated by cyclin-dependent kinase 5 in rats. PLoS ONE. 2012;7:e46666 pubmed publisher
    Mechanisms associated with cyclin-dependent kinase 5 (Cdk5)-mediated heat hyperalgesia induced by inflammation remain undefined...
  27. Tian B, Yang Q, Mao Z. Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death. Nat Cell Biol. 2009;11:211-8 pubmed publisher
    ..However, the mechanism by which DNA damage activates ATM is poorly understood. Here we show that Cdk5 (cyclin-dependent kinase 5), activated by DNA damage, directly phosphorylates ATM at Ser 794 in post-mitotic ..
  28. Sun K, Lee H, Smith M, Shah K. Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: relevance to neurotoxic insults in Alzheimer's disease. Mol Biol Cell. 2009;20:4611-9 pubmed publisher
    Significant increase in JNK, c-Jun, and Cdk5 activities are reported in Alzheimer's disease (AD). Inhibition of c-Jun prevents neuronal cell death in in vivo AD models, highlighting it as a major JNK effector...
  29. Cheung Z, Chin W, Chen Y, Ng Y, Ip N. Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. PLoS Biol. 2007;5:e63 pubmed
    ..Recent studies reveal that cyclin-dependent kinase 5 (Cdk5), a serine/threonine kinase, may modulate RTK signaling through phosphorylation of the receptor...
  30. Li T, Chalifour L, Paudel H. Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. J Biol Chem. 2007;282:6619-28 pubmed
    The transcription factor Egr-1 activates cyclin-dependent protein kinase 5 (Cdk5) during nerve growth factor (NGF)-induced differentiation of PC12 cells into neurons (Harada, T. Morooka, T., Ogawa, S., and Nishida, E. (2001) Nat...
  31. Ubeda M, Rukstalis J, Habener J. Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity. J Biol Chem. 2006;281:28858-64 pubmed
    ..Neuronal dysfunction in Alzheimer patients has been linked to overactivity of the cyclin-dependent kinase 5 (CDK5) and its activator p35. Both of these proteins are expressed in the insulin-producing beta cells of the pancreas...
  32. Wang J, Liu S, Fu Y, Wang J, Lu Y. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Nat Neurosci. 2003;6:1039-47 pubmed
    ..Ser1232 phosphorylation is catalyzed by cyclin-dependent kinase 5 (Cdk5)...
  33. Ohshima T, Ogawa M, Veeranna -, Hirasawa M, Longenecker G, Ishiguro K, et al. Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. Proc Natl Acad Sci U S A. 2001;98:2764-9 pubmed
    Cyclin-dependent kinase (Cdk) 5 is a unique member of the Cdk family, because Cdk5 kinase activity is detected only in the nervous tissue. Two neuron-specific activating subunits of Cdk5, p35 and p39, have been identified...
  34. Samuels B, Hsueh Y, Shu T, Liang H, Tseng H, Hong C, et al. Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron. 2007;56:823-37 pubmed
    ..Furthermore, Cdk5 gain of function results in an increased number of synapses in vivo...
  35. Hellmich M, Pant H, Wada E, Battey J. Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression. Proc Natl Acad Sci U S A. 1992;89:10867-71 pubmed
  36. Ko J, Humbert S, Bronson R, Takahashi S, Kulkarni A, Li E, et al. p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci. 2001;21:6758-71 pubmed
    Cyclin-dependent kinase 5 (Cdk5) plays a pivotal role in brain development and neuronal migration. Cdk5 is abundant in postmitotic, terminally differentiated neurons...
  37. Hirasawa M, Ohshima T, Takahashi S, Longenecker G, Honjo Y, Veeranna -, et al. Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects. Proc Natl Acad Sci U S A. 2004;101:6249-54 pubmed
    Cyclin-dependent kinase 5 (Cdk5) is essential for the proper development of the CNS, as is evident from the perinatal lethality of conventional Cdk5 knockout (Cdk5-/-) mice...
  38. Hawasli A, Benavides D, Nguyen C, Kansy J, Hayashi K, Chambon P, et al. Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat Neurosci. 2007;10:880-886 pubmed publisher
    ..Although the neuronal protein kinase cyclin-dependent kinase 5 (Cdk5) has been implicated in cognitive disorders, its role in learning has been obscured by the perinatal lethality of ..
  39. Kuhse J, Kalbouneh H, Schlicksupp A, Mükusch S, Nawrotzki R, Kirsch J. Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistin. J Biol Chem. 2012;287:30952-66 pubmed publisher
    ..These data indicate that collybistin and cyclin-dependent kinases are involved in regulating the phosphorylation of gephyrin at postsynaptic membrane specializations. ..
  40. O Hare M, Kushwaha N, Zhang Y, Aleyasin H, Callaghan S, Slack R, et al. Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death. J Neurosci. 2005;25:8954-66 pubmed
    Cyclin-dependent kinase 5 (cdk5) is a member of the cyclin-dependent kinase family whose activity is localized mainly to postmitotic neurons attributable to the selective expression of its activating partners p35 and p39...
  41. Xin X, Ferraro F, Bäck N, Eipper B, Mains R. Cdk5 and Trio modulate endocrine cell exocytosis. J Cell Sci. 2004;117:4739-48 pubmed
    Hormone secretion by pituitary cells is decreased by roscovitine, an inhibitor of cyclin-dependent kinase 5 (Cdk5)...
  42. Kim B, Serebreni L, Fallica J, Hamdan O, Wang L, Johnston L, et al. Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia. PLoS ONE. 2015;10:e0124189 pubmed publisher
    ..Using an in silico approach, we identified a cyclin-dependent kinase 5 (CDK5) consensus motif adjacent to the XOR flavin adenine dinucleotide (FAD) binding domain...
  43. Furusawa K, Asada A, Saito T, Hisanaga S. The effect of Cyclin-dependent kinase 5 on voltage-dependent calcium channels in PC12 cells varies according to channel type and cell differentiation state. J Neurochem. 2014;130:498-506 pubmed publisher
    Cyclin-dependent kinase 5 (Cdk5) is a Ser/Thr kinase that plays an important role in the release of neurotransmitter from pre-synaptic terminals triggered by Ca(2+) influx into the pre-synaptic cytoplasm through voltage-dependent Ca(2+) ..
  44. Brittain J, Wang Y, Eruvwetere O, Khanna R. Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2. FEBS Lett. 2012;586:3813-8 pubmed publisher
    ..2). But how cyclin dependent kinase 5 (Cdk5)-mediated phosphorylation of CRMP-2 affects its interaction/regulation with CaV2.2 is unknown...
  45. Liu W, Zhang Y, Liu S, Liu Q, Hao J, Shi Y, et al. The expression of intermediate filament protein nestin and its association with cyclin-dependent kinase 5 in the glomeruli of rats with diabetic nephropathy. Am J Med Sci. 2013;345:470-7 pubmed publisher
    ..The protein or messenger RNA levels of nestin and cyclin-dependent kinase 5 (Cdk5) were detected by Western blot and real-time polymerase chain reaction...
  46. Cancino G, Perez de Arce K, Castro P, Toledo E, von Bernhardi R, Alvarez A. c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice. Neurobiol Aging. 2011;32:1249-61 pubmed publisher
    ..Herein we show that c-Abl participates in A?-induced tau phosphorylation through Cdk5 activation...
  47. Sheng Y, Zhang L, Su S, Tsai L, Julius Zhu J. Cdk5 is a New Rapid Synaptic Homeostasis Regulator Capable of Initiating the Early Alzheimer-Like Pathology. Cereb Cortex. 2016;26:2937-51 pubmed publisher
    Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase implicated in synaptic plasticity, behavior, and cognition, yet its synaptic function remains poorly understood...
  48. Zhang H, Zhang X, Xue Q, Yan Luo -, Huang J, Zhang S, et al. The BDNF/TrkB signaling pathway is involved in heat hyperalgesia mediated by Cdk5 in rats. PLoS ONE. 2014;9:e85536 pubmed publisher
    Cyclin-dependent kinase 5 (Cdk5) has been shown to play an important role in mediating inflammation-induced heat hyperalgesia. However, the underlying mechanism remains unclear...
  49. Czapski G, Gassowska M, Wilkaniec A, Cieslik M, Adamczyk A. Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro. FEBS Lett. 2013;587:3135-41 pubmed publisher
    ..In this study we analyzed the role of cyclin-dependent kinase 5 (Cdk5) in the molecular mechanism(s) of ASN toxicity...
  50. Chang K, Multani P, Sun K, Vincent F, de Pablo Y, Ghosh S, et al. Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death. Mol Biol Cell. 2011;22:1452-62 pubmed publisher
    ..we show that nuclear lamina dispersion is an early and irreversible trigger for cell death initiated by deregulated Cdk5, rather than a consequence of apoptosis...
  51. Bermel C, Tönges L, Planchamp V, Gillardon F, Weishaupt J, Dietz G, et al. Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells. Mol Cell Neurosci. 2009;42:427-37 pubmed publisher
    ..Inhibition of ROCK has been previously shown to promote regeneration in retinal ganglion cells (RGC) whereas Cdk5 inhibition mainly promoted survival...
  52. Li X, Zhang H, Niu Q, Yuan F. [Changes of cdk5, p35 and p53 gene expression levels in arsenic-induced neural cell apoptosis]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012;30:85-8 pubmed
    To study the expression levels of cdk5, p35 and p53 genes in arsenic trioxide (As2O3O)-induced neuron apoptosis and to explore the potential mechanism...
  53. Lee J, Kim H, Lee S, Kim K. Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J Cell Sci. 2007;120:2259-71 pubmed
    ..Cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, is most active in the central nervous system and plays a variety of ..
  54. Miyamoto Y, Yamauchi J, Tanoue A. Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn. J Neurosci. 2008;28:8326-37 pubmed publisher
    ..OL development, controls the migration of oligodendrocyte precursor cells (OPCs) through cyclin-dependent kinase 5 (Cdk5)...
  55. Pant A, Veeranna -, Pant H, Amin N. Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5). Brain Res. 1997;765:259-66 pubmed
    ..In this study, an identified cyclin-dependent kinase 5 (cdk5), isolated from nervous tissue, has been shown to phosphorylate the human NF-H (hNF-H) and affects its ..
  56. Zhang X, Zhang H, Shao H, Xue Q, Yu B. ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity. PLoS ONE. 2014;9:e87788 pubmed publisher
    ..Like binding with the activators (P35 or P25), the phosphorylation of Cdk5 plays a critical role in Cdk5 activation...
  57. Fu A, Ip F, Fu W, Cheung J, Wang J, Yung W, et al. Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice. Proc Natl Acad Sci U S A. 2005;102:15224-9 pubmed
    Cyclin-dependent kinase (Cdk)5 is a key regulator of neural development. We have previously demonstrated that Cdk5/p35 are localized to the postsynaptic muscle and are implicated in the regulation of neuregulin/ErbB signaling in myotube ..
  58. Zheng Y, Amin N, Hu Y, Rudrabhatla P, Shukla V, Kanungo J, et al. A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation. J Biol Chem. 2010;285:34202-12 pubmed publisher
    The activity of Cdk5-p35 is tightly regulated in the developing and mature nervous system...
  59. Wang S, Zhu L, Shi H, Zheng H, Tian Q, Wang Q, et al. Inhibition of melatonin biosynthesis induces neurofilament hyperphosphorylation with activation of cyclin-dependent kinase 5. Neurochem Res. 2007;32:1329-35 pubmed
    ..These results suggest that inhibition of melatonin biosynthesis may activate cdk-5 and thus induces Alzheimer-like hyperphosphorylation of neurofilament proteins. ..
  60. Tian F, Guo T, Chen J. [Hippocampal mossy fiber sprouting and Cdk5/p35 expressions in the pentylenetetrazole kindling rat model]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008;33:1101-7 pubmed
    To observe the expression of cyclin-dependent kinase 5 (Cdk5) and p35 in rat hippocampus during pentetrazole kindling process and their relation with mossy fiber sprouting (MFS), and to investigate the role of Cdk5/p35 in epileptogenesis...
  61. Perlini L, Szczurkowska J, Ballif B, Piccini A, Sacchetti S, Giovedì S, et al. Synapsin III acts downstream of semaphorin 3A/CDK5 signaling to regulate radial migration and orientation of pyramidal neurons in vivo. Cell Rep. 2015;11:234-48 pubmed publisher
    ..We identify a cyclin-dependent kinase-5 (CDK5) phosphorylation site on SynIII and use phosphomutant rescue experiments to demonstrate its role in SynIII function...
  62. Zhang P, Fu W, Fu A, Ip N. S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength. Nat Commun. 2015;6:8665 pubmed publisher
    ..Here we report that S-nitrosylation of p35, the activator of cyclin-dependent kinase 5 (Cdk5), by nitric oxide (NO) is important for the regulation of excitatory synaptic strength...
  63. Jendryke T, Prochazkova M, Hall B, Nordmann G, Schladt M, Milenkovic V, et al. TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception. Sci Rep. 2016;6:22007 pubmed publisher
    ..We present behavioral and molecular data indicating that TRPV1 is strongly modulated by Cdk5-mediated phosphorylation at position threonine-407(mouse)/T406(rat)...