Gene Symbol: Cdc25c
Description: cell division cycle 25C
Alias: M-phase inducer phosphatase 3
Species: rat
Products:     Cdc25c

Top Publications

  1. Tsuda H, Hashiguchi Y, Inoue T, Yamamoto K. Alteration of G2 cell cycle regulators occurs during carcinogenesis of the endometrium. Oncology. 2003;65:159-66 pubmed
    ..We examined the ATM, chk2, CDC25C, cdc2, and cyclin B1 protein expression by immunohistochemistry...
  2. Ozen M, Ittmann M. Increased expression and activity of CDC25C phosphatase and an alternatively spliced variant in prostate cancer. Clin Cancer Res. 2005;11:4701-6 pubmed
    ..b>CDC25C plays an important role in the G2-M transition by activating Cdc2/Cyclin B1 complexes...
  3. Hashiguchi Y, Tsuda H, Nishimura S, Inoue T, Kawamura N, Yamamoto K. Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia. Oncol Rep. 2004;12:587-91 pubmed
    We examined human papillomavirus (HPV) typing and the status of ATM, chk2, CDC25C, cdc2 and cyclinB1 in cervical intraepithelial neoplasia (CIN) and invasive cancer (IC)...
  4. Hudelist G, Pacher Zavisin M, Singer C, Holper T, Kubista E, Schreiber M, et al. Use of high-throughput protein array for profiling of differentially expressed proteins in normal and malignant breast tissue. Breast Cancer Res Treat. 2004;86:281-91 pubmed
    ..that show increased expression levels in malignant breast tissues such as casein kinase Ie, p53, annexin XI, CDC25C, eIF-4E and MAP kinase 7...
  5. Lokeshwar V, Cerwinka W, Isoyama T, Lokeshwar B. HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor. Cancer Res. 2005;65:7782-9 pubmed
    ..HYAL1-AS transfectants had a G2-M block due to decreased cyclin B1, cdc25c, and cdc2/p34 expression and cdc2/p34 kinase activity...
  6. Vandyke K, White M, Nguyen Khuong T, Ow K, Luk S, Kingsley E, et al. Plant-derived MINA-05 inhibits human prostate cancer proliferation in vitro and lymph node spread in vivo. Neoplasia. 2007;9:322-31 pubmed
    ..indicated that these cell cycle changes were associated with decreased levels of regulatory proteins cyclin B1 and cdc25C. MINA-05 given daily by gavage for 39 days did not diminish primary orthotopic PC-3 growth in nude mice, but ..
  7. Lu P, Zhou X, Shen M, Lu K. Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science. 1999;283:1325-8 pubmed
    ..Phosphoserine- or phosphothreonine-binding activity was required for Pin1 to interact with its substrates in vitro and to perform its essential function in vivo. ..
  8. Srivastava S, Xiao D, Lew K, Hershberger P, Kokkinakis D, Johnson C, et al. Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo. Carcinogenesis. 2003;24:1665-70 pubmed
    ..of several proteins that regulate G2/M progression, including cyclin B1, cell division cycle (Cdc)25B and Cdc25C (44, 45 and 90% reduction, respectively, compared with control), was also observed in the tumors of AITC-treated ..
  9. Yuan L, Yu W, Qu C. DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase. J Biol Chem. 2003;278:42812-20 pubmed
    ..Further biochemical analysis revealed that SHP-2 constitutively associated with 14-3-3beta, and that Cdc25C cytoplasmic translocation induced by DNA damage was essentially blocked in SHP-2 mutant cells...

More Information


  1. Mizoguchi S, Kim K. Expression of cdc25 phosphatases in the germ cells of the rat testis. Biol Reprod. 1997;56:1474-81 pubmed
    cdc25A and cdc25C, which encode threonine/tyrosine phosphatases involved in cell cycle regulation, were found to be differentially localized in rat testicular germ cells during spermatogenesis...
  2. Sadhu K, Reed S, Richardson H, Russell P. Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. Proc Natl Acad Sci U S A. 1990;87:5139-43 pubmed
    ..These data suggest that in human cells, as in fission yeast, the accumulation of CDC25 mitotic inducer during G2 may play a key role in regulating the timing of mitosis. ..
  3. Vassileva V, Millar A, Briollais L, Chapman W, Bapat B. Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability. Cancer Res. 2002;62:4095-9 pubmed
    ..hMSH3, hMSH6, CHK1, and BAX genes in MSI-H endometrial hyperplasias and cancers, whereas mutations in ATR and CDC25C were observed only in MSI-H ECs...
  4. Bahassi E, Hennigan R, Myer D, Stambrook P. Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. Oncogene. 2004;23:2658-63 pubmed
    ..occurs by dephosphorylation of the inhibitory residues, threonine 14 (T14) and tyrosine 15 (Y15), on Cdc2 by the Cdc25C phosphatase...
  5. Su C, Deaton R, Iglewsky M, Valencia T, Grant S. PKN activation via transforming growth factor-beta 1 (TGF-beta 1) receptor signaling delays G2/M phase transition in vascular smooth muscle cells. Cell Cycle. 2007;6:739-49 pubmed
    ..In order to enter into mitosis, a phosphatase, Cdc25C, must first dephosphorylate two other critical residues: tyrosine-15 and threonine-14...
  6. Wang Z, Trope C, Flørenes V, Suo Z, Nesland J, Holm R. Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes. BMC Cancer. 2010;10:233 pubmed publisher
    ..light on their roles in the pathogenesis and to clarify their prognostic values, expression of CDC25A, CDC25B and CDC25C in a large series of vulvar squamous cell carcinomas were examined...
  7. Chang K, Vincent F, Shah K. Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death. J Cell Sci. 2012;125:5124-37 pubmed publisher
    ..Using a chemical genetic approach, we identified Cdc25A, Cdc25B and Cdc25C as direct Cdk5 substrates in mouse brain lysates...