Cdc25b

Summary

Gene Symbol: Cdc25b
Description: cell division cycle 25B
Alias: M-phase inducer phosphatase 2, dual specificity phosphatase Cdc25B
Species: rat
Products:     Cdc25b

Top Publications

  1. Lincoln A, Wickramasinghe D, Stein P, Schultz R, Palko M, De Miguel M, et al. Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Nat Genet. 2002;30:446-9 pubmed
    ..The dual specificity phosphatases Cdc25a, Cdc25b and Cdc25c are activators of cyclin-dependent kinases; consequently, they are postulated to regulate cell-cycle ..
  2. Ngan E, Hashimoto Y, Ma Z, Tsai M, Tsai S. Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer. Oncogene. 2003;22:734-9 pubmed
    b>Cdc25B is a dual-specific phosphatase that mediates cell cycle progression by activating the cyclin-dependent kinases. It has been shown to possess oncogenic potential...
  3. Oh J, Han S, Conti M. Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption. J Cell Biol. 2010;188:199-207 pubmed publisher
    ..Shortly before GV breakdown (GVBD), Cdc25B is translocated from the cytoplasm to the nucleus, whereas Wee1B is exported from the nucleus to the cytoplasm...
  4. Wang R, Morris D, Tomlins S, Lonigro R, Tsodikov A, Mehra R, et al. Development of a multiplex quantitative PCR signature to predict progression in non-muscle-invasive bladder cancer. Cancer Res. 2009;69:3810-8 pubmed publisher
    ..Immunohistochemistry was done for two genes in the signature not previously described in bladder cancer, ACTN1 and CDC25B, corroborating their up-regulation at the protein level with disease progression...
  5. Davezac N, Baldin V, Blot J, Ducommun B, Tassan J. Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation. Oncogene. 2002;21:7630-41 pubmed
    ..b>CDC25B is one of the three CDC25 phosphatase genes identified in human...
  6. Mirey G, Chartrain I, Froment C, Quaranta M, Bouché J, Monsarrat B, et al. CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. Cell Cycle. 2005;4:806-11 pubmed
    The phosphatase CDC25B is one of the key regulators that control entry into mitosis through the dephosphorylation and subsequent activation of the cyclin-dependent kinases...
  7. Wang Z, Trope C, Flørenes V, Suo Z, Nesland J, Holm R. Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes. BMC Cancer. 2010;10:233 pubmed publisher
    ..To shed light on their roles in the pathogenesis and to clarify their prognostic values, expression of CDC25A, CDC25B and CDC25C in a large series of vulvar squamous cell carcinomas were examined...
  8. Chang K, Vincent F, Shah K. Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death. J Cell Sci. 2012;125:5124-37 pubmed publisher
    ..Using a chemical genetic approach, we identified Cdc25A, Cdc25B and Cdc25C as direct Cdk5 substrates in mouse brain lysates...
  9. Meng J, Cui C, Liu Y, Jin M, Wu D, Liu C, et al. The role of 14-3-3? interaction with phosphorylated Cdc25B at its Ser321 in the release of the mouse oocyte from prophase I arrest. PLoS ONE. 2013;8:e53633 pubmed publisher
    The protein kinase A (PKA)/Cdc25B pathway plays a critical role in maintaining meiotic arrest in mouse oocytes. However, the molecular mechanism underlying this interchange is not known...

More Information

Publications13

  1. Ito Y, Yoshida H, Uruno T, Takamura Y, Miya A, Kuma K, et al. Expression of cdc25A and cdc25B phosphatase in breast carcinoma. Breast Cancer. 2004;11:295-300 pubmed
    Previous studies have indicated that cdc25B and cdc25A phosphatase stimulate cell cycle progression and also play a role in malignant transformation of cells...
  2. Schmidt A, Durgan J, Magalhaes A, Hall A. Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis. EMBO J. 2007;26:1624-36 pubmed
    ..for abscission of the midbody at the end of the cell division cycle and for phosphorylation and activation of Cdc25B, the phosphatase required for activation of mitotic cyclin/Cdk1 complexes at the G2/M transition...
  3. Wu W, Slomovitz B, Celestino J, Chung L, Thornton A, Lu K. Coordinate expression of Cdc25B and ER-alpha is frequent in low-grade endometrioid endometrial carcinoma but uncommon in high-grade endometrioid and nonendometrioid carcinomas. Cancer Res. 2003;63:6195-9 pubmed
    Overexpression of cdc25B, an important cell cycle regulator, has been shown to result in mammary gland hyperplasia in transgenic mice and to increase steroid hormone responsiveness as a direct coactivator of the estrogen receptor (ER)...
  4. Jinno S, Suto K, Nagata A, Igarashi M, Kanaoka Y, Nojima H, et al. Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J. 1994;13:1549-56 pubmed
    ..Mammals contain at least three cdc25+ homologues called cdc25A, cdc25B and cdc25C. In this study we investigate the biological function of cdc25A. Although very potent in rescuing the S...