Genomes and Genes
Gene Symbol: Cdc25b
Description: cell division cycle 25B
Alias: M-phase inducer phosphatase 2, dual specificity phosphatase Cdc25B
- Ito Y, Yoshida H, Uruno T, Takamura Y, Miya A, Kuma K, et al. Expression of cdc25A and cdc25B phosphatase in breast carcinoma. Breast Cancer. 2004;11:295-300 pubmedPrevious studies have indicated that cdc25B and cdc25A phosphatase stimulate cell cycle progression and also play a role in malignant transformation of cells...
- Schmidt A, Durgan J, Magalhaes A, Hall A. Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis. EMBO J. 2007;26:1624-36 pubmed..for abscission of the midbody at the end of the cell division cycle and for phosphorylation and activation of Cdc25B, the phosphatase required for activation of mitotic cyclin/Cdk1 complexes at the G2/M transition...
- Wu W, Slomovitz B, Celestino J, Chung L, Thornton A, Lu K. Coordinate expression of Cdc25B and ER-alpha is frequent in low-grade endometrioid endometrial carcinoma but uncommon in high-grade endometrioid and nonendometrioid carcinomas. Cancer Res. 2003;63:6195-9 pubmedOverexpression of cdc25B, an important cell cycle regulator, has been shown to result in mammary gland hyperplasia in transgenic mice and to increase steroid hormone responsiveness as a direct coactivator of the estrogen receptor (ER)...
- Jinno S, Suto K, Nagata A, Igarashi M, Kanaoka Y, Nojima H, et al. Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J. 1994;13:1549-56 pubmed..Mammals contain at least three cdc25+ homologues called cdc25A, cdc25B and cdc25C. In this study we investigate the biological function of cdc25A. Although very potent in rescuing the S...