Cdc25a

Summary

Gene Symbol: Cdc25a
Description: cell division cycle 25A
Alias: M-phase inducer phosphatase 1, dual specificity phosphatase Cdc25A
Species: rat
Products:     Cdc25a

Top Publications

  1. Chang K, Vincent F, Shah K. Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death. J Cell Sci. 2012;125:5124-37 pubmed publisher
    ..Using a chemical genetic approach, we identified Cdc25A, Cdc25B and Cdc25C as direct Cdk5 substrates in mouse brain lysates...
  2. Myer D, Robbins S, Yin M, Boivin G, Liu Y, Greis K, et al. Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors. Mutat Res. 2011;714:1-10 pubmed publisher
    ..Here we show that Plk3 phosphorylates the key cell cycle protein phosphatase Cdc25A on two serine residues in its cyclinB/cdk1 docking domain and regulates its stability in response to DNA damage...
  3. Chen S, Law C, Grigsby C, Olsen K, Gardner D. A role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation. J Steroid Biochem Mol Biol. 2010;122:326-32 pubmed publisher
    ..kinase 2 (Cdk2) activity and suppression of an ET-induced Cdk2 activator, cell division cycle 25 homolog A (Cdc25A)...
  4. Mehdipour P, Pirouzpanah S, Sarafnejad A, Atri M, Shahrestani S, Haidari M. Prognostic implication of CDC25A and cyclin E expression on primary breast cancer patients. Cell Biol Int. 2009;33:1050-6 pubmed publisher
    ..We have investigated the association of Ki67 labeling index, cyclin E and CDC25A expressions with clinical follow-up data in breast carcinomas...
  5. Jaime M, Pujol M, Serratosa J, Pantoja C, Canela N, Casanovas O, et al. The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers. Hepatology. 2002;35:1063-71 pubmed
    ..of CDK2, cyclin E, and p27(Kip1) were similar in both wild-type and p21(Cip1-/-) mice, those of the activator CDC25A were much higher in p21(Cip1-/-) quiescent and regenerating livers than in wild-type animals...
  6. Strazza M, Luddi A, Brogi A, Carbone M, Riccio M, Santi S, et al. Activation of cell cycle regulatory proteins in the apoptosis of terminally differentiated oligodendrocytes. Neurochem Res. 2004;29:923-31 pubmed
    ..the time of induction of cell death the oligodendrocytes are postmitotic, activation of c-myc and translocation of Cdc25A into the nucleus can be demonstrated...
  7. Hulit J, Lee R, Li Z, Wang C, Katiyar S, Yang J, et al. p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling. Cancer Res. 2006;66:8529-41 pubmed
    ..promoting lymphangiogenesis, cellular proliferation, and collaborative oncogenic signaling (Wnt/beta-catenin/Tcf, Cdc25a, Smad7, and Skp2). Skp2 expression was induced by ErbB2 and repressed by p27(Kip1)...
  8. Mochizuki T, Kitanaka C, Noguchi K, Muramatsu T, Asai A, Kuchino Y. Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. J Biol Chem. 1999;274:18659-66 pubmed
    ..Here we provide several lines of evidence that Cdc25A cell cycle phosphatase, a direct transcriptional target for c-Myc, is a substrate for Pim-1 kinase and functions ..
  9. Peschiaroli A, Skaar J, Pagano M, Melino G. The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival. Oncogene. 2010;29:1384-93 pubmed publisher
    ..Notably, genetic or siRNA-mediated depletion of USP47 induced accumulation of Cdc25A, decreased cell survival and augmented the cytotoxic effects of anticancer drugs...

More Information

Publications21

  1. Lee S, Masyuk T, Splinter P, Banales J, Masyuk A, Stroope A, et al. MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease. J Clin Invest. 2008;118:3714-24 pubmed publisher
    ..expression was associated with upregulation of its target, the cell-cycle regulator cell division cycle 25A (Cdc25A)...
  2. Chen S, Gardner D. Suppression of WEE1 and stimulation of CDC25A correlates with endothelin-dependent proliferation of rat aortic smooth muscle cells. J Biol Chem. 2004;279:13755-63 pubmed
    ..ET also increases expression and activity of CDC25A, the regulatory phosphatase responsible for dephosphorylating Tyr(15)...
  3. Ray D, Terao Y, Nimbalkar D, Hirai H, Osmundson E, Zou X, et al. Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice. Cancer Res. 2007;67:6605-11 pubmed
    b>CDC25A phosphatase activates multiple cyclin-dependent kinases (CDK) during cell cycle progression. Inactivation of CDC25A by ubiquitin-mediated degradation is a major mechanism of DNA damage-induced S-G(2) checkpoint...
  4. Ray D, Terao Y, Fuhrken P, Ma Z, DeMayo F, Christov K, et al. Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability. Cancer Res. 2007;67:984-91 pubmed
    ..The cell cycle-promoting phosphatase CDC25A is an activator of cyclin-dependent kinases and one of the downstream targets for the CHK1-mediated checkpoint ..
  5. Masyuk T, Radtke B, Stroope A, Banales J, Masyuk A, Gradilone S, et al. Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease. Gastroenterology. 2012;142:622-633.e4 pubmed publisher
    ..We investigated the effects of Cdc25A inhibition in mice and rats via genetic and pharmacologic approaches...
  6. Masyuk T, Lee S, Radtke B, Stroope A, Huang B, Banales J, et al. Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression. Am J Pathol. 2014;184:110-21 pubmed publisher
    ..cholangiocytes, the effects of centrosomal abnormalities on ciliogenesis, and the role of the cell-cycle regulator Cdc25A in centrosomal defects by depleting cholangiocytes of Cdc25A in vitro and in vivo and evaluating centrosome ..
  7. Zempolich K, Fuhrman C, Milash B, Flinner R, Greven K, Ryu J, et al. Changes in gene expression induced by chemoradiation in advanced cervical carcinoma: a microarray study of RTOG C-0128. Gynecol Oncol. 2008;109:275-9 pubmed publisher
    ..Further analysis comparing gene expression to clinical outcomes, acute and late toxicities awaits maturation of clinical data. Hopefully, this data will lead to the development of molecularly based therapies. ..
  8. Aziz M, Dreckschmidt N, Verma A. Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res. 2008;68:9024-32 pubmed publisher
    ..activity of transcription factors activator protein-1, nuclear factor-kappaB, and Stat3; and (c) Bcl-xL, cdc25A, and cyclooxygenase-2 expression...
  9. Wang Z, Trope C, Flørenes V, Suo Z, Nesland J, Holm R. Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes. BMC Cancer. 2010;10:233 pubmed publisher
    ..To shed light on their roles in the pathogenesis and to clarify their prognostic values, expression of CDC25A, CDC25B and CDC25C in a large series of vulvar squamous cell carcinomas were examined...
  10. Lokeshwar V, Estrella V, Lopez L, Kramer M, Gomez P, Soloway M, et al. HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer. Cancer Res. 2006;66:11219-27 pubmed
    ..Therefore, HYAL-v1 expression may negatively regulate bladder tumor growth, infiltration, and angiogenesis. ..
  11. Jinno S, Suto K, Nagata A, Igarashi M, Kanaoka Y, Nojima H, et al. Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J. 1994;13:1549-56 pubmed
    ..Mammals contain at least three cdc25+ homologues called cdc25A, cdc25B and cdc25C. In this study we investigate the biological function of cdc25A...
  12. Giessrigl B, Krieger S, Rosner M, Huttary N, Saiko P, Alami M, et al. Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells. Hum Mol Genet. 2012;21:4615-27 pubmed publisher
    ..over-expressed in pancreas carcinomas and protects a number of cell-cycle regulators such as the proto-oncogene Cdc25A. We show that inhibition of Hsp90 with geldanamycin (GD) destabilizes Cdc25A independent of Chk1/2, whereas the ..