Gene Symbol: Cd9
Description: CD9 molecule
Alias: CD9 antigen, CD9 antigen (p24)
Species: rat
Products:     Cd9

Top Publications

  1. Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, et al. A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. J Immunol. 1995;155:2661-7 pubmed
  2. Kaprielian Z, Cho K, Hadjiargyrou M, Patterson P. CD9, a major platelet cell surface glycoprotein, is a ROCA antigen and is expressed in the nervous system. J Neurosci. 1995;15:562-73 pubmed
    ..Amino acid sequence data obtained from the affinity purified 26 kDa protein showed some homology with human CD9, a tetraspan protein implicated in intercellular signaling in hematopoietic cells...
  3. Ikeyama S, Koyama M, Yamaoko M, Sasada R, Miyake M. Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. J Exp Med. 1993;177:1231-7 pubmed monoclonal antibody (mAb) M31-15 inhibiting cell motility and that the sequence of MRP-1 coincides with that of CD9. In the present study, plasmid was constructed in which human MRP-1/CD9 cDNA is expressed under the control of the ..
  4. Wolfahrt S, Herman S, Scholz C, Sauer G, Deissler H. Identification of alternative transcripts of rat CD9 expressed by tumorigenic neural cell lines and in normal tissues. Genet Mol Biol. 2013;36:276-81 pubmed publisher
    b>CD9 is the best-studied member of the tetraspanin family of transmembrane proteins. It is involved in various fundamental cellular processes and its altered expression is a characteristic of malignant cells of different origins...
  5. Le Naour F, Rubinstein E, Jasmin C, Prenant M, Boucheix C. Severely reduced female fertility in CD9-deficient mice. Science. 2000;287:319-21 pubmed
    b>CD9 is a widely expressed cell surface molecule that belongs to the tetraspanin superfamily of proteins...
  6. Kaji K, Oda S, Shikano T, Ohnuki T, Uematsu Y, Sakagami J, et al. The gamete fusion process is defective in eggs of Cd9-deficient mice. Nat Genet. 2000;24:279-82 pubmed
    The cell-surface molecule Cd9, a member of the transmembrane-4 superfamily, interacts with the integrin family and other membrane proteins. and is postulated to participate in cell migration and adhesion...
  7. Sheikh Hamad D, Youker K, Truong L, Nielsen S, Entman M. Osmotically relevant membrane signaling complex: association between HB-EGF, beta(1)-integrin, and CD9 in mTAL. Am J Physiol Cell Physiol. 2000;279:C136-46 pubmed
    The integral membrane proteins cluster of differentiation-9 (CD9), beta(1)-integrin, and heparin-binding epidermal growth factor-like (HB-EGF) exist in association in many cell lines and are linked to intracellular signaling mechanisms...
  8. Ishibashi T, Ding L, Ikenaka K, Inoue Y, Miyado K, Mekada E, et al. Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation. J Neurosci. 2004;24:96-102 pubmed
    ..Here we show that CD9, a member of the tetraspanin family, is present at the paranode...
  9. Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, et al. Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. Cancer Res. 2010;70:1668-78 pubmed publisher
    ..Unraveling these new pathways of exosome-initiated EC regulation could provide new options for therapeutic interference with tumor-induced angiogenesis. ..

More Information


  1. Mhawech P, Herrmann F, Coassin M, Guillou L, Iselin C. Motility-related protein 1 (MRP-1/CD9) expression in urothelial bladder carcinoma and its relation to tumor recurrence and progression. Cancer. 2003;98:1649-57 pubmed
    b>CD9 has been implicated in cell adhesion, motility, and proliferation, and numerous studies have demonstrated its prognostic value in different solid tumors...
  2. Wang J, Begin L, Berube N, Chevalier S, Aprikian A, Gourdeau H, et al. Down-regulation of CD9 expression during prostate carcinoma progression is associated with CD9 mRNA modifications. Clin Cancer Res. 2007;13:2354-61 pubmed
    Cluster-of-differentiation antigen 9 (CD9) protein, a member of the tetraspanin family, has been implicated in carcinogenesis of various human tumors...
  3. Caby M, Lankar D, Vincendeau Scherrer C, Raposo G, Bonnerot C. Exosomal-like vesicles are present in human blood plasma. Int Immunol. 2005;17:879-87 pubmed
    ..We observed that these plasma-derived vesicles contain tetraspanin molecules such as CD63, CD9, CD81 as well as class I and class II MHC molecules and Lamp-2 (i.e...
  4. Yu B, Kim H, Gong M, Wang J, Millard R, Wang Y, et al. Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection. Int J Cardiol. 2015;182:349-60 pubmed publisher
    ..Exo(GATA-4) upon transplantation in the damaged tissue mediate protection by releasing multiple miRs responsible for activation of the cell survival signaling pathway. ..
  5. Kierszenbaum A, Rosselot C, Rivkin E, Tres L. Role of integrins, tetraspanins, and ADAM proteins during the development of apoptotic bodies by spermatogenic cells. Mol Reprod Dev. 2006;73:906-17 pubmed
    ..Here, we have focused on ADAM proteins, tetraspanins CD9 and CD81, and the integrin beta1 subunit, which is co-expressed in testis with integrin alpha3 and integrin alpha6 ..
  6. Nakazawa Y, Sato S, Naito M, Kato Y, Mishima K, Arai H, et al. Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis. Blood. 2008;112:1730-9 pubmed publisher
    b>CD9 has been reported to play a role in tumor metastasis suppression. However, it is not fully understood how CD9 affects the hematogenous spread of tumor cells...
  7. Heit B, Kim H, Cosio G, Castaño D, Collins R, Lowell C, et al. Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev Cell. 2013;24:372-83 pubmed publisher
    ..internalization through a heteromeric complex consisting of CD36, ?1 and/or ?2 integrins, and the tetraspanins CD9 and/or CD81...
  8. Hálová I, Dráberová L, Bambousková M, Machyna M, Stegurová L, Smrz D, et al. Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis. J Biol Chem. 2013;288:9801-14 pubmed publisher
    ..In this study we prepared a new mAb specific for the tetraspanin CD9. Binding of the antibody to bone marrow-derived mast cells triggered activation events that included cell ..
  9. Sauer G, Windisch J, Kurzeder C, Heilmann V, Kreienberg R, Deissler H. Progression of cervical carcinomas is associated with down-regulation of CD9 but strong local re-expression at sites of transendothelial invasion. Clin Cancer Res. 2003;9:6426-31 pubmed
    ..We used immunohistochemical staining to assess expression of the tetraspanin adapter protein CD9 in cervical tumors because inverse correlations with tumor invasiveness, ability to form metastases, and poor ..
  10. Higginbottom A, Takahashi Y, Bolling L, Coonrod S, White J, Partridge L, et al. Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion. Biochem Biophys Res Commun. 2003;311:208-14 pubmed
    b>CD9 has been shown to be essential for sperm/oocyte fusion in mice, the only non-redundant role found for a member of the tetraspanin family...
  11. Terada N, Baracskay K, Kinter M, Melrose S, Brophy P, Boucheix C, et al. The tetraspanin protein, CD9, is expressed by progenitor cells committed to oligodendrogenesis and is linked to beta1 integrin, CD81, and Tspan-2. Glia. 2002;40:350-9 pubmed
    Previous studies identified the tetraspanin protein CD9 in myelinating oligodendrocytes...
  12. Houle C, Ding X, Foley J, Afshari C, Barrett J, Davis B. Loss of expression and altered localization of KAI1 and CD9 protein are associated with epithelial ovarian cancer progression. Gynecol Oncol. 2002;86:69-78 pubmed
    Impairment of cell adhesion plays a vital role in tumor progression. E- and N-cadherin, CD9, and KAI1 are all adhesion molecules that have been implicated in the progression of several different tumor types...
  13. Miyamoto S, Maruyama A, Okugawa K, Akazawa K, Baba H, Maehara Y, et al. Loss of motility-related protein 1 (MRP1/CD9) and integrin alpha3 expression in endometrial cancers. Cancer. 2001;92:542-8 pubmed
    MRP1/CD9 and integrin alpha3 have played crucial roles in cell adhesion, motility, and signaling events. The loss of MRP1/CD9 and integrin alpha3 has been involved in tumor growth and metastasis of cancer cells...
  14. Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash S, et al. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. J Biol Chem. 2001;276:14329-37 pubmed
    ..We have previously identified a 135-kDa molecule (CD9P-1) as a major molecular partner of CD9 in cancer cell lines...
  15. Wright M, Geary S, Fitter S, Moseley G, Lau L, Sheng K, et al. Characterization of mice lacking the tetraspanin superfamily member CD151. Mol Cell Biol. 2004;24:5978-88 pubmed
    ..CD151-null keratinocytes migrate poorly in skin explant cultures. Finally, CD151-null T lymphocytes are hyperproliferative in response to in vitro mitogenic stimulation. ..
  16. Mimori K, Kataoka A, Yoshinaga K, Ohta M, Sagara Y, Yoshikawa Y, et al. Identification of molecular markers for metastasis-related genes in primary breast cancer cells. Clin Exp Metastasis. 2005;22:59-67 pubmed
    ..As a result, the expression of motility related protein-1 (MRP-1/CD9), peripheral myelin protein-22 (PMP-22), and caspase 3 (CASP-3) were down-regulated in M compared to T...
  17. Ai X, Zhang X, Wu Z, Ma X, Ju Z, Wang B, et al. Expression of KAI1/CD82 and MRP-1/CD9 in transitional cell carcinoma of bladder. J Huazhong Univ Sci Technolog Med Sci. 2007;27:79-82 pubmed
    The expression of KAI1/CD82 and MRP-1/CD9 in transitional cell carcinoma of bladder (TCCB) and its clinical significance were investigated...
  18. Chang Y, Finnemann S. Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis. J Cell Sci. 2007;120:3053-63 pubmed
    ..Here, we show that tetraspanins CD81 and CD9 reside in a complex specifically with alpha v beta5 integrin but not the engulfment receptors Mer tyrosine kinase ..
  19. Deissler H, Blass Kampmann S, Kindler Röhrborn A, Meyer H, Rajewsky M. Characterization of rat NCA/CD9 cell surface antigen and its expression by normal and malignant neural cells. J Neurosci Res. 1996;43:664-74 pubmed
    ..with immobilized Mab alpha NCA1 and identified by N-terminal sequencing as the rat homologue of the CD9 antigen. Identification of proline as N-terminal amino acid of the purified protein suggests post-translational ..
  20. Masellis Smith A, Shaw A. CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin. J Immunol. 1994;152:2768-77 pubmed
    ..mAb against CD9 and beta 1 integrins are reported to induce the homotypic adhesion of pre-B cells...