Gene Symbol: Cd8b
Description: CD8b molecule
Alias: Cd8b1, T-cell surface glycoprotein CD8 beta chain, CD8 antigen 37 kDa chain, CD8 antigen beta-chain, OX-8 membrane antigen
Fung Leung W, Schilham M, Rahemtulla A, Kundig T, Vollenweider M, Potter J, et al
. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell. 1991;65:443-9 pubmed
Parnes J. Molecular biology and function of CD4 and CD8. Adv Immunol. 1989;44:265-311 pubmed
Johnson P, Williams A. Striking similarities between antigen receptor J pieces and sequence in the second chain of the murine CD8 antigen. Nature. 1986;323:74-6 pubmed
..This suggests that the CD8 and receptor heterodimers may have evolved directly from a common ancestor. ..
Simpson S, Mizoguchi E, Allen D, Bhan A, Terhorst C. Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol. 1995;25:2618-25 pubmed
..In light of these findings, we propose that infiltrating CD4+, but not CD8+ T cells are central to the inflammation observed in the intestinal mucosa in IL-2null colitis. ..
Lin R, Rodriguez C, Veillette A, Lodish H. Zinc is essential for binding of p56(lck) to CD4 and CD8alpha. J Biol Chem. 1998;273:32878-82 pubmed
..p56(lck) complexes. CD4. p56(lck) and CD8alpha.p56(lck) represent the first examples of intracellular proteins that require zinc as a bridge for heterodimerization. ..
Kennedy M, Glaccum M, Brown S, Butz E, Viney J, Embers M, et al
. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med. 2000;191:771-80 pubmed
..Moreover, the ability to rescue lymphoid defects in IL-15(-/-) mice by IL-15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine. ..
Allam A, Illges H. Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells. Immunobiology. 2000;202:353-62 pubmed
..The effect was specific to CD8alpha in that CD4 expression was not affected and specific for calyculin A. Okadaic acid, another phosphatase inhibitor did not show any influence on the expression of CD4 or CD8. ..
Kerry S, Buslepp J, Cramer L, Maile R, Hensley L, Nielsen A, et al
. Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement. J Immunol. 2003;171:4493-503 pubmed
..An integrated signal over time allows T cell activation with a high-affinity ligand in the absence of CD8 engagement. ..
Kang J, DiBenedetto B, Narayan K, Zhao H, Der S, Chambers C. STAT5 is required for thymopoiesis in a development stage-specific manner. J Immunol. 2004;173:2307-14 pubmed