Gene Symbol: Cd8a
Description: CD8a molecule
Alias: T-cell surface glycoprotein CD8 alpha chain, CD8 antigen 32 kDa chain, CD8 antigen, alpha-chain, OX-8 membrane antigen
Species: rat
Products:     Cd8a

Top Publications

  1. Zhou C, Robertson J, Wu J, Bartkowiak T, Parker K, McMahon J, et al. Natural recovery from antiglomerular basement membrane glomerulonephritis is associated with glomeruli-infiltrating CD8?+CD11c+MHC class II+ cells. Am J Nephrol. 2011;34:519-28 pubmed publisher
    ..We investigated if GIL CD8?(+) cells were also associated with the recovery in LEW rats...
  2. Nohara O, Kulka M, Dery R, Wills F, Hirji N, Gilchrist M, et al. Regulation of CD8 expression in mast cells by exogenous or endogenous nitric oxide. J Immunol. 2001;167:5935-9 pubmed
  3. Guerriero A, Langmuir P, Spain L, Scott E. PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells. Blood. 2000;95:879-85 pubmed
    ..PU. 1(-/-)lymphoid DC were functionally equivalent to WT DC for stimulating T-cell proliferation in mixed lymphocyte reactions. These results demonstrate that PU.1 is required for the development of myeloid DC but not lymphoid DC. ..
  4. Simpson S, Mizoguchi E, Allen D, Bhan A, Terhorst C. Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol. 1995;25:2618-25 pubmed
    ..In light of these findings, we propose that infiltrating CD4+, but not CD8+ T cells are central to the inflammation observed in the intestinal mucosa in IL-2null colitis. ..
  5. Sim B, Zerva L, Greene M, Gascoigne N. Control of MHC restriction by TCR Valpha CDR1 and CDR2. Science. 1996;273:963-6 pubmed
    ..Thus, the germline-encoded Valpha elements are a major influence on major histocompatibility class complex (MHC) restriction, most likely by a preferential interaction with one or the other class of MHC molecule. ..
  6. Kerry S, Buslepp J, Cramer L, Maile R, Hensley L, Nielsen A, et al. Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement. J Immunol. 2003;171:4493-503 pubmed
    ..An integrated signal over time allows T cell activation with a high-affinity ligand in the absence of CD8 engagement. ..
  7. Shiow L, Roadcap D, Paris K, Watson S, Grigorova I, Lebet T, et al. The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol. 2008;9:1307-15 pubmed publisher
  8. Hosoya T, Kuroha T, Moriguchi T, Cummings D, Maillard I, Lim K, et al. GATA-3 is required for early T lineage progenitor development. J Exp Med. 2009;206:2987-3000 pubmed publisher
    ..Thus, GATA-3 is required for the cell-autonomous development of the earliest characterized thymic T cell progenitors. ..
  9. Bouvier G, Watrin F, Naspetti M, Verthuy C, Naquet P, Ferrier P. Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. Proc Natl Acad Sci U S A. 1996;93:7877-81 pubmed
    ..These data formally establish the critical role played by Ebeta in cis-activation of the TCR beta locus for V(D)J recombination during alphabeta T-cell development. ..

More Information


  1. Du C, Liu C, Kang J, Zhao G, Ye Z, Huang S, et al. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol. 2009;10:1252-9 pubmed publisher
    ..Our data show a critical role for microRNA in T(H)-17 differentiation and the pathogenesis of multiple sclerosis. ..
  2. Kennedy M, Glaccum M, Brown S, Butz E, Viney J, Embers M, et al. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med. 2000;191:771-80 pubmed
    ..Moreover, the ability to rescue lymphoid defects in IL-15(-/-) mice by IL-15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine. ..
  3. Beyers A, Spruyt L, Williams A. Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc Natl Acad Sci U S A. 1992;89:2945-9 pubmed
    ..The presence of p56lck associated with CD4 or CD8 was also examined in early thymocytes, natural killer cells, and macrophages. The kinase was present in all cases except that of normal macrophages. ..
  4. Wu J, Zhou C, Robertson J, Carlock C, Lou Y. Peripheral blood CD8αα+CD11c+MHC-II+CD3- cells attenuate autoimmune glomerulonephritis in rats. Kidney Int. 2014;85:1078-90 pubmed publisher
    ..Thus, PBMC CD8αα+CD3- cells of Lewis rats were able to terminate ongoing autoimmune inflammation in the glomeruli. ..
  5. Pang D, Hayday A, Bijlmakers M. CD8 Raft localization is induced by its assembly into CD8alpha beta heterodimers, Not CD8alpha alpha homodimers. J Biol Chem. 2007;282:13884-94 pubmed
    ..Thus, heterodimer formation and raft association are intimately linked for CD8alphabeta. These results emphasize that lipid raft localization is a key feature of human CD8alphabeta that clearly distinguishes it from CD8alphaalpha. ..
  6. Kang J, DiBenedetto B, Narayan K, Zhao H, Der S, Chambers C. STAT5 is required for thymopoiesis in a development stage-specific manner. J Immunol. 2004;173:2307-14 pubmed
  7. Wang L, Wildt K, Zhu J, Zhang X, Feigenbaum L, Tessarollo L, et al. Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol. 2008;9:1122-30 pubmed publisher
    ..We propose that GATA-3 acts as a specification factor for the CD4(+) lineage 'upstream' of the ThPOK-controlled CD4(+) commitment checkpoint. ..
  8. Attinger A, Devine L, Wang Zhu Y, Martin D, Wang J, Reinherz E, et al. Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule. J Immunol. 2005;174:3501-7 pubmed
    ..These data indicate that small changes in the alpha3 domain of class I molecules potentially can have profound physiologic consequences. ..
  9. Nakatsuji T. Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver gr. Tohoku J Exp Med. 1999;187:215-25 pubmed
    ..The 22 rats with chronic graft rejection showed increased CD8a-like antigen (probably Fas ligand) on the peripheral blood T cells...
  10. Lin R, Rodriguez C, Veillette A, Lodish H. Zinc is essential for binding of p56(lck) to CD4 and CD8alpha. J Biol Chem. 1998;273:32878-82 pubmed
    ..p56(lck) complexes. CD4. p56(lck) and CD8alpha.p56(lck) represent the first examples of intracellular proteins that require zinc as a bridge for heterodimerization. ..
  11. Gartlan K, Belz G, Tarrant J, Minigo G, Katsara M, Sheng K, et al. A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity. J Immunol. 2010;185:3158-66 pubmed publisher
    ..Therefore, in the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37(-/-) or Tssc6(-/-) mice, demonstrating a complementary role for these two molecules in cellular immunity...
  12. Davidson W, Roths J, Holmes K, Rudikoff E, Morse H. Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice. J Immunol. 1984;133:1048-56 pubmed
    ..This suggests that factors other than defective IL 2 production and polyclonal B cell activation are required for the development of fulminant autoimmune disease...
  13. Johnson P, Gagnon J, Barclay A, Williams A. Purification, chain separation and sequence of the MRC OX-8 antigen, a marker of rat cytotoxic T lymphocytes. EMBO J. 1985;4:2539-45 pubmed
    ..The N-terminal part of the sequence was surprisingly different from both its mouse and human counterparts but, as in the other two species, it showed a clear relationship to Ig V domains. ..
  14. Hu M, Deshpande A, Schlichting N, Hinds E, Mao C, Dose M, et al. CDK6 kinase activity is required for thymocyte development. Blood. 2011;117:6120-31 pubmed publisher
    ..This role of CDK6 as a downstream mediator of Notch identifies CDK6 kinase activity as a potential therapeutic target in human lymphoid malignancies. ..
  15. Ling K, van Hamburg J, de Bruijn M, Kurek D, Dingjan G, Hendriks R. GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development. Eur J Immunol. 2007;37:1043-52 pubmed
    ..Because GATA3 is induced by TCR signaling in DP thymocytes, our findings indicate that GATA3 establishes a positive feedback loop that increases TCR surface expression in developing CD4 lineage cells. ..
  16. Matsuzaki J, Tsuji T, Chamoto K, Takeshima T, Sendo F, Nishimura T. Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell Immunol. 2003;224:98-105 pubmed
    ..Thus, we initially demonstrated that anti-Gr-1 mAb might become a good tool to investigate a precise role for memory-type CD8(+) T cells in vivo. ..
  17. Garcia Martinez L, Appleby M, Staehling Hampton K, Andrews D, Chen Y, McEuen M, et al. A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. J Immunol. 2004;173:2995-3001 pubmed
    ..Thus, in addition to its role in selection of CD4(+) T cells, absence of CD83 results in the generation of cells with an altered activation and cytokine profile. ..
  18. Parnes J. Molecular biology and function of CD4 and CD8. Adv Immunol. 1989;44:265-311 pubmed
  19. Gooley A, Classon B, Marschalek R, Williams K. Glycosylation sites identified by detection of glycosylated amino acids released from Edman degradation: the identification of Xaa-Pro-Xaa-Xaa as a motif for Thr-O-glycosylation. Biochem Biophys Res Commun. 1991;178:1194-201 pubmed
    ..This motif predicts the site(s) of Pro- associated Thr-O-glycosylation in O-glycosylated proteins, although it is clear that there are also other forms of Thr-O-glycosylation not associated with Pro. ..
  20. Fung Leung W, Schilham M, Rahemtulla A, Kundig T, Vollenweider M, Potter J, et al. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell. 1991;65:443-9 pubmed
  21. Mandal M, Borowski C, Palomero T, Ferrando A, Oberdoerffer P, Meng F, et al. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med. 2005;201:603-14 pubmed
    ..Finally, we suggest that pre-TCR-induced A1 overexpression can contribute to T cell leukemia in both mice and humans. ..
  22. McKee A, Pearce E. CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol. 2004;173:1224-31 pubmed
    ..The data suggest that natural Treg cells and, to a lesser extent, Th2 cells play roles in suppressing Th1 responses and ensuring Th2 polarization during schistosomiasis. ..
  23. Dai Y, Marrero I, Gros P, Zaghouani H, Wicker L, Sercarz E. Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Diabetes. 2009;58:156-64 pubmed publisher
    ..Thus, non-MHC genes could affect the MHC-restricted T-cell response through altered antigen processing and presentation. ..
  24. Stone E, Ismail M, Lee S, Luu Y, Ramirez K, Haslam S, et al. Glycosyltransferase function in core 2-type protein O glycosylation. Mol Cell Biol. 2009;29:3770-82 pubmed publisher
    ..Although the absence of C2GnT and C4GnT activities is tolerable in vivo, core 2 O glycosylation exerts a significant influence on O-glycan biosynthesis and is important in multiple physiological processes. ..
  25. Taurog J, Dorris M, Satumtira N, Tran T, Sharma R, Dressel R, et al. Spondylarthritis in HLA-B27/human beta2-microglobulin-transgenic rats is not prevented by lack of CD8. Arthritis Rheum. 2009;60:1977-84 pubmed publisher
    ..A missense mutation in the CD8a gene that causes a loss of CD8alpha expression was identified in offspring of a male Sprague-Dawley rat that had ..
  26. Allam A, Illges H. Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells. Immunobiology. 2000;202:353-62 pubmed
    ..The effect was specific to CD8alpha in that CD4 expression was not affected and specific for calyculin A. Okadaic acid, another phosphatase inhibitor did not show any influence on the expression of CD4 or CD8. ..
  27. Wiest D, Ashe J, Howcroft T, Lee H, Kemper D, Negishi I, et al. A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity. 1997;6:663-71 pubmed
    ..The developmental arrest is due to the inability of CD4+ CD8+ thymocytes to propagate TCR signals in the absence of ZAP-70 kinase activity despite tyrosine phosphorylation of TCR-associated ZAP-70 molecules. ..
  28. Li T, Ramirez K, Palacios R. Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ. 1996;7:107-14 pubmed