Cd46

Summary

Gene Symbol: Cd46
Description: CD46 molecule
Alias: Mcp, membrane cofactor protein, CD46 antigen, complement regulatory protein, CD46 molecule, complement regulatory protein
Species: rat
Products:     Cd46

Top Publications

  1. Mizuno M, Harris C, Johnson P, Morgan B. Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3. Biol Reprod. 2004;71:1374-83 pubmed
    The rat analogue of the complement regulator membrane cofactor protein (MCP; CD46) was recently cloned and analysis at the mRNA level suggested that expression was restricted to testis...
  2. Fang C, Fremeaux Bacchi V, Liszewski M, Pianetti G, Noris M, Goodship T, et al. Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. Blood. 2008;111:624-32 pubmed
    ..Genetic studies demonstrate that heterozygous mutations of membrane cofactor protein (MCP;CD46) predispose to atypical HUS (aHUS), which is not associated with exposure to Shiga toxin (Stx)...
  3. Johansson L, Rytkonen A, Bergman P, Albiger B, Källström H, Hokfelt T, et al. CD46 in meningococcal disease. Science. 2003;301:373-5 pubmed
    ..The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation...
  4. Richards A, Kemp E, Liszewski M, Goodship J, Lampe A, Decorte R, et al. Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome. Proc Natl Acad Sci U S A. 2003;100:12966-71 pubmed
    b>Membrane cofactor protein (MCP; CD46) is a widely expressed transmembrane complement regulator. Like factor H it inhibits complement activation by regulating C3b deposition on targets...
  5. Salmon J, Heuser C, Triebwasser M, Liszewski M, Kavanagh D, Roumenina L, et al. Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. PLoS Med. 2011;8:e1001013 pubmed publisher
    ..We sequenced genes encoding three complement regulatory proteins--membrane cofactor protein (MCP), complement factor I (CFI), and complement factor H (CFH)--in 40 patients who had preeclampsia and ..
  6. Kemper C, Chan A, Green J, Brett K, Murphy K, Atkinson J. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature. 2003;421:388-92 pubmed
    ..Here we show that co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4+ T cells...
  7. Lokki A, Aalto Viljakainen T, Meri S, Laivuori H. Genetic analysis of membrane cofactor protein (CD46) of the complement system in women with and without preeclamptic pregnancies. PLoS ONE. 2015;10:e0117840 pubmed publisher
    ..b>Membrane cofactor protein MCP (CD46) is among the potent complement regulators that have recently been linked to a severe form of ..
  8. Bjørge L, Hakulinen J, Vintermyr O, Jarva H, Jensen T, Iversen O, et al. Ascitic complement system in ovarian cancer. Br J Cancer. 2005;92:895-905 pubmed
    ..The lack of MAC was probably due to the expression of C membrane regulators CD46, CD55 and CD59 on the tumour cells...
  9. Simpson K, Jones A, Norman S, Holmes C. Expression of the complement regulatory proteins decay accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59 in the normal human uterine cervix and in premalignant and malignant cervical disease. Am J Pathol. 1997;151:1455-67 pubmed
    The membrane-bound complement regulators decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46), and CD59 are broadly expressed proteins that act together to protect host tissues from autologous complement...

More Information

Publications39

  1. Alvarez Lafuente R, Blanco Kelly F, Garcia Montojo M, Martinez A, De las Heras V, Domínguez Mozo M, et al. CD46 in a Spanish cohort of multiple sclerosis patients: genetics, mRNA expression and response to interferon-beta treatment. Mult Scler. 2011;17:513-20 pubmed publisher
    In a prior study of our group we found an up-regulation of CD46 expression in a cohort of Spanish multiple sclerosis (MS) patients...
  2. Alvarez Lafuente R, Garcia Montojo M, De Las Heras V, Dominguez Mozo M, Bartolome M, Arroyo R. CD46 expression and HHV-6 infection in patients with multiple sclerosis. Acta Neurol Scand. 2009;120:246-50 pubmed publisher
    The aim of this study was to investigate the possible association between the levels of the CD46 expression, and the presence and viral load of HHV-6 in patients with multiple sclerosis (MS)...
  3. Yang C, Jones J, Barnum S. Expression of decay-accelerating factor (CD55), membrane cofactor protein (CD46) and CD59 in the human astroglioma cell line, D54-MG, and primary rat astrocytes. J Neuroimmunol. 1993;47:123-32 pubmed
    ..have shown the expression of the complement regulatory proteins decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59 on human D54-MG astroglioma cells by several methods, including immunofluorescence, ..
  4. Grumelli S, Lu B, Peterson L, Maeno T, Gerard C. CD46 protects against chronic obstructive pulmonary disease. PLoS ONE. 2011;6:e18785 pubmed publisher
    ..in patients with chronic obstructive pulmonary disease and emphysema was associated with a lower expression of CD46 and verified this finding by qRT-PCR and flow cytometry...
  5. Dragon Durey M, Fremeaux Bacchi V. Atypical haemolytic uraemic syndrome and mutations in complement regulator genes. Springer Semin Immunopathol. 2005;27:359-74 pubmed
    ..groups have demonstrated genetic predisposition of atypical HUS involving complement components factor H (FH), CD46 [or membrane co-factor protein (MCP)] and factor I...
  6. Noris M, Brioschi S, Caprioli J, Todeschini M, Bresin E, Porrati F, et al. Familial haemolytic uraemic syndrome and an MCP mutation. Lancet. 2003;362:1542-7 pubmed
    ..genes that encode the complement regulatory proteins-ie, factor H related 5, complement receptor 1, and membrane cofactor protein (MCP)-by PCR-single-strand conformation polymorphism (PCR-SSCP) and by direct sequencing, in 25 ..
  7. Nuutila J, Jalava Karvinen P, Hohenthal U, Kotilainen P, Pelliniemi T, Nikoskelainen J, et al. Use of complement regulators, CD35, CD46, CD55, and CD59, on leukocytes as markers for diagnosis of viral and bacterial infections. Hum Immunol. 2013;74:522-30 pubmed publisher
    ..present study, we aimed to perform quantitative analysis of membrane-bound complement regulators, CR1 (CD35), MCP (CD46), DAF (CD55), and MIRL (CD59), on peripheral blood neutrophils, monocytes, and lymphocytes from healthy controls (n=..
  8. Peng K, Teneyck C, Galanis E, Kalli K, Hartmann L, Russell S. Intraperitoneal therapy of ovarian cancer using an engineered measles virus. Cancer Res. 2002;62:4656-62 pubmed
    ..In contrast to nontransformed cells, the ovarian tumor cells expressed high levels of the measles virus receptor CD46. When injected directly into large established s.c. SKOV3ip...
  9. Noris M, Caprioli J, Bresin E, Mossali C, Pianetti G, Gamba S, et al. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin J Am Soc Nephrol. 2010;5:1844-59 pubmed publisher
    ..Membrane-cofactor protein (MCP) mutations were associated with the best prognosis...
  10. Ong H, Timm M, Greipp P, Witzig T, Dispenzieri A, Russell S, et al. Oncolytic measles virus targets high CD46 expression on multiple myeloma cells. Exp Hematol. 2006;34:713-20 pubmed
    ..The virus is tumor selective and preferentially targets cells that express high levels of CD46 receptors. However, CD46 levels on MM have not previously been evaluated...
  11. Kamitani S, Kitadokoro K, Miyazawa M, Toshima H, Fukui A, Abe H, et al. Characterization of the membrane-targeting C1 domain in Pasteurella multocida toxin. J Biol Chem. 2010;285:25467-75 pubmed publisher
    ..Direct binding between the C1 domain and liposomes containing phospholipids was evidenced by surface plasmon resonance analyses. These results indicate that the C1 domain of C-PMT functions as a targeting signal for the plasma membrane. ..
  12. Maga T, Nishimura C, Weaver A, Frees K, Smith R. Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. Hum Mutat. 2010;31:E1445-60 pubmed publisher
    ..genes including complement factor H (CFH), complement factor H-related 5 (CFHR5), complement factor I (CFI), CD46 (MCP), complement factor B (CFB), complement component 3 (C3) and thrombomodulin (THBD)...
  13. Hofman P, Hsi B, Manie S, Fenichel P, Thyss A, Rossi B. High expression of the antigen recognized by the monoclonal antibody GB24 on human breast carcinomas: a preventive mechanism of malignant tumor cells against complement attack?. Breast Cancer Res Treat. 1994;32:213-9 pubmed
    ..GB24 detects the membrane cofactor protein (MCP, CD46), a member of the complement regulatory protein family, which serves as a cofactor for factor ..
  14. Yoshida H, Matsui H, Murayama S, Takada Y, Matsuo K, Takahashi T, et al. A CD46 transgenic mouse model for studying the histopathology of arthritis caused by subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis. J Med Microbiol. 2011;60:1860-8 pubmed publisher
    ..isolated from a patient suffering from multiple organ failure due to septicaemia, into both hind footpads of human CD46-expressing transgenic (Tg) mice...
  15. Kim Y, Lim S, Li C, Kang H, Ahn K, Yang H, et al. Activation of intrarenal complement system in mouse model for chronic cyclosporine nephrotoxicity. Yonsei Med J. 2007;48:517-25 pubmed
    ..through analysis of the expression of C3, C4d, and membrane attack complex (MAC), and the regulatory proteins, CD46 and CD55...
  16. Zhang C, Ge C, Guo R, He S. Effect of IL-4 on altered expression of complement activation regulators in rat pancreatic cells during severe acute pancreatitis. World J Gastroenterol. 2005;11:6770-4 pubmed
    ..regulators: decay accelerating factor (DAF; CD55), 20 ku homologous restriction factor (HRF20; CD59) and membrane cofactor protein (MCP; CD46), in the pancreatic acinar cells of rats at 0, 3, 6, 12, and 24 h after the induction of SAP ..
  17. Biswas B, Kumar U, Das N. Expression and significance of leukocyte membrane cofactor protein transcript in systemic lupus erythematosus. Lupus. 2012;21:517-25 pubmed publisher
    b>Membrane cofactor protein (MCP) is a complement regulatory protein ubiquitously expressed on most nucleated cells...
  18. Wirstlein P, Jasinski P, Rajewski M, Gozdziewicz T, Skrzypczak J. Complement inhibitory proteins expression in placentas of thrombophilic women. Folia Histochem Cytobiol. 2012;50:460-7 pubmed publisher
    ..was to determine the transcript and protein levels of complement decay-accelerating factor (DAF) and membrane cofactor protein (MCP) in the placentas of women with acquired and inherited thrombophilia...
  19. Mizuno M, Harris C, Suzuki N, Matsuo S, Morgan B. Expression of CD46 in developing rat spermatozoa: ultrastructural localization and utility as a marker of the various stages of the seminiferous tubuli. Biol Reprod. 2005;72:908-15 pubmed
    ..We recently described characterization of the expression of CD46 (membrane cofactor protein) in the rat using a novel monoclonal antibody...
  20. Marie J, Astier A, Rivailler P, Rabourdin Combe C, Wild T, Horvat B. Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation. Nat Immunol. 2002;3:659-66 pubmed
    b>CD46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products...
  21. Blok V, Daha M, Tijsma O, Weissglas M, Van den Broek L, Gorter A. A possible role of CD46 for the protection in vivo of human renal tumor cells from complement-mediated damage. Lab Invest. 2000;80:335-44 pubmed
    ..To address this question, the expression levels of CD46, CD55, and CD59 were measured semi-quantitatively in situ on renal cell carcinomas and compared with the expression ..
  22. Surowiak P, Materna V, Maciejczyk A, Kaplenko I, Spaczynski M, Dietel M, et al. CD46 expression is indicative of shorter revival-free survival for ovarian cancer patients. Anticancer Res. 2006;26:4943-8 pubmed
    The membrane cofactor protein CD46 represents a complement inhibitor, which protects autologous cells from complement - mediated cytotoxicity. CD46 may exhibit the potential to protect tumor cells from the immune responses of the host...
  23. Canova C, Neal J, Gasque P. Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis. J Neuroinflammation. 2006;3:22 pubmed
    ..we assessed the capacity of brain epithelial cells to express membrane-bound complement regulators (ie, CD35, CD46, CD55 and CD59) in vitro and in situ by immunostaining of control and meningitis human brain tissue sections...
  24. Mead R, Hinchliffe S, Morgan B. Molecular cloning, expression and characterization of the rat analogue of human membrane cofactor protein (MCP/CD46). Immunology. 1999;98:137-43 pubmed
    ..These include complement receptor 1 (CR1), decay-accelerating factor (DAF, CD55) and membrane cofactor protein (MCP, CD46)...
  25. Assem M, Gad W, El Sharkawy N, El Rouby M, Ghaleb F, Tarek H, et al. Prevalence of anti human herpes virus-6 IgG and its receptor in acute leukemia (membrane cofactor protein: MCP, CD46). J Egypt Natl Canc Inst. 2005;17:29-34 pubmed
    CD46 is a membrane cofactor protein, which acts as a cofactor for factor I proteolytic cleavage of C3, so it protects the cells expressing it on their surface from autologous complement attack...
  26. Lewis D, Suchindran S, Beckman M, Hooper W, Grant A, Heit J, et al. Whole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism. Thromb Res. 2015;135:659-65 pubmed publisher
    ..several genes previously implicated in thrombotic disorders by genetic analyses, including SELP, KLKB1, ANXA5, and CD46. Protein levels for several of the identified genes were not significantly different between the different groups...
  27. Madjd Z, Durrant L, Pinder S, Ellis I, Ronan J, Lewis S, et al. Do poor-prognosis breast tumours express membrane cofactor proteins (CD46)?. Cancer Immunol Immunother. 2005;54:149-56 pubmed
    CD46 or membrane cofactor protein (MCP) is a complement regulatory protein that has been identified on all nucleated cells and which protects them from attack by autologous complement...
  28. Murray K, Mathure S, Kaul R, Khan S, Carson L, Twiggs L, et al. Expression of complement regulatory proteins-CD 35, CD 46, CD 55, and CD 59-in benign and malignant endometrial tissue. Gynecol Oncol. 2000;76:176-82 pubmed
    ..to escape complement damage, we examined the distribution of complement receptor type 1 (CR1, CD35), membrane cofactor protein (MCP, CD46), decay-accelerating factor (DAF, CD55), and protectin (MACIF, CD59) on frozen endometrial ..
  29. Miwa T, Nonaka M, Okada N, Wakana S, Shiroishi T, Okada H. Molecular cloning of rat and mouse membrane cofactor protein (MCP, CD46): preferential expression in testis and close linkage between the mouse Mcp and Cr2 genes on distal chromosome 1. Immunogenetics. 1998;48:363-71 pubmed
    Human membrane cofactor protein (MCP, CD46) is widely distributed and is one of the plasma membrane complement inhibitors. We isolated cDNA clones encoding genetic homologues of human MCP from a rat testis cDNA library...
  30. Le Friec G, Sheppard D, Whiteman P, Karsten C, Shamoun S, Laing A, et al. The CD46-Jagged1 interaction is critical for human TH1 immunity. Nat Immunol. 2012;13:1213-21 pubmed publisher
    b>CD46 is a complement regulator with important roles related to the immune response...