Cd44

Summary

Gene Symbol: Cd44
Description: CD44 molecule (Indian blood group)
Alias: CD44A, METAA, RHAMM, CD44 antigen, CD44 antigen isoform d6-12, CD44 antigen isoform d6-13, CD44 antigen isoform d6-15, Cell surface glycoprotein CD44 (hyaluronate binding protein), ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, PGP-1, PGP-I, extracellular matrix receptor III, hermes antigen, hyaluronate receptor, phagocytic glycoprotein 1, phagocytic glycoprotein I
Species: rat
Products:     Cd44

Top Publications

  1. Gunthert U, Hofmann M, Rudy W, Reber S, Zoller M, Haussmann I, et al. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell. 1991;65:13-24 pubmed
    ..carcinoma cell line BSp73ASML, cDNA clones have been isolated that encode glycoproteins with partial homology to CD44, a presumed adhesion molecule...
  2. Tawfik O, Kramer B, Shideler B, Danley M, Kimler B, Holzbeierlein J. Prognostic significance of CD44, platelet-derived growth factor receptor alpha, and cyclooxygenase 2 expression in renal cell carcinoma. Arch Pathol Lab Med. 2007;131:261-7 pubmed
    ..The expression of CD44, cyclooxygenase 2, and platelet-derived growth factor receptor alpha (PDGFR-alpha) was evaluated as a potential ..
  3. Klingbeil P, Marhaba R, Jung T, Kirmse R, Ludwig T, Zoller M. CD44 variant isoforms promote metastasis formation by a tumor cell-matrix cross-talk that supports adhesion and apoptosis resistance. Mol Cancer Res. 2009;7:168-79 pubmed publisher
    b>CD44 designates a large family of proteins with a considerable structural and functional diversity, which are generated from one gene by alternative splicing...
  4. Willerford D, Chen J, Ferry J, Davidson L, Ma A, Alt F. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 1995;3:521-30 pubmed
    ..Thus, IL-2R alpha is essential for regulation of both the size and content of the peripheral lymphoid compartment, probably by influencing the balance between clonal expansion and cell death following lymphocyte activation. ..
  5. Mendiratta S, Martin W, Hong S, Boesteanu A, Joyce S, van Kaer L. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity. 1997;6:469-77 pubmed
    ..These results demonstrate a critical role for CD1 in the positive selection and function of NT cells. ..
  6. Chen Z, Benoist C, Mathis D. How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc Natl Acad Sci U S A. 2005;102:14735-40 pubmed
    ..Yet, the range of affected sites was not noticeably extended, and, surprisingly, many organs, or regions of organs, remained untouched, suggesting additional important mechanisms to enforce immunological self-tolerance. ..
  7. Coombe D, Watt S, Parish C. Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate. Blood. 1994;84:739-52 pubmed
    ..The data suggest that heparan sulfate on the 3T3 cell surface is a ligand for both CD45 and Mac-1, but the two molecules recognize different heparan sulfate structural motifs. ..
  8. Kuo K, Liang C, Hsiao C, Lin C, Chen C, Sheu B, et al. Downregulation of BRG-1 repressed expression of CD44s in cervical neuroendocrine carcinoma and adenocarcinoma. Mod Pathol. 2006;19:1570-7 pubmed
    ..Cluster differentiation 44 (CD44) is a widely expressed cell surface glycoprotein that serves as an adhesion molecule in cell-to-substrate and cell-..
  9. Skupien A, Konopka A, Trzaskoma P, Labus J, Gorlewicz A, Swiech L, et al. CD44 regulates dendrite morphogenesis through Src tyrosine kinase-dependent positioning of the Golgi. J Cell Sci. 2014;127:5038-51 pubmed publisher
    ..We report that the CD44 adhesion molecule, the main hyaluronan receptor, is localized in dendrites and plays a crucial inhibitory role in ..

More Information

Publications62

  1. Preston S, Leedham S, Oukrif D, Deheregoda M, Goodlad R, Poulsom R, et al. The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse. J Pathol. 2008;214:294-301 pubmed
    ..Serial sections of these were stained with haematoxylin and eosin for beta-catenin and its downstream target CD44, for BMPR1a, lysozyme, carbonic anhydrase II, and with MIB-1...
  2. Hu M, Deshpande A, Schlichting N, Hinds E, Mao C, Dose M, et al. CDK6 kinase activity is required for thymocyte development. Blood. 2011;117:6120-31 pubmed publisher
    ..This role of CDK6 as a downstream mediator of Notch identifies CDK6 kinase activity as a potential therapeutic target in human lymphoid malignancies. ..
  3. Freese A, Wehland M, Freese F, Bamberg C, Kreutz R, Rothermund L. Genetic low nephron number hypertension is associated with altered expression of osteopontin and CD44 during nephrogenesis. J Perinat Med. 2013;41:295-9 pubmed publisher
    The study set out to investigate whether the osteopontin (OPN)-CD44-integrin-receptor-system is differently regulated during nephrogenesis in inborn nephron deficit, a major determinant of human primary hypertension and cardiovascular ..
  4. He Q, Lesley J, Hyman R, Ishihara K, Kincade P. Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition. J Cell Biol. 1992;119:1711-9 pubmed
    We previously found that the CD44 glycoprotein on some lymphocytes can mediate adhesion to hyaluronate (HA) bearing cells...
  5. Ramos Nino M, Scapoli L, Martinelli M, Land S, Mossman B. Microarray analysis and RNA silencing link fra-1 to cd44 and c-met expression in mesothelioma. Cancer Res. 2003;63:3539-45 pubmed
    ..Results reveal that induction of cd44 and c-met is causally linked to fra-1 expression, connecting fra-1 with genes governing cell motility and invasion ..
  6. Hosoya T, Kuroha T, Moriguchi T, Cummings D, Maillard I, Lim K, et al. GATA-3 is required for early T lineage progenitor development. J Exp Med. 2009;206:2987-3000 pubmed publisher
    ..Thus, GATA-3 is required for the cell-autonomous development of the earliest characterized thymic T cell progenitors. ..
  7. Pusch A, Boeckenhoff A, Glaser T, Kaminski T, Kirfel G, Hans M, et al. CD44 and hyaluronan promote invasive growth of B35 neuroblastoma cells into the brain. Biochim Biophys Acta. 2010;1803:261-74 pubmed publisher
    Hyaluronan and its receptor CD44 are known to contribute to the invasive growth of different tumors of the central nervous system. It is not known, however, if CD44 is sufficient to activate invasive growth into the brain tissue...
  8. Gakunga P, Frost G, Shuster S, Cunha G, Formby B, Stern R. Hyaluronan is a prerequisite for ductal branching morphogenesis. Development. 1997;124:3987-97 pubmed
    ..b>CD44, the predominant receptor for hyaluronan on vertebrate cells, is a variably expressed transmembrane glycoprotein...
  9. Berdiaki A, Nikitovic D, Tsatsakis A, Katonis P, Karamanos N, Tzanakakis G. bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells. Biochim Biophys Acta. 2009;1790:1258-65 pubmed publisher
    ..bFGF regulates, in a cell-specific manner the migration capability of fibrosarcoma cells by modulating their HA metabolism. HA metabolism is suggested to be a potential therapeutic target in fibrosarcoma. ..
  10. Nicoll S, Barak O, Csoka A, Bhatnagar R, Stern R. Hyaluronidases and CD44 undergo differential modulation during chondrogenesis. Biochem Biophys Res Commun. 2002;292:819-25 pubmed
    ..we describe the differential modulation of the hyaluronidases and the up-regulation of the hyaluronan receptor, CD44, during such chondrogenesis...
  11. Gorlewicz A, Wlodarczyk J, Wilczek E, Gawlak M, Cabaj A, Majczynski H, et al. CD44 is expressed in non-myelinating Schwann cells of the adult rat, and may play a role in neurodegeneration-induced glial plasticity at the neuromuscular junction. Neurobiol Dis. 2009;34:245-58 pubmed
    b>CD44 is a multifunctional cell surface glycoprotein which regulates cell-cell and cell-matrix interactions in a variety of tissues...
  12. Kon J, Ooe H, Oshima H, Kikkawa Y, Mitaka T. Expression of CD44 in rat hepatic progenitor cells. J Hepatol. 2006;45:90-8 pubmed
    ..Immunocytochemistry for CD44 standard form (CD44s) and variant form 6 (CD44v6) was performed using cultured SHs and the d-galactosamine (GalN)-..
  13. Lou G, Gao Y, Ning X, Zhang Q. Expression and correlation of CD44v6, vascular endothelial growth factor, matrix metalloproteinase-2, and matrix metalloproteinase-9 in Krukenberg tumor. World J Gastroenterol. 2005;11:5032-6 pubmed
    ..To explore the expression and correlation of CD44v6, vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2 and matrix metalloproteinase (MMP)-9 in Krukenberg and primary epithelial ovarian carcinoma...
  14. Plantman S. Osteopontin is upregulated after mechanical brain injury and stimulates neurite growth from hippocampal neurons through ?1 integrin and CD44. Neuroreport. 2012;23:647-52 pubmed publisher
    ..Finally, growth on OPN was mediated through ?1 intregrins and CD44. These findings indicate that injury-induced OPN may support neurite sprouting, suggesting a role for this molecule ..
  15. Mandal M, Borowski C, Palomero T, Ferrando A, Oberdoerffer P, Meng F, et al. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med. 2005;201:603-14 pubmed
    ..Finally, we suggest that pre-TCR-induced A1 overexpression can contribute to T cell leukemia in both mice and humans. ..
  16. Declèves A, Caron N, Nonclercq D, Legrand A, Toubeau G, Kramp R, et al. Dynamics of hyaluronan, CD44, and inflammatory cells in the rat kidney after ischemia/reperfusion injury. Int J Mol Med. 2006;18:83-94 pubmed
    ..To determine the roles of hyaluronan (HA) and its main receptor CD44 in renal postischemic processes, we compared their localization and expression with that of neutrophils, ..
  17. Mondalek F, Fung K, Yang Q, Wu W, Lu W, Palmer B, et al. Temporal expression of hyaluronic acid and hyaluronic acid receptors in a porcine small intestinal submucosa-augmented rat bladder regeneration model. World J Urol. 2015;33:1119-28 pubmed publisher
    ..Cluster of differentiation 44 (CD44) immunoreactivity was detected in the cytoplasm of urothelial cells on day 56; and LYVE-1 immunoreactivity was ..
  18. Bai F, Pang X, Zhang L, Wang N, McKallip R, Garner R, et al. Angiotensin II AT1 receptor alters ACE2 activity, eNOS expression and CD44-hyaluronan interaction in rats with hypertension and myocardial fibrosis. Life Sci. 2016;153:141-52 pubmed publisher
    ..is involved in development of hypertension and cardiac fibrosis via modifying ACE2 activity, eNOS expression and CD44-hyaluronan interaction...
  19. Liu Y, Han S, Wu Y, Tuohy T, Xue H, Cai J, et al. CD44 expression identifies astrocyte-restricted precursor cells. Dev Biol. 2004;276:31-46 pubmed
    ..We show that CD44 identifies an astrocyte-restricted precursor cell (ARP) that is committed to generating astrocytes in vitro and in ..
  20. Schmidt D, Klingbeil P, Schnolzer M, Zoller M. CD44 variant isoforms associate with tetraspanins and EpCAM. Exp Cell Res. 2004;297:329-47 pubmed
    ..1A and CD9. EpCAM and the tetraspanins associate selectively with CD44 variant (CD44v), but not with the CD44 standard (CD44s) isoform...
  21. Pohl M, Sakurai H, Stuart R, Nigam S. Role of hyaluronan and CD44 in in vitro branching morphogenesis of ureteric bud cells. Dev Biol. 2000;224:312-25 pubmed
    ..Inhibition of HA binding to the cells by addition of blocking antibodies to CD44, the principal cell surface receptor for HA, or degradation of HA by the addition of Streptomyces hyaluronidase ..
  22. Hodgkinson G, Tresco P, Hlady V. The influence of sub-micron inhibitory clusters on growth cone substratum attachments and CD44 expression. Biomaterials. 2008;29:4227-35 pubmed publisher
    ..Direct imaging of cell adhesion molecule CD44 expression in growth cones revealed an aggrecan dose dependent upregulation in CD44 molecules...
  23. Bourguignon L, Xia W, Wong G. Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells. J Biol Chem. 2009;284:2657-71 pubmed publisher
    In this study we have investigated hyaluronan (HA)-mediated CD44 (an HA receptor) interactions with p300 (a histone acetyltransferase) and SIRT1 (a histone deacetylase) in human breast tumor cells (MCF-7 cells)...
  24. Berner H, Nesland J. Expression of CD44 isoforms in infiltrating lobular carcinoma of the breast. Breast Cancer Res Treat. 2001;65:23-9 pubmed
    Expression of CD44 has been shown to correlate with the progression and prognosis of some malignant tumors...
  25. Zhu H, Mitsuhashi N, Klein A, Barsky L, Weinberg K, Barr M, et al. The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix. Stem Cells. 2006;24:928-35 pubmed
    ..This paper examines the role of CD44-hyaluronan interaction in MSC migration, using a rat MSC line Ap8c3 and mouse CD44-/- or CD44+/+ bone marrow ..
  26. Sleeman J, Rahmsdorf U, Steffen A, Ponta H, Herrlich P. CD44 variant exon v5 encodes a tyrosine that is sulphated. Eur J Biochem. 1998;255:74-80 pubmed
    Functional differences between members of the CD44 family of cell surface glycoproteins is mediated in part by differential post-translational modification of these proteins and by alternative splicing...
  27. Ferrari L, Araldi D, Bogen O, Levine J. Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation. Neuroscience. 2016;324:390-8 pubmed publisher
    We propose that the extracellular matrix (ECM) signals CD44, a hyaluronan receptor, to increase the responsiveness to mechanical stimulation in the rat hind paw...
  28. Sun Y, He H, Ma Q, Wang X, Yang L, He D. [Clinical evaluation of BTAstat, NMP22, HA, survivin, CD44v6, vEGF and VUC in bladder cancer diagnosis]. Zhonghua Yi Xue Za Zhi. 2005;85:2507-12 pubmed
    ..9% and 81.0% for NMP22; 86.5% and 90.5% for HA; 67.3% and 85.7% for Survivin; 50.5% and 85.7% for CD44 and 69.2% and 95.2% for VEGF. The highest sensitivity of combined markers was 96...
  29. Zagorianakou N, Ioachim E, Mitselou A, Kitsou E, Zagorianakou P, Stefanaki S, et al. Glycoprotein CD44 expression in normal, hyperplasic and neoplastic endometrium. An immunohistochemical study including correlations with p53, steroid receptor status and proliferative indices (PCNA, MIB1). Eur J Gynaecol Oncol. 2003;24:500-4 pubmed
    We have studied by immunohistochemistry the presence and localization of CD44, estrogen and progesterone receptors, p53 and proliferative associated indices (MIB1, PCNA) in archival endometrial tissue, in order to determine their ..
  30. Takeo K, Kawai T, Nishida K, Masuda K, Teshima Kondo S, Tanahashi T, et al. Oxidative stress-induced alternative splicing of transformer 2beta (SFRS10) and CD44 pre-mRNAs in gastric epithelial cells. Am J Physiol Cell Physiol. 2009;297:C330-8 pubmed publisher
    ..Knockdown of Tra2beta facilitated skipping of the central variable region of the CD44 gene and suppressed cell growth...
  31. Chen Z, Herman A, Matos M, Mathis D, Benoist C. Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med. 2005;202:1387-97 pubmed
    ..Thus, T reg cells primarily impinge on autoimmune diabetes by reining in destructive T cells inside the islets, more than during the initial activation in the draining lymph nodes. ..
  32. Weigel J, Raymond R, Weigel P. The hyaluronan receptor for endocytosis (HARE) is not CD44 or CD54 (ICAM-1). Biochem Biophys Res Commun. 2002;294:918-22 pubmed
    ..Chem. 274 (1999) 33831]. The goal of the present study was to clarify this inconsistency and determine whether CD44, which is also an HA receptor, or ICAM-1 (CD54) is identical to, or is part of, HARE...
  33. Shi X, Leng L, Wang T, Wang W, Du X, Li J, et al. CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity. 2006;25:595-606 pubmed
    ..We hypothesized that signaling requires an additional molecule such as CD44, which activates nonreceptor tyrosine kinases...
  34. Li L, Asteriou T, Bernert B, Heldin C, Heldin P. Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. Biochem J. 2007;404:327-36 pubmed
    ..Importantly, inhibition of hyaluronan binding to its receptor CD44 by the monoclonal antibody Hermes-1, inhibited PDGF-BB-stimulated [3H]thymidine incorporation of dermal fibroblasts...
  35. Yaqin M, Runhua L, Fuxi Z. Analyses of Bcl-2, Survivin, and CD44v6 expressions and human papillomavirus infection in cervical carcinomas. Scand J Infect Dis. 2007;39:441-8 pubmed
    ..AI), expressions of the anti-apoptotic proteins Bcl-2 and Survivin, and expression of the cell-adhesion protein CD44 in cervical tissue samples from individuals with and without cervical carcinomas...
  36. Hellman U, Hellström M, Morner S, Engström Laurent A, Aberg A, Oliviero P, et al. Parallel up-regulation of FGF-2 and hyaluronan during development of cardiac hypertrophy in rat. Cell Tissue Res. 2008;332:49-56 pubmed publisher
    The importance of glycosaminoglycan hyaluronan (HA) and its receptor CD44 in cell proliferation is becoming increasingly evident...
  37. Milicevic N, Nohroudi K, Milicevic Z, Westermann J. Blood lymphocytes, monocytes and NK cells modulate their expression of CD44, ICAM-1, LFA-1 and MHC class II after arrival into lymphoid organs. Immunol Invest. 2004;33:439-52 pubmed
    ..The helper and cytotoxic subsets of T cells, as well as B cells, display the increased expression of CD44, ICAM-1 and LFA-1, whereas B cells additionally show the augmented expression of MHC class II...
  38. Rangwala R, Banine F, Borg J, Sherman L. Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells. J Biol Chem. 2005;280:11790-7 pubmed
    ..Collectively, these data indicate that erbin regulates MAP kinase activation in Schwann cells and suggest that erbin links merlin to both adherens junction protein complexes and the MAP kinase signaling pathway. ..
  39. Kikuchi S, Griffin C, Wang S, Bissell D. Role of CD44 in epithelial wound repair: migration of rat hepatic stellate cells utilizes hyaluronic acid and CD44v6. J Biol Chem. 2005;280:15398-404 pubmed
    The hyaluronic acid receptor, CD44, exists as multiple splice variants that appear to have a role in migration of tumor cells. The role of this receptor and its variants in normal wound repair is poorly understood...
  40. Ries A, Goldberg J, Grimpe B. A novel biological function for CD44 in axon growth of retinal ganglion cells identified by a bioinformatics approach. J Neurochem. 2007;103:1491-505 pubmed
    ..of our data mining approach, we utilized the program output to generate a hypothesis for a biological function of CD44 interaction with osteopontin (OPN) and laminin in axon outgrowth of CNS neurons...
  41. Afify A, Craig S, Paulino A, Stern R. Expression of hyaluronic acid and its receptors, CD44s and CD44v6, in normal, hyperplastic, and neoplastic endometrium. Ann Diagn Pathol. 2005;9:312-8 pubmed
    ..One of these receptors, CD44, binds to extracellular matrix component hyaluronic acid (HA)...
  42. Wu S, Sun G, Hsieh D, Chen A, Chen H, Chang S, et al. Correlation of CD44v5 expression with invasiveness and prognosis in renal cell carcinoma. J Formos Med Assoc. 2003;102:229-33 pubmed
    The expression of specific CD44 isoforms is associated with metastasis and poor prognosis in human malignant tumors...
  43. Morrison H, Sherman L, Legg J, Banine F, Isacke C, Haipek C, et al. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes Dev. 2001;15:968-80 pubmed
    ..Merlin's growth-inhibitory activity depends on specific interaction with the cytoplasmic tail of CD44, a transmembrane HA receptor...
  44. Kim Y, Kim K, Park D, Eom S, Park H, Lee H, et al. Integrin ?(5) interacts with EGFR, is necessary for Fc?RI signaling and is necessary for allergic inflammation in relation with angiogenesis. Mol Immunol. 2011;48:1035-45 pubmed publisher
    ..This enhanced angiogenic potential of RAECs was dependent on EGFR and integrin ?(5). In conclusion, EGFR, via interaction with Fc?RI and integrin ?(5), is necessary for allergic inflammation associated with cellular interaction. ..
  45. Sen M, Inan A, Yenidunya S, Ergin M, Dener C. Effect of vitamin A on the CD44 expression in the small intestine of rats with obstructive jaundice. Eur Surg Res. 2006;38:347-52 pubmed
    In this study, the influence of obstructive jaundice on the CD44 expression in the rat small intestine and the alterations of this CD44 expression by vitamin A given intraperitoneally (200 IU/g/day) are evaluated...
  46. Rampon C, Weiss N, Deboux C, Chaverot N, Miller F, Buchet D, et al. Molecular mechanism of systemic delivery of neural precursor cells to the brain: assembly of brain endothelial apical cups and control of transmigration by CD44. Stem Cells. 2008;26:1673-82 pubmed publisher
    ..validated by us and others, we show here that soluble hyaluronic acid, the major ligand of the adhesion molecule CD44, as well as anti-CD44 blocking antibodies, largely prevents NPC adhesion to and migration across brain endothelium ..
  47. Bourguignon L, Zhu H, Shao L, Chen Y. CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration. J Biol Chem. 2001;276:7327-36 pubmed
    In this study we have demonstrated that both CD44 (the hyaluronan (HA) receptor) and c-Src kinase are expressed in human ovarian tumor cells (SK-OV-3...
  48. Orian Rousseau V, Morrison H, Matzke A, Kastilan T, Pace G, Herrlich P, et al. Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin. Mol Biol Cell. 2007;18:76-83 pubmed
    ..The CD44 extracellular domain is necessary for c-Met autophosphorylation, whereas the intracellular domain is required for ..
  49. Moon C, Jeong C, Kim H, Ahn M, Kim S, Shin T. Expression of CD44 adhesion molecule in rat testis with ischemia/reperfusion injury. J Vet Med Sci. 2006;68:761-4 pubmed
    The expression pattern of CD44 was studied in the rat testis following ischemia/reperfusion (I/R) injury to elucidate the possible role of the CD44 adhesion molecule in acute experimental testicular torsion...
  50. Danielson B, Knudson C, Knudson W. Extracellular processing of the cartilage proteoglycan aggregate and its effect on CD44-mediated internalization of hyaluronan. J Biol Chem. 2015;290:9555-70 pubmed publisher
    In many cells hyaluronan receptor CD44 mediates the endocytosis of hyaluronan and its delivery to endosomes/lysosomes. The regulation of this process remains largely unknown...
  51. Piao J, Wang Y, Duncan I. CD44 is required for the migration of transplanted oligodendrocyte progenitor cells to focal inflammatory demyelinating lesions in the spinal cord. Glia. 2013;61:361-7 pubmed publisher
    ..We demonstrate that a large number of CG4 cells that had migrated, expressed the adhesion protein, CD44, and that CD44's main ligand, hyaluronic acid (HA) was robustly expressed in the inflammatory lesion...
  52. Wielenga V, Smits R, Korinek V, Smit L, Kielman M, Fodde R, et al. Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol. 1999;154:515-23 pubmed
    Overexpression of cell surface glycoproteins of the CD44 family is an early event in the colorectal adenoma-carcinoma sequence...