Cd40lg

Summary

Gene Symbol: Cd40lg
Description: CD40 ligand
Alias: Cd40l, Tnfsf5, CD40 ligand, CD40 ligand CD154, CD40-L, tumor necrosis factor ligand superfamily member 5
Species: rat
Products:     Cd40lg

Top Publications

  1. Wang C, Wu Y, Liu C, Lin M, Lee C, Huang L, et al. Expression of CD40 ligand on CD4+ T-cells and platelets correlated to the coronary artery lesion and disease progress in Kawasaki disease. Pediatrics. 2003;111:E140-7 pubmed
    Kawasaki disease (KD) is an acute febrile vasculitic syndrome in children. CD40 ligand (CD40L) has been implicated in certain types of vasculitis. We proposed that CD40L expression might be correlated with coronary artery lesions in KD...
  2. Blotta M, Marshall J, DeKruyff R, Umetsu D. Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. J Immunol. 1996;156:3133-40 pubmed
    ..synthesis, using immobilized mAbs against several T cell surface molecules, including CD3, CD28, and the CD40 ligand (CD40L)...
  3. Henn V, Slupsky J, Grafe M, Anagnostopoulos I, Forster R, Müller Berghaus G, et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature. 1998;391:591-4 pubmed
    b>CD40 ligand (CD40L, CD154), a transmembrane protein structurally related to the cytokine TNF-alpha, was originally identified on stimulated CD4+ T cells, and later on stimulated mast cells and basophils...
  4. Unek I, Bayraktar F, Solmaz D, Ellidokuz H, Sisman A, Yuksel F, et al. The levels of soluble CD40 ligand and C-reactive protein in normal weight, overweight and obese people. Clin Med Res. 2010;8:89-95 pubmed publisher
    ..Increasing evidence shows that engagement of soluble CD40 ligand (sCD40L) with its receptor plays a crucial role in the pathogenesis of atherosclerosis...
  5. Vazgiourakis V, Zervou M, Choulaki C, Bertsias G, Melissourgaki M, Yilmaz N, et al. A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis. Ann Rheum Dis. 2011;70:2184-90 pubmed publisher
    In systemic lupus erythematosus (SLE) sustained CD40L expression by T cells and platelets activates a variety of cells via its receptor CD40 contributing to disease pathogenesis...
  6. Gocmen A, Ocak G, Ozbilim G, Delibas N, Gumuslu S. Effect of atorvastatin on atherosclerotic plaque formation and platelet activation in hypercholesterolemic rats. Can J Physiol Pharmacol. 2013;91:680-5 pubmed publisher
    We aimed to investigate whether atorvastatin influenced the CD40-CD40L pathway in atherosclerosis formation in rats fed a high cholesterol diet...
  7. Aruffo A, Farrington M, Hollenbaugh D, Li X, Milatovich A, Nonoyama S, et al. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. Cell. 1993;72:291-300 pubmed
    ..The gene encoding gp39 was mapped to Xq26, the X chromosome region where the gene responsible for HIM had previously been mapped. These data suggest that a defect in gp39 is the basis of X-linked HIM. ..
  8. Peng S, McNiff J, Madaio M, Ma J, Owen M, Flavell R, et al. alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity. J Immunol. 1997;158:2464-70 pubmed
    ..T cells and gamma delta T cells regulate systemic autoimmunity, lupus-prone mice were rendered deficient in CD40 ligand and/or alpha beta T cells by intercrossing CD40L -/- and TCR-alpha -/- knockouts, generating CD40L-intact or -..
  9. Edelmann K, Wilson C. Role of CD28/CD80-86 and CD40/CD154 costimulatory interactions in host defense to primary herpes simplex virus infection. J Virol. 2001;75:612-21 pubmed
    ..primary antiviral immune response on costimulatory interactions between CD28/CD80-86 and between CD40/CD154 (CD40 ligand) has been correlated with the extent of viral replication in two models of systemic infection, lymphocytic ..
  10. Esendagli G, Canpinar G, Yilmaz G, Gunel Ozcan A, Guc M, Kansu E, et al. Primary tumor cells obtained from MNU-induced mammary carcinomas show immune heterogeneity which can be modulated by low-efficiency transfection of CD40L gene. Cancer Biol Ther. 2009;8:136-42 pubmed
    ..Low-efficiency transfection of CD40 ligand (CD40L) gene enhanced the expression of proinflammatory cytokines in the tumor cells and strengthened ..

Detail Information

Publications103 found, 100 shown here

  1. Wang C, Wu Y, Liu C, Lin M, Lee C, Huang L, et al. Expression of CD40 ligand on CD4+ T-cells and platelets correlated to the coronary artery lesion and disease progress in Kawasaki disease. Pediatrics. 2003;111:E140-7 pubmed
    Kawasaki disease (KD) is an acute febrile vasculitic syndrome in children. CD40 ligand (CD40L) has been implicated in certain types of vasculitis. We proposed that CD40L expression might be correlated with coronary artery lesions in KD...
  2. Blotta M, Marshall J, DeKruyff R, Umetsu D. Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. J Immunol. 1996;156:3133-40 pubmed
    ..synthesis, using immobilized mAbs against several T cell surface molecules, including CD3, CD28, and the CD40 ligand (CD40L)...
  3. Henn V, Slupsky J, Grafe M, Anagnostopoulos I, Forster R, Müller Berghaus G, et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature. 1998;391:591-4 pubmed
    b>CD40 ligand (CD40L, CD154), a transmembrane protein structurally related to the cytokine TNF-alpha, was originally identified on stimulated CD4+ T cells, and later on stimulated mast cells and basophils...
  4. Unek I, Bayraktar F, Solmaz D, Ellidokuz H, Sisman A, Yuksel F, et al. The levels of soluble CD40 ligand and C-reactive protein in normal weight, overweight and obese people. Clin Med Res. 2010;8:89-95 pubmed publisher
    ..Increasing evidence shows that engagement of soluble CD40 ligand (sCD40L) with its receptor plays a crucial role in the pathogenesis of atherosclerosis...
  5. Vazgiourakis V, Zervou M, Choulaki C, Bertsias G, Melissourgaki M, Yilmaz N, et al. A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis. Ann Rheum Dis. 2011;70:2184-90 pubmed publisher
    In systemic lupus erythematosus (SLE) sustained CD40L expression by T cells and platelets activates a variety of cells via its receptor CD40 contributing to disease pathogenesis...
  6. Gocmen A, Ocak G, Ozbilim G, Delibas N, Gumuslu S. Effect of atorvastatin on atherosclerotic plaque formation and platelet activation in hypercholesterolemic rats. Can J Physiol Pharmacol. 2013;91:680-5 pubmed publisher
    We aimed to investigate whether atorvastatin influenced the CD40-CD40L pathway in atherosclerosis formation in rats fed a high cholesterol diet...
  7. Aruffo A, Farrington M, Hollenbaugh D, Li X, Milatovich A, Nonoyama S, et al. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. Cell. 1993;72:291-300 pubmed
    ..The gene encoding gp39 was mapped to Xq26, the X chromosome region where the gene responsible for HIM had previously been mapped. These data suggest that a defect in gp39 is the basis of X-linked HIM. ..
  8. Peng S, McNiff J, Madaio M, Ma J, Owen M, Flavell R, et al. alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity. J Immunol. 1997;158:2464-70 pubmed
    ..T cells and gamma delta T cells regulate systemic autoimmunity, lupus-prone mice were rendered deficient in CD40 ligand and/or alpha beta T cells by intercrossing CD40L -/- and TCR-alpha -/- knockouts, generating CD40L-intact or -..
  9. Edelmann K, Wilson C. Role of CD28/CD80-86 and CD40/CD154 costimulatory interactions in host defense to primary herpes simplex virus infection. J Virol. 2001;75:612-21 pubmed
    ..primary antiviral immune response on costimulatory interactions between CD28/CD80-86 and between CD40/CD154 (CD40 ligand) has been correlated with the extent of viral replication in two models of systemic infection, lymphocytic ..
  10. Esendagli G, Canpinar G, Yilmaz G, Gunel Ozcan A, Guc M, Kansu E, et al. Primary tumor cells obtained from MNU-induced mammary carcinomas show immune heterogeneity which can be modulated by low-efficiency transfection of CD40L gene. Cancer Biol Ther. 2009;8:136-42 pubmed
    ..Low-efficiency transfection of CD40 ligand (CD40L) gene enhanced the expression of proinflammatory cytokines in the tumor cells and strengthened ..
  11. Shen X, Reng F, Gao F, Uchida Y, Busuttil R, Kupiec Weglinski J, et al. Alloimmune activation enhances innate tissue inflammation/injury in a mouse model of liver ischemia/reperfusion injury. Am J Transplant. 2010;10:1729-37 pubmed publisher
    ..These results provide new evidence that alloreactive CD4 T cells are capable of enhancing innate tissue inflammation and organ injury via an Ag-nonspecific CD154-dependent but IFN-gamma independent mechanism. ..
  12. Sobel D, Ahvazi B, Pontzer C. The Role of Type I Interferon Subtypes and Interferon-Gamma in Type I Interferon Diabetes Inhibitory Activity in the NOD Mouse. J Interferon Cytokine Res. 2016;36:238-46 pubmed publisher
    ..administration decreased the expression of Fas and ICAM on total cells, class II MHC expression on B cells, and CD40L expression on T cells by 39%, 45%, 45%, and 60%, respectively...
  13. Gocmen A, Burgucu D, Gumuslu S. Effect of resveratrol on platelet activation in hypercholesterolemic rats: CD40-CD40L system as a potential target. Appl Physiol Nutr Metab. 2011;36:323-30 pubmed publisher
    ..t-resveratrol), a red wine constituent known for its cardioprotective effects, was able to influence CD40 ligand (CD40L) and its receptor CD40 in platelets of hypercholesterolemic rats...
  14. Yang J, Xu M, Yan L, Chen X, Liu J. Zinc finger protein A20 protects rats against chronic liver allograft dysfunction. World J Gastroenterol. 2012;18:3537-50 pubmed publisher
    ..with A20 suppressed hepatic protein production of tumor growth factor (TGF)-?1, interleukin-1?, caspase-8, CD40, CD40L, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin...
  15. Pantenburg B, Heinzel F, Das L, Heeger P, Valujskikh A. T cells primed by Leishmania major infection cross-react with alloantigens and alter the course of allograft rejection. J Immunol. 2002;169:3686-93 pubmed
    ..Although donor-specific transfusion combined with costimulatory blockade (anti-CD40 ligand Ab) induced prolonged graft survival in naive animals, the same treatment was ineffective in mice previously ..
  16. Ueland T, Aukrust P, Yndestad A, Otterdal K, Frøland S, Dickstein K, et al. Soluble CD40 ligand in acute and chronic heart failure. Eur Heart J. 2005;26:1101-7 pubmed
    Inflammatory cytokines may play a pathogenic role in heart failure (HF). CD40-CD40 ligand (CD40L) interactions are important in atherogenesis and based on its role in inflammation we sought to evaluate the role of CD40L in human HF...
  17. Doublier S, Zennaro C, Musante L, Spatola T, Candiano G, Bruschi M, et al. Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in FSGS. PLoS ONE. 2017;12:e0188045 pubmed publisher
    CD40/CD40 ligand (CD40L) dyad, a co-stimulatory bi-molecular complex involved in the adaptive immune response, has also potent pro-inflammatory actions in haematopoietic and non-haematopoietic cells...
  18. Hasbold J, Corcoran L, Tarlinton D, Tangye S, Hodgkin P. Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation. Nat Immunol. 2004;5:55-63 pubmed
    ..Stochastic division-linked regulation of heterogeneity challenges the conventional paradigms linking distinct phenotypes to unique combinations of signals and has the potential to simplify our concept of immune complexity considerably. ..
  19. Gokulakrishnan K, Deepa R, Mohan V, Gross M. Soluble P-selectin and CD40L levels in subjects with prediabetes, diabetes mellitus, and metabolic syndrome--the Chennai Urban Rural Epidemiology Study. Metabolism. 2006;55:237-42 pubmed
    The aim of the study was to determine whether the levels of soluble P-selectin (sP-selectin) and soluble CD40L (sCD40L) are elevated in Asian Indian subjects with impaired glucose tolerance (IGT), diabetes, and metabolic syndrome (MS)...
  20. Guldiken S, Guldiken B, Demir M, Kabayel L, Ozkan H, Turgut N, et al. Soluble CD40 ligand and prolactin levels in migraine patients during interictal period. J Headache Pain. 2011;12:355-60 pubmed publisher
    ..the relationship between prolactin levels and subclinical atherosclerosis risk factors such as soluble CD40 ligand (sCD40L) and high-sensitivity CRP (hsCRP) in migraine patients during interictal period...
  21. Lievens D, Zernecke A, Seijkens T, Soehnlein O, Beckers L, Munnix I, et al. Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood. 2010;116:4317-27 pubmed publisher
    b>CD40 ligand (CD40L), identified as a costimulatory molecule expressed on T cells, is also expressed and functional on platelets. We investigated the thrombotic and inflammatory contributions of platelet CD40L in atherosclerosis...
  22. Blanchard C, Stucke E, Rodriguez Jimenez B, Burwinkel K, Collins M, Ahrens A, et al. A striking local esophageal cytokine expression profile in eosinophilic esophagitis. J Allergy Clin Immunol. 2011;127:208-17, 217.e1-7 pubmed publisher
    ..We identified 8 cytokines (IL-4, IL-13, IL-5, IL-6, IL-12p70, CD40 ligand, IL-1α, and IL-17) whose blood levels retrospectively distinguished 12 patients without EE from 13 patients ..
  23. Younes A, Snell V, Consoli U, Clodi K, Zhao S, Palmer J, et al. Elevated levels of biologically active soluble CD40 ligand in the serum of patients with chronic lymphocytic leukaemia. Br J Haematol. 1998;100:135-41 pubmed
    ..autologous plasma rescued CLL cells from spontaneous apoptosis, an effect that could be reversed with anti-CD40 ligand (CD40L) antibodies...
  24. Fateh Moghadam S, Li Z, Ersel S, Reuter T, Htun P, Plockinger U, et al. Platelet degranulation is associated with progression of intima-media thickness of the common carotid artery in patients with diabetes mellitus type 2. Arterioscler Thromb Vasc Biol. 2005;25:1299-303 pubmed
    ..Platelet activation was assessed with the use of immunologic markers of platelet activation (CD62P, CD63, and CD40L) and flow cytometry. The prevalence for progression of atherosclerotic carotid disease in this population was 55...
  25. Bagenstose L, Agarwal R, Silver P, Harlan D, Hoffmann S, Kampen R, et al. Disruption of CD40/CD40-ligand interactions in a retinal autoimmunity model results in protection without tolerance. J Immunol. 2005;175:124-30 pubmed
    We examined the role of CD40/CD40L interactions on the development of experimental autoimmune uveoretinitis (EAU), a cell-mediated, Th1-driven autoimmune disease that serves as a model for autoimmune uveitis in humans...
  26. Komura K, Fujimoto M, Yanaba K, Matsushita T, Matsushita Y, Horikawa M, et al. Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse. Ann Rheum Dis. 2008;67:867-72 pubmed
    To assess the association of CD40/CD40 ligand (CD40L) interactions with the development of skin fibrosis and autoimmunity in tight-skin (TSK/+) mouse, which is a mouse model for human systemic sclerosis...
  27. Calderón Sánchez E, Díaz I, Ordóñez A, Smani T. Urocortin-1 Mediated Cardioprotection Involves XIAP and CD40-Ligand Recovery: Role of EPAC2 and ERK1/2. PLoS ONE. 2016;11:e0147375 pubmed publisher
    ..mini-array, RT-qPCR and protein analyses of apoptotic genes showed that Ucn-1 upregulated the expression of CD40lg, Xiap and BAD in cells undergoing I/R, involving Epac2 and ERK1/2 activation...
  28. Erdos M, Lakos G, Derfalvi B, Notarangelo L, Durandy A, Marodi L. Molecular genetic analysis of Hungarian patients with the hyper-immunoglobulin M syndrome. Mol Immunol. 2008;45:278-82 pubmed
    ..b>CD40L mutation resulted in X-linked combined immunodeficiency in 11 patients (6 families) and AICDA mutation caused ..
  29. Li Y, Messina C, Bendaoud M, Fine D, Schreiner H, Tsiagbe V. Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. Mol Oral Microbiol. 2010;25:275-92 pubmed publisher
    ..In B cells, interleukin-2 (IL-2), macrophage-inhibiting factor, IL-19, IL-21, tumor necrosis factor (TNF), CD40 ligand (CD40L), CD70, bone morphogenetic protein 2 (BMP2), BMP3, and BMP10 were upregulated early; while IL-7, Fas ..
  30. Chen J, Wang Q, Wu H, Liu K, Wu Y, Chang Y, et al. The ginsenoside metabolite compound K exerts its anti-inflammatory activity by downregulating memory B cell in adjuvant-induced arthritis. Pharm Biol. 2016;54:1280-8 pubmed publisher
    ..B cells including CD45R(+)IgM(+) (total B cells) and CD45R(+)CD27(+) (memory B cells) and expression of CD40 and CD40L were assayed by flow cytometry...
  31. Qian Y, Qin J, Cui G, Naramura M, Snow E, Ware C, et al. Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity. 2004;21:575-87 pubmed
    ..These findings demonstrate that Act1 plays an important role in the homeostasis of B cells by attenuating CD40 and BAFFR signaling. ..
  32. Snapper C, Kehry M, Castle B, Mond J. Multivalent, but not divalent, antigen receptor cross-linkers synergize with CD40 ligand for induction of Ig synthesis and class switching in normal murine B cells. A redefinition of the TI-2 vs T cell-dependent antigen dichotomy. J Immunol. 1995;154:1177-87 pubmed
    ..in these responses, for CD40-mediated signaling mediated by binding of the inducible T cell membrane protein, CD40 ligand (CD40L)...
  33. Tousoulis D, Antoniades C, Nikolopoulou A, Koniari K, Vasiliadou C, Marinou K, et al. Interaction between cytokines and sCD40L in patients with stable and unstable coronary syndromes. Eur J Clin Invest. 2007;37:623-8 pubmed
    ..Diabetes mellitus and smoking (but not IL-6 or adhesion molecules) were the only factors independently associated with sCD40L levels in CAD and AMI patients. ..
  34. de Ramon L, Ripoll E, Merino A, Lúcia M, Aran J, Pérez Rentero S, et al. CD154-CD40 T-cell co-stimulation pathway is a key mechanism in kidney ischemia-reperfusion injury. Kidney Int. 2015;88:538-49 pubmed publisher
    ..Our data show the efficacy of our siRNA in modulating both the local and the systemic inflammatory milieu after an ischemic insult. Thus, CD40 silencing could emerge as a novel therapeutic strategy in solid organ transplantation. ..
  35. Cornelius D, Castillo J, Porter J, Amaral L, Campbell N, Paige A, et al. Blockade of CD40 ligand for intercellular communication reduces hypertension, placental oxidative stress, and AT1-AA in response to adoptive transfer of CD4+ T lymphocytes from RUPP rats. Am J Physiol Regul Integr Comp Physiol. 2015;309:R1243-50 pubmed publisher
    ..The objective of this study was to determine if blockade of communication via the CD40-CD40 ligand (CD40L) interaction between placental ischemia-induced CD4(+) T cells with endogenous normal pregnant (NP) ..
  36. da Motta N, de Brito F. Cilostazol exerts antiplatelet and anti-inflammatory effects through AMPK activation and NF-kB inhibition on hypercholesterolemic rats. Fundam Clin Pharmacol. 2016;30:327-37 pubmed publisher
    ..Expression of P-selectin, CD40L, PKC-α, IkB-α, and iNOS and activation of AMPK, NF-κB, and eNOS in the platelets were assessed using ..
  37. Shoker A, George D, Yang H, Baltzan M. Heightened CD40 ligand gene expression in peripheral CD4+ T cells from patients with kidney allograft rejection. Transplantation. 2000;70:497-505 pubmed
    b>CD40 ligand (CD40L) gene expression is increased in rejecting allograft biopsies. We, therefore, tested the possibility that CD40L gene expression is heightened in peripheral CD4+ T cells during renal allograft rejection...
  38. Tsirakis G, Pappa C, Psarakis F, Fragioudaki M, Tsioutis C, Stavroulaki E, et al. Serum concentrations and clinical significance of soluble CD40 ligand in patients with multiple myeloma. Med Oncol. 2012;29:2396-401 pubmed publisher
    ..Binding of the CD40 by its natural ligand, CD40 ligand (CD40L), produces growth arrest and/or apoptosis in MM...
  39. Feng X, Scheinberg P, Samsel L, Rios O, Chen J, McCoy J, et al. Decreased plasma cytokines are associated with low platelet counts in aplastic anemia and immune thrombocytopenic purpura. J Thromb Haemost. 2012;10:1616-23 pubmed publisher
    We previously found plasma levels of CD40 ligand (CD40L), chemokine (C-X-C motif) ligand 5 (CXCL5), chemokine (C-C motif) ligand 5 (CCL5) and epidermal growth factor (EGF) to be low in aplastic anemia (AA) patients and to be correlated ..
  40. Durie F, Fava R, Foy T, Aruffo A, Ledbetter J, Noelle R. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science. 1993;261:1328-30 pubmed
    ..Thus, interference with gp39-CD40 interactions may have therapeutic potential in the treatment of autoimmune disease. ..
  41. Ohlsson M, Szodoray P, Loro L, Johannessen A, Jonsson R. CD40, CD154, Bax and Bcl-2 expression in Sjögren's syndrome salivary glands: a putative anti-apoptotic role during its effector phases. Scand J Immunol. 2002;56:561-71 pubmed
    ..In conclusion, our study further supports the hypothesis about apoptosis resistance among SS focal IMCs and suggests a putative protective role of CD40 ligation in SS SG epithelium. ..
  42. Liu Y, Xia D, Li F, Zheng C, Xiang J. Intratumoral administration of immature dendritic cells following the adenovirus vector encoding CD40 ligand elicits significant regression of established myeloma. Cancer Gene Ther. 2005;12:122-32 pubmed
    Our previous study showed that J558 myeloma cells engineered CD40L lost their tumorigenicity in syngeneic mice, and the inoculation of J558/CD40L tumor cells further led to the protective immunity against wild tumors...
  43. Ishikawa M, Vowinkel T, Stokes K, Arumugam T, Yilmaz G, Nanda A, et al. CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion. Circulation. 2005;111:1690-6 pubmed
    CD40/CD40 ligand (CD40L) signaling contributes to proinflammatory and prothrombogenic responses in the vasculature. CD40/CD40L expression is elevated in patients after a transient ischemic attack or stroke...
  44. ElGendi S, El Sherif W. Anti-C1q antibodies, sCD40L, TWEAK and CD4/CD8 ratio in systemic lupus erythematosus and their relations to disease activity and renal involvement. Egypt J Immunol. 2009;16:135-48 pubmed
    ..Levels of serum TWEAK correlated with the development of LN in patients with SLE. We concluded that anti-C1q antibodies, sCD40L and TWEAK may be used as serum biomarkers for the assessment of disease activity and development of LN. ..
  45. Coelho F, Pradella Hallinan M, Pedrazzoli M, Soares C, Fernandes G, Murray B, et al. Low CD40L levels and relative lymphopenia in narcoleptic patients. Hum Immunol. 2011;72:817-20 pubmed publisher
    ..Although recent and important advances have been done, no study has analyzed the role of the CD40L in patients with narcolepsy...
  46. Caproni M, Torchia D, Antiga E, Giomi B, Mercuri M, Volpi W, et al. The CD40/CD40 ligand system in the skin of patients with subacute cutaneous lupus erythematosus. J Rheumatol. 2007;34:2412-6 pubmed
    To investigate whether CD40 and CD40 ligand (CD40L) is expressed in the skin of patients with subacute cutaneous lupus erythematosus (SCLE). Six female patients with SCLE were studied...
  47. Xu J, Treem W, Roman C, Anderson V, Rubenstein R, Schwarz S. Ileal immune dysregulation in necrotizing enterocolitis: role of CD40/CD40L in the pathogenesis of disease. J Pediatr Gastroenterol Nutr. 2011;52:140-6 pubmed publisher
    ..a CD40-modulated cytokine, has been described, but the role of the IL-10 receptor (IL-10R?), CD40, and its ligand CD40L in disease pathogenesis is unknown...
  48. Azzam H, Abousamra N, Goda H, El Shouky R, El Gilany A. The expression and concentration of CD40 ligand in normal pregnancy, preeclampsia, and hemolytic anemia, elevated liver enzymes and low platelet count (HELLP) syndrome. Blood Coagul Fibrinolysis. 2013;24:71-5 pubmed publisher
    ..platelet activation and inflammation leading to endothelial damage in preeclampsia can be explained by the CD40-CD40 ligand (CD40L) system...
  49. Nakamura M, Tanaka Y, Satoh T, Kawai M, Hirakata M, Kaburaki J, et al. Autoantibody to CD40 ligand in systemic lupus erythematosus: association with thrombocytopenia but not thromboembolism. Rheumatology (Oxford). 2006;45:150-6 pubmed
    To examine the prevalence, clinical associations and pathogenic roles of autoantibodies to CD40 ligand (CD40L) in patients with systemic lupus erythematosus (SLE)...
  50. Lincecum J, Vieira F, Wang M, Thompson K, De Zutter G, Kidd J, et al. From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis. Nat Genet. 2010;42:392-9 pubmed publisher
    ..A therapy using a monoclonal antibody to CD40L was developed that slows weight loss, delays paralysis and extends survival in an ALS mouse model...
  51. Chew M, Rahman M, Ihrman L, Erson A, Zhang S, Thorlacius H. Soluble CD40L (CD154) is increased in patients with shock. Inflamm Res. 2010;59:979-82 pubmed publisher
    Recent data suggest that soluble CD40L (sCD40L) plays an important role in murine sepsis...
  52. Beaudette Zlatanova B, Whalen B, Zipris D, Yagita H, Rozing J, Groen H, et al. Costimulation and autoimmune diabetes in BB rats. Am J Transplant. 2006;6:894-902 pubmed
  53. Zhu R, Liu G, Li W, Wang Z, Chen H, Zhang W. [A study of costimulatory molecules in allergic allergic rhinitis patients]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008;22:780-2, 784 pubmed
    To investigate the expression of costimulatory molecules CD28/B7 and CD40/CD40L in T and B lymphocytes as well as its relations with total IgE (TIgE), eosinophil cationic protein (ECP) in serum and nasal allergic symptoms in patients ..
  54. Iida T, Shiba H, Misawa T, Ohashi T, Eto Y, Yanaga K. Immunogene therapy against colon cancer metastasis using an adenovirus vector expressing CD40 ligand. Surgery. 2010;148:925-35 pubmed publisher
    ..We studied CD40 ligand (CD40L)-mediated immunogene therapy for metastatic liver cancer in rats...
  55. Imbeault M, Ouellet M, Giguère K, Bertin J, Bélanger D, Martin G, et al. Acquisition of host-derived CD40L by HIV-1 in vivo and its functional consequences in the B-cell compartment. J Virol. 2011;85:2189-200 pubmed publisher
    ..It has been demonstrated previously that HIV-1 particles acquire the costimulatory molecule CD40L when budding from activated CD4(+) T cells...
  56. Poggi M, Engel D, Christ A, Beckers L, Wijnands E, Boon L, et al. CD40L deficiency ameliorates adipose tissue inflammation and metabolic manifestations of obesity in mice. Arterioscler Thromb Vasc Biol. 2011;31:2251-60 pubmed publisher
    ..The CD40-CD40L costimulatory dyad plays a pivotal role in immune responses and in diseases such as atherosclerosis and may ..
  57. Moore W, Chu W, Tong P, Hess D, Benjamin C, Khalili J, et al. Prevention of autoimmune diabetes in the DRBB rat by CD40/154 blockade. J Autoimmun. 2002;19:139-45 pubmed
    ..The results indicate that the CD40/154 blockade can prevent diabetes by modifying the expansion or effector phase of the autoimmune diabetes. ..
  58. Zajkowska J, Kondrusik M, Pancewicz S, Swierzbinska R, Grygorczuk S, Hermanowska Szpakowicz T. [Soluble CD40 and soluble CD40L concentrations in the serum and the cerebrospinal fluid of patients with tick borne encephalitis and neuroborreliosis]. Neurol Neurochir Pol. 2006;40:22-7 pubmed
    The interaction between CD40 and CD40L is essential in generating of an immunological response also intrathecally...
  59. Campean V, Neureiter D, Nonnast Daniel B, Garlichs C, Gross M, Amann K. CD40-CD154 expression in calcified and non-calcified coronary lesions of patients with chronic renal failure. Atherosclerosis. 2007;190:156-66 pubmed
    ..Activation of cells and adhesion molecules in atherosclerosis is governed by CD40-CD154 (CD40 ligand) interaction...
  60. Unek I, Bayraktar F, Solmaz D, Ellidokuz H, Yuksel F, Sisman A, et al. Enhanced levels of soluble CD40 ligand and C-reactive protein in a total of 312 patients with metabolic syndrome. Metabolism. 2010;59:305-13 pubmed publisher
    ..Increasing evidence indicates that CD40-CD40 ligand interactions constitute an important mediator for vascular inflammation...
  61. Wang X, Ding X, Li Y, Liu H, Xue W, Tian X, et al. Simultaneous blockade of the CD40/CD40L and NF-?B pathways prolonged islet allograft survival. Transpl Int. 2012;25:118-26 pubmed publisher
    Activation of NF-?B pathway and co-stimulatory system CD40/CD40L promotes the inflammation, which plays a key role in the failure of islet graft...
  62. Li M, Cai R, Sun X, Hu L, Wang K, He L, et al. [Effects of electroacupuncture intervention on blood lipid levels and expression of CD 40 L and MMP-9 in the coronary artery tissue in coronary heart disease rats]. Zhen Ci Yan Jiu. 2013;38:123-8 pubmed
  63. Murray H, Lu C, Brooks E, Fichtl R, DeVecchio J, Heinzel F. Modulation of T-cell costimulation as immunotherapy or immunochemotherapy in experimental visceral leishmaniasis. Infect Immun. 2003;71:6453-62 pubmed
    b>CD40 ligand (CD40L)-deficient C57BL/6 mice failed to control intracellular Leishmania donovani visceral infection, indicating that acquired resistance involves CD40-CD40L signaling and costimulation...
  64. Lee V, Qin X, Wang Y, Zheng G, Wang Y, Wang Y, et al. The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis. Nephrol Dial Transplant. 2010;25:717-30 pubmed publisher
    Blockade of CD40-CD40 ligand (CD154) interactions protects against renal injury in adriamycin nephropathy (AN) in immunocompetent mice...
  65. Tomasson G, LaValley M, Tanriverdi K, Finkielman J, Davis J, Hoffman G, et al. Relationship between markers of platelet activation and inflammation with disease activity in Wegener's granulomatosis. J Rheumatol. 2011;38:1048-54 pubmed publisher
    ..Study subjects were participants in a clinical trial. Soluble CD40 ligand (sCD40L), C-reactive protein, interleukin 6 (IL-6), IL-8, monocyte chemoattractant protein 1 (MCP-1), P-..
  66. Chang Q, Jing H, Sun M, Xu P. Exploring the role of short-course cyclosporin a therapy in preventing homograft valve calcification after transplantation. Cell Immunol. 2014;287:36-45 pubmed publisher
    ..Homograft valves heterotopically allografted onto abdominal aorta from SD to Wistar rats. The expression of CD25, CD40L, CD71, calcium content and morphological change were observed...
  67. Mehling A, Loser K, Varga G, Metze D, Luger T, Schwarz T, et al. Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity. J Exp Med. 2001;194:615-28 pubmed
    CD40-CD40 ligand (L) interactions play a pivotal role in immune-mediated inflammatory responses via the activation of antigen-presenting cells (APCs)...
  68. Mai G, Bucher P, Morel P, Mei J, Bosco D, Andres A, et al. Role of CD40-CD154 pathway in the rejection of concordant and discordant xenogeneic islets. Transplant Proc. 2005;37:460-2 pubmed
    ..Rejection of xenografts and strong MLR responses against donor cells in vitro in CD40 or CD154 KO animals is possible through efficient activation of alternate pathways of costimulation. ..
  69. Longo C, Arvelo M, Patel V, Daniel S, Mahiou J, Grey S, et al. A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis. Circulation. 2003;108:1113-8 pubmed
    CD40/CD40 ligand (CD40L) signaling is a potent activator of endothelial cells (ECs) and promoter of atherosclerosis...
  70. Haase C, Skak K, Michelsen B, Markholst H. Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expressing CD154 on the pancreatic beta-cells. Diabetes. 2004;53:2588-95 pubmed
    ..To test the effect of activating islet-associated APCs in situ, we generated transgenic mice expressing CD154 (CD40 ligand) under control of the rat insulin promoter (RIP)...
  71. Loskog A, Fransson M, Totterman T. AdCD40L gene therapy counteracts T regulatory cells and cures aggressive tumors in an orthotopic bladder cancer model. Clin Cancer Res. 2005;11:8816-21 pubmed
    ..an immunostimulating gene therapy for the treatment of orthotopic bladder carcinoma by transferring the gene for CD40L into the tumor site...
  72. Rigaud S, Lopez Granados E, Siberil S, Gloire G, Lambert N, Lenoir C, et al. Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG. Blood. 2011;118:252-61 pubmed publisher
    ..a hypomorphic hemizygous mutation in XIAP (XIAP(G466X)) that cosegregated with a rare polymorphism in CD40LG (CD40 ligand(G219R))...
  73. Calingasan N, Erdely H, Altar C. Identification of CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury. Neurobiol Aging. 2002;23:31-9 pubmed
    ..The immune and inflammatory mediator CD40 ligand (CD40L) can augment the activation of cultured microglia by amyloid beta-protein (Abeta) and promote neuron ..
  74. Zhu W, Mix E, Jin T, Adem A, Zhu J. B cells play a cooperative role via CD40L-CD40 interaction in T cell-mediated experimental autoimmune neuritis in Lewis rats. Neurobiol Dis. 2007;25:642-8 pubmed
    The expression of co-stimulatory molecules CD40 and CD40L was examined over the course of experimental autoimmune neuritis (EAN) induced in Lewis rats by immunization with bovine peripheral nerve myelin...
  75. Esendagli G, Gunel Ozcan A, Canpinar H, Guc D. Molecular and functional analysis of a novel recombinant clone of rat (Rattus norvegicus) CD40 ligand (CD40L) gene. Mol Biol Rep. 2009;36:83-9 pubmed
    ..In this study, coding sequence of rat CD40 ligand (CD40L, CD154) was obtained from activated splenocytes, amplified, and cloned into a eukaryotic expression ..
  76. Jin L, He L, Fu D. [Changes of soluble CD40 ligand in patients with hyperlipidemia of blood stasis syndrome and its clinical significance]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011;31:315-8 pubmed
    To observe changes of soluble CD40 ligand (sCD40L) in patients with hyperlipidemia of blood stasis syndrome and its correlation with blood stasis syndrome integral, P-selectin, and high sensitive creatine reactive protein (hs-CRP), to ..
  77. Rui Kai Z, Jian L. Effects of xinfeng capsules on expression of platelet granule membrane protein 140 and platelet cluster of differentiation 40 ligand in peripheral blood of adjuvant arthritis rats. Int J Rheumatol. 2012;2012:139696 pubmed publisher
    Platelet GMP-140 and CD40L as specific markers of platelet activation play an important role in the morbidity and development of rheumatoid arthritis. The expression of GMP-140, CD40L increases in peripheral blood of AA rats...
  78. Kuo H, Chao M, Hsu Y, Lin Y, Huang Y, Yu H, et al. CD40 Gene polymorphisms associated with susceptibility and coronary artery lesions of Kawasaki disease in the Taiwanese population. ScientificWorldJournal. 2012;2012:520865 pubmed publisher
    ..Our previous studies showed expression of CD40 ligand on CD4+ T cells correlated to the coronary artery lesion (CAL) and disease progress in KD...
  79. Lei X, Ohkawara Y, Stampfli M, Mastruzzo C, Marr R, Snider D, et al. Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice. J Clin Invest. 1998;101:1342-53 pubmed
    The objective of this study was to investigate the contribution of the interaction between CD40 and its ligand (CD40L) to antigen-induced airways inflammatory responses...
  80. Isler P, de Rochemonteix B, Songeon F, Boehringer N, Nicod L. Interleukin-12 production by human alveolar macrophages is controlled by the autocrine production of interleukin-10. Am J Respir Cell Mol Biol. 1999;20:270-8 pubmed
  81. Piguet P, Kan C, Vesin C. Thrombocytopenia in an animal model of malaria is associated with an increased caspase-mediated death of thrombocytes. Apoptosis. 2002;7:91-8 pubmed
    ..The thrombocytopenia and the amount of mcp were decreased in mice treated with anti CD40L mAb, suggesting that CD40L is the main effector of the thrombocytopenia...
  82. Kim D, Hong G, Ro J. Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L. J Neuroinflammation. 2011;8:25 pubmed publisher
    ..confocal microscopy; CD40 siRNA by Silencer Express Kit; small GTPases by GTP-pull down assay; PKCs, MAPKs, CD40, CD40L, Jak1/2, STAT1, TNF receptor 1 (TNFR1) by Western blot; NF-?B and AP-1 by EMSA; cytokines by RT-PCR...
  83. Jeong J, Hong S, Hong S, Yook S, Jung Y, Park J, et al. Surface camouflage of pancreatic islets using 6-arm-PEG-catechol in combined therapy with tacrolimus and anti-CD154 monoclonal antibody for xenotransplantation. Biomaterials. 2011;32:7961-70 pubmed publisher
    ..Therefore, a newly developed protocol using 6-arm-PEG-catechol with FK506 and MR1 would certainly be an effective combination therapy for the treatment of type 1 diabetes. ..
  84. Li X, Lu Y, Sun Y, Zhang Q. Effect of curcumin on permeability of coronary artery and expression of related proteins in rat coronary atherosclerosis heart disease model. Int J Clin Exp Pathol. 2015;8:7247-53 pubmed
    ..of endarterium permeability in 3 groups, Western blot was used to detect matrix metalloproteinase-9 (MMP-9) and CD40L in coronary artery tissue, and enzyme linked immunosorbent assay (ELISA) was used to detect serum tumor necrosis ..
  85. Green K, Noelle R, Green W. Evidence for a continued requirement for CD40/CD40 ligand (CD154) interactions in the progression of LP-BM5 retrovirus-induced murine AIDS. Virology. 1998;241:260-8 pubmed
    ..onset of MAIDS is dependent on the presence of both CD4+ T and B cells, we have previously shown that anti-gp39/CD40 ligand mAb (anti-CD40L mAb) treatment of LP-BM5-infected mice is effective in inhibiting the induction of MAIDS when a ..
  86. Piguet P, Kan C, Vesin C, Rochat A, Donati Y, Barazzone C. Role of CD40-CVD40L in mouse severe malaria. Am J Pathol. 2001;159:733-42 pubmed
    We explored the role of CD40-CD40L (CD154) in the severe malaria elicited by Plasmodium berghei anka infection in mice...
  87. Stax A, Gelderman K, Kamerling S, van der Geest R, Schlagwein N, van Kooten C. Generation and characterization of a novel anti-rat CD40L antibody with inhibitory activities in vitro and in vivo. J Immunol Methods. 2008;335:46-52 pubmed publisher
    The CD40-CD40L interaction plays a critical role in cell-mediated immune responses. Blocking this interaction has been shown to be beneficial in the treatment of various diseases studied in murine models...
  88. Moore T, Shirah W, Khimenko P, Paisley P, Lausch R, Taylor A. Involvement of CD40-CD40L signaling in postischemic lung injury. Am J Physiol Lung Cell Mol Physiol. 2002;283:L1255-62 pubmed
    ..Immunoneutralization of either CD40 or CD40L, cell surface proteins important in lymphocyte-endothelial cell proinflammatory events, results in significantly ..
  89. Falco A, Romano M, Iapichino L, Collura M, Davi G. Increased soluble CD40 ligand levels in cystic fibrosis. J Thromb Haemost. 2004;2:557-60 pubmed
    ..we carried-out a cross-sectional study to evaluate circulating levels of the inflammatory mediators soluble (s) CD40L, C-reactive protein (CRP), interleukin (IL)-1beta, the coagulation markers activated factor VII (FVIIa) and ..
  90. Lavrnja I, Parabucki A, Brkić P, Jovanović T, Dacic S, Savic D, et al. Repetitive hyperbaric oxygenation attenuates reactive astrogliosis and suppresses expression of inflammatory mediators in the rat model of brain injury. Mediators Inflamm. 2015;2015:498405 pubmed publisher
    ..In addition, HBOT prevents expression of CD40 and its ligand CD40L on microglia, neutrophils, cortical neurons, and reactive astrocytes...
  91. Boumpas D, Furie R, Manzi S, Illei G, Wallace D, Balow J, et al. A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum. 2003;48:719-27 pubmed
    CD40-CD40 ligand (CD40L) interactions play a significant role in the production of autoantibodies and tissue injury in lupus nephritis...
  92. Iida T, Shiba H, Misawa T, Ohashi T, Eto Y, Yanaga K. Adenovirus-mediated CD40L gene therapy induced both humoral and cellular immunity against rat model of hepatocellular carcinoma. Cancer Sci. 2008;99:2097-103 pubmed publisher
    ..CD40L (AxCAmCD40L)-mediated gene therapy was studied for treatment of hepatocellular carcinoma (HCC) using CD40 ligand (CD40L) complementary DNA in rats...