Cd40

Summary

Gene Symbol: Cd40
Description: CD40 molecule
Alias: Tnfrsf5, tumor necrosis factor receptor superfamily member 5, CD40 antigen, TNF receptor superfamily member 5, CD40 molecule, TNF receptor superfamily member 5, tumor necrosis factor receptor superfamily, member 5
Species: rat
Products:     Cd40

Top Publications

  1. Ripoll E, Pluvinet R, Torras J, Olivar R, Vidal A, Franquesa M, et al. In vivo therapeutic efficacy of intra-renal CD40 silencing in a model of humoral acute rejection. Gene Ther. 2011;18:945-52 pubmed publisher
    The humoral branch of the immune response has an important role in acute and chronic allograft dysfunction. The CD40/CD40L costimulatory pathway is crucial in B- and T- alloresponse...
  2. Tomer Y, Concepcion E, Greenberg D. A C/T single-nucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease. Thyroid. 2002;12:1129-35 pubmed
    ..Among the genes mapped to 20q11 was the CD40 gene, an important costimulatory molecule and a good positional candidate gene for GD...
  3. Vonderheide R, Flaherty K, Khalil M, Stumacher M, Bajor D, Hutnick N, et al. Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. J Clin Oncol. 2007;25:876-83 pubmed
    The cell-surface molecule CD40 activates antigen-presenting cells and enhances immune responses. CD40 is also expressed by solid tumors, but its engagement results in apoptosis...
  4. Tan J, Town T, Mori T, Obregon D, Wu Y, DelleDonne A, et al. CD40 is expressed and functional on neuronal cells. EMBO J. 2002;21:643-52 pubmed
    We show here that CD40 mRNA and protein are expressed by neuronal cells, and are increased in differentiated versus undifferentiated N2a and PC12 cells as measured by RT-PCR, western blotting and immunofluorescence staining...
  5. Chen C, Aliesky H, Guo J, Rapoport B, McLachlan S. Blockade of costimulation between T cells and antigen-presenting cells: an approach to suppress murine Graves' disease induced using thyrotropin receptor-expressing adenovirus. Thyroid. 2006;16:427-34 pubmed
    Immune responses require costimulatory interactions between molecules on antigen-presenting cells and T cells: CD40 binding to CD40 ligand and B7 binding to CD28...
  6. Gao D, Wagner A, Fankhaenel S, Stojanovic T, Schweyer S, Panzner S, et al. CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis. Gut. 2005;54:70-7 pubmed
    CD154/CD40 interactions play a pivotal role both in humoral and cellular immune responses...
  7. Advani R, Forero Torres A, Furman R, Rosenblatt J, Younes A, Ren H, et al. Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma. J Clin Oncol. 2009;27:4371-7 pubmed publisher
    ..Dacetuzumab monotherapy was well tolerated in patients with NHL in doses up to 8 mg/kg/wk. Preliminary response data are encouraging and support additional studies of dacetuzumab in this patient population. ..
  8. Piguet P, Kan C, Vesin C, Rochat A, Donati Y, Barazzone C. Role of CD40-CVD40L in mouse severe malaria. Am J Pathol. 2001;159:733-42 pubmed
    We explored the role of CD40-CD40L (CD154) in the severe malaria elicited by Plasmodium berghei anka infection in mice...
  9. Zhu W, Mix E, Jin T, Adem A, Zhu J. B cells play a cooperative role via CD40L-CD40 interaction in T cell-mediated experimental autoimmune neuritis in Lewis rats. Neurobiol Dis. 2007;25:642-8 pubmed
    The expression of co-stimulatory molecules CD40 and CD40L was examined over the course of experimental autoimmune neuritis (EAN) induced in Lewis rats by immunization with bovine peripheral nerve myelin...

More Information

Publications91

  1. Contin C, Pitard V, Delmas Y, Pelletier N, Defrance T, Moreau J, et al. Potential role of soluble CD40 in the humoral immune response impairment of uraemic patients. Immunology. 2003;110:131-40 pubmed
    b>CD40/CD154 interaction is essential for both humoral and cellular immune response. We investigated whether this interaction could be altered in patients with kidney failure who are known to present an impaired immune response...
  2. Chu Q, Zhang J, Wu Y, Zhang Y, Xu G, Li W, et al. Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin. Clin Exp Ophthalmol. 2011;39:142-51 pubmed publisher
    ..Genes encoding pro-apoptotic effectors, like Tnfrsf5, Bid3 and Bcl2l1, were also upregulated in diabetic rats and attenuated in erythropoietin-treated group...
  3. Hang L, Setiawan T, Blum A, Urban J, Stoyanoff K, Arihiro S, et al. Heligmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity. J Immunol. 2010;185:3184-9 pubmed publisher
    ..displayed decreased expression of CD80 and CD86, and heightened expression of plasmacytoid dendritic cell Ag-1 and CD40. They were also less responsive to lamina proprias, producing less IL-12p40 and IL-10...
  4. DU A, Ji T, Yang B, Cao J, Zhang X, Li Y, et al. Neuroprotective effect of AG490 in experimental traumatic brain injury of rats. Chin Med J (Engl). 2013;126:2934-7 pubmed
    ..Therefore, we investigated the role of AG490 in regulating brain oedema, expression of CD40 and neurological function after TBI...
  5. Gerth A, Lin L, Peng S. T-bet regulates T-independent IgG2a class switching. Int Immunol. 2003;15:937-44 pubmed
    ..Specifically, T-dependent signaling through CD40, in contrast to T-independent signaling via lipopolysaccharide, can bypass a requirement for T-bet in IgG2a ..
  6. Tkacova R, Ukropec J, Skyba P, Ukropcova B, Pobeha P, Kurdiova T, et al. Increased adipose tissue expression of proinflammatory CD40, MKK4 and JNK in patients with very severe chronic obstructive pulmonary disease. Respiration. 2011;81:386-93 pubmed publisher
    b>CD40, a transmembrane receptor of the tumor necrosis factor gene superfamily, is activated in response to cellular stress, including hypoxia, and orchestrates the process of inflammation via secondary messengers such as mitogen-activated ..
  7. Zhu P, Zou L. [Expression of CD40 and CD40 ligand in peripheral blood mononuclear cells in children with bronchiolitis]. Zhongguo Dang Dai Er Ke Za Zhi. 2009;11:354-6 pubmed
    ..Immune function abnormality following virus infection may be associated with the pathogenesis. CD40 and CD40 ligand (CD40L) is a pair of co-stimulatory molecules in immunoreaction...
  8. Mann J, Oakley F, Johnson P, Mann D. CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1. J Biol Chem. 2002;277:17125-38 pubmed
    b>CD40-induced activation of cytokine gene expression in dendritic cells (DC) is an important process in the initiation of primary immune responses...
  9. Hsiao J, Hsieh M, Hsiao C, Weng H, Ke D. Association of CD40 and thyroglobulin genes with later-onset Graves' disease in Taiwanese patients. Eur J Endocrinol. 2008;159:617-21 pubmed publisher
    Graves' disease (GD) is known to be associated with thyroglobulin (TG) and CD40 genes. Therefore, we decided to investigate the relationship of age at onset of GD with CD40 and TG gene susceptibilities in a Taiwanese population...
  10. Xu J, Treem W, Roman C, Anderson V, Rubenstein R, Schwarz S. Ileal immune dysregulation in necrotizing enterocolitis: role of CD40/CD40L in the pathogenesis of disease. J Pediatr Gastroenterol Nutr. 2011;52:140-6 pubmed publisher
    b>CD40, a co-stimulatory molecule, plays a critical role in coordinating enteric inflammatory immune responses...
  11. Kim J, Majumder N, Lin H, Chen J, Falo L, You Z. Enhanced immunity by NeuEDhsp70 DNA vaccine Is needed to combat an aggressive spontaneous metastatic breast cancer. Mol Ther. 2005;11:941-9 pubmed
    ..Results from animal experiments with depletion of immune cells or with deficiency of CD40 molecules indicate that T cells and CD40 molecules are critical in the anti-tumor immunity induced by NeuEDhsp70 ..
  12. Ishikawa M, Vowinkel T, Stokes K, Arumugam T, Yilmaz G, Nanda A, et al. CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion. Circulation. 2005;111:1690-6 pubmed
    b>CD40/CD40 ligand (CD40L) signaling contributes to proinflammatory and prothrombogenic responses in the vasculature. CD40/CD40L expression is elevated in patients after a transient ischemic attack or stroke...
  13. Kong Y, Kishihara K, Sumichika H, Nakamura T, Kaneko M, Nomoto K. Differential requirements of CD45 for lymphocyte development and function. Eur J Immunol. 1995;25:3431-6 pubmed
    ..However, CD4+ T helper function was severely diminished in CD45 exon 6-deficient mice, suggesting that the requirements of CD45 molecules in antigen-specific response and development are different between T and B lymphocytes. ..
  14. Mai G, Bucher P, Morel P, Mei J, Bosco D, Andres A, et al. Role of CD40-CD154 pathway in the rejection of concordant and discordant xenogeneic islets. Transplant Proc. 2005;37:460-2 pubmed
    ..The aim of the present study was to evaluate the role of recipient CD40 and CD154 in the rejection process of concordant and discordant islet xenotransplantation (Tx)...
  15. Liu C, Lewis C, Lou Y, Xu C, Peng W, Yang Y, et al. Agonistic antibody to CD40 boosts the antitumor activity of adoptively transferred T cells in vivo. J Immunother. 2012;35:276-82 pubmed publisher
    b>CD40, a member of the tumor necrosis factor receptor superfamily, is broadly expressed on antigen-presenting cells and other cells, including fibroblasts and endothelial cells...
  16. Yang X, Ye R, Kong Q, Yang Q, Dong X, Yu X. CD40 is expressed on rat peritoneal mesothelial cells and upregulates ICAM-1 production. Nephrol Dial Transplant. 2004;19:1378-84 pubmed
    b>CD40 has been identified on a variety of cell types, and it plays an important role in adaptive immunity and inflammation. Peritoneal mesothelial cells (PMCs) are the main cell layer that line the peritoneal membrane...
  17. Otahal P, Knowles B, Tevethia S, Schell T. Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigen-induced pancreatic tumors. J Immunol. 2007;179:6686-95 pubmed
    ..In this report, we show that the conditioning of tumor-bearing RIP1-Tag4 mice with agonistic anti-CD40 Ab induces extensive expansion of naive epitope I-specific TCR transgenic (TCR-I) T cells in this tolerogenic ..
  18. Kosaka A, Ohkuri T, Okada H. Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells. Cancer Immunol Immunother. 2014;63:847-57 pubmed publisher
    Malignant gliomas are heavily infiltrated by immature myeloid cells that mediate immunosuppression. Agonistic CD40 monoclonal antibody (mAb) has been shown to activate myeloid cells and promote antitumor immunity...
  19. Oz H, Hughes W, Rehg J, Thomas E. Effect of CD40 ligand and other immunomodulators on Pneumocystis carinii infection in rat model. Microb Pathog. 2000;29:187-90 pubmed
    ..In this study the effects of five immunomodulators; recombinant CD40 ligand (CD40L), bryostatin 1, recombinant FLT3 ligand (FLT3L), recombinant granulocyte colony-stimulating factor (G-..
  20. Gandhi K, McKay F, Cox M, Riveros C, Armstrong N, Heard R, et al. The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. Hum Mol Genet. 2010;19:2134-43 pubmed publisher
    ..screen identified two novel regions with genome wide significance: one encoding the T cell co-stimulatory molecule, CD40; the other a region on chromosome 12q13-14...
  21. Wu J, Yang X, Zhang Y, Zhou S, Zhang R, Dong X, et al. Angiotensin II upregulates Toll-like receptor 4 and enhances lipopolysaccharide-induced CD40 expression in rat peritoneal mesothelial cells. Inflamm Res. 2009;58:473-82 pubmed publisher
    ..induced by angiotensin II (Ang II) and functional consequences of nuclear factor-kappaB (NF-kappaB) activation and CD40 expression in rat peritoneal mesothelial cells (RPMCs)...
  22. Campean V, Neureiter D, Nonnast Daniel B, Garlichs C, Gross M, Amann K. CD40-CD154 expression in calcified and non-calcified coronary lesions of patients with chronic renal failure. Atherosclerosis. 2007;190:156-66 pubmed
    ..Activation of cells and adhesion molecules in atherosclerosis is governed by CD40-CD154 (CD40 ligand) interaction...
  23. Zhou Q, Gault R, Kozel T, Murphy W. Immunomodulation with CD40 stimulation and interleukin-2 protects mice from disseminated cryptococcosis. Infect Immun. 2006;74:2161-8 pubmed
    ..In this study we investigated the antifungal efficacy of an agonist antibody to CD40, an important costimulator of immune function, in combination with interleukin 2 (IL-2) in a murine model of ..
  24. Martin D, King C, Pearlman E, Strine E, Heinzel F. IFN-gamma is necessary but not sufficient for anti-CD40 antibody-mediated inhibition of the Th2 response to Schistosoma mansoni eggs. J Immunol. 2000;164:779-85 pubmed
    ..We examined whether treatment with CD40-activating Abs would block the development of Th2 cytokine responses and eosinophilic tissue pathology in this ..
  25. Durand J, Huchet V, Merieau E, Usal C, Chesneau M, Rémy S, et al. Regulatory B Cells with a Partial Defect in CD40 Signaling and Overexpressing Granzyme B Transfer Allograft Tolerance in Rodents. J Immunol. 2015;195:5035-44 pubmed publisher
    ..Following anti-CD40 stimulation, IgD(-)IgM(+/low) B cells were blocked in their plasma cell differentiation pathway, maintained high ..
  26. Hayashi C, Madrigal A, Liu X, Ukai T, Goswami S, Gudino C, et al. Pathogen-mediated inflammatory atherosclerosis is mediated in part via Toll-like receptor 2-induced inflammatory responses. J Innate Immun. 2010;2:334-43 pubmed publisher
    ..mice possessing functional TLR2 induced the accumulation of macrophages as well as inflammatory mediators including CD40, IFN-gamma and the pro-inflammatory cytokines IL-1 beta, IL-6 and tumor necrosis factor-alpha in atherosclerotic ..
  27. Downer E, Cowley T, Cox F, Maher F, Berezin V, Bock E, et al. A synthetic NCAM-derived mimetic peptide, FGL, exerts anti-inflammatory properties via IGF-1 and interferon-gamma modulation. J Neurochem. 2009;109:1516-25 pubmed publisher
    ..increases in markers of glial cell activation, including major histocompatibility complex class II (MHCII) and CD40. Finally, the proclivity of FGL to attenuate IFNgamma-induced glial cell activation in vitro is IGF-1-dependent...
  28. Pawlak K, Mysliwiec M, Pawlak D. Impact of residual renal function and HCV seropositivity on plasma CD40/CD40L system and oxidative status in haemodialysis patients. Clin Biochem. 2010;43:1393-8 pubmed publisher
    We evaluated the impact of residual renal function (RRF) on oxidative stress (SOX) and CD40/CD40L system in haemodialysis (HD) patients...
  29. Godoy L, Moretti A, Jurado M, Oxer D, Janiszewski M, Ckless K, et al. Loss of CD40 endogenous S-nitrosylation during inflammatory response in endotoxemic mice and patients with sepsis. Shock. 2010;33:626-33 pubmed publisher
    Signal transduction through the surface molecule CD40 is critical for cellular activation in immunoinflammatory states such as sepsis. The mechanisms regulating this pathway are not completely understood...
  30. Horton H, Bernett M, Peipp M, Pong E, Karki S, Chu S, et al. Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies. Blood. 2010;116:3004-12 pubmed publisher
    b>CD40 is highly expressed on various B-lineage malignancies and represents an attractive immunotherapy target for neoplastic disease...
  31. Hammwohner M, Ittenson A, Dierkes J, Bukowska A, Klein H, Lendeckel U, et al. Platelet expression of CD40/CD40 ligand and its relation to inflammatory markers and adhesion molecules in patients with atrial fibrillation. Exp Biol Med (Maywood). 2007;232:581-9 pubmed
    ..However, the impact of platelet CD40 and CD40 ligand (CD40L) expression and its relation to inflammatory markers in atrial clot formation have not yet ..
  32. Krimmer D, Loseli M, Hughes J, Oliver B, Moir L, Hunt N, et al. CD40 and OX40 ligand are differentially regulated on asthmatic airway smooth muscle. Allergy. 2009;64:1074-82 pubmed publisher
    b>CD40 and OX40 Ligand (OX40L) are cell-surface molecules expressed on airway smooth muscle (ASM) that can enhance inflammatory cell activation and survival...
  33. Zajkowska J, Kondrusik M, Pancewicz S, Swierzbinska R, Grygorczuk S, Hermanowska Szpakowicz T. [Soluble CD40 and soluble CD40L concentrations in the serum and the cerebrospinal fluid of patients with tick borne encephalitis and neuroborreliosis]. Neurol Neurochir Pol. 2006;40:22-7 pubmed
    The interaction between CD40 and CD40L is essential in generating of an immunological response also intrathecally...
  34. Yuan M, Ohishi M, Wang L, Raguki H, Wang H, Tao L, et al. Association between serum levels of soluble CD40/CD40 ligand and organ damage in hypertensive patients. Clin Exp Pharmacol Physiol. 2010;37:848-51 pubmed publisher
    1. CD40 and CD40 ligand (CD40L) have a critical role in the pathophysiology and risk prediction of coronary artery syndrome, including atherothrombosis and atherosclerosis...
  35. Welniak L, Shorts L, Subleski J, Blazar B, Wiltrout R, Murphy W. Tumor regression by anti-CD40 and interleukin-2: role of CD40 in hematopoietic cells and organ-specific effects. Biol Blood Marrow Transplant. 2004;10:534-9 pubmed
    b>CD40 stimulation can synergize with interleukin (IL)-2 for antitumor responses against mouse metastatic renal cell carcinomas, with coincident increases in tumor-specific CD8+ T-cell responses and dendritic cell numbers in both the spleen ..
  36. Morales Aza B, Glennie S, Garcez T, Davenport V, Johnston S, Williams N, et al. Impaired maintenance of naturally acquired T-cell memory to the meningococcus in patients with B-cell immunodeficiency. Blood. 2009;113:4206-12 pubmed publisher
    ..Accordingly, we show that meningococcal antigens up-regulate major histocompatibility complex (MHC) class II, CD40, CD86/80 expression on mucosal and systemic associated B cells and that antigen presentation stimulates T-cell ..
  37. Lukanov T, Bojinova S, Popova V, Emin A, Veleva G, Gecheva S, et al. Flow cytometric investigation of CD40-CD40 ligand system in preeclampsia and normal pregnancy. Clin Appl Thromb Hemost. 2010;16:306-12 pubmed publisher
    Our aim was to investigate the CD40-CD40 ligand system in preeclamptic women. We also studied CD62P and platelet-monocyte aggregates, which have been closely linked to the CD40-CD40L system...
  38. Murray H, Lu C, Brooks E, Fichtl R, DeVecchio J, Heinzel F. Modulation of T-cell costimulation as immunotherapy or immunochemotherapy in experimental visceral leishmaniasis. Infect Immun. 2003;71:6453-62 pubmed
    b>CD40 ligand (CD40L)-deficient C57BL/6 mice failed to control intracellular Leishmania donovani visceral infection, indicating that acquired resistance involves CD40-CD40L signaling and costimulation...
  39. Plant D, Flynn E, Mbarek H, Dieude P, Cornelis F, Arlestig L, et al. Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers. Ann Rheum Dis. 2010;69:1548-53 pubmed publisher
    ..Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-..
  40. Merluzzi S, Moretti M, Altamura S, Zwollo P, Sigvardsson M, Vitale G, et al. CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism. J Biol Chem. 2004;279:1777-86 pubmed
    b>CD40 is a member of the growing tumor necrosis factor receptor family that has been shown to play important roles in T cell-mediated B lymphocyte activation...
  41. Lee A, Papangeli I, Park Y, Jeong H, Choi J, Kang H, et al. A PPARγ-dependent miR-424/503-CD40 axis regulates inflammation mediated angiogenesis. Sci Rep. 2017;7:2528 pubmed publisher
    ..Angiogenesis is a crucial component of the vascular response associated with inflammatory signaling. The CD40/CD40 ligand dyad in endothelial cells (EC) has a central role in promoting vascular inflammatory response; however, ..
  42. Jin Y, Xie S. Bicistronic adenovirus-mediated gene transfer of CTLA4Ig gene and CD40Ig gene result in indefinite survival of islet xenograft. Transplant Proc. 2003;35:3165-6 pubmed
    Blockade of CD40-CD154 costimulatory pathway in mice and primates with anti-CD154 monoclonal antibodies results in prolonged survival of vascularized organs and islet grafts...
  43. Meers S, Kasran A, Boon L, Lemmens J, Ravoet C, Boogaerts M, et al. Monocytes are activated in patients with myelodysplastic syndromes and can contribute to bone marrow failure through CD40-CD40L interactions with T helper cells. Leukemia. 2007;21:2411-9 pubmed
    ..The aim of this study was to evaluate the possible contribution of activated monocytes through CD40-CD40L(CD154) interactions with activated T helper cells...
  44. Chin A, Dempsey P, Bruhn K, Miller J, Xu Y, Cheng G. Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature. 2002;416:190-4 pubmed
    ..Our data reflect requirements for Rip2 in multiple pathways regulating immune and inflammatory responses. ..
  45. Moore T, Shirah W, Khimenko P, Paisley P, Lausch R, Taylor A. Involvement of CD40-CD40L signaling in postischemic lung injury. Am J Physiol Lung Cell Mol Physiol. 2002;283:L1255-62 pubmed
    ..Immunoneutralization of either CD40 or CD40L, cell surface proteins important in lymphocyte-endothelial cell proinflammatory events, results in ..
  46. Zervou M, Goulielmos G, Castro Giner F, Boumpas D, Tosca A, Krueger Krasagakis S. A CD40 and an NCOA5 gene polymorphism confer susceptibility to psoriasis in a Southern European population: a case-control study. Hum Immunol. 2011;72:761-5 pubmed publisher
    ..The genes CD40 and nuclear receptor coactivator 5 (NCOA5), located in a 400-kb region surrounding CD40, have been reported to be ..
  47. Wang M, Li Y, Li W, Xia Z, Wu Q. The CD40 gene polymorphism rs1883832 is associated with risk of acute coronary syndrome in a Chinese case-control study. DNA Cell Biol. 2011;30:173-8 pubmed publisher
    ..A functional polymorphism (-1C>T, rs1883832) in the 5' untranslated region of TNFRSF5 gene has been reported to affect CD40 expression and be associated with several chronic inflammatory and ..
  48. Pulzova L, Kovac A, Mucha R, Mlynarcik P, Bencúrová E, Madar M, et al. OspA-CD40 dyad: ligand-receptor interaction in the translocation of neuroinvasive Borrelia across the blood-brain barrier. Sci Rep. 2011;1:86 pubmed publisher
    ..Using protein-protein interaction assays we found that CD40 of BMECs and OspA of Borrelia are the primary molecules in transient tethering of Borrelia to endothelium...
  49. Ellina O, Chatzigeorgiou A, Kouyanou S, Lymberi M, Mylona Karagianni C, Tsouvalas E, et al. Extracellular matrix-associated (GAGs, CTGF), angiogenic (VEGF) and inflammatory factors (MCP-1, CD40, IFN-?) in type 1 diabetes mellitus nephropathy. Clin Chem Lab Med. 2012;50:167-74 pubmed publisher
    ..tissue growth factor (CTGF), angiogenic vascular endothelial growth factor (VEGF) and inflammatory factors (MCP-1, CD40, IFN-?) in the development of diabetic nephropathy in type 1 diabetes (T1DM)...
  50. Mason R, Jacob R, Kubant R, Walter M, Bellamine A, Jacoby A, et al. Effect of enhanced glycemic control with saxagliptin on endothelial nitric oxide release and CD40 levels in obese rats. J Atheroscler Thromb. 2011;18:774-83 pubmed
    ..was measured ex vivo using amperometric approaches and correlated with FG, postprandial glucose, insulin, soluble CD40 (sCD40) and L-citrulline levels...
  51. Chappel M, Hough M, Mittel A, Takei F, Kay R, Humphries R. Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes. J Exp Med. 1996;184:1639-49 pubmed
    ..induce apoptosis in mature splenic B cells, but instead inhibits their ability to proliferate in response to anti-CD40 + IL-4...
  52. Hsieh Y, Wan L, Chang C, Tsai C, Tsai F. STAT2*C related genotypes and allele but not TLR4 and CD40 gene polymorphisms are associated with higher susceptibility for asthma. Int J Biol Sci. 2009;5:74-81 pubmed
    ..to investigate whether signal transducer and activator of transcription (STAT2), toll-like receptors 4 (TLRs4) and CD40-related polymorphisms are associated with asthma susceptibility...
  53. McKee A, Pearce E. CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol. 2004;173:1224-31 pubmed
    ..We show that dendritic cells from infected mice are primed to make IL-12 in response to CD40 ligation, and that IL-10 acts by inhibiting this process...
  54. Mlynarcik P, Pulzova L, Bencúrová E, Kovac A, Dominguez M, Hreško S, et al. Deciphering the interface between a CD40 receptor and borrelial ligand OspA. Microbiol Res. 2015;170:51-60 pubmed publisher
    ..Here we unfold the interface between OspA and CD40 molecules, major ligand and receptor, that are involved in adhesion of Borrelia to BMECs...
  55. Caproni M, Torchia D, Antiga E, Giomi B, Mercuri M, Volpi W, et al. The CD40/CD40 ligand system in the skin of patients with subacute cutaneous lupus erythematosus. J Rheumatol. 2007;34:2412-6 pubmed
    To investigate whether CD40 and CD40 ligand (CD40L) is expressed in the skin of patients with subacute cutaneous lupus erythematosus (SCLE). Six female patients with SCLE were studied...
  56. Zhu R, Liu G, Li W, Wang Z, Chen H, Zhang W. [A study of costimulatory molecules in allergic allergic rhinitis patients]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008;22:780-2, 784 pubmed
    To investigate the expression of costimulatory molecules CD28/B7 and CD40/CD40L in T and B lymphocytes as well as its relations with total IgE (TIgE), eosinophil cationic protein (ECP) in serum and nasal allergic symptoms in patients with ..
  57. Karaoz E, Okcu A, Saglam O, Genc Z, Ayhan S, Kasap M. Pancreatic islet derived stem cells can express co-stimulatory molecules of antigen-presenting cells. Transplant Proc. 2010;42:3663-70 pubmed publisher
    ..characteristics; pluripotent-related gene expressions; transcripts coding for antigen-presenting surface proteins CD40, CD80, CD86; and major histocompatibility complex class II in addition to genes with known antiapoptotic functions ..
  58. Kalantari Dehaghi M, Molina D, Farhadieh M, Morrow W, Liang X, Felgner P, et al. New targets of pemphigus vulgaris antibodies identified by protein array technology. Exp Dermatol. 2011;20:154-6 pubmed publisher
    ..reactive with 16 antigens, most of which were cell-surface proteins, such as CD2, CD31, CD33, CD36, CD37, CD40, CD54, CD66c and CD84 molecules, nicotinamide/nicotinic acid mononucleotide adenylyltransferase, immunoglobulin ..
  59. Kim J, Park K, Kim H, Kim J, Kim H, Jung D, et al. Breaking of CD8+ T cell tolerance through in vivo ligation of CD40 results in inhibition of chronic graft-versus-host disease and complete donor cell engraftment. J Immunol. 2008;181:7380-9 pubmed
    ..In this study, we investigated the effect of an agonistic mAb against CD40 on cGVHD...
  60. Malik F, Kumar A, Bhushan S, Mondhe D, Pal H, Sharma R, et al. Immune modulation and apoptosis induction: Two sides of antitumoural activity of a standardised herbal formulation of Withania somnifera. Eur J Cancer. 2009;45:1494-509 pubmed publisher
    ..In parallel, it enhanced the proliferation of CD4(+)/CD8(+) and NK cells along with an increased expression of CD40/CD40L/CD80. In addition, WSF also enhanced T cell activation in camptothecin treated tumour-bearing mice...
  61. Hostager B, Haxhinasto S, Rowland S, Bishop G. Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J Biol Chem. 2003;278:45382-90 pubmed
    b>CD40 function is initiated by tumor necrosis factor (TNF) receptor-associated factor (TRAF) adapter proteins, which play important roles in signaling by numerous receptors...
  62. Yan J, Jie Z, Hou L, Wanderley J, Soong L, Gupta S, et al. Parenchymal expression of CD40 exacerbates adenovirus-induced hepatitis in mice. Hepatology. 2011;53:1455-67 pubmed publisher
    ..However, high levels of MHC II, CD40, and B7 family molecules are expressed in the activated Kupffer cells and hepatocytes of patients with viral ..
  63. Aiba Y, Yamazaki T, Okada T, Gotoh K, Sanjo H, Ogata M, et al. BANK negatively regulates Akt activation and subsequent B cell responses. Immunity. 2006;24:259-68 pubmed
    ..center formation and IgM production in response to T-dependent antigens, whereas this phenotype was blocked in CD40-BANK double knockout mice. Involvement of BANK in CD40 signaling was further demonstrated by in vitro analysis...
  64. de Ramon L, Ripoll E, Merino A, Lúcia M, Aran J, Pérez Rentero S, et al. CD154-CD40 T-cell co-stimulation pathway is a key mechanism in kidney ischemia-reperfusion injury. Kidney Int. 2015;88:538-49 pubmed publisher
    Ischemia-reperfusion occurs in a great many clinical settings and contributes to organ failure or dysfunction. CD154-CD40 signaling in leukocyte-endothelial cell interactions or T-cell activation facilitates tissue inflammation and injury...
  65. Blanco Kelly F, Matesanz F, Alcina A, Teruel M, Díaz Gallo L, Gómez Garcia M, et al. CD40: novel association with Crohn's disease and replication in multiple sclerosis susceptibility. PLoS ONE. 2010;5:e11520 pubmed publisher
    A functional polymorphism located at -1 from the start codon of the CD40 gene, rs1883832, was previously reported to disrupt a Kozak sequence essential for translation...
  66. Sexl V, Piekorz R, Moriggl R, Rohrer J, Brown M, Bunting K, et al. Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Blood. 2000;96:2277-83 pubmed
    ..We demonstrate that the absence of Stat5a/b is not essential for the induction of lymphoid or myeloid tumors in vivo or on the ability to transform bone marrow cells in vitro. ..
  67. Ruth A, Kitching A, Li M, Semple T, Timoshanko J, Tipping P, et al. An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity. J Immunol. 2004;173:136-44 pubmed
    ..b>CD40-CD154 interactions are critical for IL-12 production and Th1 polarization of immune responses...
  68. Wang X, Ding X, Li Y, Liu H, Xue W, Tian X, et al. Simultaneous blockade of the CD40/CD40L and NF-?B pathways prolonged islet allograft survival. Transpl Int. 2012;25:118-26 pubmed publisher
    Activation of NF-?B pathway and co-stimulatory system CD40/CD40L promotes the inflammation, which plays a key role in the failure of islet graft...
  69. Mengel M, Mueller I, Behrend M, von Wasielewski R, Radermacher J, Schwarz A, et al. Prognostic value of cytotoxic T-lymphocytes and CD40 in biopsies with early renal allograft rejection. Transpl Int. 2004;17:293-300 pubmed
    ..acute rejection episodes for the immunohistochemical expression of key molecules (perforin, granzyme B, TIA-1, CD40) in the T cell-mediated rejection process. Staining results were correlated to long-term allograft outcome...
  70. Ruth A, Kitching A, Semple T, Tipping P, Holdsworth S. Intrinsic renal cell expression of CD40 directs Th1 effectors inducing experimental crescentic glomerulonephritis. J Am Soc Nephrol. 2003;14:2813-22 pubmed
    ..b>CD40/CD154 signaling plays a key role in initiating Th1 responses and may direct Th1 effector responses...
  71. Veber D, Mutti E, Galmozzi E, Cedrola S, Galbiati S, Morabito A, et al. Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy. J Neuroimmunol. 2006;176:24-33 pubmed
    The levels of the soluble (s) CD40:sCD40 ligand (L) dyad, which belongs to the tumor necrosis factor (TNF)-alpha:TNF-alpha-receptor superfamily, are significantly increased in the cerebrospinal fluid (CSF), but not the serum of cobalamin (..
  72. Liu Y, Lin R, Zhang H, Zhang J, Ji Q, Yang Y. [Protective effect of Buyanghuanwu Decoction on myocardial ischemia induced by isoproterenol in rats]. Zhong Yao Cai. 2009;32:380-3 pubmed
    ..The expression of CD40 in whole blood was detected by flow cytometry,and the expression of CD40L in myocardial tissues was detected by ..
  73. Suzuki M, Zheng X, Zhang X, Zhang Z, Ichim T, Sun H, et al. A novel allergen-specific therapy for allergy using CD40-silenced dendritic cells. J Allergy Clin Immunol. 2010;125:737-43, 743.e1-743.e6 pubmed publisher
    ..We have previously reported that systemic administration of CD40 siRNA is capable of attenuating allergic symptoms but in an allergen-nonspecific fashion...
  74. Nemoto E, Tada H, Shimauchi H. Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production. J Leukoc Biol. 2002;72:538-45 pubmed
    b>CD40 is a crucial element in the process of fibroblast activation...
  75. Lin Q, Geng Y, Jiang Z, Tian Z. SIRT1 regulates lipopolysaccharide-induced CD40 expression in renal medullary collecting duct cells by suppressing the TLR4-NF-?B signaling pathway. Life Sci. 2017;170:100-107 pubmed publisher
    ..The co-stimulatory molecule, CD40, is expressed in a variety of inflammatory diseases in the kidney...
  76. Komura K, Fujimoto M, Yanaba K, Matsushita T, Matsushita Y, Horikawa M, et al. Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse. Ann Rheum Dis. 2008;67:867-72 pubmed
    To assess the association of CD40/CD40 ligand (CD40L) interactions with the development of skin fibrosis and autoimmunity in tight-skin (TSK/+) mouse, which is a mouse model for human systemic sclerosis...
  77. Puliaev R, Puliaeva I, Welniak L, Ryan A, Haas M, Murphy W, et al. CTL-promoting effects of CD40 stimulation outweigh B cell-stimulatory effects resulting in B cell elimination and disease improvement in a murine model of lupus. J Immunol. 2008;181:47-61 pubmed
    b>CD40/CD40L signaling promotes both B cell and CTL responses in vivo, the latter being beneficial in tumor models...
  78. Haller S, Kumarasamy S, Folt D, Wuescher L, Stepkowski S, Karamchandani M, et al. Targeted disruption of Cd40 in a genetically hypertensive rat model attenuates renal fibrosis and proteinuria, independent of blood pressure. Kidney Int. 2017;91:365-374 pubmed publisher
    High blood pressure is a common cause of chronic kidney disease. Because CD40, a member of the tumor necrosis factor receptor family, has been linked to the progression of kidney disease in ischemic nephropathy, we studied the role of ..
  79. Lavrnja I, Parabucki A, Brkić P, Jovanović T, Dacic S, Savic D, et al. Repetitive hyperbaric oxygenation attenuates reactive astrogliosis and suppresses expression of inflammatory mediators in the rat model of brain injury. Mediators Inflamm. 2015;2015:498405 pubmed publisher
    ..In addition, HBOT prevents expression of CD40 and its ligand CD40L on microglia, neutrophils, cortical neurons, and reactive astrocytes...
  80. Yang J, Xu M, Yan L, Chen X, Liu J. Zinc finger protein A20 protects rats against chronic liver allograft dysfunction. World J Gastroenterol. 2012;18:3537-50 pubmed publisher
    ..with A20 suppressed hepatic protein production of tumor growth factor (TGF)-?1, interleukin-1?, caspase-8, CD40, CD40L, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin...
  81. Ke B, Shen X, Gao F, Busuttil R, Lowenstein P, Castro M, et al. Gene therapy for liver transplantation using adenoviral vectors: CD40-CD154 blockade by gene transfer of CD40Ig protects rat livers from cold ischemia and reperfusion injury. Mol Ther. 2004;9:38-45 pubmed
    ..We attempted to modulate rat liver I/R injury by targeted gene therapy with CD40Ig, which blocks the CD40-CD154 costimulation pathway...
  82. Luhrmann A, Tschernig T, von der Leyen H, Hecker M, Pabst R, Wagner A. Decoy oligodeoxynucleotide against STAT transcription factors decreases allergic inflammation in a rat asthma model. Exp Lung Res. 2010;36:85-93 pubmed publisher
    Leukocyte infiltration and activation of the CD40-CD40 ligand costimulatory pathway may promote inflammatory processes such as asthma...