Cd36

Summary

Gene Symbol: Cd36
Description: CD36 molecule
Alias: Fat, RGD1562323, platelet glycoprotein 4, CD36 antigen (collagen type I receptor, thrombospondin receptor), CD36 molecule (thrombospondin receptor), Cd36 antigen-like, GPIIIB, GPIV, PAS IV, PAS-4, adipocyte membrane protein, collagen type I receptor thrombospondin receptor, fatty acid translocase, fatty acid transport protein, glycoprotein IIIb, platelet glycoprotein IV
Species: rat
Products:     Cd36

Top Publications

  1. Stuart L, Deng J, Silver J, Takahashi K, Tseng A, Hennessy E, et al. Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J Cell Biol. 2005;170:477-85 pubmed
    ..scavenger receptor Croquemort as a receptor for Staphylococcus aureus, implicating for the first time the CD36 family as phagocytic receptors for bacteria...
  2. Coort S, Hasselbaink D, Koonen D, Willems J, Coumans W, Chabowski A, et al. Enhanced sarcolemmal FAT/CD36 content and triacylglycerol storage in cardiac myocytes from obese zucker rats. Diabetes. 2004;53:1655-63 pubmed
    ..and the contraction-mimetic agent oligomycin on the initial rate of LCFA uptake, subcellular distribution of FAT/CD36, and LCFA metabolism...
  3. Tontonoz P, Nagy L, Alvarez J, Thomazy V, Evans R. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 1998;93:241-52 pubmed
    ..monocytic differentiation and promotes uptake of oxLDL through transcriptional induction of the scavenger receptor CD36. These results reveal a novel signaling pathway controlling differentiation and lipid metabolism in monocytic cells,..
  4. Cunha Rodrigues M, Portugal S, Febbraio M, Mota M. Bone marrow chimeric mice reveal a dual role for CD36 in Plasmodium berghei ANKA infection. Malar J. 2007;6:32 pubmed
    ..In vitro studies have shown the relevance of CD36 for adhesion phenotypes of Plasmodium falciparum iRBC such as sequestration, platelet mediated clumping and non-..
  5. Pohl J, Ring A, Korkmaz U, Ehehalt R, Stremmel W. FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol Biol Cell. 2005;16:24-31 pubmed
    ..Indeed, subcellular fractionation demonstrated that plasma membrane fatty acid translocase (FAT/CD36) is exclusively located in lipid rafts, whereas intracellular FAT/CD36 cofractionated with DSMs...
  6. Laugerette F, Passilly Degrace P, Patris B, Niot I, Febbraio M, Montmayeur J, et al. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest. 2005;115:3177-84 pubmed
    ..The fatty acid transporter CD36 appears to be a plausible candidate for this function since it has a high affinity for long-chain fatty acids (..
  7. Podrez E, Febbraio M, Sheibani N, Schmitt D, Silverstein R, Hajjar D, et al. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J Clin Invest. 2000;105:1095-108 pubmed
    ..We now identify the scavenger receptor CD36 as the major receptor responsible for high-affinity and saturable cellular recognition of NO(2)-LDL by murine and ..
  8. Chen M, Yang Y, Braunstein E, Georgeson K, Harmon C. Gut expression and regulation of FAT/CD36: possible role in fatty acid transport in rat enterocytes. Am J Physiol Endocrinol Metab. 2001;281:E916-23 pubmed
    b>Fatty acid translocase (FAT)/CD36 is one of several putative plasma membrane long-chain fatty acid (LCFA) transport proteins; however, its role in intestinal absorption of LCFA is unknown...
  9. Li W, Febbraio M, Reddy S, Yu D, Yamamoto M, Silverstein R. CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest. 2010;120:3996-4006 pubmed publisher
    b>CD36 is a membrane glycoprotein expressed on platelets, monocytes, macrophages, and several other cell types that was recently demonstrated to be involved in platelet activation in response to oxidized phospholipids, including oxidized ..

More Information

Publications87

  1. Aitman T, Glazier A, Wallace C, Cooper L, Norsworthy P, Wahid F, et al. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet. 1999;21:76-83 pubmed
    ..and radiation hybrid (RH) mapping to identify a defective SHR gene, Cd36 (also known as Fat, as it encodes fatty acid translocase), at the peak of linkage to these QTLs...
  2. Hoebe K, Georgel P, Rutschmann S, Du X, Mudd S, Crozat K, et al. CD36 is a sensor of diacylglycerides. Nature. 2005;433:523-7 pubmed
    ..Here we show that an N-ethyl-N-nitrosourea-induced nonsense mutation of Cd36 (oblivious) causes a recessive immunodeficiency phenotype in which macrophages are insensitive to the R-enantiomer ..
  3. Luiken J, Coort S, Willems J, Coumans W, Bonen A, Van der Vusse G, et al. Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signaling. Diabetes. 2003;52:1627-34 pubmed
    Contraction of rat cardiac myocytes induces translocation of fatty acid translocase (FAT)/CD36 and GLUT4 from intracellular stores to the sarcolemma, leading to enhanced rates of long-chain fatty acid (FA) and glucose uptake, respectively...
  4. Goudriaan J, Dahlmans V, Teusink B, Ouwens D, Febbraio M, Maassen J, et al. CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. J Lipid Res. 2003;44:2270-7 pubmed
    CD36 (fatty acid translocase) is involved in high-affinity peripheral fatty acid uptake. Mice lacking CD36 exhibit increased plasma free fatty acid and triglyceride (TG) levels and decreased glucose levels...
  5. Yang J, Sambandam N, Han X, Gross R, Courtois M, Kovacs A, et al. CD36 deficiency rescues lipotoxic cardiomyopathy. Circ Res. 2007;100:1208-17 pubmed
    ..We sought to define the role of the long-chain FA transporter CD36 in the pathophysiology of lipotoxic forms of cardiomyopathy...
  6. Cheung L, Andersen M, Gustavsson C, Odeberg J, Fernandez Perez L, Norstedt G, et al. Hormonal and nutritional regulation of alternative CD36 transcripts in rat liver--a role for growth hormone in alternative exon usage. BMC Mol Biol. 2007;8:60 pubmed
    b>CD36 is a multiligand receptor involved in various metabolic pathways, including cellular uptake of long-chain fatty acids. Defect function or expression of CD36 can result in dyslipidemia or insulin resistance...
  7. Kunjathoor V, Febbraio M, Podrez E, Moore K, Andersson L, Koehn S, et al. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem. 2002;277:49982-8 pubmed
    ..The genetic inactivation of either of two SR family members, SR-A or CD36, has been shown previously to reduce oxidized LDL uptake in vitro and atherosclerotic lesions in mice...
  8. Stewart C, Stuart L, Wilkinson K, van Gils J, Deng J, Halle A, et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2010;11:155-61 pubmed publisher
    ..Assembly of this newly identified heterodimer is regulated by signals from the scavenger receptor CD36, a common receptor for these disparate ligands...
  9. Love Gregory L, Sherva R, Sun L, Wasson J, Schappe T, Doria A, et al. Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol. Hum Mol Genet. 2008;17:1695-704 pubmed publisher
    ..Within this region, the CD36 gene, which encodes a membrane receptor for long-chain fatty acids and lipoproteins, is a potentially important ..
  10. van Oort M, van Doorn J, Bonen A, Glatz J, Van der Horst D, Rodenburg K, et al. Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4. Biochim Biophys Acta. 2008;1781:61-71 pubmed publisher
    ..skeletal muscles, insulin regulates the uptake of long-chain fatty acid (LCFA) via the putative LCFA transporter CD36. Biochemical studies propose an insulin-induced translocation of CD36 from intracellular pools to the plasma ..
  11. Chabowski A, Coort S, Calles Escandon J, Tandon N, Glatz J, Luiken J, et al. The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR. FEBS Lett. 2005;579:2428-32 pubmed
    Cellular fatty acid uptake is facilitated by a number of fatty acid transporters, FAT/CD36, FABPpm and FATP1. It had been presumed that FABPpm, was confined to the plasma membrane and was not regulated...
  12. Abumrad N, El Maghrabi M, Amri E, Lopez E, Grimaldi P. Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. J Biol Chem. 1993;268:17665-8 pubmed
    A cDNA for an adipocyte membrane protein, implicated in the transport of long-chain fatty acids, was isolated by screening with a synthetic oligonucleotide derived from the amino terminal sequence of the protein...
  13. Yehualaeshet T, O CONNOR R, Green Johnson J, Mai S, Silverstein R, Murphy Ullrich J, et al. Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36. Am J Pathol. 1999;155:841-51 pubmed
    ..Using immunofluorescence and antibodies to TGF-beta1 and CD36, a receptor for TSP-1, there was colocalization of TGF-beta1 with CD36...
  14. Ståhlberg N, Rico Bautista E, Fisher R, Wu X, Cheung L, Flores Morales A, et al. Female-predominant expression of fatty acid translocase/CD36 in rat and human liver. Endocrinology. 2004;145:1972-9 pubmed
    ..Most notable among the female-predominant transcripts was fatty acid translocase/CD36, with 18-fold higher mRNA levels in the female liver and 4-fold higher mRNA levels in males treated ..
  15. Ouwens D, Diamant M, Fodor M, Habets D, Pelsers M, El Hasnaoui M, et al. Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification. Diabetologia. 2007;50:1938-1948 pubmed publisher
    ..We studied cardiomyocyte substrate uptake and utilisation and the role of the fatty acid translocase CD36 in relation to in vivo cardiac function in rats fed a high-fat diet (HFD)...
  16. Pravenec M, Landa V, Zidek V, Musilova A, Kazdova L, Qi N, et al. Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension. Physiol Res. 2003;52:681-8 pubmed
    Spontaneously hypertensive rats (SHR/NIH strain) harbor a deletion variant in the Cd36 fatty acid transporter and display defective fatty acid metabolism, insulin resistance and hypertension...
  17. Tepavcevic S, Koricanac G, Zakula Z, Milosavljevic T, Stojiljkovic M, Isenovic E. Interaction between insulin and estradiol in regulation of cardiac glucose and free fatty acid transporters. Horm Metab Res. 2011;43:524-30 pubmed publisher
    ..as cardiac plasma membranes (PM) and low density microsomes (LDM) content of glucose (GLUT4 and GLUT1) and FFA (CD36) transporters...
  18. Mirza R, Koh T. Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice. Cytokine. 2011;56:256-64 pubmed publisher
    ..of the pro-inflammatory molecules and increased expression of the alternative activation markers CD206 and CD36. In contrast, in db/db mice, the pro-inflammatory phenotype persisted through day 10 post-injury and was associated ..
  19. Lovegrove F, Gharib S, Pena Castillo L, Patel S, Ruzinski J, Hughes T, et al. Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model. PLoS Pathog. 2008;4:e1000068 pubmed publisher
    ..b>Cd36(-/-) mice, which have decreased parasite lung sequestration, were relatively protected from ALI...
  20. Monks J, Rosner D, Geske F, Lehman L, Hanson L, Neville M, et al. Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release. Cell Death Differ. 2005;12:107-14 pubmed
    ..vitro, utilizing many of the same receptors used by macrophages, including the phosphatidylserine receptor (PSR), CD36, the vitronectin receptor alpha(v)beta3, and CD91...
  21. Yanai H, Chiba H, Morimoto M, Abe K, Fujiwara H, Fuda H, et al. Human CD36 deficiency is associated with elevation in low-density lipoprotein-cholesterol. Am J Med Genet. 2000;93:299-304 pubmed
    To find out whether CD36 plays a role in the human lipoprotein metabolism, we studied lipoprotein profiles in subjects with CD36 deficiency...
  22. Hanawa H, Watanabe K, Nakamura T, Ogawa Y, Toba K, Fuse I, et al. Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency. J Med Genet. 2002;39:286-91 pubmed
  23. Cecil D, Appleton C, Polewski M, Mort J, Schmidt A, Bendele A, et al. The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli. J Immunol. 2009;182:5024-31 pubmed publisher
    ..Hence, we tested the hypothesis that expression of the alternative S100/calgranulin and patterning receptor CD36, identified here as a marker of growth plate chondrocyte hypertrophy, mediates chondrocyte inflammatory and ..
  24. Chabowski A, Coort S, Calles Escandon J, Tandon N, Glatz J, Luiken J, et al. Insulin stimulates fatty acid transport by regulating expression of FAT/CD36 but not FABPpm. Am J Physiol Endocrinol Metab. 2004;287:E781-9 pubmed
    ..of LCFA transport by altering the expression and the subcellular distribution of the fatty acid transporters FAT/CD36 and FABPpm...
  25. Angin Y, Schwenk R, Nergiz Unal R, Hoebers N, Heemskerk J, Kuijpers M, et al. Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake. Am J Physiol Endocrinol Metab. 2014;307:E225-36 pubmed publisher
    ..in cardiomyocytes induces translocation of glucose transporter GLUT4 and long-chain fatty acid (LCFA) transporter CD36 from endosomal stores to the sarcolemma to enhance glucose and LCFA uptake, respectively...
  26. Le Foll C, Dunn Meynell A, Musatov S, Magnan C, Levin B. FAT/CD36: a major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice. Diabetes. 2013;62:2709-16 pubmed publisher
    ..previously found that ~50% of these neurons responded to oleic acid (OA) by using the FA translocator/receptor FAT/CD36 (CD36)...
  27. Kalantari Dehaghi M, Molina D, Farhadieh M, Morrow W, Liang X, Felgner P, et al. New targets of pemphigus vulgaris antibodies identified by protein array technology. Exp Dermatol. 2011;20:154-6 pubmed publisher
    ..05) differentially reactive with 16 antigens, most of which were cell-surface proteins, such as CD2, CD31, CD33, CD36, CD37, CD40, CD54, CD66c and CD84 molecules, nicotinamide/nicotinic acid mononucleotide adenylyltransferase, ..
  28. Salah Uddin H, Gordon M, Ford I, Tandon N, Greaves M, Duttaroy A. Surface expression of fatty acid translocase (FAT/CD36) on platelets in myeloproliferative disorders and non-insulin dependent diabetes mellitus: effect on arachidonic acid uptake. Mol Cell Biochem. 2002;239:203-11 pubmed
    ..The mechanisms of platelet hyperresponsiveness have not been fully explained. Expression of CD36 or fatty acid translocase (FAT) and its role in arachidonic acid (AA) uptake by platelets were examined in subjects with ..
  29. Gaillard D, Laugerette F, Darcel N, El Yassimi A, Passilly Degrace P, Hichami A, et al. The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. FASEB J. 2008;22:1458-68 pubmed
    ..We have recently shown that lingual CD36 contributes to fat preference and early digestive secretions in the mouse...
  30. Susztak K, Ciccone E, McCue P, Sharma K, Bottinger E. Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy. PLoS Med. 2005;2:e45 pubmed
    ..However, mechanisms leading to TED in DNP remain poorly understood. We found that expression of scavenger receptor CD36 coincided with proximal tubular epithelial cell (PTEC) apoptosis and TED specifically in human DNP...
  31. Romić S, Krskova K, Olszanecki R, Balazova L, Lory V, Koricanac G, et al. Obesity- and age-related alterations in FAT/CD36 translocation and lipin-1 subcellular localization in skeletal muscle of the Zucker rats. Gen Physiol Biophys. 2017;36:399-406 pubmed publisher
    ..FA translocase (FAT/CD36) translocation, lipin-1 subcellular localization and nuclear factor kappa B (NF-?B) p65 protein content in ..
  32. Momken I, Chabowski A, Dirkx E, Nabben M, Jain S, McFarlan J, et al. A new leptin-mediated mechanism for stimulating fatty acid oxidation: a pivotal role for sarcolemmal FAT/CD36. Biochem J. 2017;474:149-162 pubmed publisher
    ..and cardiac myocytes, whether leptin, via AMP-activated protein kinase (AMPK) activation, stimulated fatty acid translocase (FAT/CD36)-mediated fatty acid uptake to enhance fatty acid oxidation...
  33. Cai L, Wang Z, Ji A, Meyer J, van der Westhuyzen D. Scavenger receptor CD36 expression contributes to adipose tissue inflammation and cell death in diet-induced obesity. PLoS ONE. 2012;7:e36785 pubmed publisher
    ..The objective of this study was to investigate the role of the scavenger receptor CD36 in high fat diet-induced obesity and adipose tissue inflammation and cell death...
  34. Sheedy F, Grebe A, Rayner K, Kalantari P, Ramkhelawon B, Carpenter S, et al. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol. 2013;14:812-20 pubmed publisher
    ..Here we identify an endocytic pathway mediated by the pattern-recognition receptor CD36 that coordinated the intracellular conversion of those soluble ligands into crystals or fibrils, which resulted in ..
  35. Chen Y, Tsai C, Shen C, Day C, Yeh Y, Chen R, et al. Palmitic acid interferes with energy metabolism balance by adversely switching the SIRT1-CD36-fatty acid pathway to the PKC zeta-GLUT4-glucose pathway in cardiomyoblasts. J Nutr Biochem. 2016;31:137-49 pubmed publisher
    ..Moreover, PA enhances cluster of differentiation 36 (CD36) and reduces glucose transporter type 4 (GLUT4) pathway protein levels following a short period of treatment, but ..
  36. Wang X, Wei J, Pan L, Shi Y, Lin H, Gong H. The Role of CD36 in the Effect of Arginine in Atherosclerotic Rats. Med Sci Monit. 2015;21:1494-9 pubmed publisher
    ..development of atherosclerosis in rats fed a high-fat diet supplemented with arginine and to evaluate the role of CD36 in this process...
  37. Jeppesen J, Albers P, Rose A, Birk J, Schjerling P, Dzamko N, et al. Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent. J Lipid Res. 2011;52:699-711 pubmed publisher
    The aim of this study was to investigate the molecular mechanisms regulating FA translocase CD36 (FAT/CD36) translocation and FA uptake in skeletal muscle during contractions...
  38. Kim E, Tolhurst A, Szeto H, Cho S. Targeting CD36-mediated inflammation reduces acute brain injury in transient, but not permanent, ischemic stroke. CNS Neurosci Ther. 2015;21:385-91 pubmed publisher
    The pathology of stroke consists of multiple pro-death processes, and CD36 has been suggested as a multimodal target to reduce oxidative stress and inflammation in ischemic stroke...
  39. Wang X, Lv L, Chen Y, Chen J. A CD36 synthetic peptide inhibits silica-induced lung fibrosis in the mice. Toxicol Ind Health. 2010;26:47-53 pubmed publisher
    ..b>CD36 is involved in the transformation of latent TGF-beta1 (L-TGF-beta1) to active TGF-beta1...
  40. Carley A, Bi J, Wang X, Banke N, Dyck J, O Donnell J, et al. Multiphasic triacylglycerol dynamics in the intact heart during acute in vivo overexpression of CD36. J Lipid Res. 2013;54:97-106 pubmed publisher
    ..in the intact beating heart, under normal conditions and in response to acute gene expression-induced changes in CD36. Dynamic mode (13)C NMR elucidated multiple kinetic processes in (13)C-palmitate incorporation into TAG: an initial,..
  41. Handberg A, Levin K, Højlund K, Beck Nielsen H. Identification of the oxidized low-density lipoprotein scavenger receptor CD36 in plasma: a novel marker of insulin resistance. Circulation. 2006;114:1169-76 pubmed
    Macrophage CD36 scavenges oxidized low-density lipoprotein, leading to foam cell formation, and appears to be a key proatherogenic molecule...
  42. Flores J, Klebe D, Rolland W, Lekic T, Krafft P, Zhang J. PPARγ-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats. Neurobiol Dis. 2016;87:124-33 pubmed publisher
    ..We evaluated if upregulating CD36 scavenger receptor expression in microglia and macrophages through PPARγ stimulation, which was effective in ..
  43. Nakamura T, Saito Y, Ohyama Y, Uchiyama T, Sumino H, Kurabayashi M. Effect of cerivastatin on endothelial dysfunction and aortic CD36 expression in diabetic hyperlipidemic rats. Hypertens Res. 2004;27:589-98 pubmed
    A mutation of the CD36 gene that encodes a fatty acid transporter has been reported to play a role in insulin resistance in spontaneously hypertensive rat (SHR). Statins reduce circulating cholesterol and triglyceride concentrations...
  44. Deitch E, Condon M, Feketeova E, Machiedo G, Mason L, Vinluan G, et al. Trauma-hemorrhagic shock induces a CD36-dependent RBC endothelial-adhesive phenotype. Crit Care Med. 2014;42:e200-10 pubmed publisher
    ..RBC adhesion to endothelium as well as increasing several putative RBC surface adhesion molecules including CD36. The critical factor leading to RBC-endothelial cell adhesion was increased surface RBC CD36 expression...
  45. Lim H, Lee S, Lee K, Park J, Jang Y, Lee E, et al. PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs. Prostaglandins Other Lipid Mediat. 2006;80:165-74 pubmed
    ..Our results strongly suggest that PPARgamma expression induces CD36 expression and adipocyte differentiation gene activation in the process of atherosclerosis and might be one of the ..
  46. Hu Y, Yeh H, Tsao H, Tai C, Lin Y, Chang S, et al. Impact of circulating monocyte CD36 level on atrial fibrillation and subsequent catheter ablation. Heart Rhythm. 2011;8:650-6 pubmed publisher
    Inflammation, an important mechanism in the pathogenesis of atrial fibrillation (AF), can be regulated by CD36 in monocytes. The purpose of this study was to test the hypothesis that CD36 in monocytes contributes to the pathogenesis of AF...
  47. Hawkes M, Li X, Crockett M, Diassiti A, Finney C, Min oo G, et al. CD36 deficiency attenuates experimental mycobacterial infection. BMC Infect Dis. 2010;10:299 pubmed publisher
    Members of the CD36 scavenger receptor family have been implicated as sensors of microbial products that mediate phagocytosis and inflammation in response to a broad range of pathogens...
  48. Nassir F, Wilson B, Han X, Gross R, Abumrad N. CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J Biol Chem. 2007;282:19493-501 pubmed
    b>CD36, a membrane protein that facilitates fatty acid uptake, is highly expressed in the intestine on the luminal surface of enterocytes...
  49. Fang H, Chen J, Lin S, Wang P, Wang Y, Xiong X, et al. CD36-mediated hematoma absorption following intracerebral hemorrhage: negative regulation by TLR4 signaling. J Immunol. 2014;192:5984-92 pubmed publisher
    ..The present study explored the function and potential mechanism of CD36 in hematoma absorption using in vitro and in vivo ICH models...
  50. Cho K, Kim H, Kamanna V, Vaziri N. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Biochim Biophys Acta. 2010;1800:6-15 pubmed publisher
    ..Present study sought to determine efficacy of niacin supplementation on renal tissue lipid metabolism in CRF...
  51. Bieghs V, Verheyen F, van Gorp P, Hendrikx T, Wouters K, Lutjohann D, et al. Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. PLoS ONE. 2012;7:e34378 pubmed publisher
    ..Recently, we demonstrated that combined deletion of the two main scavenger receptors, CD36 and macrophage scavenger receptor 1 (MSR1), which are important for modified cholesterol-rich lipoprotein uptake, ..
  52. Siddiqi S, Saleem U, Abumrad N, Davidson N, Storch J, Siddiqi S, et al. A novel multiprotein complex is required to generate the prechylomicron transport vesicle from intestinal ER. J Lipid Res. 2010;51:1918-28 pubmed publisher
    ..membrane protein 7 (VAMP7), apolipoprotein B48 (apoB48), liver fatty acid-binding protein (L-FABP), CD36, and the COPII proteins were associated on incubation of the ER with cytosol and ATP...
  53. Lepretre F, Vasseur F, Vaxillaire M, Scherer P, Ali S, Linton K, et al. A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes. Hum Mutat. 2004;24:104 pubmed
    Mutations in CD36 / fatty acid translocase (FAT) gene are responsible for insulin resistance in the rat but contribution to human Type 2 diabetes is unknown...
  54. Campbell S, Tandon N, Woldegiorgis G, Luiken J, Glatz J, Bonen A. A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria. J Biol Chem. 2004;279:36235-41 pubmed
    b>Fatty acid translocase (FAT)/CD36 is a long chain fatty acid transporter present at the plasma membrane, as well as in intracellular pools of skeletal muscle...
  55. Leelahavanichkul A, Bocharov A, Kurlander R, Baranova I, Vishnyakova T, Souza A, et al. Class B scavenger receptor types I and II and CD36 targeting improves sepsis survival and acute outcomes in mice. J Immunol. 2012;188:2749-58 pubmed publisher
    Class B scavenger receptors (SR-Bs), such as SR-BI/II or CD36, bind lipoproteins but also mediate bacterial recognition and phagocytosis...
  56. Krupková M, Sedova L, Liska F, Krenova D, Kren V, Seda O. Pharmacogenetic interaction between dexamethasone and Cd36-deficient segment of spontaneously hypertensive rat chromosome 4 affects triacylglycerol and cholesterol distribution into lipoprotein fractions. Lipids Health Dis. 2010;9:38 pubmed publisher
    ..shr-(il6-cd36)/cub (bn.shr4)...
  57. Pravenec M, Churchill P, Churchill M, Viklicky O, Kazdova L, Aitman T, et al. Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. Nat Genet. 2008;40:952-4 pubmed publisher
    ..with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.
  58. Giunta M, Rigamonti A, Scarpini E, Galimberti D, Bonomo S, Venturelli E, et al. The leukocyte expression of CD36 is low in patients with Alzheimer's disease and mild cognitive impairment. Neurobiol Aging. 2007;28:515-8 pubmed
    b>CD36, a scavenger receptor of class B (SR-B), helps mediate microglial and macrophage response to beta-amyloid fibrils (betaA), and seems to play a key role in the proinflammatory events associated with Alzheimer disease (AD) in many ..
  59. Handberg A, Skjelland M, Michelsen A, Sagen E, Krohg Sørensen K, Russell D, et al. Soluble CD36 in plasma is increased in patients with symptomatic atherosclerotic carotid plaques and is related to plaque instability. Stroke. 2008;39:3092-5 pubmed publisher
    ..Recently, we found that soluble CD36 is increased in plasma from patients with diabetes strongly correlated with insulin resistance...
  60. Thibert V, Bellucci S, Cristofari M, Gluckman E, Legrand C. Increased platelet CD36 constitutes a common marker in myeloproliferative disorders. Br J Haematol. 1995;91:618-24 pubmed
    The distribution of the major platelet membrane glycoproteins (GP), Ib, IX, IIb-IIIa and IV (or CD36), which play important roles as receptors for adhesive molecules in haemostasis and thrombosis, was studied in 34 patients with ..
  61. Parathath S, Connelly M, Rieger R, Klein S, Abumrad N, de la Llera Moya M, et al. Changes in plasma membrane properties and phosphatidylcholine subspecies of insect Sf9 cells due to expression of scavenger receptor class B, type I, and CD36. J Biol Chem. 2004;279:41310-8 pubmed
    ..These activities were diminished or absent upon expression of the related scavenger receptor CD36. Thus, SR-BI has fundamental effects on cholesterol flux and membrane properties that occur in cells of ..
  62. Stefanyk L, Bonen A, Dyck D. Fatty acid transport proteins chronically relocate to the transverse-tubules in muscle from obese Zucker rats but are resistant to further insulin-induced translocation. Metabolism. 2013;62:1296-304 pubmed publisher
    ..Chronic relocation of the FA transport protein FAT/CD36 to the sarcolemma is observed in obese rodents and humans, and correlates with intramuscular lipid accumulation and ..
  63. Neckar J, Silhavy J, Zidek V, Landa V, Mlejnek P, Simakova M, et al. CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis. Physiol Genomics. 2012;44:173-82 pubmed publisher
    CD36 fatty acid translocase plays a key role in supplying heart with its major energy substrate, long-chain fatty acids (FA)...
  64. Liu F, Xie M, Chen D, Li J, Ding W. Effect of V(IV)O(dipic-Cl)(H2O)2 on Lipid Metabolism Disorders in the Liver of STZ-Induced Diabetic Rats. J Diabetes Res. 2013;2013:956737 pubmed publisher
    ..Moreover, the upregulation of fatty acid translocase (FAT/CD36) mRNA (4.0-fold) and protein (8...
  65. Heit B, Kim H, Cosio G, Castaño D, Collins R, Lowell C, et al. Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev Cell. 2013;24:372-83 pubmed publisher
    b>CD36 is a versatile receptor known to play a central role in the development of atherosclerosis, the pathogenesis of malaria, and the removal of apoptotic cells...
  66. Chen M, Yang Y, Loux T, Georgeson K, Harmon C. The role of hyperglycemia in FAT/CD36 expression and function. Pediatr Surg Int. 2006;22:647-54 pubmed
    FAT/CD36 is a long-chain fatty acid transporter and scavenger receptor for oxidized LDL. Defects in FAT/CD36 have been linked to the hypertriglyceridemia and insulin resistance...
  67. Yufu Y, Ideguchi H, Narishige T, Suematsu E, Toyoda K, Nishimura J, et al. Familial macrothrombocytopenia associated with decreased glycosylation of platelet membrane glycoprotein IV. Am J Hematol. 1990;33:271-3 pubmed
    ..Studies on the platelets from the propositus showed decreased glycosylation of platelet membrane glycoprotein IV, which would distinguish the case from other FM previously described. ..
  68. Gandhi R, Takahashi M, Virtanen C, Syed K, Davey J, Mahomed N. Microarray analysis of the infrapatellar fat pad in knee osteoarthritis: relationship with joint inflammation. J Rheumatol. 2011;38:1966-72 pubmed publisher
    ..proliferator-activated receptor-? (PPAR-?), diacylglycerol acyltransferase 2 (DGAT2), cluster of differentiation (CD36), and thyroid hormone responsive spot (THRSP) in the severe OA fat pads as compared to the controls...
  69. Laudien M, Hasler R, Wohlers J, Bock J, Lipinski S, Bremer L, et al. Molecular signatures of a disturbed nasal barrier function in the primary tissue of Wegener's granulomatosis. Mucosal Immunol. 2011;4:564-73 pubmed publisher
    ..1, NOD-like receptor C3: -2.1, scavenger receptor CD36: +2.9), and cytokines (interferon-?: -14, transforming growth factor-? 1: -1.4, interleukin-17D: -2.7)...
  70. Lee T, Lin C, Tsai J, Wu Y, Su K, Lu K, et al. Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages. Life Sci. 2009;84:97-104 pubmed publisher
    ..In macrophages, lipid uptake is regulated by scavenger receptors (SR-A and CD36), while the cholesterol efflux is regulated by SR-BI, ATP-binding cassette transporter-A1 (ABCA1) and ABCG1...
  71. Tran T, Poirier H, Clément L, Nassir F, Pelsers M, Petit V, et al. Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. J Biol Chem. 2011;286:25201-10 pubmed publisher
    The membrane glycoprotein CD36 binds nanomolar concentrations of long chain fatty acids (LCFA) and is highly expressed on the luminal surface of enterocytes. CD36 deficiency reduces chylomicron production through unknown mechanisms...
  72. Kalinowska A, Gorski J, Harasim E, Harasiuk D, Bonen A, Chabowski A. Differential effects of chronic, in vivo, PPAR's stimulation on the myocardial subcellular redistribution of FAT/CD36 and FABPpm. FEBS Lett. 2009;583:2527-34 pubmed publisher
    ..that the activation of either PPARalpha (WY 14643) or PPARbeta (GW0742) each induce the translocation of FAT/CD36 from an intracellular pool(s) to the plasma membrane, while PPARbeta also induces the subcellular redistribution of ..
  73. Teupser D, Mueller M, Koglin J, Wilfert W, Ernst J, von Scheidt W, et al. CD36 mRNA expression is increased in CD14+ monocytes of patients with coronary heart disease. Clin Exp Pharmacol Physiol. 2008;35:552-6 pubmed
    ..scavenger receptor class B member 1 (SRB1), lectin-like oxidized low-density lipoprotein (LDL) receptor 1 (LOX1), CD36, LDL receptor (LDLR)), reverse cholesterol transport (apolipoprotein E (ApoE), ATP-binding cassette sub-family A ..
  74. Chen Y, Wang X, Weng D, Tao S, Lv L, Chen J. A TSP-1 functional fragment inhibits activation of latent transforming growth factor-beta1 derived from rat alveolar macrophage after bleomycin treatment. Exp Toxicol Pathol. 2009;61:67-73 pubmed publisher
    ..to the activation of L (latent)-TGF-beta1 by virtue of an association of the TSP-1/L-TGF-beta1 complex with CD36, involving the sequence CSVTCG of the TSP-1 functional fragment...
  75. Rock G, Clark W, Sternbach M, Kolajova M, McLaine P. Haemolytic uraemic syndrome is an immune-mediated disease: role of anti-CD36 antibodies. Br J Haematol. 2005;131:247-52 pubmed
    ..in a protein blot and all samples showed reactivity against a band at 88 kDa, corresponding to the membrane antigen CD36. This was confirmed by probing with Mo91, a monoclonal antibody to CD36...
  76. Vaswani K, Hum M, Chan H, Ryan J, Wood Bradley R, Nitert M, et al. The effect of gestational age on angiogenic gene expression in the rat placenta. PLoS ONE. 2013;8:e83762 pubmed publisher
    ..Five genes (4 up regulated: Cd36, Mmp14, Rhob and Angpt4 and 1 down regulated: Foxm1) involved in angiogenesis and blood vessel morphogenesis were ..
  77. Chorner Z, Barbeau P, Castellani L, Wright D, Chabowski A, Holloway G. Dietary α-linolenic acid supplementation alters skeletal muscle plasma membrane lipid composition, sarcolemmal FAT/CD36 abundance, and palmitate transport rates. Am J Physiol Regul Integr Comp Physiol. 2016;311:R1234-R1242 pubmed publisher
    ..These changes coincided with increased sarcolemmal palmitate transport rates (+20%), plasma membrane fatty acid translocase (FAT/CD36; +20%) abundance, skeletal muscle triacylglycerol content (approximately twofold), and rates of ..
  78. Douglas Braymer H, Zachary H, Schreiber A, Primeaux S. Lingual CD36 and nutritional status differentially regulate fat preference in obesity-prone and obesity-resistant rats. Physiol Behav. 2017;174:120-127 pubmed publisher
    Lingual fatty acid receptors (i.e. CD36) mediate the orosensory perception of fat/fatty acids and may contribute to the susceptibility to develop obesity...