Gene Symbol: Cd226
Description: CD226 molecule
Alias: CD226 antigen
Tahara Hanaoka S, Miyamoto A, Hara A, Honda S, Shibuya K, Shibuya A. Identification and characterization of murine DNAM-1 (CD226) and its poliovirus receptor family ligands. Biochem Biophys Res Commun. 2005;329:996-1000 pubmed
The leukocyte adhesion molecule DNAM-1 (CD226) is a member of the immunoglobulin superfamily and constitutively expressed on the majority of CD4+ and CD8+ T lymphocytes, natural killer (NK) cells, monocytes/macrophages, and a subset of B ..
Liu C, Wang G, Liu H, Li Y, Li J, Dai Y, et al
. CD226 Gly307Ser association with neuromyelitis optica in Southern Han Chinese. Can J Neurol Sci. 2012;39:488-90 pubmed
..There has been more evidence that a non-synonymous exchange (rs763361/Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including multiple sclerosis (MS)...
Chan C, Martinet L, Gilfillan S, Souza Fonseca Guimaraes F, Chow M, Town L, et al
. The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions. Nat Immunol. 2014;15:431-8 pubmed publisher
CD96, CD226 (DNAM-1) and TIGIT belong to an emerging family of receptors that interact with nectin and nectin-like proteins. CD226 activates natural killer (NK) cell-mediated cytotoxicity, whereas TIGIT reportedly counterbalances CD226...
Pende D, Castriconi R, Romagnani P, Spaggiari G, Marcenaro S, Dondero A, et al
. Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction. Blood. 2006;107:2030-6 pubmed
Bachelet I, Munitz A, Mankutad D, Levi Schaffer F. Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 2006;281:27190-6 pubmed
..Here, we show that human mast cells and eosinophils express DNAX accessory molecule 1 (DNAM-1, CD226) and its ligand Nectin-2 (CD112)...
Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, et al
. Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J Exp Med. 2003;198:557-67 pubmed
..PVR-Fc and Nectin-2-Fc soluble hybrid molecules brightly stained COS-7 cells transfected with the DNAM-1 (CD226) construct, thus providing direct evidence that both PVR and Nectin-2 represent specific ligands for the DNAM-1 ..
Dong Z, Cruz Munoz M, Zhong M, Chen R, Latour S, Veillette A. Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells. Nat Immunol. 2009;10:973-80 pubmed publisher
..Hence, the SAP family is essential for the elimination of unwanted hematopoietic cells by NK cells. ..
Zhu Y, Paniccia A, Schulick A, Chen W, Koenig M, Byers J, et al
. Identification of CD112R as a novel checkpoint for human T cells. J Exp Med. 2016;213:167-76 pubmed publisher
T cell immunoglobulin and ITIM domain (TIGIT) and CD226 emerge as a novel T cell cosignaling pathway in which CD226 and TIGIT serve as costimulatory and coinhibitory receptors, respectively, for the ligands CD155 and CD112...