Cd14

Summary

Gene Symbol: Cd14
Description: CD14 molecule
Alias: monocyte differentiation antigen CD14, CD14 antigen, myeloid cell-specific leucine-rich glycoprotein
Species: rat
Products:     Cd14

Top Publications

  1. Dessing M, Knapp S, Florquin S, de Vos A, van der Poll T. CD14 facilitates invasive respiratory tract infection by Streptococcus pneumoniae. Am J Respir Crit Care Med. 2007;175:604-11 pubmed
    b>CD14 is a pattern recognition receptor that can interact with a variety of bacterial ligands...
  2. Liu S, Khemlani L, Shapiro R, Johnson M, Liu K, Geller D, et al. Expression of CD14 by hepatocytes: upregulation by cytokines during endotoxemia. Infect Immun. 1998;66:5089-98 pubmed
    Studies were undertaken to examine hepatocyte CD14 expression during endotoxemia. Our results show that lipopolysaccharide (LPS) treatment in vivo caused a marked upregulation in CD14 mRNA and protein levels in rat hepatocytes...
  3. Liu S, Shapiro R, Nie S, Zhu D, Vodovotz Y, Billiar T. Characterization of rat CD14 promoter and its regulation by transcription factors AP1 and Sp family proteins in hepatocytes. Gene. 2000;250:137-47 pubmed
    b>CD14, a 55kDa glycoprotein, serves as a lipopolysaccharide (LPS) recognition molecule...
  4. Chou M, Chuang J, Eng H, Chen C, Wang C, Chen C, et al. Endotoxin and CD14 in the progression of biliary atresia. J Transl Med. 2010;8:138 pubmed publisher
    ..The aim of this study was to investigate endotoxin levels in patients with BA and the relation of these levels with the expression of the endotoxin receptor, CD14.
  5. Chmielinska J, Tejero Taldo M, Mak I, Weglicki W. Intestinal and cardiac inflammatory response shows enhanced endotoxin receptor (CD14) expression in magnesium deficiency. Mol Cell Biochem. 2005;278:53-7 pubmed
    ..Immunohistochemical staining for endotoxin (lipopolysaccaride, LPS) receptor, CD14 was prominent in macrophage-type cells in intestinal tissue; more importantly, cardiac tissue revealed both CD11b (..
  6. Zhang C, Hou B. [Expression of lipopolysaccharide receptors CD14 and TLR4 in a model of rat molar apical periodontitis]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2007;42:148-9 pubmed
    To characterize the expression of lipopolysaccharide (LPS) receptors-CD14 and TLR4 in rat peri-radicular tissue and to investigate the signal transduction pathway of LPS and its receptors in periapical periodontitis...
  7. Yang L, Zhao Z, Zhao Y, Liu Z, Niu C, Zhang J. [Role of endotoxin translocation on mesenteric lymph reperfusion aggravating multiple organ injury in SMAO shock rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012;28:74-8 pubmed
    ..tachypleus amebocyte lysate, the contents of lipopolysaccharide-binding protein (LBP), lipopolysaccharide receptor (CD14) and tumor necrosis factor-alpha (TNF-alpha) in homogenates were determined with enzyme-linked immunosorbent assay ..
  8. Kitazawa T, Tsujimoto T, Kawaratani H, Fujimoto M, Fukui H. Expression of Toll-like receptor 4 in various organs in rats with D-galactosamine-induced acute hepatic failure. J Gastroenterol Hepatol. 2008;23:e494-8 pubmed
    ..a transmembrane protein Toll-like receptor 4 (TLR4), which recognizes endotoxin (lipopolysaccharide; LPS) or LPS-CD14 complex and mediates macrophage activation and pro-inflammatory cytokine release...
  9. Qu C, Guo S, Guo H, Wang C, Ma L, He Y, et al. Increased serum endotoxin and elevated CD14 and IL-1beta expression in a rat model of cerebrogenic multiple organ dysfunction syndrome. Med Chem. 2009;5:462-7 pubmed
    ..dysfunction syndrome (CMODS) through investigation of endotoxin levels and the expression of endotoxin receptor CD14 and interleukin IL-1beta mRNAs in a rat CMODS model...

More Information

Publications78

  1. Inoue Y, Shimojo N, Suzuki Y, Campos Alberto E, Yamaide A, Suzuki S, et al. CD14 -550 C/T, which is related to the serum level of soluble CD14, is associated with the development of respiratory syncytial virus bronchiolitis in the Japanese population. J Infect Dis. 2007;195:1618-24 pubmed
    The contribution that genetic polymorphisms of Toll-like receptor (TLR) 4 and of CD14--both of which recognize respiratory syncytial virus (RSV) in the innate immune response--make to RSV bronchiolitis in the Japanese population has not ..
  2. Smit L, Siroux V, Bouzigon E, Oryszczyn M, Lathrop M, Demenais F, et al. CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. Am J Respir Crit Care Med. 2009;179:363-8 pubmed publisher
    ..To study whether single nucleotide polymorphisms (SNPs) in CD14 and Toll-like receptor (TLR) 2, TLR4 and TLR9 genes are associated with asthma in adults, and whether these SNPs ..
  3. Schröder N, Heine H, Alexander C, Manukyan M, Eckert J, Hamann L, et al. Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses. J Immunol. 2004;173:2683-91 pubmed
    ..It was first described to bind LPS of Gram-negative bacteria and transfer it via a CD14-enhanced mechanism to a receptor complex including TLR-4 and MD-2, initiating a signal transduction cascade leading ..
  4. Chan K, Wong K, Luk J. Role of LPS/CD14/TLR4-mediated inflammation in necrotizing enterocolitis: pathogenesis and therapeutic implications. World J Gastroenterol. 2009;15:4745-52 pubmed
    To establish the roles of lipopolysaccharide (LPS)/CD14/toll-like receptor 4 (TLR4)-mediated inflammation in a rat model of human necrotizing enterocolitis (NEC)...
  5. Haziot A, Chen S, Ferrero E, Low M, Silber R, Goyert S. The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage. J Immunol. 1988;141:547-52 pubmed
    b>CD14 is a myeloid differentiation Ag expressed primarily on peripheral blood monocytes and macrophages. Although its function is unknown, the CD14 gene maps to a region encoding several myeloid growth factors and receptors...
  6. da Silveira Cruz Machado S, Carvalho Sousa C, Tamura E, Pinato L, Cecon E, Fernandes P, et al. TLR4 and CD14 receptors expressed in rat pineal gland trigger NFKB pathway. J Pineal Res. 2010;49:183-92 pubmed publisher
    ..Here, we show that pineal glands possess both CD14 and toll-like receptor 4 (TLR4), membrane proteins that bind LPS and trigger the NFKB pathway...
  7. Fang H, Liu A, Dirsch O, Sun J, Jin H, Lu M, et al. Serum LBP levels reflect the impaired synthetic capacity of the remnant liver after partial hepatectomy in rats. J Immunol Methods. 2012;382:68-75 pubmed publisher
    ..Our results speak against using LBP as diagnostic marker of the acute phase response after liver resection as its elevation is related to the size and thereby the synthetic capacity of the small remnant liver. ..
  8. Triantafilou M, Gamper F, Haston R, Mouratis M, Morath S, Hartung T, et al. Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J Biol Chem. 2006;281:31002-11 pubmed
    ..This localization and targeting is ligand-specific. Activation occurs at the cell surface, and the observed trafficking is independent of signaling. ..
  9. Tanimura N, Saitoh S, Ohto U, Akashi Takamura S, Fujimoto Y, Fukase K, et al. The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane. Int Immunol. 2014;26:307-14 pubmed publisher
    ..senses lipid A, activating the MyD88-signaling pathway on the plasma membrane and the TRIF-signaling pathway after CD14-mediated TLR4/MD-2 internalization into endosomes...
  10. Zhang G, Khoo S, Laatikainen T, Pekkarinen P, Vartiainen E, von Hertzen L, et al. Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy. Allergy. 2009;64:1333-41 pubmed publisher
    ..We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women...
  11. Choi H, Lee K. CD14 glycoprotein expressed in vascular smooth muscle cells. J Pharmacol Sci. 2004;95:65-70 pubmed
    ..Western blottings and immunoreaction for iNOS, nuclear factor kappaB (NFkappaB) p65, and CD14 protein were performed. mRNAs of iNOS and tumor necrosis factor (TNF) alpha were analyzed by RT-PCR...
  12. Deininger M, Meyermann R, Schluesener H. Expression and release of CD14 in astrocytic brain tumors. Acta Neuropathol. 2003;106:271-7 pubmed
    b>CD14 is a membrane-bound lipopolysaccharide receptor or, lacking the glycosylphosphatidylinositol anchor, is secreted to modulate cellular and humoral immune response by interacting directly with T and B cells...
  13. Kawaratani H, Tsujimoto T, Kitazawa T, Kitade M, Yoshiji H, Uemura M, et al. Innate immune reactivity of the liver in rats fed a choline-deficient L-amino-acid-defined diet. World J Gastroenterol. 2008;14:6655-61 pubmed
    ..the innate immune reactivity of tumor necrosis factor-alpha (TNF-alpha), Toll-like receptor 4 (TLR4), and CD14 in the liver of non-alcoholic steatohepatitis (NASH) model rats...
  14. Shinzawa M, Yamamoto R, Nagasawa Y, Shoji T, Obi Y, Namba T, et al. Gene polymorphisms contributing to hypertension in immunoglobulin A nephropathy. Clin Exp Nephrol. 2012;16:250-8 pubmed publisher
    ..Baseline characteristics: hypertension 36.3%. Among 28 polymorphisms, the Chi-squared test revealed that CD14 (-159CC vs CT/TT, P = 0.03) and ACE (DD vs DI/II, P = 0...
  15. Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone J, Herold K, et al. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest. 2006;116:1371-81 pubmed
    ..Since Tregs act site-specifically, this strategy should also be expected to reduce the potential for systemic side effects. ..
  16. Gong J, Dai L, Liu C, Wu C, Shi Y, Li S, et al. Expression of CD14 protein and its gene in liver sinusoidal endothelial cells during endotoxemia. World J Gastroenterol. 2002;8:551-4 pubmed
    To observe expression of CD14 protein and CD14 gene in rat liver sinusoidal endothelial cells (LSECs) during endotoxemia, and the role of CD14 protein in the activation of lipopolysaccharide (LPS)-induced LSECs...
  17. Leong J, Zhou M, Jacob A, Wang P. Aging-related hyperinflammation in endotoxemia is mediated by the alpha2A-adrenoceptor and CD14/TLR4 pathways. Life Sci. 2010;86:740-6 pubmed publisher
    ..Splenic tissues were harvested and mRNA and protein were extracted. The protein expression of CD14 and TLR4, key mediators of LPS in the innate response, as well as alpha-2A adrenergic receptor (alpha(2A)-AR) and ..
  18. Zhou J, Ouyang X, Cui X, Schoeb T, Smythies L, Johnson M, et al. Renal CD14 expression correlates with the progression of cystic kidney disease. Kidney Int. 2010;78:550-60 pubmed publisher
    ..We show here that one of these markers, CD14, is abnormally transcribed, activated and shed in cystic kidneys...
  19. Luan X, Liu Y, Li M. The role of CD14 and Toll-like receptor 4 of Kupffer cells in hepatic ischemia-reperfusion injury in rats. Transplant Proc. 2012;44:937-41 pubmed publisher
    The objective of this study was to study the role of CD14 and Toll-like receptor 4 (TLR4) in Kupffer cells (KCs) on ischemia reperfusion injury (IRI) in rat liver grafts.
  20. Kuronuma K, Mitsuzawa H, Takeda K, Nishitani C, Chan E, Kuroki Y, et al. Anionic pulmonary surfactant phospholipids inhibit inflammatory responses from alveolar macrophages and U937 cells by binding the lipopolysaccharide-interacting proteins CD14 and MD-2. J Biol Chem. 2009;284:25488-500 pubmed publisher
    ..interactions between the palmitoyl-oleoyl-phosphatidylglycerol and the Toll-like receptor 4-interacting proteins CD14 and MD-2...
  21. Suzuki T, Won K, Horiguchi K, Kinoshita K, Hori M, Torihashi S, et al. Muscularis inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null rat. Am J Physiol Gastrointest Liver Physiol. 2004;287:G638-46 pubmed
    ..Expression of IL-1beta and IL-6 mRNA was also significantly increased, and the level of CD14 (LPS receptors) were increased significantly in the tunica muscularis...
  22. Zanoni I, Ostuni R, Marek L, Barresi S, Barbalat R, Barton G, et al. CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell. 2011;147:868-80 pubmed publisher
    ..Here, we report that the plasma membrane localized Pattern Recognition Receptor (PRR) CD14 is required for the microbe-induced endocytosis of TLR4...
  23. Park S, Kim N, Jung J, Lee C, Han S, Kim Y. Myeloid differentiation 2 as a therapeutic target of inflammatory disorders. Pharmacol Ther. 2012;133:291-8 pubmed publisher
  24. Rosas Taraco A, Revol A, Salinas Carmona M, Rendon A, Caballero Olin G, Arce Mendoza A. CD14 C(-159)T polymorphism is a risk factor for development of pulmonary tuberculosis. J Infect Dis. 2007;196:1698-706 pubmed
    Neither the expression of CD14 and Toll-like receptor 4 (TLR4) on monocytes' surface nor the mutations CD14 -159TT and TLR4 Asp299Gly have yet been evaluated as risk factors for development of pulmonary tuberculosis (TB) in the Mexican ..
  25. Tsai C, Yeh C, Sheen Chen S, Huang C, Liu Y, Huang C, et al. The kinetic expression of lipopolysaccharide-binding protein and CD14 gene in obstructive jaundice. J Invest Surg. 2015;28:18-23 pubmed publisher
    Binding lipopolysaccharide (LPS) with high-affinity, lipopolysaccharide-binding protein (LBP) and CD14 lower the threshold stimulatory concentrations of LPS dramatically and enhance the rate of cytokine production markedly...
  26. Zang Q, Maass D, Wigginton J, Barber R, Martinez B, Idris A, et al. Burn serum causes a CD14-dependent mitochondrial damage in primary cardiomyocytes. Am J Physiol Heart Circ Physiol. 2010;298:H1951-8 pubmed publisher
    ..Remarkably, the increase in mtROS was abolished by an antibody-mediated blockade of CD14. Furthermore, burn injury-induced mitochondrial damage in cardiomyocytes was prevented in CD14 knockout mice...
  27. Hohda S, Kimura A, Sasaoka T, Hayashi T, Ueda K, Yasunami M, et al. Association study of CD14 polymorphism with myocardial infarction in a Japanese population. Jpn Heart J. 2003;44:613-22 pubmed
    ..and found that there is a significant association of MI with the polymorphisms in the genes for E-selectin and CD14 receptor...
  28. Patino R, Ibarra J, Rodriguez A, Yagüe M, Pintor E, Fernandez Cruz A, et al. Circulating monocytes in patients with diabetes mellitus, arterial disease, and increased CD14 expression. Am J Cardiol. 2000;85:1288-91 pubmed
    ..There was no significant difference in the numbers of the CD14+/CD16+ monocyte subpopulations between the 3 groups...
  29. Losito A, Kalidas K, Santoni S, Errico R, Jeffery S. Association of the -159C/T polymorphism of the endotoxin receptor (CD14) with carotid artery disease and cardiovascular mortality in dialysis patients. Blood Purif. 2005;23:128-33 pubmed
    ..Endotoxin is mainly cleared from plasma by the sCD14, the soluble form of the endotoxin receptor CD14. The levels of sCD14 are associated with a polymorphism, -159 C/T, of the CD14 gene...
  30. Marcos V, Latzin P, Hector A, Sonanini S, Hoffmann F, Lacher M, et al. Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases. Respir Res. 2010;11:32 pubmed publisher
    ..Bacterial lipopolysaccharide (LPS) is recognized via Toll-like receptors and CD14. CD14 exists as a soluble (sCD14) and membrane-associated (mCD14) protein, present on the surface of leukocytes...
  31. Takai N, Kataoka M, Higuchi Y, Matsuura K, Yamamoto S. Primary structure of rat CD14 and characteristics of rat CD14, cytokine, and NO synthase mRNA expression in mononuclear phagocyte system cells in response to LPS. J Leukoc Biol. 1997;61:736-44 pubmed
    Rat CD14 cDNA clones were isolated. The predicted protein sequence exhibits 82, 61.6, and 64% identity with the mouse, rabbit, and human CD14, respectively...
  32. Dai L, Gong J, Zuo G, Wu C, Shi Y, Li X, et al. Synthesis of endotoxin receptor CD14 protein in Kupffer cells and its role in alcohol-induced liver disease. World J Gastroenterol. 2003;9:622-6 pubmed
    To observe the synthesis of endotoxin receptor CD14 protein and its mRNA expression in Kupffer cells (KCs), and evaluate the role of CD14 in the pathogenesis of liver injury in rats with alcohol-induced liver disease (ALD)...
  33. Han D, She W, Zhang L. Association of the CD14 gene polymorphism C-159T with allergic rhinitis. Am J Rhinol Allergy. 2010;24:e1-3 pubmed publisher
    Altered expression of the cluster differentiation antigen, CD14, may affect the proportion of T-helper type 1 (Th1) to Th2 cells, thereby influencing the immunoglobulin E (IgE) response and associated inflammatory phenotype in allergic ..
  34. Faria E, Faria I, Ribeiro J, Ribeiro A, Hessel G, Bertuzzo C. Association of MBL2, TGF-beta1 and CD14 gene polymorphisms with lung disease severity in cystic fibrosis. J Bras Pneumol. 2009;35:334-42 pubmed
    To identify associations between genetic polymorphisms (in the MBL2, TGF-beta1 and CD14 genes) and the severity of the lung disease in patients with cystic fibrosis (CF), as well as between the presence of DeltaF508 alleles and lung ..
  35. Kedda M, Lose F, Duffy D, Bell E, Thompson P, Upham J. The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population. Thorax. 2005;60:211-4 pubmed
    b>CD14 functions as a multifunctional receptor for bacterial cell wall components including endotoxin and lipopolysaccharide and is likely to play a role in the polarisation of T lymphocytes into Th1 and Th2 subsets, thereby influencing the ..
  36. Nicola J, Vélez M, Lucero A, Fozzatti L, Pellizas C, Masini Repiso A. Functional toll-like receptor 4 conferring lipopolysaccharide responsiveness is expressed in thyroid cells. Endocrinology. 2009;150:500-8 pubmed publisher
    ..LPS is mainly recognized by the Toll-like receptor (TLR) 4/MD2/Cluster of differentiation 14 complex (CD14)...
  37. Markus H, Labrum R, Bevan S, Reindl M, Egger G, Wiedermann C, et al. Genetic and acquired inflammatory conditions are synergistically associated with early carotid atherosclerosis. Stroke. 2006;37:2253-9 pubmed
    ..This may help to explain the substantial variability of disease expression in subjects with proinflammatory risk factors such as smoking, diabetes and chronic infection. ..
  38. Dezsofi A, Szebeni B, Hermann C, Kapitany A, Veres G, Sipka S, et al. Frequencies of genetic polymorphisms of TLR4 and CD14 and of HLA-DQ genotypes in children with celiac disease, type 1 diabetes mellitus, or both. J Pediatr Gastroenterol Nutr. 2008;47:283-7 pubmed publisher
    ..T1DM) frequently coexist because of a common genetic predisposition, our aim was to study the frequency of CD14 C-260T and TLR4 A+896G single nucleotide polymorphisms (SNPs) and the distribution of HLA-DQ genotypes in children ..
  39. Nadeau S, Rivest S. Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia. J Neurosci. 2000;20:3456-68 pubmed
    Systemic injection of the endotoxin lipopolysaccharide (LPS) upregulates the gene encoding CD14 early in the circumventricular organs (CVOs) and later in the brain parenchyma...
  40. Nadeau S, Rivest S. Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14. J Immunol. 2002;169:3370-81 pubmed
    ..of NF-kappaB signaling events and transcriptional activation of genes that encode TNF-alpha and the LPS receptor CD14. The present study investigated whether circulating LPS has the ability to modulate the cerebral innate immune ..
  41. Zambelli Weiner A, Ehrlich E, Stockton M, Grant A, Zhang S, Levett P, et al. Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study. J Allergy Clin Immunol. 2005;115:1203-9 pubmed
    Both a functional promoter polymorphism in the gene encoding CD14 (C-260T) and exposure to endotoxin are believed to play key roles in modulating the immune response and expression of atopic disease...
  42. Gekara N, Weiss S. Lipid rafts clustering and signalling by listeriolysin O. Biochem Soc Trans. 2004;32:712-4 pubmed
    ..By immunofluorescence microscopy, we show that the glycosylphosphatidylinositol-anchored proteins CD14 and CD24, which normally exhibit uniform distribution on J774 cells, undergo clustering upon treatment with LLO...
  43. Zhang Z, Zhang Z, Schluesener H. Toll-like receptor-2, CD14 and heat-shock protein 70 in inflammatory lesions of rat experimental autoimmune neuritis. Neuroscience. 2009;159:136-42 pubmed publisher
    ..In this study, we examined the spatiotemporal expressions of TLR2, CD14 and Hsp70 in EAN rats using immunohistochemistry and RT-PCR...
  44. Morrissey J, Guo G, McCracken R, Tolley T, Klahr S. Induction of CD14 in tubular epithelial cells during kidney disease. J Am Soc Nephrol. 2000;11:1681-90 pubmed
    ..of gene expression in a mouse model of unilateral ureteral obstruction (UUO) revealed significant induction of CD14 mRNA in kidneys with obstructed ureters...
  45. Feng J, Shi J, Liu Y. The effect of lipopolysaccharides on the expression of CD14 and TLR4 in rat Kupffer cells. Hepatobiliary Pancreat Dis Int. 2003;2:265-9 pubmed
    To assess the effect of lipopolysaccharides (LPS) on the expression of CD14 and TLR4 in rat Kupffer cells (KCs)...
  46. Zhang W, Wang F, Wang B, Zhang J, Yu J. Intraarticular gene delivery of CTLA4-FasL suppresses experimental arthritis. Int Immunol. 2012;24:379-88 pubmed publisher
    ..Our results indicate that rAAV.CTLA4-FasL profoundly suppressed experimental model of RA, implicating the potential therapeutic applications for suppression of RA by local joint delivery of CTLA4-FasL. ..
  47. Grigoryev D, Liu M, Hassoun H, Cheadle C, Barnes K, Rabb H. The local and systemic inflammatory transcriptome after acute kidney injury. J Am Soc Nephrol. 2008;19:547-58 pubmed publisher
    ..transcriptome (109 genes) of both organs changed with marked similarity, including the innate immunity genes Cd14, Socs3, Saa3, Lcn2, and Il1r2...
  48. Fridlender Z, Schwartz A, Kohan M, Amir G, Glazer M, Berkman N. Association between CD14 gene polymorphisms and disease phenotype in sarcoidosis. Respir Med. 2010;104:1336-43 pubmed publisher
    ..An association between sarcoidosis and the protein "CD14", a molecule that is part of the lipopolysaccharide (LPS) cell surface receptor complex, has been suggested...
  49. Yoon H, Shin J, Yang S, Chae D, Kim H, Lee D, et al. Association of the CD14 gene -159C polymorphism with progression of IgA nephropathy. J Med Genet. 2003;40:104-8 pubmed
    ..It has been suggested that CD14 signalling in response to various microbes affects the natural history of chronic inflammatory conditions...
  50. Fang W, Yao Y, Shi Z, Yu Y, Wu Y, Lu L, et al. [Gene expression of lipopolysaccharide receptor CD14 and tumor necrosis factor-alpha in rats after thermal injury]. Zhonghua Wai Ke Za Zhi. 1999;37:271-3 pubmed
    To investigate changes in lipopolysaccharide receptor CD14 and tumor necrosis factor-alpha (TNF-alpha) gene expression in vital organs, and their significance in the pathogenesis of systemic inflammation after burns...
  51. Fang C, Yao Y, Shi Z, Yu Y, Wu Y, Lu L, et al. Lipopolysaccharide-binding protein and lipopolysaccharide receptor CD14 gene expression after thermal injury and its potential mechanism(s). J Trauma. 2002;53:957-67 pubmed
    We hypothesized that lipopolysaccharide-binding protein (LBP) and lipopolysaccharide receptor CD14 would present a pair of key molecules in pathophysiologic alterations induced by low concentrations of endotoxin after trauma...
  52. Lukkari T, Järveläinen H, Oinonen T, Kettunen E, Lindros K. Short-term ethanol exposure increases the expression of Kupffer cell CD14 receptor and lipopolysaccharide binding protein in rat liver. Alcohol Alcohol. 1999;34:311-9 pubmed
    ..endotoxins (lipopolysaccharide, LPS) complexed to LPS-binding protein (LBP) activate liver Kupffer cells via their CD14 receptor. Pro-inflammatory cytokines are released and this is postulated to promote liver injury...
  53. Haziot A, Ferrero E, Kontgen F, Hijiya N, Yamamoto S, Silver J, et al. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity. 1996;4:407-14 pubmed
    ..b>CD14, a GPI-anchored glycoprotein expressed strongly by monocyte/macrophages, is one of several receptors for endotoxin/..
  54. Blandino P, Barnum C, Solomon L, Larish Y, Lankow B, Deak T. Gene expression changes in the hypothalamus provide evidence for regionally-selective changes in IL-1 and microglial markers after acute stress. Brain Behav Immun. 2009;23:958-68 pubmed publisher
    ..At the level of the hypothalamus, mRNA for IL-1 and CD14 were significantly increased, while at the same time CD200R mRNA was significantly decreased...
  55. Lachheb J, Dhifallah I, Chelbi H, Hamzaoui K, Hamzaoui A. Toll-like receptors and CD14 genes polymorphisms and susceptibility to asthma in Tunisian children. Tissue Antigens. 2008;71:417-25 pubmed publisher
    Many studies have shown the implication of CD14 and toll-like receptors (TLRs) 2, 4 and 9 in the pathogenesis of asthma or atopy...
  56. Edelman D, Jiang Y, Tyburski J, Wilson R, Steffes C. Toll-like receptor-4 message is up-regulated in lipopolysaccharide-exposed rat lung pericytes. J Surg Res. 2006;134:22-7 pubmed
    ..Pericyte TLR-4 recognition of LPS could play a role in capillary leak seen in sepsis. These data also demonstrates that pericytes, once thought to be passive participants in the inflammatory cascade, may be active members. ..
  57. Hayashi T, Kishiwada M, Fujii K, Yuasa H, Nishioka J, Ido M, et al. Lipopolysaccharide-induced decreased protein S expression in liver cells is mediated by MEK/ERK signaling and NFkappaB activation: involvement of membrane-bound CD14 and toll-like receptor-4. J Thromb Haemost. 2006;4:1763-73 pubmed
    ..LPS increased CD14 in hepatocytes and decreased it in SECs, but did not affect toll-like receptor-4 (TLR-4) expression in both cells...
  58. Zuo G, He S, Liu C, Gong J. [Expression of lipopolysaccharide binding protein and lipopolysaccharide receptor CD14 in experimental alcoholic liver disease]. Zhonghua Gan Zang Bing Za Zhi. 2002;10:207-10 pubmed
    To observe the expression of lipopolysaccharide binding protein (LBP) and CD14 mRNA in alcohol-induced liver disease (ALD) and evaluate the relationship between the expression of LBP and CD14 mRNA and the severity of liver injury in ..
  59. Rechcinski T, Grebowska A, Kurpesa M, Peruga Z, Dziuba M, Krzemińska Pakuła M, et al. CD14 gene polymorphism 159C/T in a group of patients with coronary artery disease from a population with high morbidity of cardiovascular diseases. Kardiol Pol. 2007;65:237-44; discussion 245 pubmed
    A role of CD14 receptor in the inflammatory response is stimulation of monocytes and endothelial cells by lipopolysaccharide of Gram-negative bacteria...
  60. Granato D, Bergonzelli G, Pridmore R, Marvin L, Rouvet M, Corthésy Theulaz I. Cell surface-associated elongation factor Tu mediates the attachment of Lactobacillus johnsonii NCC533 (La1) to human intestinal cells and mucins. Infect Immun. 2004;72:2160-9 pubmed
    ..HT29 cells showed that EF-Tu recombinant protein can induce a proinflammatory response in the presence of soluble CD14. Our in vitro results indicate that EF-Tu, through its binding to the intestinal mucosa, might participate in gut ..
  61. Banerjee I, Pandey U, Hasan O, Parihar R, Tripathi V, Ganesh S. Association between inflammatory gene polymorphisms and coronary artery disease in an Indian population. J Thromb Thrombolysis. 2009;27:88-94 pubmed
    ..study, we performed a genetic association study on the single nucleotide polymorphisms (SNPs) present in the genes CD14 (-159 C/T), TNFalpha (-308 G/A), IL-1alpha (-889 C/T), IL-6 (-174 G/C), PSMA6 (-8 C/G), and PDE4D (SNP83 T/C, ..
  62. Martin A, Laing I, Khoo S, Zhang G, Rueter K, Teoh L, et al. Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity. Am J Respir Crit Care Med. 2006;173:617-22 pubmed
    ..b>CD14 and CC16 each play a key role in biologically important inflammatory pathways and the gene of each has a functional ..
  63. Chou M, Chuang J, Eng H, Tsai P, Hsieh C, Liu H, et al. Effects of hepatocyte CD14 upregulation during cholestasis on endotoxin sensitivity. PLoS ONE. 2012;7:e34903 pubmed publisher
    ..Our previous investigation revealed a significant increase in plasma endotoxin and CD14 levels during biliary atresia...
  64. Leynaert B, Guilloud Bataille M, Soussan D, Benessiano J, Guenegou A, Pin I, et al. Association between farm exposure and atopy, according to the CD14 C-159T polymorphism. J Allergy Clin Immunol. 2006;118:658-65 pubmed
    ..To assess whether the protective effect of farm exposure on atopy is influenced by a CD14 promoter functional polymorphism...
  65. Unkelbach K, Gardemann A, Kostrzewa M, Philipp M, Tillmanns H, Haberbosch W. A new promoter polymorphism in the gene of lipopolysaccharide receptor CD14 is associated with expired myocardial infarction in patients with low atherosclerotic risk profile. Arterioscler Thromb Vasc Biol. 1999;19:932-8 pubmed
    ..which activates monocytes to expression of cytokines, growth factors, and procoagulatory factors via LPS receptor CD14. Endothelial cells and smooth muscle cells are stimulated by a complex of LPS and soluble CD14...
  66. Jeyaseelan S, Chu H, Young S, Freeman M, Worthen G. Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun. 2005;73:1754-63 pubmed
    ..LPS binding and signaling involves CD14 and Toll-like receptor 4 (TLR4)...
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    ..that lipopolysaccharide (LPS) initiates its biological activities through a heteromeric receptor complex containing CD14, TLR4, and at least one other protein, MD-2...
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    ..might be linked to asthma or bronchial hyperresponsiveness (BHR), and TNF-alpha production might be modulated by CD14(+) cells...
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    ..baumannii infection have not been elucidated. To gain first insight into the role of CD14 and Toll-like receptors 4 and 2 in host response to A. baumannii pneumonia...