Gene Symbol: Ccp110
Description: centriolar coiled-coil protein 110
Alias: Cp110, RGD1310509, centriolar coiled-coil protein of 110 kDa, centriolar coiled coil protein 110kDa, centrosomal protein of 110 kDa
Species: rat
Products:     Ccp110

Top Publications

  1. Chen Z, Indjeian V, McManus M, Wang L, Dynlacht B. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev Cell. 2002;3:339-50 pubmed
    ..Here, we have performed a screen for CDK substrates and have isolated a target, CP110, which is phosphorylated by CDKs in vitro and in vivo. Human CP110 localizes to centrosomes...
  2. Kleylein Sohn J, Westendorf J, Le Clech M, Habedanck R, Stierhof Y, Nigg E. Plk4-induced centriole biogenesis in human cells. Dev Cell. 2007;13:190-202 pubmed
    ..Plk4, hSas-6, CPAP, Cep135, gamma-tubulin, and CP110 were required at different stages of procentriole formation and in association with different centriolar ..
  3. Spektor A, Tsang W, Khoo D, Dynlacht B. Cep97 and CP110 suppress a cilia assembly program. Cell. 2007;130:678-90 pubmed
    ..We have purified complexes associated with CP110, a protein that plays an essential role in centrosome duplication and cytokinesis, and have identified a ..
  4. Habedanck R, Stierhof Y, Wilkinson C, Nigg E. The Polo kinase Plk4 functions in centriole duplication. Nat Cell Biol. 2005;7:1140-6 pubmed
    ..Both gain- and loss-of-function experiments demonstrate that Plk4 is required--in cooperation with Cdk2, CP110 and Hs-SAS6--for the precise reproduction of centrosomes during the cell cycle...
  5. D Angiolella V, Donato V, Vijayakumar S, Saraf A, Florens L, Washburn M, et al. SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature. 2010;466:138-42 pubmed publisher
    ..Starting from an unbiased screen, we identified CP110, a protein that is essential for centrosome duplication, as an interactor and substrate of Cyclin F...
  6. Courtois A, Schuh M, Ellenberg J, Hiiragi T. The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development. J Cell Biol. 2012;198:357-70 pubmed publisher
    ..The typical mitotic spindle with centrin-, odf2-, kinesin-12-, and CP110-positive centrosomes was established only in the blastocyst...
  7. Tsang W, Spektor A, Luciano D, Indjeian V, Chen Z, Salisbury J, et al. CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. Mol Biol Cell. 2006;17:3423-34 pubmed
    ..We have undertaken a series of biochemical and RNA interference (RNAi) studies to elucidate a role for CP110 in the centrosome cycle...
  8. Cao J, Shen Y, Zhu L, Xu Y, Zhou Y, Wu Z, et al. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat Cell Biol. 2012;14:697-706 pubmed publisher
    Ciliogenesis requires the removal of CP110 from the mother centriole; actin dynamics also influence ciliation, at least partly by affecting the centrosomal accumulation of ciliogenic membrane vesicles...
  9. Li J, D Angiolella V, Seeley E, Kim S, Kobayashi T, Fu W, et al. USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. Nature. 2013;495:255-9 pubmed publisher
    ..Centrosome duplication is controlled in part by CP110, a centriolar protein that positively regulates centriole duplication while restricting centriole elongation and ..

More Information


  1. Yadav S, Sharma N, Liu C, Dong L, Li T, Swaroop A. Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis. Development. 2016;143:1491-501 pubmed publisher
    ..Centriolar coiled coil protein 110 (CP110) caps the distal end of the mother centriole and is known to act as a suppressor to control the timing of ..