Gene Symbol: Ccne2
Description: cyclin E2
Alias: G1/S-specific cyclin-E2
Geng Y, Yu Q, Sicinska E, Das M, Schneider J, Bhattacharya S, et al
. Cyclin E ablation in the mouse. Cell. 2003;114:431-43 pubmed
..These findings define a molecular function for E type cyclins in cell cycle reentry and reveal a differential requirement for cyclin E in normal versus oncogenic proliferation. ..
Lauper N, Beck A, Cariou S, Richman L, Hofmann K, Reith W, et al
. Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. Oncogene. 1998;17:2637-43 pubmed
..We speculate that cyclin E2 is not simply redundant with cyclin E, but may regulate distinct rate-limiting pathway(s) in G1-S control. ..
Sherr C. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res. 2000;60:3689-95 pubmed
..Lesions in the p16--cyclin D-CDK4--Rb and ARF--Mdm2--p53 pathways occur so frequently in cancer, regardless of patient age or tumor type, that they appear to be part of the life history of most, if not all, cancer cells. ..
Boylan J, Gruppuso P. D-type cyclins and G1 progression during liver development in the rat. Biochem Biophys Res Commun. 2005;330:722-30 pubmed
..We speculate that the switch in D-type cyclins may be associated with the dependence on mitogenic signaling that develops as hepatocytes mature. ..
Malumbres M, Barbacid M. Mammalian cyclin-dependent kinases. Trends Biochem Sci. 2005;30:630-41 pubmed
..These findings have important implications both for our current understanding of the role of Cdks in regulating the mammalian cell cycle and for their potential use as therapeutic targets in cancer. ..
Martinerie L, Manterola M, Chung S, Panigrahi S, Weisbach M, Vasileva A, et al
. Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis. PLoS Genet. 2014;10:e1004165 pubmed publisher
..during spermatogenesis, we characterized their expression patterns and produced additional deletions of Ccne1 and Ccne2 alleles in the germline, revealing unexpected meiotic functions...
Wan L, Tan H, Thomas Ahner J, Pearl D, Erdman J, Moran N, et al
. Dietary tomato and lycopene impact androgen signaling- and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis. Cancer Prev Res (Phila). 2014;7:1228-39 pubmed publisher
..05). In TRAMP, expression of Birc5, Mki67, Aurkb, Ccnb2, Foxm1, and Ccne2 is greater compared with WT and is decreased by castration...
Zhang L, Zhang X, Liu C, Lu K, Huang Y, Wang Y, et al
. miRNA-30a functions as a tumor suppressor by downregulating cyclin E2 expression in castration-resistant prostate cancer. Mol Med Rep. 2016;14:2077-84 pubmed publisher
..Aberrant expression of cyclin E2 (CCNE2) has been reported in a variety of types of cancer including prostate cancer, and correlates with clinical outcome...