Ccne1

Summary

Gene Symbol: Ccne1
Description: cyclin E1
Alias: CYCLE, Ccne, G1/S-specific cyclin-E1, cyclin E
Species: rat
Products:     Ccne1

Top Publications

  1. Tanner F, Greutert H, Barandier C, Frischknecht K, Luscher T. Different cell cycle regulation of vascular smooth muscle in genetic hypertension. Hypertension. 2003;42:184-8 pubmed
    ..Western blot analysis demonstrated that the level of cyclin D, cyclin E, and cyclin A was higher in SHR cells progressing through G1 phase, whereas expression of cyclin-dependent kinase ..
  2. Mauriz J, Gonzalez P, Duran M, Molpeceres V, Culebras J, Gonzalez Gallego J. Cell-cycle inhibition by TNP-470 in an in vivo model of hepatocarcinoma is mediated by a p53 and p21WAF1/CIP1 mechanism. Transl Res. 2007;149:46-53 pubmed
    ..TNP-470 on cell proliferation and effectors of the apoptotic pathway, including p53, p21WAF1/CIP1, cyclin D, and cyclin E. Tumor was induced in male Wistar rats by diethylnitrosamine and promoted by two-thirds hepatectomy plus ..
  3. Weroha S, Lingle W, Hong Y, Li S, Li J. Specific overexpression of cyclin E·CDK2 in early preinvasive and primary breast tumors in female ACI rats induced by estrogen. Horm Cancer. 2010;1:34-43 pubmed publisher
    ..b>Cyclin E·CDK2 positive staining was confined to the large round cells found within focal dysplasias, ductal carcinomas in ..
  4. Geng Y, Yu Q, Sicinska E, Das M, Schneider J, Bhattacharya S, et al. Cyclin E ablation in the mouse. Cell. 2003;114:431-43 pubmed
    ..However, endoreplication of trophoblast giant cells and megakaryocytes is severely impaired in the absence of cyclin E. Cyclin E-deficient cells proliferate actively under conditions of continuous cell cycling but are unable to ..
  5. Ryu J, Whang J, Park H, Im J, Kim J, Ahn M, et al. Di(2-ethylhexyl) phthalate induces apoptosis through peroxisome proliferators-activated receptor-gamma and ERK 1/2 activation in testis of Sprague-Dawley rats. J Toxicol Environ Health A. 2007;70:1296-303 pubmed
    ..Results showed that the levels of pRB, cyclin D, CDK2, cyclin E, and CDK4 were significantly lower in rats given 500 and 750 mg/kg/d DEHP, while levels of p21 were significantly ..
  6. Singer J, Gurian West M, Clurman B, Roberts J. Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 1999;13:2375-87 pubmed
    b>Cyclin E is an unstable protein that is degraded in a ubiquitin- and proteasome- dependent pathway. Two factors stimulate cyclin E ubiquitination in vivo: when it is free of its CDK partner, and when it is phosphorylated on threonine 380...
  7. Yao A, Li X, Pu L, Zhong J, Liu X, Yu Y, et al. Impaired hepatic regeneration by ischemic preconditioning in a rat model of small-for-size liver transplantation. Transpl Immunol. 2007;18:37-43 pubmed
    ..These findings were correlated with down-regulation of cyclin E and cyclin D1, and decreased numbers of PCNA-positive nuclei in IPC grafts...
  8. Kopplow K, Wayss K, Enzmann H, Mayer D. Dehydroepiandrosterone causes hyperplasia and impairs regeneration in rat liver. Int J Oncol. 2005;27:1551-8 pubmed
    ..after 3 days of treatment (100 mg/kg body weight per day) as indicated by significantly enhanced expression of cyclin E, PCNA and Ki-67 and an elevated number of mitotic figures...
  9. Matsumoto Y, Maller J. A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. Science. 2004;306:885-8 pubmed
    Excess cyclin E-Cdk2 accelerates entry into S phase of the cell cycle and promotes polyploidy, which may contribute to genomic instability in cancer cells...

More Information

Publications62

  1. Ray J, Garcia J, Jurisicova A, Caniggia I. Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia. Cell Death Differ. 2010;17:846-59 pubmed publisher
    ..Mtd expression in proliferating cells colocalized with cyclin E1, a G(1)/S phase cell cycle regulator...
  2. Tosca L, Solnais P, Ferre P, Foufelle F, Dupont J. Metformin-induced stimulation of adenosine 5' monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells. Biol Reprod. 2006;75:342-51 pubmed
    Metformin is an anti-diabetic drug commonly used to treat cycle disorders and anovulation in women with polycystic ovary syndrome. However, the effects and molecular mechanism of metformin in the ovary are not entirely understood...
  3. Bahnassy A, Zekri A, Alam El Din H, Aboubakr A, Kamel K, El Sabah M, et al. The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma. J Egypt Natl Canc Inst. 2006;18:292-302 pubmed
    ..for HPV16 and/or 18 as well as 20 normal cervical tissue (NCT) samples for abnormal expression of cyclin D1, cyclin E, CDK4, cyclin inhibitors (p21 (waf), p27, p16 (INK4A)) and Ki-67 using immunohistochemistry and differential PCR ..
  4. Erlandsson F, Martinsson Ahlzén H, Wallin K, Hellström A, Andersson S, Zetterberg A. Parallel cyclin E and cyclin A expression in neoplastic lesions of the uterine cervix. Br J Cancer. 2006;94:1045-50 pubmed
    b>Cyclin E levels are high during late G1 and early S-phase in normal cells. The cyclin E expression over the cell cycle in tumours is not fully known...
  5. Kolupaeva V, Basilico C. Overexpression of cyclin E/CDK2 complexes overcomes FGF-induced cell cycle arrest in the presence of hypophosphorylated Rb proteins. Cell Cycle. 2012;11:2557-66 pubmed publisher
    ..In cells overexpressing cyclin D1/CDK4, FGF-induced downregulation of cyclin E/CDK2 activity was absent...
  6. Cho I, Sung D, Kang K, Kim S. Oltipraz promotion of liver regeneration after partial hepatectomy: The role of PI3-kinase-dependent C/EBPbeta and cyclin E regulation. Arch Pharm Res. 2009;32:625-35 pubmed publisher
    ..The expression of cyclin E and the activity of cyclin E-dependent kinase were both enhanced by oltipraz treatment of PH rats...
  7. Tian D, Wang W, Xu Y, Yu Z, Xie M, Wang P, et al. [Effects of cyclin dependent protein kinase inhibitor olomoucine on the microenvironment of axonal regeneration after spinal cord injury: an experiment with rats]. Zhonghua Yi Xue Za Zhi. 2006;86:901-5 pubmed
    ..Western blotting was used to detect the expression of the cell cycle related proteins, cyclin A, cyclin B, cyclin E, and proliferating cell nuclear antigen (PCNA)...
  8. Maddison L, Huss W, Barrios R, Greenberg N. Differential expression of cell cycle regulatory molecules and evidence for a "cyclin switch" during progression of prostate cancer. Prostate. 2004;58:335-44 pubmed
    ..Levels of the D-type cyclins decreased during progression while expression of cyclin E increased both at the mRNA and protein levels...
  9. Hur K, Kim J, Yoon B, Lee J, Choi J, Oh G, et al. Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis. J Vet Sci. 2000;1:121-6 pubmed
    ..dihydrochloride (DMH)-induced rat colon carcinogenesis, we studied the expression of cyclin D1 and cyclin E by quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis and immunohistochemistry (IHC)...
  10. Woo M, Hakem R, Furlonger C, Hakem A, Duncan G, Sasaki T, et al. Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. Nat Immunol. 2003;4:1016-22 pubmed
    ..Our genetic and biochemical data demonstrate that caspase-3 is essential in the regulation of B cell homeostasis. ..
  11. Drobic V, Cunnington R, Bedosky K, Raizman J, Elimban V, Rattan S, et al. Differential and combined effects of cardiotrophin-1 and TGF-beta1 on cardiac myofibroblast proliferation and contraction. Am J Physiol Heart Circ Physiol. 2007;293:H1053-64 pubmed
    ..TGF-beta(1) treatment also increased expression of p27 and decreased expression of cyclin E and Cdk2 in primary cells...
  12. Zhao G, Nakano K, Chijiiwa K, Ueda J, Tanaka M. Inhibited activities in CCAAT/enhancer-binding protein, activating protein-1 and cyclins after hepatectomy in rats with thioacetamide-induced liver cirrhosis. Biochem Biophys Res Commun. 2002;292:474-81 pubmed
    ..AP)-1 and CCAAT/enhancer-binding protein (C/EBP) plays an important role in liver regeneration by modulating cell cycle regulators...
  13. Neliudova A, Aksenov N, Pospelova T. [Changes in the activity of cyclin-kinase complexes governing cell transition from G1 phase to DNA replication phase in E1A + c-Ha-ras transformants transfected with the bcl-2 gene]. Tsitologiia. 2003;45:149-57 pubmed
    ..Bcl-2 antiproliferative effect in E1A + c-Ha-ras-transformants was not associated with alterations in Cdk2, cyclin E and A contents...
  14. Akli S, Van Pelt C, Bui T, Multani A, Chang S, Johnson D, et al. Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway. Cancer Res. 2007;67:7212-22 pubmed
    In tumor cells, cyclin E deregulation results in the appearance of five low molecular weight (LMW) isoforms...
  15. Zhang Y, Shi Y, Liu Y, Dong H, Liu M, Li Y, et al. Growth pattern switch of renal cells and expression of cell cycle related proteins at the early stage of diabetic nephropathy. Biochem Biophys Res Commun. 2007;363:159-64 pubmed
    ..b>Cyclin E, CDK(2) and P(27) were found significantly up-regulated in diabetic kidney...
  16. Oka K, Ohya Shimada W, Mizuno S, Nakamura T. Up-regulation of cyclin-E(1) via proline-mTOR pathway is responsible for HGF-mediated G(1)/S progression in the primary culture of rat hepatocytes. Biochem Biophys Res Commun. 2013;435:120-5 pubmed publisher
    ..This is the first report to demonstrate the molecular bridge between amino acids and growth factors that drive mitogenic outcomes...
  17. Koroxenidou L, Ohlson L, Porsch Hällström I. Long-term 17alpha-ethinyl estradiol treatment decreases cyclin E and cdk2 expression, reduces cdk2 kinase activity and inhibits S phase entry in regenerating rat liver. J Hepatol. 2005;43:478-84 pubmed
    ..Cyclin D1 and D3 were unaffected, while cdk4 was moderately decreased. Cyclin E and cdk2 were markedly decreased with concomitant marked reduction of cdk2 kinase activity...
  18. Eder A, Sui X, Rosen D, Nolden L, Cheng K, Lahad J, et al. Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci U S A. 2005;102:12519-24 pubmed
    ..model, overexpression of persistently active atypical PKC results in defects in apical-basal polarity, increased Cyclin E protein expression, and increased proliferation...
  19. Szuplewski S, Sandmann T, Hietakangas V, Cohen S. Drosophila Minus is required for cell proliferation and influences Cyclin E turnover. Genes Dev. 2009;23:1998-2003 pubmed publisher
    ..Here we present a novel cell cycle regulator, called minus, which influences Cyclin E turnover in Drosophila...
  20. Ito K, Kajikawa S, Nii A, Doi K. Nitrofurazone-induced gene expressions in rat hepatocytes and their modification by N-acetylcysteine. Exp Toxicol Pathol. 2005;56:333-9 pubmed
    ..followed by tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-alpha (TGF-alpha), c-Ha-ras, and cyclin E. The increases were blocked by concomitant administration of NAC...
  21. Shai A, Brake T, Somoza C, Lambert P. The human papillomavirus E6 oncogene dysregulates the cell cycle and contributes to cervical carcinogenesis through two independent activities. Cancer Res. 2007;67:1626-35 pubmed
    ..tumors arising in E6 transgenic mice, we learned that E6 induces expression of the E2F-responsive genes, Mcm7 and cyclin E, in the absence of the E7 oncogene...
  22. Aikawa T, Segre G, Lee K. Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2. J Biol Chem. 2001;276:29347-52 pubmed
    ..FGF2 increased p21 expression in RCS cells, which assembled with the cyclin E-Cdk2 complexes, although the expression of neither cyclin E nor Cdk2 increased...
  23. Beijersbergen R, Carlee L, Kerkhoven R, Bernards R. Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes Dev. 1995;9:1340-53 pubmed
    ..Consistent with this, we show that a cyclin D1/cdk4 complex, but not a cyclin E/cdk2 complex, can phosphorylate p107 in vivo...
  24. Shariat S, Ashfaq R, Sagalowsky A, Lotan Y. Association of cyclin D1 and E1 expression with disease progression and biomarkers in patients with nonmuscle-invasive urothelial cell carcinoma of the bladder. Urol Oncol. 2007;25:468-75 pubmed
    ..Tissue expression of cyclin D1 or E1 seems not to add independent prognostic value to standard features in patients with nonmuscle -invasive urothelial cell carcinoma of the bladder. ..
  25. Martinerie L, Manterola M, Chung S, Panigrahi S, Weisbach M, Vasileva A, et al. Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis. PLoS Genet. 2014;10:e1004165 pubmed publisher
    ..cyclins during spermatogenesis, we characterized their expression patterns and produced additional deletions of Ccne1 and Ccne2 alleles in the germline, revealing unexpected meiotic functions...
  26. Jiang W, Zhu Z, Thompson H. Effect of energy restriction on cell cycle machinery in 1-methyl-1-nitrosourea-induced mammary carcinomas in rats. Cancer Res. 2003;63:1228-34 pubmed
    ..01), and levels of cyclin E were reduced...
  27. Chen B, Wang W. The expression of cyclins in neurons of rats after focal cerebral ischemia. J Huazhong Univ Sci Technolog Med Sci. 2008;28:60-4 pubmed publisher
    ..expression of Cyclin D1 and B1 in neurons was notably gradually down-regulated at 7th and 14th day, and that of Cyclin E and A was significantly up-regulated at 14th day after reperfusion as compared with that in control group (all P&..
  28. Burke K, Cheng Y, Li B, Petrov A, Joshi P, Berman R, et al. Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E. Neurotoxicology. 2006;27:970-81 pubmed
    ..At 6h, MeHg decreased by 75% levels of cyclin E, a cell cycle regulator with roles in proliferation and apoptosis, without altering p57, p27, or CDK2 nor levels ..
  29. Kan Q, Jinno S, Yamamoto H, Kobayashi K, Okayama H. ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6. Proc Natl Acad Sci U S A. 2008;105:4757-62 pubmed publisher
    ..These results reveal the never anticipated function of Cdc6 and redefine its role in the control of S-phase progression in mammalian cells. ..
  30. Pujol M, Jaime M, Serratosa J, Jaumot M, Agell N, Bachs O. Differential association of p21Cip1 and p27Kip1 with cyclin E-CDK2 during rat liver regeneration. J Hepatol. 2000;33:266-74 pubmed
    ..The aim of this study was to examine the association of p21Cip1 and p27Kip1 with cyclin E-CDK2 and cyclin A-CDK2 complexes during rat liver regeneration and to correlate the association of both ..
  31. Kim K, Shim J, Kim J. Overexpression of p21, cyclin E and decreased expression of p27 in DMBA (7, 12-dimethylbenzanthracene)-induced rat ovarian carcinogenesis. Pathol Int. 2003;53:291-6 pubmed
    ..Inactivation of the tumor suppressor gene and deregulation of cyclin E are frequent in human ovarian cancer...
  32. Park C, Kim S, Lee M, Youn C, Kim D, Jho E, et al. Modulation of beta-catenin phosphorylation/degradation by cyclin-dependent kinase 2. J Biol Chem. 2004;279:19592-9 pubmed
    ..Here we demonstrate that cyclin-dependent kinase 2 (CDK2) in association with cyclin A or cyclin E directly binds to beta-catenin...
  33. Morante M, Sandoval J, Gomez Cabrera M, Rodriguez J, Pallardo F, Viña J, et al. Vitamin E deficiency induces liver nuclear factor-kappaB DNA-binding activity and changes in related genes. Free Radic Res. 2005;39:1127-38 pubmed
    ..and up-regulated transcription of gamma-glutamylcysteine synthetase (gamma-GCSM; gamma-GCSC), cyclin D1 and cyclin E. We also showed down-regulation of p21(Waf1/Cip1) transcription...
  34. Sherr C. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res. 2000;60:3689-95 pubmed
    ..inhibitors of the Cip/Kip family, complementing the effects of the E2F transcriptional program by facilitating cyclin E-cdk2 activation at the G1-S transition...
  35. Dong P, Maddali M, Srimani J, Thélot F, Nevins J, Mathey Prevot B, et al. Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. Nat Commun. 2014;5:4750 pubmed publisher
    A body of evidence has shown that the control of E2F transcription factor activity is critical for determining cell cycle entry and cell proliferation...
  36. Berglund P, Stighall M, Jirstrom K, Ryden L, Fernö M, Nordenskjold B, et al. Cyclin E confers a prognostic value in premenopausal breast cancer patients with tumours exhibiting an infiltrative growth pattern. J Clin Pathol. 2008;61:184-91 pubmed
    To investigate the prognostic value of cyclin E in relation to tumour growth pattern by analysing stage II primary breast cancers from premenopausal women not subjected to any further adjuvant treatment...
  37. Santegoets L, Seters M, Helmerhorst T, Heijmans Antonissen C, Hanifi Moghaddam P, Ewing P, et al. HPV related VIN: highly proliferative and diminished responsiveness to extracellular signals. Int J Cancer. 2007;121:759-66 pubmed
    ..observed differences, we found that VIN appears to be a highly proliferative disease; many cyclins (CCNA, CCNB and CCNE) and almost all prereplication complex proteins are upregulated...
  38. Geisen C, Moroy T. The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein. J Biol Chem. 2002;277:39909-18 pubmed
    We have previously shown that cyclin E can malignantly transform primary rat embryo fibroblasts in cooperation with constitutively active Ha-Ras...
  39. Boylan J, Gruppuso P. D-type cyclins and G1 progression during liver development in the rat. Biochem Biophys Res Commun. 2005;330:722-30 pubmed
    ..In fetal liver, Rb was highly phosphorylated at both cyclin D- and cyclin E-dependent sites...
  40. Tamura K, Kanaoka Y, Jinno S, Nagata A, Ogiso Y, Shimizu K, et al. Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1. Oncogene. 1993;8:2113-8 pubmed
    ..Cig1, a B-type cyclin, of Schizosaccharomyces pombe, which has been suggested to act at the G1/S phase of the cell cycle. Cyclin G mRNA is induced within 3 h after growth stimulation and remains elevated with no apparent cell cycle ..
  41. Shah N, Schulien A, Clemens K, Aizenman T, Hageman T, Wills Z, et al. Cyclin e1 regulates Kv2.1 channel phosphorylation and localization in neuronal ischemia. J Neurosci. 2014;34:4326-31 pubmed publisher
    ..These results support a novel role for neuronal cyclin E1 in regulating the phosphorylation status and localization of Kv2.1 channels, a likely component of signaling cascades leading to ischemic preconditioning. ..
  42. Mendonça P, Lotfi C. The proliferative effect of synthetic N-POMC(1-28) peptides in rat adrenal cortex: a possible role for cyclin E. Mol Cell Endocrinol. 2011;336:156-61 pubmed publisher
    ..In addition, we examine the cyclin E expression in rat adrenal cortex...
  43. Rider V, Potapova T, Dai G, Soares M. Stimulation of a rat uterine stromal cell line in culture reveals a molecular switch for endocrine-dependent differentiation. J Endocrinol. 2005;184:119-27 pubmed
    ..Comparison of cyclin E/Cdk2 activity between proliferating and differentiating cells showed a 3-fold increase (P< 0...
  44. Adélaïde J, Finetti P, Bekhouche I, Repellini L, Geneix J, Sircoulomb F, et al. Integrated profiling of basal and luminal breast cancers. Cancer Res. 2007;67:11565-75 pubmed
    ..Rare high-level amplifications contained BCL2L2, CCNE, EGFR, FGFR2, IGF1R, NOTCH2, and PIK3CA. Potential gene breaks involved ETV6 and FLT3...
  45. Stallings J, Zeng Y, Narvaez F, Rebecchi M. Phospholipase C-delta1 expression is linked to proliferation, DNA synthesis, and cyclin E levels. J Biol Chem. 2008;283:13992-4001 pubmed publisher
    ..The levels of cyclin E, a key regulator of the G1/S transition and DNA synthesis, were elevated in asynchronous cultures as well as ..
  46. Hurlin P, Zhou Z, Toyo oka K, Ota S, Walker W, Hirotsune S, et al. Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J. 2003;22:4584-96 pubmed
    ..Defective cell cycle control in the absence of Mnt is linked to upregulation of Cdk4 and cyclin E and the Cdk4 gene appears to be a direct target of Mnt-Myc antagonism...
  47. Shariat S, Ashfaq R, Sagalowsky A, Lotan Y. Correlation of cyclin D1 and E1 expression with bladder cancer presence, invasion, progression, and metastasis. Hum Pathol. 2006;37:1568-76 pubmed
    ..to determine the correlation of the expression of cyclin D1 and E1 with the expression of commonly altered cell cycle regulators and bladder cancer presence, staging, and clinical outcomes...
  48. Bora P, Kaliappan S, Xu Q, Kumar S, Wang Y, Kaplan H, et al. Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization. FEBS J. 2006;273:1403-14 pubmed
    ..The increased accumulation of ethyl esters was associated with a 3.0-fold increased expression of cyclin E and cyclin E/CDK2; however, the level of the cyclin kinase inhibitor, p27Kip, did not change...
  49. Kaczmarek P, Tosik D, Majewska E, Baj Z. Quantitative analysis of cyclin E and protein p34 cdc2 expression in superficial bladder cancer. Pol J Pathol. 2006;57:41-4 pubmed
    In the present study, the expression of cyclin E and kinase p34 cdc2 was investigated in preinvasive bladder tumors...
  50. Yu M, Liu X, Wu H, Xiang M, Xu Y. ERK1/2 promotes cigarette smoke-induced rat pulmonary artery smooth muscle cells proliferation and pulmonary vascular remodeling via up-regulating cycline1 expression. J Huazhong Univ Sci Technolog Med Sci. 2013;33:315-322 pubmed publisher
    ..Our data demonstrated that increased expression of ERK1/2 and cyclinE1 might be involved in the pathogenesis of abnormal rPASMCs proliferation and rat pulmonary vascular remodelling induced by cigarette smoke exposure. ..
  51. Jaime M, Pujol M, Serratosa J, Pantoja C, Canela N, Casanovas O, et al. The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers. Hepatology. 2002;35:1063-71 pubmed
    ..These cells also show a premature induction of cyclin E/cyclin-dependent kinase (CDK) 2 activity...
  52. Cannon J, Cherian Shaw M, Lovekamp Swan T, Chaffin C. Granulosa cell expression of G1/S phase cyclins and cyclin-dependent kinases in PMSG-induced follicle growth. Mol Cell Endocrinol. 2007;264:6-15 pubmed
    ..In addition, Cdk 2 protein increased transiently 12-24h after PMSG. Cyclin E expression increased significantly by 12h but remained elevated through 48 h, and multiple isoforms of Cyclin E ..
  53. Davidson B, Skrede M, Silins I, Shih I, Trope C, Flørenes V. Low-molecular weight forms of cyclin E differentiate ovarian carcinoma from cells of mesothelial origin and are associated with poor survival in ovarian carcinoma. Cancer. 2007;110:1264-71 pubmed
    The authors recently reported on the role of cyclin E in differentiating ovarian/primary peritoneal carcinoma from malignant peritoneal mesothelioma using gene expression arrays...