Gene Symbol: Ccl5
Description: C-C motif chemokine ligand 5
Alias: Rantes, Scya5, C-C motif chemokine 5, SIS-delta, T-cell-specific protein RANTES, chemokine (C-C motif) ligand 5, regulated upon activation normal T-cell expressed and secreted, small-inducible cytokine A5
Species: rat
Products:     Ccl5

Top Publications

  1. Oh S, Tran P, Gillard S, Hurley R, Hammond D, Miller R. Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. J Neurosci. 2001;21:5027-35 pubmed
    ..Chemokine receptor antagonists may be important therapeutic interventions in the pain that is associated with HIV-1 infection and inflammation. ..
  2. Veillard N, Kwak B, Pelli G, Mulhaupt F, James R, Proudfoot A, et al. Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice. Circ Res. 2004;94:253-61 pubmed
    ..In this study, we report that blocking a chemokine pathway in vivo with the CC chemokine antagonist Met-RANTES reduces the progression of atherosclerosis in a hypercholesterolemic mouse model...
  3. Meleth A, Agrón E, Chan C, Reed G, Arora K, Byrnes G, et al. Serum inflammatory markers in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2005;46:4295-301 pubmed
    ..NEI) clinical center: the chemokines regulated on activation, normal T-cell expressed and presumably secreted (RANTES)/CCL5, epithelial neutrophil activator (ENA)-78/CXCL5, interferon-induced protein (IP)-10/CXCL10, stromal cell-..
  4. Tripathy D, Thirumangalakudi L, Grammas P. RANTES upregulation in the Alzheimer's disease brain: a possible neuroprotective role. Neurobiol Aging. 2010;31:8-16 pubmed publisher
    ..However, emerging literature suggests that neuroinflammation can also be neuroprotective. The chemokine RANTES has been implicated in neurodegenerative diseases including AD...
  5. Schafer A, Pfrang J, Neumüller J, Fiedler S, Ertl G, Bauersachs J. The cannabinoid receptor-1 antagonist rimonabant inhibits platelet activation and reduces pro-inflammatory chemokines and leukocytes in Zucker rats. Br J Pharmacol. 2008;154:1047-54 pubmed publisher
    ..We investigated the effect of rimonabant on inflammation and enhanced platelet reactivity in type 2 diabetic Zucker rats, an experimental model of impaired glucose tolerance and the metabolic syndrome...
  6. Le Goffic R, Mouchel T, Aubry F, Patard J, Ruffault A, Jégou B, et al. Production of the chemokines monocyte chemotactic protein-1, regulated on activation normal T cell expressed and secreted protein, growth-related oncogene, and interferon-gamma-inducible protein-10 is induced by the Sendai virus in human and rat test. Endocrinology. 2002;143:1434-40 pubmed
    ..The ability of the Sendai virus to induce chemokine production in somatic cells (mostly peritubular and Leydig cells) may therefore increase the recruitment of leukocytes to sites of infection. ..
  7. Benamar K, Geller E, Adler M. Elevated level of the proinflammatory chemokine, RANTES/CCL5, in the periaqueductal grey causes hyperalgesia in rats. Eur J Pharmacol. 2008;592:93-5 pubmed publisher vivo evidence that the proinflammatory chemokine, Regulated on Activation Normal T cell Expressed and Secreted (RANTES/CCL5) microinjected directly into the periaqueductal grey in rats, a brain region critical to the processing of ..
  8. Herder C, Haastert B, Müller Scholze S, Koenig W, Thorand B, Holle R, et al. Association of systemic chemokine concentrations with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4). Diabetes. 2005;54 Suppl 2:S11-7 pubmed
    ..IGT), and 244 normoglycemic control subjects were studied for circulating concentrations of interleukin (IL)-8; RANTES (regulated on activation, normal T-cell expressed, and secreted); interferon-gamma-inducible protein-10 (IP-10), ..
  9. Zeng Y, Gu B, Ji X, Ding X, Song C, Wu F. Sinomenine, an antirheumatic alkaloid, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalolmyelitis. Biol Pharm Bull. 2007;30:1438-44 pubmed
    ..The mRNA levels of CC chemokines, RANTES, MIP-1alpha and MCP-1, are inhibited in SIN-treated EAE rats...

More Information

Publications104 found, 100 shown here

  1. Wender Ozegowska E, Michalowska Wender G, Zawiejska A, Pietryga M, Brazert J, Wender M. Concentration of chemokines in peripheral blood in first trimester of diabetic pregnancy. Acta Obstet Gynecol Scand. 2008;87:14-9 pubmed
    ..protein (IP-10), monocyte chemotactic peptide-1(MCP-1), cytokines regulated upon activation normal T cell expressed and secreted (RANTES) and matrix metalloproteinase-9 (MMP-9)) concentrations in diabetic patients ..
  2. Tang M, Alexander H, Clark R, Kochanek P, Kagan V, Bayir H. Minocycline reduces neuronal death and attenuates microglial response after pediatric asphyxial cardiac arrest. J Cereb Blood Flow Metab. 2010;30:119-29 pubmed publisher
    ..inflammatory protein-1alpha (MIP-1alpha), regulated upon activation, normal T-cell expressed and secreted (RANTES), and growth-related oncogene (GRO-KC) (P<0.05)...
  3. Serag A, Hazaa S, Afifi I, Ghoname N, Serag A. Regulated upon activation, normal T-cell expressed and secreted chemokine and interleukin-6 in rheumatic pulmonary hypertension, targets for therapeutic decisions. Eur J Cardiothorac Surg. 2010;37:853-8 pubmed publisher
    ..Serum levels of the chemokine, regulated upon activation, normal T-cell expressed and secreted (RANTES) and the cytokine interleukin-6 (IL-6) were measured by enzyme-linked immunosorbent assay (ELISA) in 35 patients ..
  4. Huang W, Yen F, Shie F, Pan C, Shiao Y, Yang C, et al. TGF-beta1 blockade of microglial chemotaxis toward Abeta aggregates involves SMAD signaling and down-regulation of CCL5. J Neuroinflammation. 2010;7:28 pubmed publisher
    ..Previously, we identified CCL5 and CCL2 as prominent chemokines that mediate the chemotaxis of microglia toward beta-amyloid (Abeta)aggregates...
  5. Kimoff R, Hamid Q, Divangahi M, Hussain S, Bao W, Naor N, et al. Increased upper airway cytokines and oxidative stress in severe obstructive sleep apnoea. Eur Respir J. 2011;38:89-97 pubmed publisher
    ..Expression levels of interleukin (IL)-1?, IL-6, interferon-?, RANTES (regulated on activation, normal T-cell expressed and secreted), transforming growth factor (TGF)-? and l-selectin ..
  6. Kokkotou E, Sankale J, Mani I, Gueye Ndiaye A, Schwartz D, Essex M, et al. In vitro correlates of HIV-2-mediated HIV-1 protection. Proc Natl Acad Sci U S A. 2000;97:6797-802 pubmed
    ..Our results suggest that beta-chemokine-mediated resistance may be an important correlate of HIV protection against HIV-1 infection and relevant to HIV vaccine design. ..
  7. Jeschke M, Einspanier R, Klein D, Jauch K. Insulin attenuates the systemic inflammatory response to thermal trauma. Mol Med. 2002;8:443-50 pubmed
    ..2 days posttrauma; insulin increased anti-inflammatory signal transcription factor mRNA expression of SOCS-3 and RANTES 7 days after the injury (p< 0.05)...
  8. Tyner J, Uchida O, Kajiwara N, Kim E, Patel A, O Sullivan M, et al. CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Nat Med. 2005;11:1180-7 pubmed
    ..Here we identify one such mechanism. We show that mice lacking the chemokine Ccl5 are immune compromised to the point of delayed viral clearance, excessive airway inflammation and respiratory death ..
  9. Vera P, Wang X, Meyer Siegler K. Upregulation of macrophage migration inhibitory factor (MIF) and CD74, receptor for MIF, in rat bladder during persistent cyclophosphamide-induced inflammation. Exp Biol Med (Maywood). 2008;233:620-6 pubmed publisher
    ..CYP-induced bladder inflammation (even at 40 mg/kg; 8-day treatment) also upregulated other inflammatory cytokines (CCL5, IL-11, iNOS) in the bladder...
  10. Rosón M, Della Penna S, Cao G, Gorzalczany S, Pandolfo M, Toblli J, et al. Different protective actions of losartan and tempol on the renal inflammatory response to acute sodium overload. J Cell Physiol. 2010;224:41-8 pubmed publisher
    ..growth factor beta1 (TGF-beta1), smooth muscle actin (alpha-SMA), endothelial nitric oxide synthase (eNOS), and RANTES renal expression was evaluated by immunohistochemistry...
  11. Mukaino M, Nakamura M, Yamada O, Okada S, Morikawa S, Renault Mihara F, et al. Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation. Exp Neurol. 2010;224:403-14 pubmed publisher
    ..of relevant cytokines within the injured spinal cord; the expression of recruiting chemokines including CCL2, CCL5, and CXCL10 was decreased, while that of Granulocyte/Macrophage-Colony Stimulating Factor (GM-CSF), a known mitogen ..
  12. Chen Y, Lui V, Rooijen N, Tam P. Depletion of intestinal resident macrophages prevents ischaemia reperfusion injury in gut. Gut. 2004;53:1772-80 pubmed
    ..Protein levels of the proinflammatory cytokines RANTES and MCP-1 were increased in IR gut...
  13. Bhangoo S, Ren D, Miller R, Henry K, Lineswala J, Hamdouchi C, et al. Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. Mol Pain. 2007;3:38 pubmed
    ..monocyte chemoattractant protein-1 (MCP-1/CCL2), Regulated on Activation, Normal T Expressed and Secreted (RANTES/CCL5) and interferon gamma-inducing protein-10 (IP-10/CXCL10) were also evident following nerve injury, although ..
  14. Chung J, Lee H, Chung H, Yoon T, Kim H. Salicylideneamino-2-thiophenol inhibits inflammatory mediator genes (RANTES, MCP-1, IL-8 and HIF-1alpha) expression induced by tert-butyl hydroperoxide via MAPK pathways in rat peritoneal macrophages. Biotechnol Lett. 2008;30:1553-8 pubmed publisher
    ..The inductions of regulated upon activation, normal T-cell expressed and secreted (RANTES), monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8) and hypoxia inducible factor-1alpha (HIF-1alpha)..
  15. Nguyen Y, McGuffie B, Anderson V, Weinberg J. Gammaherpesvirus modulation of mouse adenovirus type 1 pathogenesis. Virology. 2008;380:182-90 pubmed publisher
    ..infection led to persistently upregulated IFN-gamma in lungs and spleen and persistently upregulated CCL2 and CCL5 in the lungs...
  16. Avdoshina V, Biggio F, Palchik G, CAMPBELL L, Mocchetti I. Morphine induces the release of CCL5 from astrocytes: potential neuroprotective mechanism against the HIV protein gp120. Glia. 2010;58:1630-9 pubmed publisher
    ..the potential mechanism(s) of neuroprotection, we determined the effect of morphine on the release of chemokines CCL5 and CXCL12 in neurons, astrocytes, and microglia cultures...
  17. van Driel B, Liao G, Romero X, O Keeffe M, Wang G, Faubion W, et al. Signaling lymphocyte activation molecule regulates development of colitis in mice. Gastroenterology. 2012;143:1544-1554.e7 pubmed publisher
    ..Antibodies that inhibit Slamf1 reduce colitis in mice, so human SLAMF1 might be a therapeutic target for inflammatory bowel disease. ..
  18. Kim H, Park H, Sul K, Chung H, Chung J. Induction of RANTES and CCR5 through NF-kappaB activation via MAPK pathway in aged rat gingival tissues. Biotechnol Lett. 2006;28:17-23 pubmed
    ..In the 24-month-old (Old) rat gingival tissues, RANTES and CCR5 mRNA and protein levels were 2-4 fold increased over those of the 6-month-old (Young) rats...
  19. Saad Y, Garrett M, Manickavasagam E, Yerga Woolwine S, Farms P, Radecki T, et al. Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Genomics. 2007;89:343-53 pubmed
    ..A thorough transcript analysis revealed that 3 of these 18 genes, Ccl5, Ddx52, and RGD1559577, had nonsynonymous allelic variations between the S rat and the LEW rat...
  20. Bogdanski P, Pupek Musialik D, Dytfeld J, Jagodzinski P, Jablecka A, Kujawa A, et al. Influence of insulin therapy on expression of chemokine receptor CCR5 and selected inflammatory markers in patients with type 2 diabetes mellitus. Int J Clin Pharmacol Ther. 2007;45:563-7 pubmed
    ..Serum concentrations of RANTES, TNF-alpha, IL-6 and hsCRP were assessed...
  21. Umezawa M, Sakata C, Tanaka N, Kudo S, Tabata M, Takeda K, et al. Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosis. Cytokine. 2008;43:105-9 pubmed publisher
    ..protein, macrophage inflammatory protein-1alpha, and regulated on activation normal T cell expressed and secreted (RANTES) and CC chemokine receptor 1 in endometriotic lesions in a rat model in which endometrium is autotransplanted onto ..
  22. Reverter J, Nadal J, Fernández Novell J, Ballester J, Ramió Lluch L, Rivera M, et al. Tyrosine phosphorylation of vitreous inflammatory and angiogenic peptides and proteins in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2009;50:1378-82 pubmed publisher interferon-gamma; macrophage inflammatory protein 1-gamma; and normal T expressed and secreted cytokine (RANTES) in comparison with that in the control subjects...
  23. Sanchez A, Tripathy D, Grammas P. RANTES release contributes to the protective action of PACAP38 against sodium nitroprusside in cortical neurons. Neuropeptides. 2009;43:315-20 pubmed publisher to determine whether PACAP38 affects expression of regulated on activation normal T expressed and secreted (RANTES) and macrophage inflammatory protein 1-alpha (MIP-1alpha) in cultured neurons and if these chemokines contribute ..
  24. Jungraithmayr W, Vogt P, Inci I, Hillinger S, Arni S, Korom S, et al. A model of chronic lung allograft rejection in the rat. Eur Respir J. 2010;35:1354-63 pubmed publisher
    ..This model will permit better understanding of the pathological changes of small airways during the development of bronchiolitis obliterans, and may serve as an in vivo set-up for testing the efficacy of novel therapeutic interventions. ..
  25. Peng Y, Cheng L, Zeng Q, Shi Y, Bao X, Mao X, et al. The role of RANTES as a crucial downstream cytokine in calcineurin-dependent VSMC apoptosis stimulated by INFgamma and CD40L. Cell Biol Int. 2010;34:447-53 pubmed publisher
    ..using RNAi (RNA interference) technology and a CaN (calcineurin) antagonist, the correlation between CaN and RANTES (regulated upon activation, normal T-cell expressed and secreted) in cultured rat apoptotic VSMCs stimulated by ..
  26. Lines J, Hoskins S, Hollifield M, Cauley L, Garvy B. The migration of T cells in response to influenza virus is altered in neonatal mice. J Immunol. 2010;185:2980-8 pubmed publisher
    ..In influenza-infected neonates, CXCL2, CCL5, and CCL3 were expressed at adult levels, whereas the chemokines CXCL1, CXCL9, and CCL2 remained at baseline levels,..
  27. Suga M, MacLean A, Keshavjee S, Fischer S, Moreira J, Liu M. RANTES plays an important role in the evolution of allograft transplant-induced fibrous airway obliteration. Am J Respir Crit Care Med. 2000;162:1940-8 pubmed
    ..We investigated the role of RANTES, a C-C chemokine, in the evolution of fibrous airway obliteration (FAO) using a rat heterotopic tracheal ..
  28. Palaniappan R, Singh S, Singh U, Singh R, Ades E, Briles D, et al. CCL5 modulates pneumococcal immunity and carriage. J Immunol. 2006;176:2346-56 pubmed
    ..Recently, it has been shown that genetic polymorphisms can result in diminished expression of CCL5, which results in increased susceptibility to and progression of infectious diseases...
  29. Akyildiz H, Akcan A, Sozuer E, Kucuk C, Yilmaz N, Deniz K. The preventive effect of Met-RANTES on postoperative intraperitoneal adhesion formation in the rat model. Surgery. 2008;144:404-9 pubmed publisher
    ..The chemokine antagonist Met-RANTES (Regulated upon Activation Normal T cell Expressed and Secreted) has been shown to be efficacious in decreasing inflammation in several animal disease ..
  30. Heeger P, Wolf G, Meyers C, Sun M, O Farrell S, Krensky A, et al. Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes. Kidney Int. 1992;41:220-5 pubmed
    ..Some of the new intercrines are potential candidates. In this report we have isolated cDNA encoding murine Rantes (MuRantes) from renal tubular epithelium (MCT cells)...
  31. Manczak M, Jiang S, Orzechowska B, Adamus G. Crucial role of CCL3/MIP-1alpha in the recurrence of autoimmune anterior uveitis induced with myelin basic protein in Lewis rats. J Autoimmun. 2002;18:259-70 pubmed
    In this study, we examined the role of CCL2/MCP-1, CCL3/MIP-1alpha, CCL4/MIP-1beta, and CCL5/RANTES during recurrent anterior uveitis (RAU)...
  32. Garcia G, Truong L, Li P, Zhang P, Du J, Chen J, et al. Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis. FASEB J. 2008;22:445-54 pubmed
    ..with suppression of the glomerular expression of the MDC/CCL22 chemokine and down-regulation of MIP-1alpha/CCL3, RANTES/CCL5, MIP-1beta/CCL4, and MCP-1/CCL2 chemokines...
  33. Sugawa T, Fujiwara Y, Yamagami H, Watanabe K, Tanigawa T, Shiba M, et al. A novel rat model to determine interaction between reflux oesophagitis and bronchial asthma. Gut. 2008;57:575-81 pubmed publisher
    ..infiltration in the oesophageal submucosa and levels of mRNA expression of cytokines such as IL5, IL10, IL13, and RANTES were significantly increased...
  34. Park M, Lee Y, Lee Y, Kim Y, Yun Y, Nam S, et al. Chemokines released from astrocytes promote chemokine receptor 5-mediated neuronal cell differentiation. Exp Cell Res. 2009;315:2715-26 pubmed publisher
    ..Cytokine assays identified that the IL-4, MIP-1, KC, and RANTES as were released from astrocyte, and these chemokines promote differentiation of rat embryonic neuronal cells...
  35. Brattström A, Schapowal A, Kamal M, Maillet I, Ryffel B, Moser R. The plant extract Isatis tinctoria L. extract (ITE) inhibits allergen-induced airway inflammation and hyperreactivity in mice. Phytomedicine. 2010;17:551-6 pubmed publisher
    ..Diminution of AHR and inflammation was associated with reduced IL-4, IL-5, and RANTES production in the BAL fluid at the 30 microg ITE dose, while OVA specific IgE and eotaxin serum levels remained ..
  36. Uller L, Emanuelsson C, Andersson M, Erjefalt J, Greiff L, Persson C. Early phase resolution of mucosal eosinophilic inflammation in allergic rhinitis. Respir Res. 2010;11:54 pubmed publisher
    ..that steroid-induced resolution of human airway eosinophilic inflammation involves inhibition of CCL5 (RANTES), a CC-chemokine regulating eosinophil and lymphocyte traffic, and elimination of eosinophils without evident ..
  37. Yin Q, Fan Q, Zhao Y, Cheng M, Liu H, Li J, et al. Spinal NF-κB and chemokine ligand 5 expression during spinal glial cell activation in a neuropathic pain model. PLoS ONE. 2015;10:e0115120 pubmed publisher
    The NF-κB pathway and chemokine (C-C motif) ligand 5 (CCL5) are involved in pain modulation; however, the precise mechanisms of their interactions in chronic neuropathic pain have yet to be established...
  38. Appay V, Brown A, Cribbes S, Randle E, Czaplewski L. Aggregation of RANTES is responsible for its inflammatory properties. Characterization of nonaggregating, noninflammatory RANTES mutants. J Biol Chem. 1999;274:27505-12 pubmed
    The biology of RANTES (regulated on activation normal T cell expressed) aggregation has been investigated using RANTES and disaggregated variants, enabling comparison of aggregated, tetrameric, and dimeric RANTES forms...
  39. Wu H, Wang Y, Tay Y, Zheng G, Zhang C, Alexander S, et al. DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy. Kidney Int. 2005;67:2178-86 pubmed
    ..monocyte chemoattractant protein-1 (MCP-1) and regulated upon activation, normal T-cell expressed and secreted (RANTES) are significantly increased in renal cortex in adriamycin nephropathy...
  40. Roffê E, Oliveira F, Souza A, Pinho V, Souza D, Souza P, et al. Role of CCL3/MIP-1alpha and CCL5/RANTES during acute Trypanosoma cruzi infection in rats. Microbes Infect. 2010;12:669-76 pubmed publisher
    ..We investigated the role of CCL3 and CCL5 during infection by using DNA vaccination encoding for each chemokine separately or simultaneously...
  41. Farivar A, Krishnadasan B, Naidu B, Woolley S, Mulligan M. The role of the beta chemokines in experimental obliterative bronchiolitis. Exp Mol Pathol. 2003;75:210-6 pubmed
    ..Rats received 200 microg/day of either anti-RANTES or anti-MCP-1 antibody for 14 days. Luminal obstruction and epithelial loss were calculated...
  42. Ignatov A, Robert J, Gregory Evans C, Schaller H. RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75. Br J Pharmacol. 2006;149:490-7 pubmed
    b>RANTES is an inflammatory chemokine with a critical role in T-lymphocyte activation and proliferation. Its effects are mediated through G protein-coupled heptahelical receptors (GPCRs)...
  43. Zhang M, Gao X, Wu J, Liu D, Cai H, Fu L, et al. Oxidized high-density lipoprotein enhances inflammatory activity in rat mesangial cells. Diabetes Metab Res Rev. 2010;26:455-63 pubmed publisher
    ..factors, including tumour necrosis factor-alpha, regulated upon activation, normal T-cell expressed and secreted (RANTES), monocyte chemoattractant protein-1 and CXC chemokine ligand-1 by rat mesangial cells dose in a dependent fashion...
  44. Lau Y, Peiris J. Association of cytokine and chemokine gene polymorphisms with severe acute respiratory syndrome. Hong Kong Med J. 2009;15 Suppl 2:43-6 pubmed
    1. The IFN-gamma +874A allele and RANTES -28 G allele are risk factors for SARS susceptibility. 2. The RANTES -28 G allele plays a role in the pathogenesis of SARS. 3...
  45. Murooka T, Rahbar R, Platanias L, Fish E. CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1. Blood. 2008;111:4892-901 pubmed publisher
    ..Here, we examined the role for CCL5-mediated initiation of mRNA translation in CD4(+) T-cell chemotaxis...
  46. Schwarz M, Radeke H, Resch K, Uciechowski P. Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells. Kidney Int. 1997;52:1521-31 pubmed
    ..monocyte chemoattractant protein-1 (MCP-1), regulated upon activation, normal T cell expressed and secreted (RANTES), macrophage inflammatory protein-1 alpha (MIP-1 alpha), and the C-X-C or alpha chemokine interleukin-8 (IL-8) in ..
  47. Nguyen K, Fohner A, Booker J, Dong C, Krensky A, Nadeau K. XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma. J Immunol. 2008;181:5386-95 pubmed
    ..Altogether, these results suggest an association between dysregulated XCL1 expression and reduced Treg activities in AA, as well as a potential role of XCL1 in reversing defective Treg function in the disease. ..
  48. Carrigan S, Junkins R, Yang Y, MacNeil A, Richardson C, Johnston B, et al. IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice. J Immunol. 2010;185:3602-9 pubmed publisher
    ..In vitro, macrophages from IRF3-deficient mice showed complete inhibition of CCL5 (RANTES) and CXCL10 (IP-10) production, partial inhibition of TNF, but no effect on CXCL2 (MIP-2) or CXCL1 (keratinocyte-..
  49. Mu W, Ouyang X, Agarwal A, Zhang L, Long D, Cruz P, et al. IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease. J Am Soc Nephrol. 2005;16:3651-60 pubmed the renal expression of monocyte (renal monocyte chemoattractant protein-1 mRNA and protein) and T cell (RANTES mRNA) chemokines. rAAV1-IL-10 administration decreased mRNA levels of IFN-gamma and IL-2 in the kidney...
  50. Schall T, Bacon K, Toy K, Goeddel D. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature. 1990;347:669-71 pubmed
    ..the C-X-C class of the superfamily and a group of cytokines produced by haematopoietic cells constitute the RANTES/sis or C-C class...
  51. Wong M, Fish E. RANTES and MIP-1alpha activate stats in T cells. J Biol Chem. 1998;273:309-14 pubmed
    The chemokines RANTES (regulated on activation, normal T cell expressed and secreted) and MIP (macrophage inflammatory protein)-1alpha have been implicated in regulating T cell functions...
  52. Westerweel P, Rabelink T, Rookmaaker M, Grone H, Verhaar M. RANTES is required for ischaemia-induced angiogenesis, which may hamper RANTES-targeted anti-atherosclerotic therapy. Thromb Haemost. 2008;99:794-5 pubmed publisher
  53. Toblli J, Cao G, Casas G, Stella I, Inserra F, Angerosa M. NF-kappaB and chemokine-cytokine expression in renal tubulointerstitium in experimental hyperoxaluria. Role of the renin-angiotensin system. Urol Res. 2005;33:358-67 pubmed
    ..the study, the inflammatory response to Hox was evaluated using anti-NF-kappaB (p50), anti-IL-6, anti-MCP-1; anti-RANTES and anti-ED1 (monocytes/macrophages) in each group...
  54. Barbe M, Elliott M, Abdelmagid S, Amin M, Popoff S, Safadi F, et al. Serum and tissue cytokines and chemokines increase with repetitive upper extremity tasks. J Orthop Res. 2008;26:1320-6 pubmed publisher
    ..In HRNF rats, serum IL-1 alpha, IL-1 beta, TNFalpha, MIP2, MIP3a, and RANTES were elevated in weeks 6 and 8. In contrast, only MIP2 and MIP3a increased in serum of LRNF rats...
  55. Kawai T, Seki M, Hiromatsu K, Eastcott J, Watts G, Sugai M, et al. Selective diapedesis of Th1 cells induced by endothelial cell RANTES. J Immunol. 1999;163:3269-78 pubmed
    ..Enhanced transmigration of Th1-type cells was dependent on the chemokine RANTES produced by endothelial cells, as indicated by the findings that Ab neutralizing RANTES, or Ab to its receptor ..
  56. Bonaros N, Sondermeijer H, Sondermejer H, Schuster M, Rauf R, Wang S, et al. CCR3- and CXCR4-mediated interactions regulate migration of CD34+ human bone marrow progenitors to ischemic myocardium and subsequent tissue repair. J Thorac Cardiovasc Surg. 2008;136:1044-53 pubmed publisher
    ..Ischemic rat myocardium demonstrated induced messenger RNA expression for the CCR3-binding chemokines eotaxin, RANTES (regulated on activation, normal T expressed and secreted), and monocyte chemotactic protein-3, but not the CXCR4-..
  57. Thorne P, Adamcakova Dodd A, Kelly K, O neill M, Duchaine C. Metalworking fluid with mycobacteria and endotoxin induces hypersensitivity pneumonitis in mice. Am J Respir Crit Care Med. 2006;173:759-68 pubmed
    ..scale) exhibited significantly elevated macrophage inflammatory protein-1alpha and IL-10 and a trend toward higher RANTES 96 h after the final dose. Endotoxin coexposure augmented lung pathology...
  58. Geppert A. Constitutive patterns of RANTES, MCP-1 and MIP-1 alpha expression at the mRNA and protein level during postnatal development of the rat brain. Folia Neuropathol. 2003;41:79-88 pubmed
    ..Primary sensory neurones have been shown to migrate towards RANTES in vitro...
  59. Duell E, Casella D, Burk R, Kelsey K, Holly E. Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2006;15:726-31 pubmed
    ..factor-alpha (TNF-A -308G/A), regulated upon activation, normally T cell-expressed, and presumably secreted (RANTES -403G/A), and CC chemokine receptor 5 (CCR5-Delta32) polymorphisms...
  60. Goodwill A, Frisbee S, Stapleton P, James M, Frisbee J. Impact of chronic anticholesterol therapy on development of microvascular rarefaction in the metabolic syndrome. Microcirculation. 2009;16:667-84 pubmed publisher
    ..However, using multivariate discriminant analyses, plasma RANTES (regulated on activation, normal T-cell expressed and secreted), interleukin-10, monocyte chemoattractant protein-..
  61. Duo J, Stenken J. In vitro and in vivo affinity microdialysis sampling of cytokines using heparin-immobilized microspheres. Anal Bioanal Chem. 2011;399:783-93 pubmed publisher
    ..monocyte chemoattractant protein-1 (or CCL2), and regulation upon activation normal T cell express sequence (or CCL5)...
  62. Liu H, Ning H, Men H, Hou R, Fu M, Zhang H, et al. Regulation of CCL5 expression in smooth muscle cells following arterial injury. PLoS ONE. 2012;7:e30873 pubmed publisher
    ..Chemokine CCL5 has been shown to be involved in atherosclerosis progression...
  63. Nibbs R, Wylie S, Pragnell I, Graham G. Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J Biol Chem. 1997;272:12495-504 pubmed
    ..of competition for 125I-murine MIP-1alpha on D6 was murine MIP-1alpha > human and murine MIP-1beta > human RANTES approximately JE > human MCP-3 > human MCP-1. Human MIP-1alpha and the alpha-chemokines did not compete...
  64. Oshima M, Maeda A, Ishioka S, Hiyama K, Yamakido M. Expression of C-C chemokines in bronchoalveolar lavage cells from patients with granulomatous lung diseases. Lung. 1999;177:229-40 pubmed
    ..diseases, we studied the mRNA levels of C-C chemokines, regulated on activation normal T expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and monocyte chemoattractant protein (MCP)-1 in ..
  65. Gong R, Rifai A, Tolbert E, Biswas P, Centracchio J, Dworkin L. Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTES. J Am Soc Nephrol. 2004;15:2868-81 pubmed
    ..with reductions in the tubular expression of the chemokines macrophage chemoattractant protein-1 (MCP-1) and RANTES (regulated upon expression normal T cell expressed and secreted)...
  66. Xie J, Dong J, Cui Y. [Effect of epimedium herb on RANTES and monocyte chemotactic protein-3 expression in lung tissue of asthmatic rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008;28:238-41 pubmed
    ..herb (EH), a Chinese herb for replenishing Shen, on regulated on activation, normal T call expressed and secreted (RANTES) and monocyte chemotactic protein-3 (MCP-3) expression in lung tissue of asthmatic rats, for further exploring the ..
  67. Knight B, Brunton C, Modi N, Wallace G, Stanford M. The effect of Toxoplasma gondii infection on expression of chemokines by rat retinal vascular endothelial cells. J Neuroimmunol. 2005;160:41-7 pubmed
    ..genes such as GRO1 (Growth Regulated Oncogene 1), MCP-1 (Monocyte Chemotactic Protein-1), FKN (Fractalkine) and RANTES (Regulated upon Activation, Normal T Cell Expressed and Secreted) were found to be up-regulated and protein ..
  68. Doupis J, Lyons T, Wu S, Gnardellis C, Dinh T, Veves A. Microvascular reactivity and inflammatory cytokines in painful and painless peripheral diabetic neuropathy. J Clin Endocrinol Metab. 2009;94:2157-63 pubmed publisher
    ..Compared to the other two groups, the neuropathic group also had higher serum levels of PDGF AA/BB (P < 0.05), RANTES (P < 0.01), leptin (P < 0.0001), osteoprotegerin (P < 0.01), G-CSF (P < 0.05), sE-Selectin (P < 0...
  69. Schaier M, Vorwalder S, Sommerer C, Dikow R, Hug F, Gross M, et al. Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. Am J Physiol Renal Physiol. 2009;297:F769-80 pubmed publisher
    ..Treatment with high-dose FTY720 tended to normalize RANTES and MCP-1 renal gene expression...
  70. Samuel I, Yorek M, Zaheer A, Fisher R. Bile-pancreatic juice exclusion promotes Akt/NF-kappaB activation and chemokine production in ligation-induced acute pancreatitis. J Gastrointest Surg. 2006;10:950-9 pubmed
    ..ELISA), inhibitory protein I-kappaB (IkappaB) activation (immunoblotting), and production of chemokines MCP-1 and RANTES (ELISA) were measured in pancreatic homogenates...
  71. Xie M, Liu X, Xu Y, Zhang Z, Bai J, Ni W, et al. Role of the extracellular signal-regulated kinase 1/2 signaling pathway in regulating the secretion of bronchial smooth muscle cells in a rat model of chronic asthma. Chin Med J (Engl). 2008;121:73-7 pubmed
    ..tissue growth factor (CTGF)), cytokines (regulated upon activation, normal T cell-expressed and secreted (RANTES) and eotaxin), and extracellular matrix (fibronectin and collagen I) compared with normal controls...
  72. Lloyd A, Oppenheim J, Kelvin D, Taub D. Chemokines regulate T cell adherence to recombinant adhesion molecules and extracellular matrix proteins. J Immunol. 1996;156:932-8 pubmed
    ..The chemokines (macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, RANTES, and IFN-inducible protein-10) have recently been reported to be chemotactic for T cells...
  73. Grau V, Gemsa D, Steiniger B, Garn H. Time course of chemokine expression in acutely rejecting rat kidneys. Transplant Proc. 1999;31:1571 pubmed
  74. Castellani M, Shanmugham L, Petrarca C, Simeonidou I, Frydas S, De Colli M, et al. Expression and secretion of RANTES (CCL5) in granulomatous calcified tissue before and after lipopolysaccharide treatment in vivo. Calcif Tissue Int. 2007;80:60-7 pubmed
    b>RANTES (regulated on activation, normal T cell-expressed and secreted) is a CC chemokine appearing to be involved in the recruitment of leukocytes at inflammation sites...
  75. Pan H, Chin C, Yang D, Ho S, Chen C, Hwang S, et al. Human amniotic fluid mesenchymal stem cells in combination with hyperbaric oxygen augment peripheral nerve regeneration. Neurochem Res. 2009;34:1304-16 pubmed publisher
    ..AFS in combination with HBO augment peripheral nerve regeneration, which may involve the suppression of apoptotic death in implanted AFS and the attenuation of an inflammatory response detrimental to peripheral nerve regeneration. ..
  76. Sharma A, Linden J, Kron I, Laubach V. Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. Respir Res. 2009;10:58 pubmed publisher
    ..Significant induction of TNF-alpha, KC (CXCL1), MIP-2 (CXCL2) and RANTES (CCL5) occurred after IR which was also attenuated by ATL313 treatment...
  77. Louboutin J, Chekmasova A, Marusich E, Agrawal L, Strayer D. Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage. FASEB J. 2011;25:737-53 pubmed publisher
    ..In control rats, seizures induced elevated expression of CCR5 ligands MIP-1? and RANTES in the microvasculature, increased BBB leakage and CCR5(+) cells, as well as neuronal loss, inflammation, and ..
  78. Kuo P, Hsu Y, Huang M, Chiang S, Ko Y. Bronchial epithelium-derived IL-8 and RANTES increased bronchial smooth muscle cell migration and proliferation by Krüppel-like factor 5 in areca nut-mediated airway remodeling. Toxicol Sci. 2011;121:177-90 pubmed publisher
    ..and arecoline increased interleukin 8 (IL-8) and Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES) production...
  79. Combadiere C, Ahuja S, Tiffany H, Murphy P. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES. J Leukoc Biol. 1996;60:147-52 pubmed
    ..Macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and RANTES were all potent agonists for CC CKR5 (EC50 = 3-30 nM) when calcium flux was measured in transfected HEK 293 cells, ..
  80. Nesbeth Y, Martinez D, Toraya S, Scarlett U, Cubillos Ruiz J, Rutkowski M, et al. CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells. J Immunol. 2010;184:5654-62 pubmed publisher
    ..mechanism whereby tumor-primed CD4(+) T cells transferred into ovarian cancer-bearing mice secrete high levels of CCL5, which recruits endogenous CCR5(+) dendritic cells to tumor locations and activate them through CD40-CD40L ..
  81. Tian M, Liu F, Wen G, Shi S, Chen R, Zhao D. Effect of variation in RANTES promoter on serum RANTES levels and risk of recurrent wheezing after RSV bronchiolitis in children from Han, Southern China. Eur J Pediatr. 2009;168:963-7 pubmed publisher
    To investigate the association among RANTES (regulated on activation normal T cell expressed and secreted) gene promoter polymorphism, serum RANTES levels, and recurrent wheezing after RSV (respiratory syncytial virus) bronchiolitis in ..
  82. Zietkowski Z, Skiepko R, Tomasiak Lozowska M, Mroczko B, Szmitkowski M, Bodzenta Lukaszyk A. RANTES in exhaled breath condensate of allergic asthma patients with exercise-induced bronchoconstriction. Respiration. 2010;80:463-71 pubmed publisher
    ..The aim of this study was to evaluate changes in RANTES levels in exhaled breath condensate (EBC) following intensive exercise in allergic asthmatics...
  83. Tinsley J, Chiasson V, South S, Mahajan A, Mitchell B. Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension. Am J Hypertens. 2009;22:1107-14 pubmed publisher
    ..serum T helper-1 (Th1)-type inflammatory cytokines interleukin (IL)-2, IL-12, interferon-gamma (IFNgamma), and RANTES were significantly elevated in hypertensive pregnant rats while the Th2-type cytokine IL-4 was elevated in normal ..
  84. Wen X, Li Y, Liu Y. Opposite action of peroxisome proliferator-activated receptor-gamma in regulating renal inflammation: functional switch by its ligand. J Biol Chem. 2010;285:29981-8 pubmed publisher
    ..Both natural and synthetic PPAR? agonists potently inhibited RANTES (regulated upon activation, normal T cell expressed and secreted) and monocyte chemoattractant protein-1 ..
  85. Hu B, Elinav E, Huber S, Strowig T, Hao L, Hafemann A, et al. Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Proc Natl Acad Sci U S A. 2013;110:9862-7 pubmed publisher
    ..Enhanced tumorigenesis is dependent on microbiota-induced chemokine (C-C motif) ligand 5 (CCL5)-driven inflammation, which in turn promotes epithelial cell proliferation through local activation of the IL-6 ..
  86. Maier R, Weger M, Haller Schober E, El Shabrawi Y, Wedrich A, Theisl A, et al. Multiplex bead analysis of vitreous and serum concentrations of inflammatory and proangiogenic factors in diabetic patients. Mol Vis. 2008;14:637-43 pubmed
    ..inflammatory protein (MIP)-1alpha, MIP-1beta, regulated upon activation, normal T-expressed and secreted (RANTES), and vascular endothelial growth factor (VEGF)...
  87. Russo R, Alessandri A, Garcia C, Cordeiro B, Pinho V, Cassali G, et al. Therapeutic effects of evasin-1, a chemokine binding protein, in bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2011;45:72-80 pubmed publisher
    ..accompanied by increased number of leukocytes and elevated levels of CCL2/monocyte chemoattractant protein (MCP)-1, CCL5/regulated upon activation, normal T cell expressed and secreted, TNF-? and transforming growth factor-?(1), and ..
  88. Hoshino Y, Tse D, Rochford G, Prabhakar S, Hoshino S, Chitkara N, et al. Mycobacterium tuberculosis-induced CXCR4 and chemokine expression leads to preferential X4 HIV-1 replication in human macrophages. J Immunol. 2004;172:6251-8 pubmed
    ..lavage fluid from TB patients had elevated levels of CCL4 (macrophage inflammatory protein-1beta), CCL5 (RANTES), and CX3CL1 (fractalkine), but not CXCL12 (stromal-derived factor-1alpha). We found that M...
  89. Liu B, Hassan Z, Amisten S, King A, Bowe J, Huang G, et al. The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis. Diabetologia. 2013;56:2467-76 pubmed publisher
    Chemokine (C-C motif) ligand 5 (CCL5) acts at C-C chemokine receptors (CCRs) to promote immune cell recruitment to sites of inflammation, but is also an agonist at G-protein-coupled receptor 75 (GPR75), which has very limited homology ..
  90. Ben Baruch A, Xu L, Young P, Bengali K, Oppenheim J, Wang J. Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3. J Biol Chem. 1995;270:22123-8 pubmed
    ..sequenced and found to be identical to the known C-C CKR1 or macrophage inflammatory protein-1 alpha (MIP1 alpha)/Rantes receptor...
  91. Laubli H, Spanaus K, Borsig L. Selectin-mediated activation of endothelial cells induces expression of CCL5 and promotes metastasis through recruitment of monocytes. Blood. 2009;114:4583-91 pubmed publisher
    ..cells with platelets and leukocytes activated endothelial cells and induced production of C-C chemokine ligand 5 (CCL5)...
  92. Kim H, Kim H. IL-10 up-regulates CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats. Cytokine. 2014;68:40-9 pubmed publisher
    ..However, chemokine CCL5 has down-regulatory effects on angiotensin II (Ang II)-induced hypertensive mediators...