Ccdc88a

Summary

Gene Symbol: Ccdc88a
Description: coiled coil domain containing 88A
Alias: Ape, GIV, Hkrp1, RGD1306694, girdin, Akt-phosphorylation enhancer, Galpha-interacting vesicle-associated protein, Hook-related protein 1
Species: rat
Products:     Ccdc88a

Top Publications

  1. Ota H, Hikita T, Nishioka T, Matsumoto M, Ito J, Asai N, et al. Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain. Biochem Biophys Res Commun. 2013;442:16-21 pubmed publisher
    ..that control postnatal neuronal migration, we performed a global proteomic search for proteins interacting with Girdin, an essential protein for postnatal neuronal migration...
  2. Kim J, Duan X, Liu C, Jang M, Guo J, Pow Anpongkul N, et al. DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron. 2009;63:761-73 pubmed publisher
  3. Garcia Marcos M, Ghosh P, Ear J, Farquhar M. A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem. 2010;285:12765-77 pubmed publisher
    ..Here we investigated the structural determinants in G alpha(i3) necessary for its regulation by GIV/girdin, a guanine-nucleotide exchange factor (GEF) that activates G alpha(i) subunits...
  4. Le Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar M. Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. J Biol Chem. 2005;280:22012-20 pubmed
    In this report, we characterize GIV (Galpha-interacting vesicle-associated protein), a novel protein that binds members of the Galpha(i) and Galpha subfamilies of heterotrimeric G proteins...
  5. Simpson F, Martin S, Evans T, Kerr M, James D, Parton R, et al. A novel hook-related protein family and the characterization of hook-related protein 1. Traffic. 2005;6:442-58 pubmed
    ..This domain has been shown to bind microtubules in the Hook protein and show that the HkRP1 protein is microtubule-associated...
  6. Enomoto A, Murakami H, Asai N, Morone N, Watanabe T, Kawai K, et al. Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell. 2005;9:389-402 pubmed
    ..Here, we identify an Akt substrate, designated Girdin/APE (Akt-phosphorylation enhancer), which is an actin binding protein...
  7. Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, et al. A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. J Biol Chem. 2005;280:18525-35 pubmed
    ..Thus, we termed this Akt-specific binding protein APE (Akt-phosphorylation enhancer)...
  8. Albrecht C, Knaapen A, Becker A, Höhr D, Haberzettl P, Van Schooten F, et al. The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species formation and APE/Ref-1 induction in rat lung. Respir Res. 2005;6:129 pubmed
    ..were also investigated for the expression of the bifunctional apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) by Western blotting and immunohistochemistry...
  9. Miyake H, Maeda K, Asai N, Shibata R, Ichimiya H, Isotani Sakakibara M, et al. The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury. Circ Res. 2011;108:1170-9 pubmed publisher
    ..Our previous study showed that the Akt substrate Girdin, which is expressed in VSMCs and endothelial cells, is essential for postnatal angiogenesis...

More Information

Publications10

  1. Wang H, Misaki T, Taupin V, Eguchi A, Ghosh P, Farquhar M. GIV/girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin. J Am Soc Nephrol. 2015;26:314-27 pubmed publisher
    ..We show here that G?-interacting, vesicle-associated protein (GIV)/girdin mediates VEGF receptor 2 (VEGFR2) signaling and compensates for nephrin loss...