Gene Symbol: Ccdc88a
Description: coiled coil domain containing 88A
Alias: Ape, GIV, Hkrp1, RGD1306694, girdin, Akt-phosphorylation enhancer, Galpha-interacting vesicle-associated protein, Hook-related protein 1
Ota H, Hikita T, Nishioka T, Matsumoto M, Ito J, Asai N, et al
. Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain. Biochem Biophys Res Commun. 2013;442:16-21 pubmed publisher
..that control postnatal neuronal migration, we performed a global proteomic search for proteins interacting with Girdin, an essential protein for postnatal neuronal migration...
Kim J, Duan X, Liu C, Jang M, Guo J, Pow Anpongkul N, et al
. DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron. 2009;63:761-73 pubmed publisher
Garcia Marcos M, Ghosh P, Ear J, Farquhar M. A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem. 2010;285:12765-77 pubmed publisher
..Here we investigated the structural determinants in G alpha(i3) necessary for its regulation by GIV/girdin, a guanine-nucleotide exchange factor (GEF) that activates G alpha(i) subunits...
Le Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar M. Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. J Biol Chem. 2005;280:22012-20 pubmed
In this report, we characterize GIV (Galpha-interacting vesicle-associated protein), a novel protein that binds members of the Galpha(i) and Galpha subfamilies of heterotrimeric G proteins...
Simpson F, Martin S, Evans T, Kerr M, James D, Parton R, et al
. A novel hook-related protein family and the characterization of hook-related protein 1. Traffic. 2005;6:442-58 pubmed
..This domain has been shown to bind microtubules in the Hook protein and show that the HkRP1 protein is microtubule-associated...
Enomoto A, Murakami H, Asai N, Morone N, Watanabe T, Kawai K, et al
. Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell. 2005;9:389-402 pubmed
..Here, we identify an Akt substrate, designated Girdin/APE (Akt-phosphorylation enhancer), which is an actin binding protein...
Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, et al
. A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. J Biol Chem. 2005;280:18525-35 pubmed
..Thus, we termed this Akt-specific binding protein APE (Akt-phosphorylation enhancer)...
Albrecht C, Knaapen A, Becker A, Höhr D, Haberzettl P, Van Schooten F, et al
. The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species formation and APE/Ref-1 induction in rat lung. Respir Res. 2005;6:129 pubmed
..were also investigated for the expression of the bifunctional apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) by Western blotting and immunohistochemistry...
Miyake H, Maeda K, Asai N, Shibata R, Ichimiya H, Isotani Sakakibara M, et al
. The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury. Circ Res. 2011;108:1170-9 pubmed publisher
..Our previous study showed that the Akt substrate Girdin, which is expressed in VSMCs and endothelial cells, is essential for postnatal angiogenesis...