Gene Symbol: Cbfb
Description: core-binding factor, beta subunit
Alias: Pebp2, core-binding factor subunit beta, core binding factor beta
Chen G, Zeng W, Yuan P, Huang L, Jiang Y, Zhao Z, et al
. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. J Neurochem. 1999;72:879-82 pubmed
..Both treatments also increased the DNA binding activity of PEBP2 alphabeta and robustly increased the levels of bcl-2 (known to be transcriptionally regulated by PEBP2) in FCx...
Miller J, Horner A, Stacy T, Lowrey C, Lian J, Stein G, et al
. The core-binding factor beta subunit is required for bone formation and hematopoietic maturation. Nat Genet. 2002;32:645-9 pubmed
..5 significant impairments in lymphopoiesis and myelopoiesis are observed. Thus, we conclude that the Cbfbeta subunit is required for HSC emergence, bone formation and normal differentiation of lymphoid and myeloid lineage cells. ..
Liu P, Tarle S, Hajra A, Claxton D, Marlton P, Freedman M, et al
. Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science. 1993;261:1041-4 pubmed
..On 16q the inversion occurred near the end of the coding region for CBF beta, also known as PEBP2 beta, a subunit of a heterodimeric transcription factor regulating genes expressed in T cells; on 16p a smooth ..
Niki M, Okada H, Takano H, Kuno J, Tani K, Hibino H, et al
. Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor. Proc Natl Acad Sci U S A. 1997;94:5697-702 pubmed
..subunit of the heterodimeric transcription factor, polyomavirus enhancer binding protein 2/core binding factor (PEBP2/CBF), and is rearranged in inversion of chromosome 16 associated with human acute myeloid leukemia...
Kundu M, Javed A, Jeon J, Horner A, Shum L, Eckhaus M, et al
. Cbfbeta interacts with Runx2 and has a critical role in bone development. Nat Genet. 2002;32:639-44 pubmed
..Although all Runx family members can interact with Cbfbeta (core-binding factor b, encoded by Cbfb), a role for Cbfbeta in bone development has not been demonstrated owing to lethality in Cbfb(-/-) mouse embryos at ..
Yamamoto C, Banaiee N, Yount N, Patel B, Selsted M. Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes. J Leukoc Biol. 2004;75:332-41 pubmed
..suggested the involvement of the CAAT box and a putative polyoma enhancer-binding protein 2/core-binding factor (PEBP2/CBF) site in defensin gene transcription...
Park E, Lind A, Dahm Kähler P, Brannstrom M, Carletti M, Christenson L, et al
. RUNX2 transcription factor regulates gene expression in luteinizing granulosa cells of rat ovaries. Mol Endocrinol. 2010;24:846-58 pubmed publisher
..Collectively, the present data indicate that the LH surge-induced RUNX2 is involved in various aspects of luteal function by directly regulating the expression of diverse luteal genes. ..
Zhang W, Du J, Evans S, Yu Y, Yu X. T-cell differentiation factor CBF-? regulates HIV-1 Vif-mediated evasion of host restriction. Nature. 2011;481:376-9 pubmed publisher
..Considering the importance of the interaction between Vif and CBF-?, disrupting this interaction represents an attractive pharmacological intervention against HIV-1. ..