Cav1

Summary

Gene Symbol: Cav1
Description: caveolin 1
Alias: Cav, caveolin-1, caveolin 1, caveolae protein, caveolin caveolae protein 22 kDa, caveolin-like
Species: rat
Products:     Cav1

Top Publications

  1. Elçioğlu K, Kabasakal L, Cetinel S, Conturk G, Sezen S, Ayanoğlu Dülger G. Changes in caveolin-1 expression and vasoreactivity in the aorta and corpus cavernosum of fructose and streptozotocin-induced diabetic rats. Eur J Pharmacol. 2010;642:113-20 pubmed publisher
  2. Tan W, Rouen S, Barkus K, Dremina Y, Hui D, Christianson J, et al. Nerve growth factor blocks the glucose-induced down-regulation of caveolin-1 expression in Schwann cells via p75 neurotrophin receptor signaling. J Biol Chem. 2003;278:23151-62 pubmed
    ..Caveolin-1 (Cav-1) is highly expressed in adult SCs, and changes in its expression can regulate signaling through Erb B2, a co-..
  3. Thorleifsson G, Walters G, Hewitt A, Masson G, Helgason A, Dewan A, et al. Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. Nat Genet. 2010;42:906-9 pubmed publisher
    ..42, P = 0.0021). The risk variant identified here is located close to CAV1 and CAV2, both of which are expressed in the trabecular meshwork and retinal ganglion cells that are involved in ..
  4. Patel H, Zhang S, Murray F, Suda R, Head B, Yokoyama U, et al. Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J. 2007;21:2970-9 pubmed
    ..We tested the hypothesis that PASMC from IPAH patients express more caveolin-1 (Cav-1) and caveolae, which contribute to increased capacitative Ca2+ entry (CCE) and DNA synthesis...
  5. Razani B, Wang X, Engelman J, Battista M, Lagaud G, Zhang X, et al. Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Mol Cell Biol. 2002;22:2329-44 pubmed
    ..We now directly address the functional significance of caveolin-2 by genetically targeting the caveolin-2 locus (Cav-2) in mice...
  6. Sargiacomo M, Scherer P, Tang Z, Kübler E, Song K, Sanders M, et al. Oligomeric structure of caveolin: implications for caveolae membrane organization. Proc Natl Acad Sci U S A. 1995;92:9407-11 pubmed
    ..In this regard, it may be useful to think of caveolin homooligomers as "fishing lures" with multiple "hooks" or attachment sites for caveolin-interacting molecules. ..
  7. Sato Y, Sagami I, Shimizu T. Identification of caveolin-1-interacting sites in neuronal nitric-oxide synthase. Molecular mechanism for inhibition of NO formation. J Biol Chem. 2004;279:8827-36 pubmed
  8. Gonzalez M, Krizman Genda E, Robinson M. Caveolin-1 regulates the delivery and endocytosis of the glutamate transporter, excitatory amino acid carrier 1. J Biol Chem. 2007;282:29855-65 pubmed
    ..In the present study we tested the hypothesis that a structural component of lipid rafts, caveolin-1 (Cav-1), may participate in EAAC1 trafficking...
  9. Shin T, Kim H, Jin J, Moon C, Ahn M, Tanuma N, et al. Expression of caveolin-1, -2, and -3 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. J Neuroimmunol. 2005;165:11-20 pubmed
    ..Taking all the findings into consideration, we postulate that the expression levels of each caveolin begin to increase when EAE is initiated, possibly contributing to the modulation of signal transduction pathways in the affected cells. ..

More Information

Publications62

  1. Engelman J, Lee R, Karnezis A, Bearss D, Webster M, Siegel P, et al. Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer. J Biol Chem. 1998;273:20448-55 pubmed
    ..Taken together, our data suggest that a novel form of reciprocal negative regulation exists between c-Neu and caveolin-1. ..
  2. Kiss A, Turi A, Mullner N, Timar J. Caveolin isoforms in resident and elicited rat peritoneal macrophages. Eur J Cell Biol. 2000;79:343-9 pubmed
    ..Elicitation significantly increased the expression of caveolin-1, and the increased amount of caveolin-1 resulted in caveolae formation on the cell surface. ..
  3. Hansen C, Bright N, Howard G, Nichols B. SDPR induces membrane curvature and functions in the formation of caveolae. Nat Cell Biol. 2009;11:807-14 pubmed publisher
    ..STB colocalizes extensively with both SDPR and caveolin 1. Loss of caveolae reduces the propensity of STB to induce membrane tubulation...
  4. Scherer P, Okamoto T, Chun M, Nishimoto I, Lodish H, Lisanti M. Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. Proc Natl Acad Sci U S A. 1996;93:131-5 pubmed
    ..However, caveolin-1 and caveolin-2 differ in their functional interactions with heterotrimeric G proteins, possibly explaining why caveolin-1 and -2 are coexpressed within a single cell. ..
  5. Das M, Cui J, Das D. Generation of survival signal by differential interaction of p38MAPKalpha and p38MAPKbeta with caveolin-1 and caveolin-3 in the adapted heart. J Mol Cell Cardiol. 2007;42:206-13 pubmed
  6. Orlichenko L, Huang B, Krueger E, McNiven M. Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells. J Biol Chem. 2006;281:4570-9 pubmed
    Caveolae are flask-shaped endocytic structures composed primarily of caveolin-1 (Cav1) and caveolin-2 (Cav2) proteins...
  7. Pramudji C, Shimura S, Ebara S, Yang G, Wang J, Ren C, et al. In situ prostate cancer gene therapy using a novel adenoviral vector regulated by the caveolin-1 promoter. Clin Cancer Res. 2001;7:4272-9 pubmed
    ..The mouse cav-1 promoter was cloned and placed upstream of the HSV-tk gene in an adenoviral vector (Adcav-1tk) and compared with ..
  8. Williams T, Medina F, Badano I, Hazan R, Hutchinson J, Muller W, et al. Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J Biol Chem. 2004;279:51630-46 pubmed
    Caveolin-1 (Cav-1) is the principal structural component of caveolae membrane domains in non-muscle cells, including mammary epithelia. There is now clear evidence that caveolin-1 influences the development of human cancers...
  9. Koneru S, Penumathsa S, Thirunavukkarasu M, Samuel S, Zhan L, Han Z, et al. Redox regulation of ischemic preconditioning is mediated by the differential activation of caveolins and their association with eNOS and GLUT-4. Am J Physiol Heart Circ Physiol. 2007;292:H2060-72 pubmed
    ..we demonstrated involvement of ROS in IP-mediated GLUT-4 translocation along with increased expression of caveolin (Cav)-3, phospho (p)-endothelial nitric oxide synthase (eNOS), p-Akt, and decreased expression of Cav-1...
  10. Shen J, Ma S, Chan P, Lee W, Fung P, Cheung R, et al. Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion injury. J Neurochem. 2006;96:1078-89 pubmed
    ..These results, when taken together, suggest that NO modulates the expression of caveolin-1 in the brain and that the loss of caveolin-1 is associated with NO production in the ischemic brain. ..
  11. Dupree P, Parton R, Raposo G, Kurzchalia T, Simons K. Caveolae and sorting in the trans-Golgi network of epithelial cells. EMBO J. 1993;12:1597-605 pubmed
    ..This connection is confirmed by the recent finding that the amino acid sequence of VIP21 is almost identical to that of caveolin, a protein previously localized to caveolae. ..
  12. Scherer P, Lewis R, Volonte D, Engelman J, Galbiati F, Couet J, et al. Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. J Biol Chem. 1997;272:29337-46 pubmed
    ..These results suggest that expression levels of caveolins 1, 2, and 3 can be independently up-regulated or down-regulated in response to a variety of distinct cellular cues. ..
  13. Morgado N, Rigotti A, Valenzuela A. Comparative effect of fish oil feeding and other dietary fatty acids on plasma lipoproteins, biliary lipids, and hepatic expression of proteins involved in reverse cholesterol transport in the rat. Ann Nutr Metab. 2005;49:397-406 pubmed
  14. Qian N, Ueno T, Kawaguchi Sakita N, Kawashima M, Yoshida N, Mikami Y, et al. Prognostic significance of tumor/stromal caveolin-1 expression in breast cancer patients. Cancer Sci. 2011;102:1590-6 pubmed publisher
    Caveolin-1 (Cav-1) has been extensively characterized in cancer biological research. However, the role of Cav-1 in the interaction between tumor and stromal cells remains unclear...
  15. Wang Y, Maciejewski B, Drouillard D, Santos M, Hokenson M, Hawwa R, et al. A role for caveolin-1 in mechanotransduction of fetal type II epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2010;298:L775-83 pubmed publisher
    ..Caveolin-1 is translocated from the plasma membrane to the cytoplasm by mechanical stretch and functions as an inhibitory protein in stretch-induced type II cell differentiation via the ERK pathway. ..
  16. Ballard Croft C, Locklar A, Kristo G, Lasley R. Regional myocardial ischemia-induced activation of MAPKs is associated with subcellular redistribution of caveolin and cholesterol. Am J Physiol Heart Circ Physiol. 2006;291:H658-67 pubmed
    ..These results show the importance of caveolar membrane/lipid rafts in MAPK signaling and suggest that subcellular compartmentation of p44/p42 ERKs and p38 MAPK may play distinct roles in the response to myocardial ischemia-reperfusion. ..
  17. Gu Y, Zheng G, Xu M, Li Y, Chen X, Zhu W, et al. Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury. J Neurochem. 2012;120:147-56 pubmed publisher
    The roles of caveolin-1 (cav-1) in regulating blood-brain barrier (BBB) permeability are unclear yet...
  18. Cai T, Wang H, Chen Y, Liu L, Gunning W, Quintas L, et al. Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase. J Cell Biol. 2008;182:1153-69 pubmed publisher
    Here, we show that the Na/K-ATPase interacts with caveolin-1 (Cav1) and regulates Cav1 trafficking...
  19. Hunt C, Kolokoltsov A, Davey R, Maury W. The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus. J Virol. 2011;85:334-47 pubmed publisher
    ..Our findings demonstrate for the first time that Axl enhances macropinocytosis, thereby increasing productive ZEBOV entry. ..
  20. Zhang S, Liu Y, Zhao Z, Xue Y. Effects of green tea polyphenols on caveolin-1 of microvessel fragments in rats with cerebral ischemia. Neurol Res. 2010;32:963-70 pubmed publisher
  21. Woudenberg J, Rembacz K, van den Heuvel F, Woudenberg Vrenken T, Buist Homan M, Geuken M, et al. Caveolin-1 is enriched in the peroxisomal membrane of rat hepatocytes. Hepatology. 2010;51:1744-53 pubmed publisher
    ..Targeting of peroxisomal matrix proteins and peroxisome number and shape were not altered in rat hepatocytes with 70%-80% reduced caveolin-1 levels and in livers of caveolin-1 knockout mice...
  22. Cathcart M, Reynolds J, O Byrne K, Pidgeon G. The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer. Biochim Biophys Acta. 2010;1805:153-66 pubmed publisher
    ..Finally, we discuss current therapeutic strategies aimed at targeting these enzymes for the prevention/treatment of cancer. ..
  23. Sun Y, Hu G, Zhang X, Minshall R. Phosphorylation of caveolin-1 regulates oxidant-induced pulmonary vascular permeability via paracellular and transcellular pathways. Circ Res. 2009;105:676-85, 15 p following 685 pubmed publisher
    ..Caveolin-1-deficient mice (cav-1(-/-)) were resistant to H(2)O(2)-induced pulmonary vascular albumin hyperpermeability and edema formation...
  24. Watson C, Jeng Y, Hu G, Wozniak A, Bulayeva N, Guptarak J. Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-? interactions with G protein-?i and caveolin I. Steroids. 2012;77:424-32 pubmed publisher
    ..Xenoestrogens, like physiologic estrogens, can evoke downstream kinase signaling involving selective interactions of ER? with G(?i) and caveolin I, but with some different characteristics, which could explain their disruptive actions. ..
  25. Hulstrøm V, Prats C, Vinten J. Adipocyte size and cellular expression of caveolar proteins analyzed by confocal microscopy. Am J Physiol Cell Physiol. 2013;304:C1168-75 pubmed publisher
    ..The different relation between adipocyte size and cellular expression levels of caveolar proteins within and between individuals of different age shows that caveolar density is an age-sensitive characteristic of adipocytes. ..
  26. Zhang B, Peng F, Wu D, Ingram A, Gao B, Krepinsky J. Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells. Cell Signal. 2007;19:1690-700 pubmed
    ..with cyclodextrin or filipin prevented Akt activation, and both EGFR and Akt activation were lost in caveolin-1 (cav-1) knockout MC. The latter was rescued with reexpression of cav-1...
  27. Lopez I, Milagro F, Marti A, Moreno Aliaga M, Martinez J, de Miguel C. High-fat feeding period affects gene expression in rat white adipose tissue. Mol Cell Biochem. 2005;275:109-15 pubmed
  28. McGuire J, Rouen S, Siegfreid E, Wright D, Dobrowsky R. Caveolin-1 and altered neuregulin signaling contribute to the pathophysiological progression of diabetic peripheral neuropathy. Diabetes. 2009;58:2677-86 pubmed publisher
    Evaluate if Erb B2 activation and the loss of caveolin-1 (Cav1) contribute to the pathophysiological progression of diabetic peripheral neuropathy (DPN)...
  29. Kamishima T, Burdyga T, Gallagher J, Quayle J. Caveolin-1 and caveolin-3 regulate Ca2+ homeostasis of single smooth muscle cells from rat cerebral resistance arteries. Am J Physiol Heart Circ Physiol. 2007;293:H204-14 pubmed
    ..Our results suggest that caveolin-1 and caveolin-3 are important in Ca(2+) removal of resistance artery smooth muscle cells. ..
  30. Takaguri A, Shirai H, Kimura K, Hinoki A, Eguchi K, Carlile Klusacek M, et al. Caveolin-1 negatively regulates a metalloprotease-dependent epidermal growth factor receptor transactivation by angiotensin II. J Mol Cell Cardiol. 2011;50:545-51 pubmed publisher
    ..Here we hypothesized that caveolin-1 (Cav1), the major structural protein of a caveolae, a membrane microdomain, is involved in the regulation of ADAM17...
  31. Luo D, Cheng J, Xiong Y, Li J, Xia C, Xu C, et al. Static pressure drives proliferation of vascular smooth muscle cells via caveolin-1/ERK1/2 pathway. Biochem Biophys Res Commun. 2010;391:1693-7 pubmed publisher
    ..Our data also showed that a siRNA-mediated caveolin-1 knock down increased ERK1/2 phosphorylation and VSMC proliferation. These results demonstrate that static pressure promotes VSMC proliferation via the Caveolin-1/ERK1/2 pathway. ..
  32. Luo D, Xia C, Li J, Xiong Y, Yuan H, Tang Z, et al. Static pressure accelerates ox-LDL-induced cholesterol accumulation via SREBP-1-mediated caveolin-1 downregulation in cultured vascular smooth muscle cells. Biochem Biophys Res Commun. 2010;403:52-8 pubmed publisher
    ..Static pressures stimulate ox-LDL-induced cholesterol accumulation in cultured VSMCs through decreasing caveolin-1 expression via inducing the maturation and nuclear translocation of SREBP-1. ..
  33. Parton R, Way M, Zorzi N, Stang E. Caveolin-3 associates with developing T-tubules during muscle differentiation. J Cell Biol. 1997;136:137-54 pubmed
    ..The results suggest that caveolin-3 transiently associates with T-tubules during development and may be involved in the early development of the T-tubule system in muscle. ..
  34. Haeusler J, Hoegel J, Bachmann N, Herkommer K, Paiss T, Vogel W, et al. Association of a CAV-1 haplotype to familial aggressive prostate cancer. Prostate. 2005;65:171-7 pubmed
    Multiple lines of evidence have implicated the CAV-1 gene in prostate cancer progression. CAV-1 is located within the prostate cancer aggressiveness locus at 7q31-33, and was identified as being overexpressed in prostate tumors...
  35. Chen H, Yang H, Xu C, Yue H, Xia P, Strappe P, et al. Gene expression profiling of common signal transduction pathways affected by rBMSCs/F92A-Cav1 in the lungs of rat with pulmonary arterial hypertension. Biomed Pharmacother. 2016;83:100-106 pubmed publisher
    ..have found that rat bone marrow-derived mesenchymal stem cells (rBMSCs) transduced with a mutant caveolin-1(F92A-Cav1) could enhance endothelial nitric oxide synthase (eNOS) activity and improve pulmonary vascular remodeling, but the ..
  36. Gong J, Dong J, Wang Y, Xu H, Wei W, Zhong J, et al. Developmental iodine deficiency and hypothyroidism impair neural development, up-regulate caveolin-1 and down-regulate synaptophysin in rat hippocampus. J Neuroendocrinol. 2010;22:129-39 pubmed publisher
    ..Our findings implicate decreases in the number of surviving cells and alterations in the levels of caveolin-1 and synaptophysin in the impairments in neural development induced by developmental iodine deficiency and hypothyroidism. ..
  37. Alioua A, Lu R, Kumar Y, Eghbali M, Kundu P, Toro L, et al. Slo1 caveolin-binding motif, a mechanism of caveolin-1-Slo1 interaction regulating Slo1 surface expression. J Biol Chem. 2008;283:4808-17 pubmed
    ..Because the caveolin-1 scaffolding domain is juxtamembrane, it is tempting to suggest that Slo1-caveolin-1 interaction facilitates the tethering of the Slo1 C-terminal end to the membrane. ..
  38. Lin Y, Ma C, Hsu W, Lo H, Yang V. Molecular interaction between caveolin-1 and ABCA1 on high-density lipoprotein-mediated cholesterol efflux in aortic endothelial cells. Cardiovasc Res. 2007;75:575-83 pubmed
    ..In this study, we analyzed the relationships between caveolin-1 and ABCA1 on high-density lipoprotein (HDL)-mediated cholesterol efflux in rat aortic endothelial cells...
  39. Hu G, Vogel S, Schwartz D, Malik A, Minshall R. Intercellular adhesion molecule-1-dependent neutrophil adhesion to endothelial cells induces caveolae-mediated pulmonary vascular hyperpermeability. Circ Res. 2008;102:e120-31 pubmed publisher
  40. Kato T, Meguro A, Nomura E, Uemoto R, Nomura N, Ota M, et al. Association study of genetic variants on chromosome 7q31 with susceptibility to normal tension glaucoma in a Japanese population. Eye (Lond). 2013;27:979-83 pubmed publisher
    The caveolin 1 to caveolin 2 (CAV1-CAV2) gene region on chromosome 7q31 has been reported to be associated with susceptibility to primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) in previous studies...
  41. Mukherjee R, Kim S, Choi M, Yun J. Sex-dependent expression of caveolin 1 in response to sex steroid hormones is closely associated with development of obesity in rats. PLoS ONE. 2014;9:e90918 pubmed publisher
    Caveolin-1 (CAV1) is a conserved group of structural membrane proteins that form special cholesterol and sphingolipid-rich compartments, especially in adipocytes...
  42. Cohen A, Park D, Woodman S, Williams T, Chandra M, Shirani J, et al. Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts. Am J Physiol Cell Physiol. 2003;284:C457-74 pubmed
    Recently, development of a caveolin-1-deficient (Cav-1 null) mouse model has allowed the detailed analysis of caveolin-1's function in the context of a whole animal...
  43. Oh Y, Cho K, Ryu S, Khil L, Jun H, Yoon J, et al. Regulation of insulin response in skeletal muscle cell by caveolin status. J Cell Biochem. 2006;99:747-58 pubmed
  44. Liao L, Zheng B, Yi B, Liu C, Chen L, Zeng Z, et al. Annexin A2-modulated proliferation of pulmonary arterial smooth muscle cells depends on caveolae and caveolin-1 in hepatopulmonary syndrome. Exp Cell Res. 2017;359:266-274 pubmed publisher
    ..The over-expression of Cav-1 resulted in the relocation of ANXA2 from caveolae and negatively regulated ERK1/2 and NF-?B activation, which ..
  45. Feher A, Rutkai I, Beleznai T, Ungvari Z, Csiszar A, Edes I, et al. Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesity. Cardiovasc Res. 2010;87:732-9 pubmed publisher
    Caveolin-1 (Cav-1) interacts with large conductance Ca(2+)-activated potassium channels (BKCa) and likely exerts a negative regulatory effect on the channel activity...
  46. Sundivakkam P, Kwiatek A, Sharma T, Minshall R, Malik A, Tiruppathi C. Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells. Am J Physiol Cell Physiol. 2009;296:C403-13 pubmed publisher
    Caveolin-1 (Cav-1) regulates agonist-induced Ca(2+) entry in endothelial cells; however, how Cav-1 regulates this process is poorly understood...
  47. Wunderlich C, Schober K, Kasper M, Heerwagen C, Marquetant R, Ebner B, et al. Nitric oxide synthases are crucially involved in the development of the severe cardiomyopathy of caveolin-1 knockout mice. Biochem Biophys Res Commun. 2008;377:769-74 pubmed publisher
    Targeted ablation of caveolin-1 (cav-1) results in a severe cardiomyopathy. How the loss of cav-1 mediates these abnormalities is currently under investigation...
  48. Kawabe J, Okumura S, Lee M, Sadoshima J, Ishikawa Y. Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2004;286:H1845-52 pubmed
    ..We suggest that stretch-induced translocation of caveolin to noncaveolar sites plays an important role in mediating stretch-induced ERK activation in VSMCs. ..
  49. Bhatnagar A, Sheffler D, Kroeze W, Compton Toth B, Roth B. Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors. J Biol Chem. 2004;279:34614-23 pubmed
    ..In a search for 5-HT(2A) receptor-interacting proteins, we discovered that caveolin-1 (Cav-1), a scaffolding protein enriched in caveolae, complexes with 5-HT(2A) receptors in a number of cell types ..
  50. Sampson L, Hayabuchi Y, Standen N, Dart C. Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels. Circ Res. 2004;95:1012-8 pubmed
  51. Costa M, Senou M, Van Rode F, Ruf J, Capello M, Dequanter D, et al. Reciprocal negative regulation between thyrotropin/3',5'-cyclic adenosine monophosphate-mediated proliferation and caveolin-1 expression in human and murine thyrocytes. Mol Endocrinol. 2007;21:921-32 pubmed
    ..This demonstrates, for the first time, the in vivo significance of the specific caveolin-1 down-regulation by one mitogenic cascade and its relation to a human disease. ..
  52. Adebiyi A, Zhao G, Cheranov S, Ahmed A, Jaggar J. Caveolin-1 abolishment attenuates the myogenic response in murine cerebral arteries. Am J Physiol Heart Circ Physiol. 2007;292:H1584-92 pubmed
    ..Since caveolin-1 (cav-1) ablation abolishes caveolae formation in arterial smooth muscle cells, myogenic mechanisms were compared in ..
  53. Kwak J, Kim H, Jung S, Song J, Hong S, Oh K, et al. Co-localization and interaction of b0,+-type amino acid transporter 1 (BAT1) with caveolin-1 in rat kidney. J Nephrol. 2005;18:681-9 pubmed
    ..In this study, protein-protein interaction between rBAT1 and caveolin (Cav)-1 was investigated...