cathepsin H


Gene Symbol: cathepsin H
Description: cathepsin H
Alias: pro-cathepsin H, cathepsin B3, cathepsin BA
Species: rat
Products:     cathepsin H

Top Publications

  1. Fukada Y, Yasui K, Kitayama M, Doi K, Nakano T, Watanabe Y, et al. Gene expression analysis of the murine model of amyotrophic lateral sclerosis: studies of the Leu126delTT mutation in SOD1. Brain Res. 2007;1160:1-10 pubmed
    ..inhibitor clade A member 3N (Serpina3n), complement component 1q subcomponent beta polypeptide (C1qb), cathepsin H (Ctsh) and polyadenylate binding protein-interacting protein 1 (Paip1)...
  2. Takio K, Towatari T, Katunuma N, Teller D, Titani K. Homology of amino acid sequences of rat liver cathepsins B and H with that of papain. Proc Natl Acad Sci U S A. 1983;80:3666-70 pubmed
    ..The 252-residue sequence of cathepsin B and the 220-residue sequence of cathepsin H were determined largely by automated Edman degradation of their intact polypeptide chains and of the two chains ..
  3. Ishidoh K, Imajoh S, Emori Y, Ohno S, Kawasaki H, Minami Y, et al. Molecular cloning and sequencing of cDNA for rat cathepsin H. Homology in pro-peptide regions of cysteine proteinases. FEBS Lett. 1987;226:33-7 pubmed
    A cDNA for rat cathepsin H was isolated and sequenced...
  4. Rothe M, Dodt J. Studies on the aminopeptidase activity of rat cathepsin H. Eur J Biochem. 1992;210:759-64 pubmed
    ..Cit, citrulline) were used to characterize specificity requirements for the P1-S1 interaction of cathepsin H from rat liver...
  5. Ueno T, Linder S, Na C, Rice W, Johansson J, Weaver T. Processing of pulmonary surfactant protein B by napsin and cathepsin H. J Biol Chem. 2004;279:16178-84 pubmed
    ..b>Cathepsin H, a cysteine protease also implicated in pro-SP-B processing, cleaved SP-B/EGFP fusion protein 13 amino acids ..
  6. Brguljan P, Turk V, Nina C, Brzin J, Krizaj I, Popovic T. Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme. Peptides. 2003;24:1977-84 pubmed
    Highly purified human brain cathepsin H (EC was used to study its involvement in degradation of different brain peptides. Its action was determined to be selective...
  7. Torikai H, Akatsuka Y, Miyazaki M, Tsujimura A, Yatabe Y, Kawase T, et al. The human cathepsin H gene encodes two novel minor histocompatibility antigen epitopes restricted by HLA-A*3101 and -A*3303. Br J Haematol. 2006;134:406-16 pubmed
    ..from different post-HSCT recipients, we identified two novel mHag epitopes encoded by the leader sequence of cathepsin H (CTSH) isoform a...
  8. Gocheva V, Chen X, Peters C, Reinheckel T, Joyce J. Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer. Biol Chem. 2010;391:937-45 pubmed publisher
    ..This is also the case for cathepsin H, a member of the cysteine cathepsin family, and its utility as a prognostic marker has been analyzed ..
  9. Popovic T, Puizdar V, Ritonja A, Brzin J. Simultaneous isolation of human kidney cathepsins B, H, L and C and their characterisation. J Chromatogr B Biomed Appl. 1996;681:251-62 pubmed
    ..The main isoform of cathepsin H was separated from cathepsin C by cation-exchange chromatography on CM-Sephadex C-50...

More Information


  1. Ma J, Tanaka K, Yamada G, Ikenaka K. Induced expression of cathepsins and cystatin C in a murine model of demyelination. Neurochem Res. 2007;32:311-20 pubmed
    ..We propose that in MS, remyelination may be impaired by increasing activity of cathepsins inadequately controlled by cystatin C. ..
  2. Irwin L, Byers D. Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus. Brain Res. 2012;1489:1-7 pubmed publisher
    ..This suggests considerable variation in the way that olfactory information is processed at the cellular level in different brain regions and by the two sexes. ..
  3. Sivaparvathi M, Sawaya R, Gokaslan Z, Chintala S, Rao J, Chintala K. Expression and the role of cathepsin H in human glioma progression and invasion. Cancer Lett. 1996;104:121-6 pubmed
    ..In this study, we determined the levels of cathepsin H in human glioma progression and the significance of cathepsin H in glioma cell invasion...
  4. Dahlmann B, Kuehn L, Heinrich P, Kirschke H, Wiederanders B. ATP-activated, high-molecular-mass proteinase-I from rat skeletal muscle is a cysteine proteinase-alpha 1-macroglobulin complex. Biochim Biophys Acta. 1989;991:253-62 pubmed
    ..and Neubauer, H.-P. (1989) Biochim. Biophys. Acta 991, 263), we conclude that the ATP-stimulated high-molecular-mass proteolytic activity is partly due to the presence of a complex of alpha-macroglobulin and cysteine proteinases. ..
  5. Zavasnik Bergant V, Schweiger A, Bevec T, Golouh R, Turk V, Kos J. Inhibitory p41 isoform of invariant chain and its potential target enzymes cathepsins L and H in distinct populations of macrophages in human lymph nodes. Immunology. 2004;112:378-85 pubmed
    ..Co-localization of p41 Ii with cathepsin H was confirmed in strongly CD68(+) sinus-lining macrophages, acting as APC...
  6. Barrett A, Davies M, Grubb A. The place of human gamma-trace (cystatin C) amongst the cysteine proteinase inhibitors. Biochem Biophys Res Commun. 1984;120:631-6 pubmed
    ..The inhibition constants of cystatin C, taken together with its widespread distribution in human tissues and extracellular fluids, suggest that a physiological function could well be the regulation of cysteine proteinase activity. ..
  7. Woischnik M, Bauer A, Aboutaam R, Pamir A, Stanzel F, De Blic J, et al. Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis. Eur Respir J. 2008;31:1197-204 pubmed publisher
    ..of these two forms, the present authors studied the surfactant protein processing proteases napsin A and cathepsin H. In total, 16 controls, 20 patients with juvenile PAP and 13 adults with idiopathic PAP were enrolled...
  8. Schweiger A, Stabuc B, Popovic T, Turk V, Kos J. Enzyme-linked immunosorbent assay for the detection of total cathepsin H in human tissue cytosols and sera. J Immunol Methods. 1997;201:165-72 pubmed
    An enzyme-linked immunosorbent assay (ELISA) was constructed for the determination of total human cathepsin H concentration in clinical samples...
  9. Nishimura Y, Tsuji H, Kato K, Sato H, Amano J, Himeno M. Biochemical properties and intracellular processing of lysosomal cathepsins B and H. Biol Pharm Bull. 1995;18:829-36 pubmed
    ..The specific radioactivity derived from each protein band of lysosomal cathepsin H in SDS-PAGE at 1, 3, 6, 12, 24 and 48 h after the injection of a radiolabel showed that the peak of specific ..
  10. LU J, Qian J, Keppler D, Cardoso W. Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis. J Biol Chem. 2007;282:22176-84 pubmed
    ..In a global screen for transcriptional targets of Fgf10, we identified Ctsh (cathepsin H), a gene encoding a lysosomal cysteine protease of the papain family, highly up-regulated in the developing ..
  11. Nagai A, Terashima M, Harada T, Shimode K, Takeuchi H, Murakawa Y, et al. Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasis. Clin Chim Acta. 2003;329:53-60 pubmed
    ..A high enzyme activity/cystatin C concentration ratio in the CSF could be useful when diagnosing LM in combination with other parameters. ..
  12. D Angelo M, Bird P, Peters C, Reinheckel T, Trapani J, Sutton V. Cathepsin H is an additional convertase of pro-granzyme B. J Biol Chem. 2010;285:20514-9 pubmed publisher
    ..Here, we describe an assay to assess activation of proGrB and show that the amino-peptidase cathepsin H (CatH) has proGrB convertase activity in vitro, whereas dipeptidylpeptidase II does not...
  13. Wu S, Huang Y, Yeh C, Tsai M, Liao C, Cheng W, et al. Cathepsin H regulated by the thyroid hormone receptors associate with tumor invasion in human hepatoma cells. Oncogene. 2011;30:2057-69 pubmed publisher
    ..Previous microarray analysis revealed that cathepsin H (CTSH) is upregulated by T(3) in HepG2-TR cells...
  14. Cataldo A, Paskevich P, Kominami E, Nixon R. Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease. Proc Natl Acad Sci U S A. 1991;88:10998-1002 pubmed
    ..The actions of membrane-degrading acid hydrolases could also explain how the intramembrane portion of APP containing the C terminus of beta-amyloid becomes accessible to proteases. ..
  15. Haraguchi C, Ishido K, Kominami E, Yokota S. Expression of cathepsin H in differentiating rat spermatids: immunoelectron microscopic study. Histochem Cell Biol. 2003;120:63-71 pubmed
    The expression of cathepsin H (CH) in differentiating rat spermatids was studied by an immunoelectron microscopic technique...
  16. Bihoreau M, Megel N, Brown J, Kränzlin B, Crombez L, Tychinskaya Y, et al. Characterization of a major modifier locus for polycystic kidney disease (Modpkdr1) in the Han:SPRD(cy/+) rat in a region conserved with a mouse modifier locus for Alport syndrome. Hum Mol Genet. 2002;11:2165-73 pubmed
    ..It may also have strong implications in the identification of pathophysiological factors common to different renal disorders. ..
  17. Farges M, Balcerzak D, Fisher B, Attaix D, Bechet D, Ferrara M, et al. Increased muscle proteolysis after local trauma mainly reflects macrophage-associated lysosomal proteolysis. Am J Physiol Endocrinol Metab. 2002;282:E326-35 pubmed
    ..showed increased cathepsin B activity (+327%) and mRNA encoding cathepsin B (+670%), cathepsin L (+298%), cathepsin H (+159%), and cathepsin C (+268%)...
  18. Moreau T, Esnard F, Gutman N, Degand P, Gauthier F. Cysteine-proteinase-inhibiting function of T kininogen and of its proteolytic fragments. Eur J Biochem. 1988;173:185-90 pubmed
  19. Staack A, Tolic D, Kristiansen G, Schnorr D, Loening S, Jung K. Expression of cathepsins B, H, and L and their inhibitors as markers of transitional cell carcinoma of the bladder. Urology. 2004;63:1089-94 pubmed
    ..Increased cathepsin concentrations in the supernatant of the poorly differentiated J82 carcinoma cell culture, as well as in cancerous bladder tissue, are indicative of a proteolytic imbalance and potential indicators of bladder cancer. ..
  20. Brasch F, ten Brinke A, Johnen G, Ochs M, Kapp N, Müller K, et al. Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes. Am J Respir Cell Mol Biol. 2002;26:659-70 pubmed
    ..2-kD dipalmitoylated protein. To characterize the processing of proSP-C and the role of the cysteine protease cathepsin H, we studied the localization of proSP-C and cathepsin H in human as well as proSP-C in rat lungs, the enzymatic ..
  21. González Rivera R, Navarro L, Martínez Vargas M, Guzman Vasquez K, León Rosario P, Landa A, et al. Potential participation of cystatin C in rapid eye movement sleep (REMS) modulation. Neurosci Lett. 2006;408:178-82 pubmed
    ..We further showed that REMS deprivation increases the expression of Cathepsin H (CH), a protease inhibited by CC...
  22. Mathur P, Grima J, Mo M, Zhu L, Aravindan G, Calcagno K, et al. Differential expression of multiple cathepsin mRNAs in the rat testis during maturation and following lonidamine induced tissue restructuring. Biochem Mol Biol Int. 1997;42:217-33 pubmed
    ..steady-state mRNA levels of cathepsin B, C, D, L, and S remain relatively unchanged with the exception of cathepsin H whose mRNA level increased during maturation and peaked at 45-60 days of age...
  23. Mantle D, Falkous G, Ishiura S, Perry R, Perry E. Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease. J Neurol Sci. 1995;131:65-70 pubmed
    ..Alzheimer's disease; however the finding of significant increases in activity of dipeptidyl aminopeptidase II, cathepsin H and cathepsin D specifically in cases with Huntington's disease is of particular note...
  24. Ishidoh K, Kominami E, Katunuma N, Suzuki K. Gene structure of rat cathepsin H. FEBS Lett. 1989;253:103-7 pubmed
    The gene structure of rat cathepsin H was determined. It comprises at least 12 exons of various lengths (32-433 bp) spanning in total more than 17.5 kbp...
  25. Schaefer L, Han X, Gretz N, Schaefer R. Alterations of cathepsins B, H and L in proximal tubules from polycystic kidneys of the Han:SPRD rat. Kidney Int. 1996;50:424-31 pubmed
  26. Vattimo M, Santos O. Functional interface between cathepsins and growth factors in the kidney development. Ren Fail. 2005;27:615-22 pubmed
    ..chain reaction (RT-PCR) techniques in order to investigate the expression of cathepsins S (CS) and cathepsin H (CH) during metanephrogenesis and their functional interface with hepatic growth factor (HGF) and nerve growth ..
  27. Qian F, Frankfater A, Miller R, Chan S, Steiner D. Molecular cloning of rat precursor cathepsin H and the expression of five lysosomal cathepsins in normal tissues and in a rat carcinosarcoma. Int J Biochem. 1990;22:1457-64 pubmed
    1. A rat cathepsin H cDNA was isolated from a rat liver cDNA library with synthetic oligonucleotide probes. 2. DNA sequence analysis indicated that it codes for rat preprocathepsin H. 3...
  28. Ishii Y, Hashizume Y, Watanabe T, Waguri S, Sato N, Yamamoto M, et al. Cysteine proteinases in bronchoalveolar epithelial cells and lavage fluid of rat lung. J Histochem Cytochem. 1991;39:461-8 pubmed
    ..Immunodeposits for cathepsin H only were demonstrated in lamellar bodies of Type II alveolar epithelial cells, suggesting the cosecretion of ..
  29. Fl yel T, Brorsson C, Nielsen L, Miani M, Bang Berthelsen C, Friedrichsen M, et al. CTSH regulates ?-cell function and disease progression in newly diagnosed type 1 diabetes patients. Proc Natl Acad Sci U S A. 2014;111:10305-10 pubmed publisher vitro and in vivo experiments with clinical studies to determine how genetic variation of the candidate gene cathepsin H (CTSH) affects disease mechanisms and progression in T1D...
  30. Oda K, Luo Y, Yoshihara A, Ishido Y, Sekihata K, Usukura K, et al. Follicular thyroglobulin induces cathepsin H expression and activity in thyrocytes. Biochem Biophys Res Commun. 2017;483:541-546 pubmed publisher
    ..We found that in the rat thyroid cell line FRTL-5 follicular Tg induced cathepsin H mRNA and protein expression, as well as cathepsin H enzyme activity...