caspase 3

Summary

Gene Symbol: caspase 3
Description: caspase 3
Alias: Lice, CASP-3, CPP-32, CPP32beta, Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease), Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease), IRP, SCA-1, SREBP cleavage activity 1, apopain, caspase-3, cysteine protease CPP32, protein Yama, yama protein
Species: rat

Top Publications

  1. ncbi Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3
    Xuchen Zhang
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 278:1248-58. 2003
  2. ncbi Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Neurosci Lett 459:47-51. 2009
  3. ncbi Caspase-3-mediated cyclic stretch-induced myoblast apoptosis via a Fas/FasL-independent signaling pathway during myogenesis
    Jiaqiang Liu
    Department of Orthodontics, The Fourth Military Medical University, Xi an, Shanxi Province, People s Republic of China
    J Cell Biochem 107:834-44. 2009
  4. ncbi [Temporal expression and significance of caspase-3 and interleukin-8 in the lungs of preterm rats exposed to hyperoxia]
    Wei Liu
    Department of Pediatrics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Er Ke Za Zhi 46:229-33. 2008
  5. ncbi Effect of hydrogen peroxide on secretory response, calcium mobilisation and caspase-3 activity in the isolated rat parotid gland
    Antonio Mata
    Cidade Universitaria, Lisbon, Portugal
    Mol Cell Biochem 319:23-31. 2008
  6. ncbi Proliferation related acidic leucine-rich protein PAL31 functions as a caspase-3 inhibitor
    Weiyong Sun
    Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences Veterinary Medical Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Biochem Biophys Res Commun 342:817-23. 2006
  7. ncbi Anti-tumor effect of endostatin mediated by retroviral gene transfer in mice bearing renal cell carcinoma
    Enia Lúcia Coutinho
    Division of Nephrology, Department of Medicine, Universidade Federal de Sao Paulo, SP, Brazil
    FASEB J 21:3153-61. 2007
  8. ncbi Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression
    Carmine Morisco
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Napoli, Italy
    Cardiovasc Res 76:453-64. 2007
  9. ncbi The apoptotic effects of oxidative stress and antiapoptotic effects of caspase inhibitors on rat notochordal cells
    Ki Won Kim
    Department of Orthopedic Surgery, St Mary s Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea
    Spine (Phila Pa 1976) 32:2443-8. 2007
  10. ncbi Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat
    Erik Vahtola
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    J Hypertens 26:334-44. 2008

Research Grants

  1. STRUCTURE/FUNCTION OF NERVE GROWTH FACTOR/NEUROTROPHINS
    KENNETH NEET; Fiscal Year: 2007
  2. NADPH oxidase and pancreatic cancer cell survival
    Anna Gukovskaya; Fiscal Year: 2009
  3. HSP25 and HSP20 Regulation in Skeletal Muscle Adapt
    KIMBERLY HUEY; Fiscal Year: 2006
  4. A Staged Strategy for Virus Identification and Discovery
    W Ian Lipkin; Fiscal Year: 2005
  5. Mass Tag PCR Detection of Respiratory Pathogens
    W Ian Lipkin; Fiscal Year: 2004
  6. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2004
  7. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2004
  8. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2007
  9. Calcium Homeostasis and Neonatal Brain Injury
    Christopher Turner; Fiscal Year: 2007
  10. Calcium Homeostasis and Neonatal Brain Injury
    Christopher Turner; Fiscal Year: 2009

Detail Information

Publications121 found, 100 shown here

  1. ncbi Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3
    Xuchen Zhang
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 278:1248-58. 2003
    ..CO, through p38 MAPK, indirectly modulates caspase 3. Furthermore, we correlate our in vitro apoptosis model with an in vivo model of A-R by showing that CO can ..
  2. ncbi Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Neurosci Lett 459:47-51. 2009
    ..Based on the current data, it could be concluded that high glucose-induced apoptosis in PC12 cells is mediated, in part, by activation of caspase-8, -9, and -3 dependent pathways...
  3. ncbi Caspase-3-mediated cyclic stretch-induced myoblast apoptosis via a Fas/FasL-independent signaling pathway during myogenesis
    Jiaqiang Liu
    Department of Orthodontics, The Fourth Military Medical University, Xi an, Shanxi Province, People s Republic of China
    J Cell Biochem 107:834-44. 2009
    ..Furthermore, we had provided evidence that caspase-3 mediated cyclic stretch-induced myoblast apoptosis. Mechanical forces induced activation of caspase-3 via signaling pathways independent of Fas/FasL system...
  4. ncbi [Temporal expression and significance of caspase-3 and interleukin-8 in the lungs of preterm rats exposed to hyperoxia]
    Wei Liu
    Department of Pediatrics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Er Ke Za Zhi 46:229-33. 2008
    ..To explore the temporal expression and significance of Caspase-3 and interleukin-8 (IL-8) in hyperoxia-induced lung injury in preterm rats...
  5. ncbi Effect of hydrogen peroxide on secretory response, calcium mobilisation and caspase-3 activity in the isolated rat parotid gland
    Antonio Mata
    Cidade Universitaria, Lisbon, Portugal
    Mol Cell Biochem 319:23-31. 2008
    ..This effect of H(2)O(2) may be due to its activity to induce apoptosis in the parotid gland, since H(2)O(2) can stimulate the activity of caspase-3, a marker of cellular apoptosis...
  6. ncbi Proliferation related acidic leucine-rich protein PAL31 functions as a caspase-3 inhibitor
    Weiyong Sun
    Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences Veterinary Medical Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Biochem Biophys Res Commun 342:817-23. 2006
    ..In conclusion, PAL31 is a multifunctional protein working as a cell cycle progression factor as well as a cell survival factor...
  7. ncbi Anti-tumor effect of endostatin mediated by retroviral gene transfer in mice bearing renal cell carcinoma
    Enia Lúcia Coutinho
    Division of Nephrology, Department of Medicine, Universidade Federal de Sao Paulo, SP, Brazil
    FASEB J 21:3153-61. 2007
    ..A second mechanism may also be implied in endostatin-dependent tumor regression, associated with tumor infiltration of leukocytes. Besides its antiangiogenic properties, endostatin may be a promising adjuvant to immunotherapy...
  8. ncbi Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression
    Carmine Morisco
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Napoli, Italy
    Cardiovasc Res 76:453-64. 2007
    ..Caspases are a family of cysteine proteases that regulate apoptosis. We explored the effects of insulin resistance on hypoxia-induced caspase-3 activation in cardiomyocytes...
  9. ncbi The apoptotic effects of oxidative stress and antiapoptotic effects of caspase inhibitors on rat notochordal cells
    Ki Won Kim
    Department of Orthopedic Surgery, St Mary s Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea
    Spine (Phila Pa 1976) 32:2443-8. 2007
    ..Western blotting and flow cytometric analyses were performed using rat notochordal cells...
  10. ncbi Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat
    Erik Vahtola
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    J Hypertens 26:334-44. 2008
    ....
  11. ncbi 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action
    W Wang
    Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham AL 35294, USA
    Br J Cancer 98:792-802. 2008
    ..In conclusion, our preclinical data indicate that 25-OCH3-PPD is a potential therapeutic agent against both androgen-dependent and androgen-independent prostate cancer...
  12. ncbi A new lactoferrin- and iron-dependent lysosomal death pathway is induced by benzo[a]pyrene in hepatic epithelial cells
    Morgane Gorria
    INSERM U620, Toxicity of polycyclic aromatic hydrocarbons group Equipe Labellisée Ligue contre le Cancer, Faculte de Pharmacie, Universite Rennes I, 2 Avenue Pr Léon Bernard, Rennes Cedex, France
    Toxicol Appl Pharmacol 228:212-24. 2008
    ....
  13. ncbi Implication of caspases and subcellular compartments in tert-butylhydroperoxide induced apoptosis
    Khadidja Haidara
    Departement de Chimie, TOXEN, Universite du Quebec a Montreal, Montreal, Canada
    Toxicol Appl Pharmacol 229:65-76. 2008
    ..This study demonstrates that caspase-9 and caspase-12 are activated in t-BHP-induced apoptosis in hepatocytes. We highlight the importance of subcellular compartments such as mitochondria, ER and nuclei in the apoptotic process...
  14. ncbi Hyperbaric oxygen attenuates apoptosis and decreases inflammation in an ischemic wound model
    Qixu Zhang
    Division of Plastic Surgery, Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    J Invest Dermatol 128:2102-12. 2008
    ..These results indicate that HBO improves ischemic wound healing by downregulation of HIF-1alpha and subsequent target gene expression with attenuation of cell apoptosis and reduction of inflammation...
  15. ncbi P2X(7) nucleotide receptors mediate caspase-8/9/3-dependent apoptosis in rat primary cortical neurons
    Qiongman Kong
    Interdisciplinary Neuroscience Program, University of Missouri Columbia, Columbia, Missouri, USA
    Purinergic Signal 1:337-47. 2005
    ..Taken together, these data indicate that extracellular nucleotides mediate neuronal apoptosis through activation of P2X(7)Rs and their downstream signaling pathways involving JNK1, ERK and caspases 8/9/3...
  16. ncbi VX-induced cell death involves activation of caspase-3 in cultured rat cortical neurons
    Catherine C Tenn
    Medical Therapy Group, DRDC Suffield, P O Box 4000, Station Main, Medicine Hat, Alberta T1A 8K6, Canada
    Neurosci Lett 417:155-9. 2007
    ..These data suggested that in rat cortical neurons, VX-induced cell death via a programmed cell death pathway that involves changes in caspase-3 protease...
  17. ncbi [Protective effects of minocycline against apoptosis of olfactory sensory neurons]
    Fanglei Ye
    Department of Otorhinolaryngology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 20:1135-7. 2006
    ..To investigate the protective effects of minocycline against apoptosis of olfactory sensory neurons induced by sinusitis...
  18. ncbi Erythropoietin preconditioning on hippocampus neuronal apoptosis following status epilepticus induced by Li-pilocarpine in rats through anti-caspase-3 expression
    XiaoNi Wen
    Department of Neurology, Xijing Hospital, The Fourth Military Medical University of Chinese PLA, China
    Neurol India 54:58-63; discussion 63. 2006
    ..Recently, erythropoietin (Epo) has been shown to have potent anti-apoptosis activity in central nervous system neurons in animal models of ischaemic injury...
  19. ncbi ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures
    Young Hae Chong
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University, Yangcheonku, Seoul, 158 710, Korea
    J Biol Chem 281:20315-25. 2006
    ....
  20. ncbi Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1
    Julie D Atkin
    Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, USA
    J Biol Chem 281:30152-65. 2006
    ..The possibility that PDI may be a therapeutic target to prevent SOD1 aggregation is also raised by this study...
  21. ncbi The role of caspase-3 activation in phencyclidine-induced neuronal death in postnatal rats
    Cheng Z Wang
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555 1031, USA
    Neuropsychopharmacology 32:1178-94. 2007
    ..These data demonstrate that caspase-3 activation plays a necessary role in the regionally selective neuronal death induced by PCP in the developing rat brain...
  22. ncbi Evidence of HIF-1 functional binding activity to caspase-3 promoter after photothrombotic cerebral ischemia
    Michael van Hoecke
    Laboratoire de Pharmacodynamie et Physiologie Pharmaceutique, Faculte de Pharmacie, 7 Boulevard Jeanne d Arc, BP 87900, 21079 Dijon Cedex, France
    Mol Cell Neurosci 34:40-7. 2007
    ..Altogether the present data provide strong arguments for a causative relationship between HIF-1alpha and caspase-3 inductions through a functional binding activity to the caspase-3 gene promoter...
  23. ncbi Inhibition of HtrA2/Omi ameliorates heart dysfunction following ischemia/reperfusion injury in rat heart in vivo
    Md Shenuarin Bhuiyan
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Eur J Pharmacol 557:168-77. 2007
    ..These results suggest that UCF-101 rescues cardiomyocytes from ischemia/reperfusion injury by inhibiting XIAP degradation and Fas/Fas-ligand-induced apoptosis, thereby ameliorating ischemia/reperfusion-induced myocardial dysfunction...
  24. ncbi Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis
    Keren Yacobi
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
    Endocrinology 148:1717-26. 2007
    ..Thus, this study reveals a linkage between two seemingly distinct processes in which LH-induced caspase activation in cultured rat preovulatory follicles is coupled to mitochondrial steroidogenesis via P450scc...
  25. ncbi Use of combined apoptosis biomarkers for prediction of bladder cancer recurrence and mortality after radical cystectomy
    Jose A Karam
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Lancet Oncol 8:128-36. 2007
    ....
  26. ncbi Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation
    Makio Saeki
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 282:11786-94. 2007
    ..These results suggest that calcineurin B potentiates the activation of procaspase-3 by accelerating its proteolytic maturation...
  27. ncbi Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c
    Takeshi Kanno
    Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan
    J Cell Physiol 226:2329-37. 2011
    ....
  28. ncbi Antiapoptosis and mitochondrial effect of pioglitazone preconditioning in the ischemic/reperfused heart of rat
    Jian Li
    Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No 1277 Jiefang Road, Wuhan 430022, China
    Cardiovasc Drugs Ther 22:283-91. 2008
    ..Furthermore, we investigated whether the protective effect of pioglitazone was related to opening of the mitochondrialATP-sensitive potassium channels...
  29. ncbi Tocotrienol attenuates oxidative-nitrosative stress and inflammatory cascade in experimental model of diabetic neuropathy
    Anurag Kuhad
    Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh 160 014, India
    Neuropharmacology 57:456-62. 2009
    ....
  30. ncbi Attenuation of renoinflammatory cascade in experimental model of diabetic nephropathy by sesamol
    Anurag Kuhad
    Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh 160 014, India
    J Agric Food Chem 57:6123-8. 2009
    ..The data reveal that sesamol modulates the release of profibrotic cytokines, oxidative stress, ongoing chronic inflammation, and apoptosis and thus exerts a marked renoprotective effect...
  31. ncbi Evaluation of transcriptional activity of caspase-3 gene as a marker of acute neurotoxicity in rat cerebellar granular cells
    Jaume Folch
    Unitat de Bioquimica, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, C St Llorenç 21, 43201 Reus, Tarragona, Spain
    Toxicol In Vitro 24:465-71. 2010
    ..Transcriptional activity of caspase-3 correlates significantly with these changes and it could be a good indicator of acute neurotoxicity...
  32. ncbi [Expression of caspase-3 in rat kidney with renal tubular damage induced by lipopolysaccharide and hypoxia]
    Fang Yang
    Department of Pediatrics, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510630, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:2091-3. 2009
    ..To observe the expression of caspase-3 in the kidney of a rat model of renal tubular damage induced by endotoxin and hypoxia and explore the mechanism of renal tubular damage...
  33. ncbi Maternal oral consumption of morphine increases Bax/Bcl-2 ratio and caspase 3 activity during early neural system development in rat embryos
    Shiva Nasiraei-Moghadam
    Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    J Mol Neurosci 41:156-64. 2010
    ..Immunohistochemical assay was used to reveal the protein expression of Bax, Bcl2, and the activation of caspase 3. The results showed a significant increase in Bax immunoreactivity in all of the mentioned embryonic days (E9...
  34. ncbi Prevention of lung ischemia-reperfusion injury by short hairpin RNA-mediated caspase-3 gene silencing
    Yong Xing Zhang
    Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China
    J Thorac Cardiovasc Surg 139:758-64. 2010
    ..Silencing gene expression of caspase-3 by short hairpin RNA (shRNA) can downregulate the caspase cascade. Therefore, we evaluated the therapeutic efficacy of caspase-3 shRNA in a rat model of lung ischemia-reperfusion injury...
  35. ncbi 7,3'-dimethoxy hesperetin induces apoptosis of fibroblast-like synoviocytes in rats with adjuvant arthritis through caspase 3 activation
    Rong Li
    School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei, China
    Phytother Res 24:1850-6. 2010
    ..Bcl-2, Bax, caspase 3 gene expressions and caspase 3 activity were assayed to identify whether caspase 3 was involved in the apoptosis ..
  36. ncbi Vasoactive intestinal peptide inhibits TNF-alpha-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands
    Mario Calafat
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon II, Buenos Aires, Argentina
    Arthritis Res Ther 11:R53. 2009
    ..Our goal was to analyse the effect of TNF-alpha on apoptotic mediators in isolated acinar cells from NOD submandibular gland and their modulation by VIP...
  37. ncbi The many roles of FAS receptor signaling in the immune system
    Andreas Strasser
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Immunity 30:180-92. 2009
    ..This review describes current understanding of Fas-induced apoptosis signaling and proposes experimental strategies for future advances...
  38. ncbi Nuclear translocation of X-linked inhibitor of apoptosis (XIAP) determines cell fate after hypoxia ischemia in neonatal brain
    Juliet C Russell
    The Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, Maryland, USA
    J Neurochem 106:1357-70. 2008
    ..HI triggered the mitochondrial release of cytochrome c, Smac/DIABLO, and caspase 3 activation...
  39. ncbi Time-dependent increases in protease activities for neuronal apoptosis in spinal cords of Lewis rats during development of acute experimental autoimmune encephalomyelitis
    Arabinda Das
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci Res 86:2992-3001. 2008
    ..From these findings, we conclude that increases in calpain and caspase activities play crucial roles in neuronal apoptosis during the development of acute EAE...
  40. ncbi Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model
    Jianmei Cai
    Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China
    Neurosci Lett 441:167-72. 2008
    ..These results indicated H2 administration after HI appeared to provide brain protection via inhibition of neuronal apoptosis...
  41. ncbi Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation
    M Bhattacharjee
    Department of Laboratory Medicine, School of Tropical Medicine, 108, Chittaranjan Avenue Road, Kolkata 700073
    Int Immunol 20:1489-505. 2008
    ..The present work focuses on the mechanistic approach of how T11TS mediates apoptosis and hence is the first approach of its kind in the field of immunology where the immunotherapeutic molecule's mode of action has been worked out...
  42. ncbi Inhibition of nNOS reduces ischemic cell death through down-regulating calpain and caspase-3 after experimental stroke
    Ming Sun
    Department of Neurochemistry, Beijing Neurosurgical Institute, China
    Neurochem Int 54:339-46. 2009
    ....
  43. ncbi Caspase-dependent retinal ganglion cell apoptosis in the rat model of acute diabetes
    Yong hao Li
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, Guangdong, China
    Chin Med J (Engl) 121:2566-71. 2008
    ..Neural apoptosis is generally believed to be mediated by two distinct pathways, caspase-dependant and caspase-independent pathways. This study investigated the apoptotic pathways involved in retinal ganglion cells in acute diabetes in rats...
  44. ncbi Activation of caspase-3 may not contribute to postresuscitation myocardial dysfunction
    Jeejabai Radhakrishnan
    Medical Service 111F North Chicago VA Medical Center, 3001 Green Bay Road, North Chicago, IL 60064, USA
    Am J Physiol Heart Circ Physiol 296:H1164-74. 2009
    ..Concomitant activation of intrinsic antiapoptotic mechanisms could play a protective role downstream to caspase-3 activation...
  45. ncbi Protective effects of chitosan oligosaccharide on paraquat-induced nephrotoxicity in rats
    Sang Pil Yoon
    Korean DNA Repair Research Center, Chosun University, Gwangju, Republic of Korea
    Food Chem Toxicol 49:1828-33. 2011
    ..These results showed that PQ-induced nephrotoxicity may be caused by apoptosis in rat kidneys and that COS could protect kidneys from PQ-induced toxicity in association with the basal higher level of APE...
  46. ncbi Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity
    David C Zebrowski
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, 07103, USA
    J Mol Cell Cardiol 40:605-18. 2006
    ....
  47. ncbi Caspase-3-dependent reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures
    Elizabeth A Hunsperger
    Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA
    J Neurovirol 9:390-8. 2003
    ..Interestingly, the caspase-3 inhibitor had no effect on productive HSV-1 infection. Furthermore, activation of caspase-3 with either C2-ceramide or a recombinant adenovirus expressing caspase-3 caused significant HSV-1 reactivation...
  48. ncbi PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone
    Gang Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Second Medical University, Shanghai, China
    FEBS Lett 579:4005-11. 2005
    ....
  49. ncbi The effect of C-peptide on cognitive dysfunction and hippocampal apoptosis in type 1 diabetic rats
    Anders A F Sima
    Wayne State University School of Medicine, Department of Pathology, 540 E Canfield Ave, Detroit, MI 48201, USA
    Diabetes 54:1497-505. 2005
    ..These findings were associated with the prevention of increased expression of Bax and active caspase 3 and the frequency of caspase 3-positive neurons...
  50. ncbi Caspase-3 and -6 expression and activation are targeted by hormone action in the rat ventral prostate during the apoptotic cell death process
    Asma Omezzine
    Institut National de la Santé et de la Recherche Médicale INSERM U 407, Faculté de médecine Lyon Sud, 69921, Oullins, France
    Biol Reprod 69:752-60. 2003
    ....
  51. ncbi Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain
    Ramanjit Gill
    F Hoffmann La Roche Ltd, Preclinical Research Basel, CNS Department, Basel, Switzerland
    J Cereb Blood Flow Metab 22:420-30. 2002
    ....
  52. ncbi Inhibition of TNFalpha in vivo prevents hyperoxia-mediated activation of caspase 3 in type II cells
    Florian Guthmann
    Humboldt Universitat zu Berlin, Klinik für Neonatologie, Charite Campus Mitte, D 10098 Berlin, Germany
    Respir Res 6:10. 2005
    ..We hypothesised that, in the initial phase of hyperoxia, TNFalpha activates the caspase cascade in type II pneumocytes (TIIcells)...
  53. ncbi Caspase 3 activation is essential for neuroprotection in preconditioning
    BethAnn McLaughlin
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:715-20. 2003
    ..In an in vivo model of ischemic tolerance, we were surprised to observe widespread caspase 3 cleavage, without cell death, in preconditioned tissue...
  54. ncbi Arachidonic acid converts the glutathione depletion-induced apoptosis to necrosis by promoting lipid peroxidation and reducing caspase-3 activity in rat glioma cells
    Yoshihiro Higuchi
    Department of Molecular Pharmacology, Kanazawa University Graduate School of Medical Science, Kanazawa 920 8640, Japan
    Arch Biochem Biophys 400:133-40. 2002
    ..Some ROS such as hydroperoxide produced by unknown pathway make hydroxy radicals and induce 8-OH-dG formation in the cells. The conversion of apoptosis to necrosis may be a possible event under GSH depleted conditions...
  55. ncbi Inflammation and caspase activation in long-term renal ischemia/reperfusion injury and immunosuppression in rats
    Bin Yang
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, UK
    Kidney Int 68:2050-67. 2005
    ..For the first time, we have now investigated the effects of I/R and immunosuppression on inflammation and caspase activation...
  56. ncbi Endurance exercise training inhibits activity of plasma GOT and liver caspase-3 of mice [correction of rats] exposed to stress by induction of heat shock protein 70
    Toshio Mikami
    Department of Health and Sports Science, Nippon Medical School, 2 297 2 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 0063, Japan
    J Appl Physiol 96:1776-81. 2004
    ..These results suggest that exercise training enhanced the resting level of liver HSP70 and hepatic protection against various stresses, at least partly attributing to the suppression of caspase-3 activity by the increase in HSP70...
  57. ncbi Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle
    J A Flaws
    Department of Population Dynamics, Johns Hopkins University, Baltimore, Maryland 21205 2179, USA
    Endocrinology 136:5042-53. 1995
    ..Finally, we tested the requirement for IRP activity in granulosa cell apoptosis and follicular atresia by incubating follicles without and with IRP inhibitors...
  58. ncbi Caspase-3-dependent and -independent apoptosis in focal brain ischemia
    Vladimir V Didenko
    Department of Neurosurgery and Surgical Service, Baylor College of Medicine and VAMC, Houston, Texas 77030, USA
    Mol Med 8:347-52. 2002
    ..This raises the question whether caspase-3 synthesis and activation are essential for execution of the apoptotic program and DNA fragmentation in permanent brain ischemia, a condition that impairs cellular protein synthesis...
  59. ncbi Comparing calpain- and caspase-3-mediated degradation patterns in traumatic brain injury by differential proteome analysis
    Ming Cheng Liu
    Center for Neuroproteomics and Biomarkers Research, Department of Psychiatry, McKnight Brain Institute, University of Florida, P O Box 100256, Gainesville, FL 32610, USA
    Biochem J 394:715-25. 2006
    ..In summary, we demonstrated that HTPI is a novel and powerful method for studying proteolytic pathways in vivo and in vitro...
  60. ncbi The membrane attack complex of complement induces caspase activation and apoptosis
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 32:783-92. 2002
    ..In line with this observation, complement induced cleavage and activation of caspase 3. Importantly, cellular exposure to purified cytolytically inactive C5b-9, in the absence of antibody and early ..
  61. ncbi Caspase activity is essential for long-term potentiation
    Natalia V Gulyaeva
    Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia
    J Neurosci Res 73:853-64. 2003
    ..Candidate caspase-3 substrates that may be cleaved for LTP induction and maintenance are discussed...
  62. ncbi Cyclophilin-A is involved in excitotoxin-induced caspase activation in rat neuronal B50 cells
    Michela Capano
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 363:29-36. 2002
    ..It is concluded that neuroprotection by cyclosporin A against excitotoxin-induced apoptosis is, at least partly, due to inhibition of cyclophilin-A...
  63. ncbi Formation of high molecular weight caspase-3 complex in neonatal rat brain
    Kazuhide Kurosu
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurochem Int 44:199-204. 2004
    ..These results indicate that procaspase-3 exists as a high molecular weight complex during brain development...
  64. ncbi Nicotine suppresses tunicamycin-induced, but not thapsigargin-induced, expression of GRP78 during ER stress-mediated apoptosis in PC12 cells
    Harue Sasaya
    Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering and High Technology Research Center, Kansai University, 3 3 35 Yamate cho, Suita, Osaka 564 8680, Japan
    J Biochem 144:251-7. 2008
    ....
  65. ncbi Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide
    Eduardo Latorre
    Departamento de Bioquimica y Biologia Molecular I, Facultad de Quimicas, Universidad Complutense de Madrid, Madrid, Spain
    Eur J Biochem 270:36-46. 2003
    ..Furthermore, experiments with Ac-DEVD-CMK (caspase-3 specific inhibitor) have led us to conclude that caspase-3 is downstream of ceramide in activating the brain plasmalogen-selective phospholipase A2...
  66. ncbi Negative regulation of caspase-3 expression in the neonatal cerebral cortex by alpha2A-adrenoceptors
    P N Men'shanov
    Laboratory of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk
    Bull Exp Biol Med 143:277-9. 2007
    ..The relationship between the observed effect and low expression of alpha2-adrenoceptors was confirmed by the possibility of correcting this phenomenon by clonidine (stimulator of alpha2-adrenoceptors)...
  67. ncbi Central injection of caspase inhibitors facilitates the formation of freezing behavior in rats
    E V Markina
    P K Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia
    Bull Exp Biol Med 143:566-8. 2007
    We studied the effects of central administration of pancaspase inhibitor z-VAD-fmk and specific caspase 3 inhibitor z-DEVD-fmk on learning and memory in rats...
  68. ncbi Sepsis stimulates calpain activity in skeletal muscle by decreasing calpastatin activity but does not activate caspase-3
    Wei Wei
    Dept of Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Am J Physiol Regul Integr Comp Physiol 288:R580-90. 2005
    ..The results suggest that sepsis-induced muscle wasting is associated with increased calpain activity, secondary to reduced calpastatin activity, and that caspase-3 activity is not involved in the catabolic response to sepsis...
  69. ncbi Chronic low-dose oxidative stress induces caspase-3-dependent PKCdelta proteolytic activation and apoptosis in a cell culture model of dopaminergic neurodegeneration
    Martha Carvour
    Parkinson s Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, and Department of Biomedical Sciences, Iowa State University, Ames, Iowa, USA
    Ann N Y Acad Sci 1139:197-205. 2008
    ....
  70. ncbi Inhibiting caspase-3 activity blocks beta-catenin degradation after focal ischemia in rat
    Hanfeng Zhang
    Department of Neurosurgery, Stanford University, Stanford, California 94305 5327, USA
    Neuroreport 19:821-4. 2008
    ..The caspase 3-specific inhibitor, Z-DQMD-FMK, attenuated beta-catenin degradation, but it did not affect phosphorylation of ..
  71. ncbi Increased acetylcholinesterase and capase-3 expression in the brain and peripheral immune system of focal cerebral ischemic rats
    Tao Hu
    Department of Immunology, Binzhou Medical College, Yantai, PR China
    J Neuroimmunol 211:84-91. 2009
    ..We propose that this pro-apoptotic activity may result in a T helper cell (Th1/Th2) imbalance and impaired immune function in ischemia...
  72. ncbi Non-lethal active caspase-3 expression in Bergmann glia of postnatal rat cerebellum
    Sowmini Oomman
    Department of Physiology, Texas Tech University Health Sciences Center, Room 5A163, Lubbock, TX 79430, USA
    Brain Res Dev Brain Res 160:130-45. 2005
    ..Thus, this study supports the hypothesis that active caspase-3 may be regulating both differentiation of Bergmann glia by allowing the cells to exit the cell cycle and their morphogenesis...
  73. ncbi Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury
    Byung Hee Han
    Department of Neurology, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 277:30128-36. 2002
    ....
  74. ncbi Involvement of proinflammatory factors, apoptosis, caspase-3 activation and Ca2+ disturbance in microglia activation-mediated dopaminergic cell degeneration
    Xijin Wang
    Department of Neurology and Institute of Neurology, Clinical and Research Center for Parkinson Disease, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, PR China
    Mech Ageing Dev 126:1241-54. 2005
    ..Understanding the mechanism for microglia activation-mediated dopaminergic neurodegeneration may contribute to the development of new neuroprotective strategies against PD...
  75. ncbi Tyrosine hydroxylase and dopamine transporter expression in lactotrophs from postlactating rats: involvement in dopamine-induced apoptosis
    Arnaud Jaubert
    Laboratoire de Signalisation et Mécanismes Moléculaires de l Apoptose, INSERM E347, Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Endocrinology 148:2698-707. 2007
    ..The fact that this process requires DAT and TH expression by lactotrophs themselves suggests that it may be "autocrine" in nature...
  76. ncbi Identification and functional analysis of the rat caspase-3 gene promoter
    Wenfang Liu
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20007, USA
    J Biol Chem 277:8273-8. 2002
    ..Homology analysis revealed that the 5'-flanking region of the human caspase-3 gene exhibits significant similarity to a regulatory region of the rat gene...
  77. ncbi ER stress-induced caspase-12 activation is inhibited by PKC in neuronal cells
    W Lee
    Biomedical Research Center, The Functional Proteomics Center, Korea
    Apoptosis 10:407-15. 2005
    ..These results suggest that an ER stress induces the activation of caspase-12 via caspase-3, and that PKC regulates both caspase-12 and caspase-3 activations in Cas-12 cells...
  78. ncbi Role of inhibitor of apoptosis protein in gentamicin-induced cochlear hair cell damage
    K Tabuchi
    Department of Surgery, Division Otolaryngology and Neurosciences, University of California, San Diego School of Medicine, 9500 Gilman Drive 0666, La Jolla, CA 92093, USA
    Neuroscience 149:213-22. 2007
    ..The results indicate that XIAP normally acts to decrease caspase-3 activation and hair cell loss during gentamicin ototoxicity, as part of a protective response to potentially damaging stimuli...
  79. ncbi Caspase-3 activation in astrocytes following postnatal excitotoxic damage correlates with cytoskeletal remodeling but not with cell death or proliferation
    Laia Acarin
    Medical Histology, Department of Cell Biology, Physiology and Immunology, Faculty of Medicine and Institute of Neurosciences, Autonomous University of Barcelona, Spain
    Glia 55:954-65. 2007
    ....
  80. ncbi MK801-induced activated caspase-3 exhibits selective co-localization with GAD67
    Christopher P Turner
    Neurobiology and Anatomy, Wake Forest University School of Medicine, 1 Medical Center Blvd, Winston Salem, NC 27157 1010, United States
    Neurosci Lett 462:152-6. 2009
    ..These data suggest that whereas somatic expression of AC3 and GAD67 may be non-overlapping, areas that exhibit punctate GAD67 (and are high in synaptic turnover) may be more vulnerable to MK801 exposure...
  81. ncbi Cancer during pregnancy alters the activity of rat placenta and enhances the expression of cleaved PARP, cytochrome-c and caspase 3
    Mércia Tancredo Toledo
    Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, CP 6109, 13083 970, SP, Brazil
    BMC Cancer 6:168. 2006
    ..In this work, we investigated the placental alterations produced by tumour growth and the effects on the expression of apoptotic factors in placental tissue...
  82. ncbi Development-dependent disappearance of caspase-3 in skeletal muscle is post-transcriptionally regulated
    Louis Bruno Ruest
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital and Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Cell Biochem 86:21-8. 2002
    ..The post-transcriptional regulation of caspase-3 might serve as a fail-safe mechanism to avoid accidental cell death...
  83. ncbi Neuroprotective mechanism of taurine due to up-regulating calpastatin and down-regulating calpain and caspase-3 during focal cerebral ischemia
    Ming Sun
    Department of Neurochemistry, Beijing Neurosurgical Institute, 6 Tiantan Xi Li, 100050 Beijing, PR China
    Cell Mol Neurobiol 28:593-611. 2008
    ....
  84. ncbi [Time-dependent expression of caspase-3 during contused skeletal muscle wound healing in rats]
    Qi Wang
    School of Forensic Medicine, China Medical University, Shenyang 110001, China
    Fa Yi Xue Za Zhi 24:5-7, 11. 2008
    ..Objective: To investigate the expression of caspase-3 during contused skeletal muscle wound healing in rats and to explore the applicability of caspase-3 in wound age estimation...
  85. ncbi Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12
    Amie J Dirks
    Biochemistry of Aging Laboratory, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 36:27-39. 2004
    ..Calorie restriction is able to lower the apoptotic potential in aged skeletal muscle by altering several key apoptotic proteins toward cellular survival, thereby reducing the potential for sarcopenia...
  86. ncbi Leptin protects H9c2 rat cardiomyocytes from H2O2-induced apoptosis
    Megumi Eguchi
    Department of Biology, York University, Toronto, Ontario, Canada
    FEBS J 275:3136-44. 2008
    ..In summary, we have demonstrated that acute leptin pretreatment mediates anti-apoptotic effects in H9c2 rat cardiomyocytes, which may be of significance in clarifying the direct impact of leptin on the heart...
  87. ncbi RNA expression bcl-w, a new related protein Bcl-2 family, and caspase-3 in isolated sertoli cells from pre-pubertal rat testes
    A Giannattasio
    Department of Virology, Ascalesi Hospital, Naples, Italy
    J Endocrinol Invest 25:RC23-5. 2002
    ..These 2 mechanisms are used extensively by cells for the activation of the effectors caspases: caspase 3, caspase 6, and/or caspase 7...
  88. ncbi Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis
    Anna S Gukovskaya
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and the UCLA, Los Angeles, California 90073, USA
    J Biol Chem 277:22595-604. 2002
    ..Protection against necrosis and trypsin activation by caspases can explain why the severity of pancreatitis in experimental models correlates inversely with the extent of apoptosis...
  89. ncbi Taurocholate potentiates ethanol-induced NF-kappaB activation and inhibits caspase-3 activity in cultured rat gastric mucosal cells
    Harri Mustonen
    Department of Surgery, Helsinki University Central Hospital, Box 700, 00029, HUS, Helsinki, Finland
    Dig Dis Sci 54:928-36. 2009
    ..The TC (5 mM)-induced protection in EtOH exposed tissues seems to have two distinct pathways, inhibition of apoptosis and enhancement of NF-kappaB signaling...
  90. ncbi The effects of lidocaine and bupivacaine on protein expression of cleaved caspase 3 and tyrosine phosphorylation in the rat hippocampal slice
    Souhayl Dahmani
    Department of Anesthesia, Beaujon University Hospital, assistance publique des hôpitaux de Paris and Paris 7 university, Clichy, France
    Anesth Analg 104:119-23. 2007
    ..Here, we compared the effects of lidocaine and bupivacaine on FAK phosphorylation and cleaved caspase 3 expression in rat hippocampal slices. Slices were treated with increasing concentrations of lidocaine (4...
  91. ncbi Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase
    Teruyoshi Uetani
    Department of Biochemistry and Molecular Genetics, Center for Regenerative Medicine CEREM, Ehime University, Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    J Biol Chem 284:12399-409. 2009
    ..These data indicate that insufficiency of proHB-EGF shedding under hypoxic stress leads to cardiomyocyte apoptosis via Caspase-3- and JNK-dependent pathways...
  92. ncbi [Caspase-3-mediated alpha-smooth muscle actin cleavage during staurosporine-induced myofibroblast apoptosis]
    Ayako Nakazono
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Nihon Yakurigaku Zasshi 120:94P-95P. 2002
    ..These results suggested that alpha-smooth muscle actin is directly degraded by caspase-3 in response to apoptotic stimuli in myofibroblasts...
  93. ncbi Chronic hypobaric hypoxia induced apoptosis in CA1 region of hippocampus: a possible role of NMDAR mediated p75NTR upregulation
    Sunil K Hota
    Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, India
    Exp Neurol 212:5-13. 2008
    ..chromatin condensation using Hoechst staining along with estimation of caspase activity and expression of active Caspase 3. Expression of p75(NTR) was studied to determine its possible role in triggering apoptosis in hypobaric hypoxia...
  94. ncbi Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria
    Jinzhao Wang
    Department of Cell Biology and Anatomy, Medical College of Georgia, 1459 Laney Walker Boulevard, Augusta, GA 30912, USA
    J Biol Chem 279:19948-54. 2004
    ..Thus, minocycline can protect neuronal as well as nonneuronal cells and tissues. One mechanism for minocycline protection involves the induction of Bcl-2, an antiapoptotic protein...
  95. ncbi Differential activation of c-fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia
    Jayne M Ness
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Neurosci Res 86:1115-24. 2008
    ..The differential expression of c-Fos in HI-resistant hippocampal subpopulations vs. cleaved caspase-3 in dying neurons suggests a neuroprotective role for c-Fos expression in neonatal HI...
  96. ncbi Hyperosmotic stress-induced caspase-3 activation is mediated by p38 MAPK in the hippocampus
    Julie M Niswander
    Department of Neurology, The University of Toledo College of Medicine, Toledo, OH 43614 5809, USA
    Brain Res 1186:1-11. 2007
    ....
  97. ncbi Enhancement of TNF-alpha-mediated cell death in vascular smooth muscle cells through cytochrome c-independent pathway by the proteasome inhibitor
    Hak Hyung Kim
    College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, South Korea
    FEBS Lett 535:190-4. 2003
    ..These results suggest that proteasome inhibition potentiates TNF-mediated death in VSMCs in a cyt c-independent pathway. The present study proposes a new mechanism by which VSMCs undergo death by cytokines...
  98. ncbi Mesenchymal stem cells from rat bone marrow downregulate caspase-3-mediated apoptotic pathway after spinal cord injury in rats
    Venkata Ramesh Dasari
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL 61656, USA
    Neurochem Res 32:2080-93. 2007
    ..The ability of rMSC to incorporate into the spinal cord, differentiate and to improve locomotor recovery hold promise for a potential cure after SCI...
  99. ncbi Expression time course and spatial distribution of activated caspase-3 after experimental status epilepticus: contribution of delayed neuronal cell death to seizure-induced neuronal injury
    Jens Weise
    Department of Neurology University of Goettingen Medical School, Robert Koch Str 40, 37075 Goettingen, Germany
    Neurobiol Dis 18:582-90. 2005
    ..These results demonstrate that apoptosis contributes significantly to PCSE-induced neuronal cell death...
  100. ncbi Role of Caspase-3 in acute light damage to retina of rats
    Xiao Wang
    Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060
    Chin Med Sci J 22:44-8. 2007
    ..To investigate the role of Caspase-3 in retinal damage caused by light exposure in rats...
  101. ncbi Caspase inhibition reduces cardiac myocyte dyshomeostasis and improves cardiac contractile function after major burn injury
    Deborah L Carlson
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 9160, USA
    J Appl Physiol 103:323-30. 2007
    ..The present data suggest that signaling through myocardial caspases plays a pivotal role in burn-related myocyte sodium dyshomeostasis and myocyte inflammation, perhaps contributing to burn-related contractile dysfunction...

Research Grants62

  1. STRUCTURE/FUNCTION OF NERVE GROWTH FACTOR/NEUROTROPHINS
    KENNETH NEET; Fiscal Year: 2007
    ....
  2. NADPH oxidase and pancreatic cancer cell survival
    Anna Gukovskaya; Fiscal Year: 2009
    ....
  3. HSP25 and HSP20 Regulation in Skeletal Muscle Adapt
    KIMBERLY HUEY; Fiscal Year: 2006
    ....
  4. A Staged Strategy for Virus Identification and Discovery
    W Ian Lipkin; Fiscal Year: 2005
    ..Our initial focus will be two chronic diseases where specific viral taxa are associated and potentially implicated in pathogenesis: bronchioalveolar cell carcinoma and amyotrophic lateral sclerosis. ..
  5. Mass Tag PCR Detection of Respiratory Pathogens
    W Ian Lipkin; Fiscal Year: 2004
    ..abstract_text> ..
  6. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2004
    ..Consistent with aims proposed in AI51292, our initial clinical application will be to analyze enteroviral serotypes implicated in human disease in North America. ..
  7. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2004
    ..4) Determine how opoptosis contributes to the neuropathology observed after neonatal infection. (5) Analyze regional changes in neurotransmitter systems following neonatal infection. ..
  8. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2007
    ....
  9. Calcium Homeostasis and Neonatal Brain Injury
    Christopher Turner; Fiscal Year: 2007
    ....
  10. Calcium Homeostasis and Neonatal Brain Injury
    Christopher Turner; Fiscal Year: 2009
    ....
  11. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2009
    ....
  12. Apoptosis and Necrosis in Pancreatitis
    Anna Gukovskaya; Fiscal Year: 2009
    ..Our hypothesis proposes a mechanism for this pathological process and, further, links it to pancreatic cell death. ..
  13. STRUCTURE/FUNCTION OF NERVE GROWTH FACTOR/NEUROTROPHINS
    KENNETH NEET; Fiscal Year: 2009
    ..abstract_text> ..
  14. NADPH oxidase and pancreatic cancer cell survival
    Anna Gukovskaya; Fiscal Year: 2007
    ....
  15. Viral Arrays for Biodefense
    W Ian Lipkin; Fiscal Year: 2007
    ....
  16. STRUCTURE/FUNCTION OF NERVE GROWTH FACTOR/NEUROTROPHINS
    KENNETH NEET; Fiscal Year: 2003
    ....
  17. MOLECULAR ANALYIS OF A NEUROTROPIC AGENT, BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 1993
    ..to continue our studies in the molecular biology of the BD agent; 2. to use our molecular probes for the BD agent to ask whether BD can be implicated in selected human neuropsychiatric diseases...
  18. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2002
    ....
  19. STRUCTURE/FUNCTION OF TRK RECEPTORS FOR NEUROTROPHINS
    KENNETH NEET; Fiscal Year: 2001
    ....
  20. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER LIPKIN; Fiscal Year: 2002
    ..This study will be the first to collect and process human sera and PBMC samples in clinical laboratories with no history of BDV research and dispense aliquots to a central laboratory for randomized, blinded analysis. ..
  21. STRUCTURE & FUNCTION OF NERVE GROWTH FACTOR
    KENNETH NEET; Fiscal Year: 1993
    ..this information will eventually lead to better understanding of neurodevelopmental problems and related diseased such as Alzheimer's and Huntington's diseases...