Gene Symbol: Casp1
Description: caspase 1
Alias: Ice, Il1bc, caspase-1, CASP-1, IL-1 beta-converting enzyme, IL-1BC, Interleukin 1beta converting enzyme, interleukin 1, beta, convertase, interleukin-1 beta-converting enzyme, p45
Species: rat
Products:     Casp1

Top Publications

  1. Boost K, Hoegl S, Hofstetter C, Flondor M, Stegewerth K, Platacis I, et al. Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia. Intensive Care Med. 2007;33:863-871 pubmed publisher
    ..These results further underscore that inhalation may constitute an effective route of anti-inflammatory drug administration, beneficial in the clinical setting of ARDS. ..
  2. Thomas P, Dash P, Aldridge J, Ellebedy A, Reynolds C, Funk A, et al. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity. 2009;30:566-75 pubmed publisher
    ..Here, we demonstrated that Nlrp3(-/-) and Casp1(-/-) mice were more susceptible than wild-type mice after infection with a pathogenic influenza A virus...
  3. de Rivero Vaccari J, Lotocki G, Alonso O, Bramlett H, Dietrich W, Keane R. Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. J Cereb Blood Flow Metab. 2009;29:1251-61 pubmed publisher
  4. Silverman W, de Rivero Vaccari J, Locovei S, Qiu F, Carlsson S, Scemes E, et al. The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem. 2009;284:18143-51 pubmed publisher
    ..Thus, in contrast to macrophages and monocytes in which low intracellular K(+) has been suggested to trigger inflammasome activation, in neural cells, high extracellular K(+) activates caspase-1 probably through pannexin 1. ..
  5. Schroder K, Tschopp J. The inflammasomes. Cell. 2010;140:821-32 pubmed publisher
    ..Regulatory mechanisms that potentiate or limit inflammasome activation are examined, as well as emerging links between the inflammasome and pyroptosis and autophagy. ..
  6. Agostini L, Martinon F, Burns K, McDermott M, Hawkins P, Tschopp J. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity. 2004;20:319-25 pubmed
    ..Macrophages from Muckle-Wells patients spontaneously secrete active IL-1beta. Increased inflammasome activity is therefore likely to be the molecular basis of the symptoms associated with NALP3-dependent autoinflammatory disorders. ..
  7. Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 2002;10:417-26 pubmed
    ..Thus, the inflammasome constitutes an important arm of the innate immunity. ..
  8. Dinarello C. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol. 2009;27:519-50 pubmed publisher
  9. Amantea D, Bagetta G, Tassorelli C, Mercuri N, Corasaniti M. Identification of distinct cellular pools of interleukin-1beta during the evolution of the neuroinflammatory response induced by transient middle cerebral artery occlusion in the brain of rat. Brain Res. 2010;1313:259-69 pubmed publisher
    ..Depending on the stage and intensity of the insult, the different cellular origin of the cytokine may suggest a distinct role of this neuroinflammatory mediator in ischemic pathophysiology. ..

More Information


  1. Roe M, Bloxham D, White D, Ross Russell R, Tasker R, O Donnell D. Lymphocyte apoptosis in acute respiratory syncytial virus bronchiolitis. Clin Exp Immunol. 2004;137:139-45 pubmed
    ..This is a mechanism through which lymphopenia may occur and T cell memory may be altered. ..
  2. Trueblood K, Mohr S, Dubyak G. Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1. Am J Physiol Cell Physiol. 2011;301:C1213-23 pubmed publisher
  3. Zheng Y, Humphry M, Maguire J, Bennett M, Clarke M. Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1?, controlling necrosis-induced sterile inflammation. Immunity. 2013;38:285-95 pubmed publisher
    ..Thus, we report a cell type-dependent process that fundamentally governs IL-1? activity postnecrosis and the mechanism allowing conditional release of this blockade. ..
  4. Doi T, Doi S, Nakashima A, Ueno T, Yokoyama Y, Kohno N, et al. Mizoribine ameliorates renal injury and hypertension along with the attenuation of renal caspase-1 expression in aldosterone-salt-treated rats. PLoS ONE. 2014;9:e93513 pubmed publisher
  5. Deng C, Zang Z, Sun X, Huang X, Wang H, Wang D, et al. [Expression and significance of caspase-1 in benign hyperplastic prostate tissues]. Zhonghua Nan Ke Xue. 2005;11:810-2 pubmed
    ..01). The expression of caspase-1 is dramatically reduced in the hyperplastic prostate tissues, which indicates that the decline of caspase-1-dependent apoptosis might be involved in the progress of benign prostatic hyperplasia. ..
  6. Lu C, Wang Y, Furukawa K, Fu W, Ouyang X, Mattson M. Evidence that caspase-1 is a negative regulator of AMPA receptor-mediated long-term potentiation at hippocampal synapses. J Neurochem. 2006;97:1104-10 pubmed
    ..These findings suggest that, by selectively reducing AMPA currents and calcium influx, caspase-1 functions as a negative regulator of LTP at hippocampal synapses. ..
  7. Ha S, Park S, Han C, Nguyen M, Kim S. Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol Cell Biol. 2012;32:4846-60 pubmed publisher
    ..This study demonstrates for the first time that MLN64 plays a key role in LeTx/caspase-1-induced mitochondrial dysfunction...
  8. Sarkar A, Duncan M, Hart J, Hertlein E, Guttridge D, Wewers M. ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. J Immunol. 2006;176:4979-86 pubmed
    ..These data suggest that ASC may direct caspase-1 away from RIP2-mediated NF-kappaB activation, toward caspase-1-mediated processing of proIL-1beta by interfering with the RIP2 caspase-1 interaction. ..
  9. Carlson D, Maass D, White J, Sikes P, Horton J. Caspase inhibition reduces cardiac myocyte dyshomeostasis and improves cardiac contractile function after major burn injury. J Appl Physiol (1985). 2007;103:323-30 pubmed
    ..The present data suggest that signaling through myocardial caspases plays a pivotal role in burn-related myocyte sodium dyshomeostasis and myocyte inflammation, perhaps contributing to burn-related contractile dysfunction. ..
  10. Zhang X, Li M, Wang B, Guo M, Zhu R. Caspase-1 inhibition alleviates acute renal injury in rats with severe acute pancreatitis. World J Gastroenterol. 2014;20:10457-63 pubmed publisher
    ..treated with saline (SAP-S, n = 18), or SAP rats treated with a caspase-1/interleukin (IL)-1?-converting-enzyme (ICE) inhibitor (SAP-I-ICE, n = 18)...
  11. Merkle S, Frantz S, Schön M, Bauersachs J, Buitrago M, Frost R, et al. A role for caspase-1 in heart failure. Circ Res. 2007;100:645-53 pubmed
    ..Our findings support a functional role for caspase-1-mediated myocardial apoptosis contributing to the progression of heart failure. ..
  12. Winter R, Kramer A, Borkowski A, Kyprianou N. Loss of caspase-1 and caspase-3 protein expression in human prostate cancer. Cancer Res. 2001;61:1227-32 pubmed
    ..This study suggests that the pattern of caspase-1 and -3 expression in prostatic tumors may have prognostic significance in disease progression. ..
  13. Aries A, Whitcomb J, Shao W, Komati H, Saleh M, Nemer M. Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate. Cell Death Dis. 2014;5:e1566 pubmed publisher
    ..The data identify a caspase-1 nuclear substrate and suggest a direct role for caspase-1 in transcriptional regulation. This mechanism may underlie the inflammation-independent action of caspase-1 in other organs. ..
  14. Oshikawa K, Shi F, Rakhmilevich A, Sondel P, Mahvi D, Yang N. Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1beta converting enzyme cDNA. Proc Natl Acad Sci U S A. 1999;96:13351-6 pubmed that a cancer gene therapy protocol using a combination of IL-12, pro-IL-18, and IL-1beta converting enzyme (ICE) cDNA expression vectors simultaneously delivered via gene gun can significantly augment antitumor effects, ..
  15. Wang X, Narayanan M, Bruey J, Rigamonti D, Cattaneo E, Reed J, et al. Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death. Biochim Biophys Acta. 2006;1762:742-54 pubmed
    ..Cop, as an inhibitor of an important apical caspase cell death axis, may provide a tool for modulating pathological cell death. ..
  16. Ravizza T, Lucas S, Balosso S, Bernardino L, Ku G, Noe F, et al. Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy. Epilepsia. 2006;47:1160-8 pubmed blocking the brain production of IL-1beta, by using selective inhibitors of interleukin-converting enzyme (ICE/caspase-1) or through caspase-1 gene deletion. Caspase-1 was selectively blocked by using pralnacasan or VX-765...
  17. Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, et al. Non-canonical inflammasome activation targets caspase-11. Nature. 2011;479:117-21 pubmed publisher
    ..This finding is important because published targeting of the Casp1 gene was done using strain 129 embryonic stem cells...
  18. Ravizza T, Noe F, Zardoni D, Vaghi V, Sifringer M, Vezzani A. Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production. Neurobiol Dis. 2008;31:327-33 pubmed publisher
    ..We show here that the selective inhibition of Interleukin Converting Enzyme (ICE), which cleaves the biologically active form of IL-1beta using VX-765, blocks kindling development in rats by ..
  19. Cao Y, Gu Z, Lin F, Han R, Qin Z. Caspase-1 inhibitor Ac-YVAD-CHO attenuates quinolinic acid-induced increases in p53 and apoptosis in rat striatum. Acta Pharmacol Sin. 2005;26:150-4 pubmed
    ..Caspase-1 is involved in QA-induced p53 upregulation but not IkappaB-alpha degradation. Inhibition of caspase-1 attenuates QA-induced apoptosis in rat striatum. ..
  20. Izawa M, Kimura M, Yamada T, Saji M. Castration-induced expression of caspase-1 in epithelia of accessory sex organs in male rats. Asian J Androl. 2001;3:105-8 pubmed
    ..Castration induces the expression of caspase-1 transcripts in the epithelia of ventral prostate and seminal vesicle. These observations suggest a possible role of caspase-1 in apoptosis in male accessory sex organs. ..
  21. Barnoy S, Kosower N. Caspase-1-induced calpastatin degradation in myoblast differentiation and fusion: cross-talk between the caspase and calpain systems. FEBS Lett. 2003;546:213-7 pubmed
  22. Lu A, Magupalli V, Ruan J, Yin Q, Atianand M, Vos M, et al. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell. 2014;156:1193-1206 pubmed publisher
    ..We propose that ASC-dependent inflammasomes in both families share a unified assembly mechanism that involves two successive steps of nucleation-induced polymerization. PAPERFLICK:..
  23. Imeri L, Bianchi S, Opp M. Inhibition of caspase-1 in rat brain reduces spontaneous nonrapid eye movement sleep and nonrapid eye movement sleep enhancement induced by lipopolysaccharide. Am J Physiol Regul Integr Comp Physiol. 2006;291:R197-204 pubmed
    ..These results, in agreement with previous evidence, support the involvement of brain IL-1beta in physiological promotion of NREM sleep and in mediating NREM sleep enhancement induced by peripheral immune challenge. ..
  24. Kim N, Lee H, Son E, Kwon O, Park J, Park J, et al. Hypoxic induction of caspase-11/caspase-1/interleukin-1beta in brain microglia. Brain Res Mol Brain Res. 2003;114:107-14 pubmed
    ..caspase-11, which is required for the activation of caspase-1 or interleukin-1beta (IL-1beta) converting enzyme (ICE)...
  25. Hoshino T, Okamoto M, Sakazaki Y, Kato S, Young H, Aizawa H. Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice. Am J Respir Cell Mol Biol. 2009;41:661-70 pubmed publisher
    ..Thus, our results provide evidence for an important role of IL-1beta and IL-18 in chemotherapy-induced lung injury. ..
  26. Grzegorczyk J, Kowalski M, Pilat A, Iwaszkiewicz J. Increased apoptosis of peripheral blood mononuclear cells in patients with perennial allergic asthma/rhinitis: relation to serum markers of apoptosis. Mediators Inflamm. 2002;11:225-33 pubmed
    ..monocytes) undergo the apoptosis and to determine relations between apoptosis and serum levels of sFas/APO-1, ICE/caspase-1 or TNF-alpha...
  27. Ozgocer T, Yildiz S, Elbe H, Vardi N. Endotoxin exposure and puberty in female rats: the role of nitric oxide and caspase-1 inhibition in neonates. Can J Physiol Pharmacol. 2015;93:603-14 pubmed publisher
    ..NO or IL-1β inhibitors improved both of these parameters, suggesting that the early detrimental effects of LPS on puberty and primordial follicle pool are mediated by NO and IL-1β. ..
  28. Qi J, Yu X, Shi X, Gao H, Yi Q, Tan H, et al. NF-κB Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1. Cardiovasc Toxicol. 2016;16:345-54 pubmed publisher
  29. Homsi E, Janino P, de Faria J. Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure. Kidney Int. 2006;69:1385-92 pubmed
    ..Rats were treated with pan-caspase or selective caspase 1 and 3 inhibitors at the moment we injected glycerol...
  30. Chong Z, Kang J, Maiese K. AKT1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-xL and caspase 1, 3, and 9. Exp Cell Res. 2004;296:196-207 pubmed
    ..prevention of cysteine protease degradation of Bcl-x(L) that is intimately linked to the specific inhibition of caspase 1-, 3-, and 9-like activities and the modulation of mitochondrial membrane potential and cytochrome c release...
  31. Wlodarska M, Thaiss C, Nowarski R, Henao Mejia J, Zhang J, Brown E, et al. NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell. 2014;156:1045-59 pubmed publisher
  32. Zhang X, Zhu R, Xu W, Wan H, Lu H. Therapeutic effects of caspase-1 inhibitors on acute lung injury in experimental severe acute pancreatitis. World J Gastroenterol. 2007;13:623-7 pubmed
    To assess the therapeutic effect of Caspase-1 inhibitors (ICE-I) on acute lung injury (ALI) in experimental severe acute pancreatitis (SAP)...
  33. Abdul Muneer P, Long M, Conte A, Santhakumar V, Pfister B. High Ca2+ Influx During Traumatic Brain Injury Leads to Caspase-1-Dependent Neuroinflammation and Cell Death. Mol Neurobiol. 2017;54:3964-3975 pubmed publisher
    ..We conclude that excess IL-1? production and cell death may contribute to neuronal dysfunction and cognitive impairment associated with TBI. ..
  34. Li W, Guo T, Liang D, Shi X, Wei T, Kingery W, et al. The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome. Pain. 2009;147:277-86 pubmed publisher
    ..These findings highlight the possible importance of neuro-cutaneous signaling and innate immunity mechanisms in the development of CRPS...
  35. Verhoef P, Kertesy S, Lundberg K, Kahlenberg J, Dubyak G. Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor. J Immunol. 2005;175:7623-34 pubmed
    ..These results suggest that under physiological conditions P2X7R are maintained in a conformationally restrained state that limits channel gating and coupling of the receptor to signaling pathways that regulate caspase-1. ..
  36. Solle M, Labasi J, Perregaux D, Stam E, Petrushova N, Koller B, et al. Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem. 2001;276:125-32 pubmed
    ..Together these results demonstrate that P2X(7)R activation can provide a signal that leads to maturation and release of IL-1 beta and initiation of a cytokine cascade. ..
  37. Kofoed E, Vance R. Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature. 2011;477:592-5 pubmed publisher
    ..cytosolic multiprotein complexes that initiate innate immune responses to pathogenic microbes by activating the caspase 1 protease...
  38. Clark A, D Aquisto F, Gentry C, Marchand F, McMahon S, Malcangio M. Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation. J Neurochem. 2006;99:868-80 pubmed
    ..inhibition of glial cell metabolism and by inhibitors of either p38 mitogen-activated protein kinase (MAPK) or caspase 1. LPS superfusion also induced rapid secretion of active caspase 1 and apoptosis-associated speck-like protein ..
  39. Lu A, Li Y, Schmidt F, Yin Q, Chen S, Fu T, et al. Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism. Nat Struct Mol Biol. 2016;23:416-25 pubmed publisher
    ..Whereas caspase-1(CARD) uses six complementary surfaces of three types for filament assembly, INCA is defective in two of the six interfaces and thus terminates the caspase-1 filament. ..
  40. Raju U, Mei L, Seema S, Hina Q, Wolman S, Worsham M. Molecular classification of breast carcinoma in situ. Curr Genomics. 2006;7:523-32 pubmed
    ..Loss of CASP1 was predictive of LCIS (n=4) with one misclassified PLCIS...
  41. Lamkanfi M, Denecker G, Kalai M, D hondt K, Meeus A, Declercq W, et al. INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. J Biol Chem. 2004;279:51729-38 pubmed
    ..The INCA gene is located on chromosome 11q22 between the genes of COP/Pseudo-ICE and ICEBERG, two other CARD proteins that arose from caspase-1 gene duplications...
  42. Razmara M, Srinivasula S, Wang L, Poyet J, Geddes B, DiStefano P, et al. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J Biol Chem. 2002;277:13952-8 pubmed
    ..human protein, CARD-8, which contains a C-terminal CARD domain with high similarity to the CARD domain of caspase-1/ICE. We demonstrate that CARD-8 interacts physically with caspase-1 and negatively regulates caspase-1-dependent IL-..
  43. de Rivero Vaccari J, Lotocki G, Marcillo A, Dietrich W, Keane R. A molecular platform in neurons regulates inflammation after spinal cord injury. J Neurosci. 2008;28:3404-14 pubmed publisher
    ..Thus, rat spinal cord neurons contain a caspase-1, pro-ILbeta, and pro-IL-18 activating complex different from the human NALP1 inflammasome that constitutes an important arm of the innate CNS inflammatory response after SCI. ..
  44. Bhanoori M, Yellaturu C, Ghosh S, Hassid A, Jennings L, Rao G. Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1). Oncogene. 2003;22:117-30 pubmed
    ..and activation of STATs, particularly STAT1, by thiol alkylation correlated with increased production of active caspase 1 and apoptosis in VSMC...
  45. Druilhe A, Srinivasula S, Razmara M, Ahmad M, Alnemri E. Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. Cell Death Differ. 2001;8:649-57 pubmed
    ..of two new human caspase recruitment domain (CARD) molecules, termed Pseudo-interleukin-1beta converting enzyme (ICE) and ICEBERG...
  46. Henao Mejia J, Elinav E, Jin C, Hao L, Mehal W, Strowig T, et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature. 2012;482:179-85 pubmed publisher
  47. Gemma C, Fister M, Hudson C, Bickford P. Improvement of memory for context by inhibition of caspase-1 in aged rats. Eur J Neurosci. 2005;22:1751-6 pubmed
    ..Chronic infusion of a specific caspase-1 inhibitor in aged rats ameliorated age-related increases in hippocampal IL-1beta and improved memory for context. ..
  48. Mariathasan S, Newton K, Monack D, Vucic D, French D, Lee W, et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature. 2004;430:213-8 pubmed
    ..Notably, cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways. ..
  49. Muehlbauer S, Lima H, Goldman D, Jacobson L, Rivera J, Goldberg M, et al. Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin. Am J Pathol. 2010;177:735-43 pubmed publisher
    ..Our studies indicate that pharmacological inhibition of NLR signaling and caspase-1 can be used to treat inflammatory diseases. ..
  50. Kong Q, Peterson T, Baker O, Stanley E, Camden J, Seye C, et al. Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y(2) receptor. J Neurochem. 2009;109:1300-10 pubmed publisher
    ..These results demonstrate that elevated levels of pro-inflammatory cytokines associated with neurodegenerative diseases, such as IL-1beta, can enhance non-amyloidogenic APP processing through up-regulation of the P2Y(2)R in neurons. ..
  51. Dinis Oliveira R, Sousa C, Remião F, Duarte J, Ferreira R, Sanchez Navarro A, et al. Sodium salicylate prevents paraquat-induced apoptosis in the rat lung. Free Radic Biol Med. 2007;43:48-61 pubmed
    ..NaSAL, a recently implemented antidote for PQ intoxications, proved to protect lungs from PQ-induced apoptosis. ..
  52. Cavailles P, Flori P, Papapietro O, Bisanz C, Lagrange D, Pilloux L, et al. A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage. PLoS Pathog. 2014;10:e1004005 pubmed publisher
    ..These data represent new insights towards the identification of a major pathway of innate resistance to toxoplasmosis and the prediction of individual resistance. ..
  53. Zhang W, Wang X, Narayanan M, Zhang Y, Huo C, Reed J, et al. Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death. Proc Natl Acad Sci U S A. 2003;100:16012-7 pubmed
  54. Pelegrin P, Surprenant A. Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J. 2006;25:5071-82 pubmed
  55. Pelegrin P, Barroso Gutierrez C, Surprenant A. P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol. 2008;180:7147-57 pubmed
    ..None of these release responses were associated with cell damage or cytolytic effects. This provides the first direct demonstration of a distinct signaling mechanism responsible for ATP-induced release of pro-IL-1beta. ..
  56. Fernandes Alnemri T, Yu J, Datta P, Wu J, Alnemri E. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 2009;458:509-13 pubmed publisher
    ..This study identifies AIM2 as an important inflammasome component that senses potentially dangerous cytoplasmic DNA, leading to activation of the ASC pyroptosome and caspase-1. ..
  57. Sifringer M, Stefovska V, Endesfelder S, Stahel P, Genz K, Dzietko M, et al. Activation of caspase-1 dependent interleukins in developmental brain trauma. Neurobiol Dis. 2007;25:614-22 pubmed
    ..These findings indicate that IL-18 is involved in trauma-induced neuronal cell death in the immature rodent brain and might serve as a potential therapeutic target. ..
  58. Oh H, Kim H, Jeong H. Beneficial effects of chelidonic acid on a model of allergic rhinitis. Int Immunopharmacol. 2011;11:39-45 pubmed publisher
    ..Furthermore, CA decreased the caspase-1 activity in the same nasal mucosa tissue and human mast cell line, HMC-1. Our results indicate that CA may attenuate allergic reaction by inhibition of caspase-1 activity. ..
  59. Flaws J, Kugu K, Trbovich A, DeSanti A, Tilly K, Hirshfield A, et al. Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle. Endocrinology. 1995;136:5042-53 pubmed
    ..ced-3, has a number of homologs in vertebrate species, including interleukin-1 beta (IL-1 beta)-converting enzyme (ICE), Ich-1long, and CPP32...
  60. Gustavsson C, Agardh C, Hagert P, Agardh E. Inflammatory markers in nondiabetic and diabetic rat retinas exposed to ischemia followed by reperfusion. Retina. 2008;28:645-52 pubmed publisher
    ..Intervention on lipid-based structures by omega-3-polyunsaturated fatty acids or statins seemed to have beneficial effects on inflammation in diabetes. ..
  61. Buck M, Poli V, Hunter T, Chojkier M. C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. Mol Cell. 2001;8:807-16 pubmed
    ..C/EBPbeta-/- and C/EBPbeta-Ala(217) stellate cells were rescued from apoptosis by the cell permeant KE(217)VD tetrapeptide or C/EBPbeta-Glu(217). ..
  62. Li X, Cheng W, Li J, Guo X, Guo C, Meng X, et al. Protective effect of estrogen on apoptosis in a cell culture model of Parkinson's disease. Clin Invest Med. 2008;31:E258-64 pubmed
    ..expression of apoptosis-suppression protein Bcl-x and apoptosis-acceleration protein IL-1 beta converting enzyme (ICE) were measured...
  63. Keane K, Giegel D, Lipinski W, Callahan M, Shivers B. Cloning, tissue expression and regulation of rat interleukin 1 beta converting enzyme. Cytokine. 1995;7:105-10 pubmed
    Using oligomer primers based on the cDNA sequence of human interleukin 1 beta converting enzyme (ICE), we have employed the RT-PCR method and rat spleen RNA to clone and sequence rat ICE...
  64. O SHEA E, Sanchez V, Orio L, Escobedo I, Green A, Colado M. 3,4-Methylenedioxymethamphetamine increases pro-interleukin-1beta production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: role of interleukin-1beta in neurotoxicity. Neuroscience. 2005;135:1095-105 pubmed
  65. Gamblin T, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet A, et al. Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci U S A. 2003;100:10032-7 pubmed
  66. Newman Z, Crown D, Leppla S, Moayeri M. Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages. Biochem Biophys Res Commun. 2010;398:785-9 pubmed publisher
    ..The activation of the rat Nlrp1 inflammasome is required for LT-mediated rat macrophage lysis and contributes to animal death. ..
  67. Lee S, Stehlik C, Reed J. Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. J Biol Chem. 2001;276:34495-500 pubmed
    ..Our data indicate that COP can regulate IL-1beta secretion, implying that COP may play a role in down-regulating inflammatory responses analogous to the CARD protein ICEBERG. ..