Calr

Summary

Gene Symbol: Calr
Description: calreticulin
Alias: calreticulin, CABP3, CALBP, CRP55, ERp60, HACBP, calcium-binding protein 3, calregulin, endoplasmic reticulum resident protein 60
Species: rat
Products:     Calr

Top Publications

  1. Obeid M, Tesniere A, Ghiringhelli F, Fimia G, Apetoh L, Perfettini J, et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med. 2007;13:54-61 pubmed
    ..Here we show that anthracyclins induce the rapid, preapoptotic translocation of calreticulin (CRT) to the cell surface...
  2. Cheng S, Nguyen T, Yang Y, Capra J, Sontheimer R. Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen. J Immunol. 1996;156:4484-91 pubmed
    b>Calreticulin (CR) is a multifunctional, calcium-binding protein that has recently been shown to bind to and promote the replication of the rubella virus genome in mammalian cells...
  3. Dedhar S, Rennie P, Shago M, Hagesteijn C, Yang H, Filmus J, et al. Inhibition of nuclear hormone receptor activity by calreticulin. Nature. 1994;367:480-3 pubmed
    ..shown that a polypeptide of M(r) 60,000 (60K) that shares N-terminal homology with a calcium-binding protein, calreticulin, can bind to an amino-acid sequence motif, KXGFFKR, found in the cytoplasmic domains of all integrin alpha-..
  4. Nomura R, Orii M, Senda T. Calreticulin-2 is localized in the lumen of the endoplasmic reticulum but is not a Ca2+ -binding protein. Histochem Cell Biol. 2011;135:531-8 pubmed publisher
    b>Calreticulin (CRT)-1 is a major Ca(2+)-buffering protein in the lumen of the endoplasmic reticulum. Human and murine CRT-2 was isolated in 2002, but the subcellular localization and function is still unclear...
  5. Shao L, Sun X, Xu L, Young L, Wang J. Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cells. Life Sci. 2006;78:1317-23 pubmed
    ..valproate in rat brain increased the expression of endoplasmic reticulum (ER) stress proteins GRP78, GRP94 and calreticulin. We report here that in primary cultured rat cerebral cortical cells, expression of GRP78, GRP94 and ..
  6. Holaska J, Black B, Love D, Hanover J, Leszyk J, Paschal B. Calreticulin Is a receptor for nuclear export. J Cell Biol. 2001;152:127-40 pubmed
    ..Acad. Sci. USA. 95: 14739-14744). Here, we describe the purification and characterization of the activity as calreticulin (CRT), a protein previously ascribed to functions in the lumen of the ER...
  7. Vegh Z, Kew R, Gruber B, Ghebrehiwet B. Chemotaxis of human monocyte-derived dendritic cells to complement component C1q is mediated by the receptors gC1qR and cC1qR. Mol Immunol. 2006;43:1402-7 pubmed
    ..These results clearly demonstrate that C1q functions as a chemotactic factor for immature DC, and migration is mediated through ligation of both gC1qR and cC1qR/CR. ..
  8. Zhang M, Wei J, Shan H, Wang H, Zhu Y, Xue J, et al. Calreticulin-STAT3 signaling pathway modulates mitochondrial function in a rat model of furazolidone-induced dilated cardiomyopathy. PLoS ONE. 2013;8:e66779 pubmed publisher
    b>Calreticulin is a Ca(2+)-binding chaperone of the endoplasmic reticulum which regulates the signal transducer and activator of transcription 3 (STAT3)...
  9. Howe C, Garstka M, Al Balushi M, Ghanem E, Antoniou A, Fritzsche S, et al. Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules. EMBO J. 2009;28:3730-44 pubmed publisher
    b>Calreticulin is a lectin chaperone of the endoplasmic reticulum (ER). In calreticulin-deficient cells, major histocompatibility complex (MHC) class I molecules travel to the cell surface in association with a sub-optimal peptide load...

More Information

Publications80

  1. Imanaka Yoshida K, Amitani A, Ioshii S, Koyabu S, Yamakado T, Yoshida T. Alterations of expression and distribution of the Ca(2+)-storing proteins in endo/sarcoplasmic reticulum during differentiation of rat cardiomyocytes. J Mol Cell Cardiol. 1996;28:553-62 pubmed
    Calsequestrin (CS) is a Ca(2+)-storing protein present in the sarcoplasmic reticulum (SR) of muscle cells. Calreticulin (CR) is a functional homologue of CS in the endoplasmic reticulum (ER) of non-muscle cells...
  2. Jansen G, Maattanen P, Denisov A, Scarffe L, Schade B, Balghi H, et al. An interaction map of endoplasmic reticulum chaperones and foldases. Mol Cell Proteomics. 2012;11:710-23 pubmed publisher
  3. Zhang W, Liu Z, Zhang Y, Bao Q, Wu W, Huang H, et al. Silencing calreticulin gene might protect cardiomyocytes from angiotensin II-induced apoptosis. Life Sci. 2018;198:119-127 pubmed publisher
    b>Calreticulin (CRT), as a chaperone, contributes to protein folding and quality control cycle. CRT is an important factor regulating Ca2+ that participates in cell apoptosis...
  4. Crawford K, Kalionis B, Stevenson J, Brennecke S, Gude N. Calreticulin has opposing effects on the migration of human trophoblast and myometrial endothelial cells. Placenta. 2012;33:416-23 pubmed publisher
    b>Calreticulin is a calcium binding, endoplasmic reticulum resident protein best known for its roles in intracellular calcium homeostasis and the quality control processes of the endoplasmic reticulum...
  5. Kageyama K, Ihara Y, Goto S, Urata Y, Toda G, Yano K, et al. Overexpression of calreticulin modulates protein kinase B/Akt signaling to promote apoptosis during cardiac differentiation of cardiomyoblast H9c2 cells. J Biol Chem. 2002;277:19255-64 pubmed
    b>Calreticulin is a Ca(2+)-binding molecular chaperone of the lumen of the endoplasmic reticulum...
  6. Lombard D, Alt F, Cheng H, Bunkenborg J, Streeper R, Mostoslavsky R, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007;27:8807-14 pubmed
    ..Overall, our results extend the recent finding of lysine acetylation of mitochondrial proteins and demonstrate that SIRT3 has evolved to control reversible lysine acetylation in this organelle. ..
  7. Tefferi A, Guglielmelli P, Lasho T, Rotunno G, Finke C, Mannarelli C, et al. CALR and ASXL1 mutations-based molecular prognostication in primary myelofibrosis: an international study of 570 patients. Leukemia. 2014;28:1494-500 pubmed publisher
    ..We recently reported DIPSS-plus independent prognostic significance for calreticulin (CALR) (favorable) and ASXL1 (unfavorable) mutations...
  8. Nakamura M, Moriya M, Baba T, Michikawa Y, Yamanobe T, Arai K, et al. An endoplasmic reticulum protein, calreticulin, is transported into the acrosome of rat sperm. Exp Cell Res. 1993;205:101-10 pubmed
    ..Biophys. Res. Commun. 176, 135-1364, 1991]. In the present study, this protein was identified as calreticulin, which is a resident protein of the endoplasmic reticulum (ER)...
  9. Ní Fhlathartaigh M, McMahon J, Reynolds R, Connolly D, Higgins E, Counihan T, et al. Calreticulin and other components of endoplasmic reticulum stress in rat and human inflammatory demyelination. Acta Neuropathol Commun. 2013;1:37 pubmed publisher
    b>Calreticulin (CRT) is a chaperone protein, which aids correct folding of glycosylated proteins in the endoplasmic reticulum (ER)...
  10. Qiu Y, Lynch J, Guo L, Yatsula B, Perkins A, Michalak M. Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factors. Biochemistry. 2008;47:3697-704 pubmed publisher
    b>Calreticulin is a Ca (2+)-buffering chaperone of the endoplasmic reticulum...
  11. Nair K, Hmani Aifa M, Ali Z, Kearney A, Ben Salem S, Macalinao D, et al. Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nat Genet. 2011;43:579-84 pubmed publisher
    ..Together, these data suggest that alterations of this serine protease may contribute to a spectrum of human ocular conditions including reduced ocular size and ACG...
  12. Somogyi E, Petersson U, Hultenby K, Wendel M. Calreticulin--an endoplasmic reticulum protein with calcium-binding activity is also found in the extracellular matrix. Matrix Biol. 2003;22:179-91 pubmed
    Previous studies have reported that calreticulin (CRT), a calcium-binding and chaperoning protein, is expressed only in the endoplasmatic reticulum, nucleus and at the cell surface...
  13. Zhu H, Larade K, Jackson T, Xie J, Ladoux A, Acker H, et al. NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum. J Biol Chem. 2004;279:30316-25 pubmed
    ..fractionation of subcellular organelles and confocal microscopy, we show that NCB5OR colocalizes with calreticulin, a marker for endoplasmic reticulum...
  14. Simovich M, Conrad M, Umbreit J, Moore E, Hainsworth L, Smith H. Cellular location of proteins related to iron absorption and transport. Am J Hematol. 2002;69:164-70 pubmed
    ..raised against DMT-1 (Nramp-2, DCT-1), transferrin receptor (CD71), beta(3) integrin (CD61), mobilferrin (calreticulin), and Hephaestin...
  15. Marty C, Pecquet C, Nivarthi H, El Khoury M, Chachoua I, Tulliez M, et al. Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis. Blood. 2016;127:1317-24 pubmed publisher
    Frameshift mutations in the calreticulin (CALR) gene are seen in about 30% of essential thrombocythemia and myelofibrosis patients...
  16. Hatle K, Gummadidala P, Navasa N, Bernardo E, Dodge J, Silverstrim B, et al. MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations. Mol Cell Biol. 2013;33:2302-14 pubmed publisher
    ..Impaired expression or loss of MCJ expression may therefore result in a "rapid" metabolism that mitigates the consequences of metabolic disorders. ..
  17. Tuan R, Cavanaugh S. Identification and characterization of a calcium-binding protein in the mouse chorioallantoic placenta. Biochem J. 1986;233:41-9 pubmed
    ..These properties suggest that the MCaBP may be involved in transplacental calcium transport. ..
  18. Feng X, Tonnesen M, Peerschke E, Ghebrehiwet B. Cooperation of C1q receptors and integrins in C1q-mediated endothelial cell adhesion and spreading. J Immunol. 2002;168:2441-8 pubmed
    ..In this study we examined the roles of two C1q binding proteins, cC1q-R/calreticulin and gC1q-R/p33, in C1q-mediated adhesion and spreading of human dermal microvascular endothelial cells (HDMVEC)...
  19. Liu H, Han F, Shi Y. Effect of calreticulin on Ca2+/CaM kinaseII? and endoplasmic reticulum stress in hippocampal in a rat model of post-traumatic stress disorder. Neurochem Res. 2013;38:1407-14 pubmed publisher
    The purpose of the present study was to examine the changes in the molecular chaperone calreticulin (CRT), calcium signaling pathway Ca(2+)-calmodulin (CaM)-CaM kinaseII? (CaMKII?), and the endoplasmic reticulum (ER) apoptotic modulator ..
  20. Mueller C, Wassmann K, Berger A, Holz S, Wassmann S, Nickenig G. Differential phosphorylation of calreticulin affects AT1 receptor mRNA stability in VSMC. Biochem Biophys Res Commun. 2008;370:669-74 pubmed publisher
    ..Recently, we identified calreticulin as a novel binding protein within the 3'untranslated region of the AT1 receptor mRNA...
  21. Tutuncu L, Stein P, Ord T, Jorgez C, Williams C. Calreticulin on the mouse egg surface mediates transmembrane signaling linked to cell cycle resumption. Dev Biol. 2004;270:246-60 pubmed
    b>Calreticulin, a protein best known as an endoplasmic reticulum chaperone, also is found on the extracellular plasma membrane surface of many cell types where it serves as a mediator of adhesion and as a regulator of the immune response...
  22. Zhang Z, Yuan B, Bao M, Lu N, Kim T, Liu Y. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat Immunol. 2011;12:959-65 pubmed publisher
    ..Our results suggest that DDX41 is an additional DNA sensor that depends on STING to sense pathogenic DNA. ..
  23. Iakova P, Wang G, Timchenko L, Michalak M, Pereira Smith O, Smith J, et al. Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. EMBO J. 2004;23:406-17 pubmed
    ..Two RNA-binding proteins, CUGBP1 and calreticulin (CRT), interact with the same nucleotide sequences within the 5' region of p21 mRNA, but have opposite effects ..
  24. Pocanschi C, Kozlov G, Brockmeier U, Brockmeier A, Williams D, Gehring K. Structural and functional relationships between the lectin and arm domains of calreticulin. J Biol Chem. 2011;286:27266-77 pubmed publisher
    b>Calreticulin and calnexin are key components in maintaining the quality control of glycoprotein folding within the endoplasmic reticulum...
  25. Barrow K, Ward C, Rutter J, Ali S, Stern P. Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia. Dev Dyn. 2005;233:1535-45 pubmed
    ..Our data demonstrate a limited 5T4 expression profile during embryogenesis associated with actively cycling, undifferentiated epithelial progenitor cells that may contribute to their migration. ..
  26. Mohrlüder J, Stangler T, Hoffmann Y, Wiesehan K, Mataruga A, Willbold D. Identification of calreticulin as a ligand of GABARAP by phage display screening of a peptide library. FEBS J. 2007;274:5543-55 pubmed
    ..In this article, it is demonstrated that calreticulin is a high affinity ligand of GABARAP...
  27. Yokoi T, Nagayama S, Kajiwara R, Kawaguchi Y, Horiuchi R, Kamataki T. Identification of protein disulfide isomerase and calreticulin as autoimmune antigens in LEC strain of rats. Biochim Biophys Acta. 1993;1158:339-44 pubmed
    ..2 and 4.0 pI values and were estimated to be protein disulfide isomerase (PDI) and calreticulin, respectively, from NH2-terminal amino acid sequence analysis...
  28. Cullinan S, Zhang D, Hannink M, Arvisais E, Kaufman R, Diehl J. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol. 2003;23:7198-209 pubmed
    ..Our data demonstrate that Nrf2 is a critical effector of PERK-mediated cell survival. ..
  29. Ahmad S, Basak T, Anand Kumar K, Bhardwaj G, Lalitha A, Yadav D, et al. Maternal micronutrient deficiency leads to alteration in the kidney proteome in rat pups. J Proteomics. 2015;127:178-84 pubmed publisher
    ..Importantly, proteins like calreticulin, cofilin 1 and nucleoside diphosphate kinase B that are involved in the functioning of the kidney were ..
  30. Lynch J, Guo L, Gelebart P, Chilibeck K, Xu J, Molkentin J, et al. Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J Cell Biol. 2005;170:37-47 pubmed
    We uncovered a new pathway of interplay between calreticulin and myocyte-enhancer factor (MEF) 2C, a cardiac-specific transcription factor...
  31. Kim H, Kim T, Jeong B, Cho I, Han D, Takegahara N, et al. Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab. 2013;17:249-60 pubmed publisher
    ..These data demonstrate that Tmem64 is a positive modulator of osteoclast differentiation via SERCA2-dependent Ca(2+) signaling. ..
  32. Chen B, Wang J, Young L. Chronic valproate treatment increases expression of endoplasmic reticulum stress proteins in the rat cerebral cortex and hippocampus. Biol Psychiatry. 2000;48:658-64 pubmed
    ..the effect of this drug on the other members of the endoplasmic reticulum stress protein family, GRP94 and calreticulin, and we studied the brain regional distribution of GRP78, GRP94, and calreticulin...
  33. Valkova C, Albrizio M, Röder I, Schwake M, Betto R, Rudolf R, et al. Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits. Proc Natl Acad Sci U S A. 2011;108:621-5 pubmed publisher
    ..Our data show that Rer1 is a functionally important unique factor that controls surface expression of muscle acetylcholine receptors by localizing unassembled ?-subunits to the early secretory pathway. ..
  34. Li W, Li Y, Song D, Wang X, Liu M, Wu X, et al. Calreticulin protects rat microvascular endothelial cells against microwave radiation-induced injury by attenuating endoplasmic reticulum stress. Microcirculation. 2014;21:506-15 pubmed publisher
    ..Exogenous CRT attenuates MR-induced ER stress-related apoptosis by suppressing CHOP-mediated apoptotic signaling pathways in MMECs. ..
  35. Theocharides A, Lundberg P, Lakkaraju A, Lysenko V, Myburgh R, Aguzzi A, et al. Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency. Blood. 2016;127:3253-9 pubmed publisher
    ..MPO is a glycoprotein (GP) chaperoned by calreticulin (CALR) in the endoplasmic reticulum...
  36. Rojiani M, Finlay B, Gray V, Dedhar S. In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits. Biochemistry. 1991;30:9859-66 pubmed
    ..60-kDa polypeptide was found to be highly homologous to the Ro/SS-A antigen, a 60-kDa protein homologous to calreticulin and Aplysia "memory molecule"...
  37. Blake C, Brown L, Duncan M, Hunsucker S, Helmke S. Estrogen regulation of the rat anterior pituitary gland proteome. Exp Biol Med (Maywood). 2005;230:800-7 pubmed
    ..g., eukaryotic translation elongation factor 2, ERp57, ERp29, Hsc70-ps1, calreticulin, coatomer delta subunit, and secretogranin II) and of some metabolic enzymes (e.g...
  38. Hirano M, Imagawa A, Totani K. Stratified analysis of lectin-like chaperones in the folding disease-related metabolic syndrome rat model. Biochem Biophys Res Commun. 2016;478:247-253 pubmed publisher
    ..However, little is known about the alterations in the components of the calnexin/calreticulin (CNX/CRT) cycle, which promote glycoprotein folding in obese and diabetic conditions...
  39. Zhang M, Wei J, Li Y, Shan H, Yan R, Lin L, et al. Novel distribution of calreticulin to cardiomyocyte mitochondria and its increase in a rat model of dilated cardiomyopathy. Biochem Biophys Res Commun. 2014;449:62-8 pubmed publisher
    b>Calreticulin (CRT), a Ca(2+)-binding chaperone of the endoplasmic reticulum, can also be found in several other locations including the cytosol, nucleus, secretory granules, the outer side of the plasma membrane, and the extracellular ..
  40. Di Jeso B, Park Y, Ulianich L, Treglia A, Urbanas M, High S, et al. Mixed-disulfide folding intermediates between thyroglobulin and endoplasmic reticulum resident oxidoreductases ERp57 and protein disulfide isomerase. Mol Cell Biol. 2005;25:9793-805 pubmed
    ..These data point towards mixed disulfides with the ERp57 oxidoreductase in conjunction with calreticulin/calnexin chaperones acting as normal early Tg folding intermediates that can be "substituted" by PDI ..
  41. Sönnichsen B, Fullekrug J, Nguyen Van P, Diekmann W, Robinson D, Mieskes G. Retention and retrieval: both mechanisms cooperate to maintain calreticulin in the endoplasmic reticulum. J Cell Sci. 1994;107 ( Pt 10):2705-17 pubmed
    ..morphological and mutational analysis we have studied the mechanisms that determine the localization of calreticulin, a soluble 60 kDa KDEL-protein of the ER...
  42. Crawford K, Stevenson J, Wlodek M, Gude N. No change in calreticulin with fetal growth restriction in human and rat pregnancies. Placenta. 2013;34:1066-71 pubmed publisher
    b>Calreticulin is a ubiquitously expressed protein that was detected in the circulation and is significantly increased in maternal blood during human pregnancy compared to the non-pregnant state...
  43. Ellgaard L, Bettendorff P, Braun D, Herrmann T, Fiorito F, Jelesarov I, et al. NMR structures of 36 and 73-residue fragments of the calreticulin P-domain. J Mol Biol. 2002;322:773-84 pubmed
    b>Calreticulin (CRT) is an abundant, soluble molecular chaperone of the endoplasmic reticulum. Similar to its membrane-bound homolog calnexin (CNX), it is a lectin that promotes the folding of proteins carrying N-linked glycans...
  44. Lee D, Michalak M. Membrane associated Ca2+ buffers in the heart. BMB Rep. 2010;43:151-7 pubmed
    ..b>Calreticulin is a well studied Ca2+-buffering protein in the endoplasmic reticulum, and calreticulin deficiency is embryonic ..
  45. Nakamura M, Michikawa Y, Baba T, Okinaga S, Arai K. Calreticulin is present in the acrosome of spermatids of rat testis. Biochem Biophys Res Commun. 1992;186:668-73 pubmed
    ..The NH2-terminal amino acid sequence obtained for rat CalBP was identical to that of calreticulin obtained for the skeletal muscle of mice and closely resembled that for rabbit calreticulin...
  46. Massaeli H, Jalali S, Viswanathan D, Mesaeli N. Loss of calreticulin function decreases NF?B activity by stabilizing I?B protein. Biochim Biophys Acta. 2014;1843:2385-93 pubmed publisher
    ..b>Calreticulin (CRT) is an ER Ca(2+)-binding chaperone that regulates many cellular processes...
  47. Conrad M, Umbreit J, Moore E. Rat duodenal iron-binding protein mobilferrin is a homologue of calreticulin. Gastroenterology. 1993;104:1700-4 pubmed
    ..of mobilferrin was Asp-Pro-Ala-Ile-Tyr-Phe-Lys-Glu-Gln-Phe-Leu-Asp-Gly-Asp-Ala-Ser-Thr- and is a homologue of calreticulin (calregulin). The proteins had a similar molecular mass (56 kilodalton) and isoelectric point (4.7)...
  48. Fukaya M, Kato A, Lovett C, Tonegawa S, Watanabe M. Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc Natl Acad Sci U S A. 2003;100:4855-60 pubmed
  49. Vuppalanchi D, Coleman J, Yoo S, Merianda T, Yadhati A, Hossain J, et al. Conserved 3'-untranslated region sequences direct subcellular localization of chaperone protein mRNAs in neurons. J Biol Chem. 2010;285:18025-38 pubmed publisher
    ..The 3'-untranslated regions (UTRs) of calreticulin and Grp78/BiP mRNAs show no homology to one another, but each shows extensive regions of high sequence identity ..
  50. Lee K, Lee N, Lim S, Jung H, Ko Y, Park H, et al. Calreticulin inhibits the MEK1,2-ERK1,2 pathway in alpha 1-adrenergic receptor/Gh-stimulated hypertrophy of neonatal rat cardiomyocytes. J Steroid Biochem Mol Biol. 2003;84:101-7 pubmed
    ..Recently, it has been shown that the calreticulin (CRT) down-regulates both GTP binding and transglutaminase activities of TGII...
  51. Murthy K, Banville D, Srikant C, Carrier F, Holmes C, Bell A, et al. Structural homology between the rat calreticulin gene product and the Onchocerca volvulus antigen Ral-1. Nucleic Acids Res. 1990;18:4933 pubmed
  52. Hassanein M, Bojja A, Glazewski L, Lu G, Mason R. Protein processing by the placental protease, cathepsin P. Mol Hum Reprod. 2009;15:433-42 pubmed publisher
    ..Two endoplasmic reticulum (ER) proteins, gp96 and calreticulin, emerged as potential substrates, and western blotting showed that these proteins are processed by cathepsin P ..
  53. Frickel E, Riek R, Jelesarov I, Helenius A, Wuthrich K, Ellgaard L. TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain. Proc Natl Acad Sci U S A. 2002;99:1954-9 pubmed
    The lectin chaperone calreticulin (CRT) assists the folding and quality control of newly synthesized glycoproteins in the endoplasmic reticulum (ER)...
  54. Kypreou K, Kavvadas P, Karamessinis P, Peroulis M, Alberti A, Sideras P, et al. Altered expression of calreticulin during the development of fibrosis. Proteomics. 2008;8:2407-19 pubmed publisher
    ..Data analysis demonstrates a correlation between calreticulin up-regulation and progression of fibrosis...
  55. Hong S, Misek D, Wang H, Puravs E, Giordano T, Greenson J, et al. An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer. Cancer Res. 2004;64:5504-10 pubmed
    ..Autoantibodies were detected against either one or two calreticulin isoforms identified by mass spectrometry in sera from 21 of 36 patients with pancreatic cancer...
  56. Copray J, Liem R, Kernell D. Calreticulin expression in spinal motoneurons of the rat. J Chem Neuroanat. 1996;11:57-65 pubmed
    We have examined the expression of calreticulin in rat spinal motoneurons in order to reveal the occurrence and distribution of Ca2(+)-storage organelles in these neurons...
  57. Di Jeso B, Ulianich L, Pacifico F, Leonardi A, Vito P, Consiglio E, et al. Folding of thyroglobulin in the calnexin/calreticulin pathway and its alteration by loss of Ca2+ from the endoplasmic reticulum. Biochem J. 2003;370:449-58 pubmed
    ..Tg) is known to interact with calnexin and other ER molecular chaperones, but its interaction with calreticulin has not been examined previously...
  58. Decca M, Carpio M, Bosc C, Galiano M, Job D, Andrieux A, et al. Post-translational arginylation of calreticulin: a new isospecies of calreticulin component of stress granules. J Biol Chem. 2007;282:8237-45 pubmed
    ..demonstrated in vitro the post-translational incorporation of arginine into the calcium-binding protein calreticulin (CRT)...
  59. Shaffer K, Sharma A, Snapp E, Hegde R. Regulation of protein compartmentalization expands the diversity of protein function. Dev Cell. 2005;9:545-54 pubmed
    ..A cytosolic form of the ER chaperone calreticulin was found to arise by an aborted translocation mechanism dependent on its signal sequence and factors in the ER ..
  60. Macias M, Escames G, Leon J, Coto A, Sbihi Y, Osuna A, et al. Calreticulin-melatonin. An unexpected relationship. Eur J Biochem. 2003;270:832-40 pubmed
    ..N-Terminal sequence analysis showed that the 60 kDa protein shares a high homology with rat calreticulin, whereas the 74 kDa protein shows no homology with any known protein...
  61. Zimmerman K, Graham L, Pallero M, Murphy Ullrich J. Calreticulin regulates transforming growth factor-?-stimulated extracellular matrix production. J Biol Chem. 2013;288:14584-98 pubmed publisher
    ..b>Calreticulin (CRT) is an ER chaperone and regulator of Ca(2+) signaling up-regulated by ER stress and in fibrotic tissues...
  62. Tharin S, Hamel P, Conway E, Michalak M, Opas M. Regulation of calcium binding proteins calreticulin and calsequestrin during differentiation in the myogenic cell line L6. J Cell Physiol. 1996;166:547-60 pubmed
    In this report we defined the structural and temporal limits within which calreticulin and calsequestrin participate in the muscle cell phenotype, in the L6 model myogenic system...
  63. Rardin M, Wiley S, Murphy A, Pagliarini D, Dixon J. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J Biol Chem. 2008;283:15440-50 pubmed publisher
    ..This work rigorously demonstrates the unique location of two highly similar DSPs on opposing sides of the mitochondrial inner membrane...
  64. Miller M, Tam A, Cho J, Doherty T, Pham A, Khorram N, et al. ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A. 2012;109:16648-53 pubmed publisher
    ..These studies provide evidence of the inducible nature of ORMDL3 ER expression in particular in bronchial epithelial cells and suggest an ER UPR pathway through which ORMDL3 may be linked to asthma. ..
  65. Banushi B, Forneris F, Straatman Iwanowska A, Strange A, Lyne A, Rogerson C, et al. Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis. Nat Commun. 2016;7:12111 pubmed publisher
    ..Thus, regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis and for the development and function of multiple organs and tissues. ..
  66. Yao Q, Zhou J, Gale R, Li J, Li L, Li N, et al. A rapid, highly accurate method for quantifying CALR mutant allele burden in persons with myeloproliferative neoplasms. Hematology. 2015;20:517-22 pubmed publisher
    b>Calreticulin (CALR) mutations were recently identified in a substantial proportion of persons with essential thrombocythemia (ET) and with primary myelofibrosis (PMF) without JAK2(V617F)...
  67. Li B, Xu J, Wang J, Gale R, Xu Z, Cui Y, et al. Calreticulin mutations in Chinese with primary myelofibrosis. Haematologica. 2014;99:1697-700 pubmed publisher
    We tested 357 Chinese with primary myelofibrosis for mutations in CALR, JAK2 and MPL. CALR mutations were detected in 76 subjects (21%). There were 24 (32%) type-1 (L367fs*46) and 49 (64%) type-2 (K385fs*47) mutations...
  68. Gao B, Adhikari R, Howarth M, Nakamura K, Gold M, Hill A, et al. Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin. Immunity. 2002;16:99-109 pubmed
    MHC class I molecules expressed in a calreticulin-deficient cell line (K42) assembled with beta 2-microglobulin (beta2-m) normally, but their subsequent loading with optimal peptides was defective...
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