Gene Symbol: Cacnb3
Description: calcium voltage-gated channel auxiliary subunit beta 3
Alias: CACH3B, voltage-dependent L-type calcium channel subunit beta-3, CAB3, Calcium channel subunit beta 3, calcium channel voltage-dependent subunit beta 3, calcium channel, voltage-dependent, beta 3 subunit
Species: rat
Products:     Cacnb3

Top Publications

  1. Bell D, Butcher A, Berrow N, Page K, Brust P, Nesterova A, et al. Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents. J Neurophysiol. 2001;85:816-27 pubmed
  2. Opatowsky Y, Chomsky Hecht O, Kang M, Campbell K, Hirsch J. The voltage-dependent calcium channel beta subunit contains two stable interacting domains. J Biol Chem. 2003;278:52323-32 pubmed
    ..Domain II is responsible for this binding, but domain I enhances it. ..
  3. Chen Y, Li M, Zhang Y, He L, Yamada Y, Fitzmaurice A, et al. Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. Nature. 2004;429:675-80 pubmed
    ..The presence of multiple protein-interacting modules in the beta-subunit opens a new dimension to its function as a multi-functional protein. ..
  4. Fan M, Buraei Z, Luo H, Levenson Palmer R, Yang J. Direct inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavbeta interaction. Proc Natl Acad Sci U S A. 2010;107:14887-92 pubmed publisher
  5. Beguin P, Ng Y, Krause C, Mahalakshmi R, Ng M, Hunziker W. RGK small GTP-binding proteins interact with the nucleotide kinase domain of Ca2+-channel beta-subunits via an uncommon effector binding domain. J Biol Chem. 2007;282:11509-20 pubmed
    ..2 subunits could be revealed in vivo using coimmunoprecipitation experiments. Intriguingly, docking of the RGK protein to the NK domain of the Cavbeta subunit is reminiscent of the binding of GMP to guanylate kinase. ..
  6. Castellano A, Wei X, Birnbaumer L, Perez Reyes E. Cloning and expression of a third calcium channel beta subunit. J Biol Chem. 1993;268:3450-5 pubmed
    ..In addition, beta 3 accelerates the rate of inactivation at positive test potentials. ..
  7. Leroy J, Richards M, Richards M, Butcher A, Nieto Rostro M, Pratt W, et al. Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties. J Neurosci. 2005;25:6984-96 pubmed
  8. Li L, Cao X, Chen S, Han H, Lopez Berestein G, Sood A, et al. Up-regulation of Cav?3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain. J Biol Chem. 2012;287:6002-13 pubmed publisher
    ..Targeting the Cav?(3) subunit at the spinal level represents an effective strategy for treating neuropathic pain. ..
  9. Kim D, Park Y, Jang D, Suh B. Dynamic phospholipid interaction of β2e subunit regulates the gating of voltage-gated Ca2+ channels. J Gen Physiol. 2015;145:529-41 pubmed publisher
    ..The phospholipid-protein interaction observed here provides structural insight into mechanisms of membrane-protein association and the role of phospholipids in ion channel regulation. ..

More Information


  1. Yasuda T, Lewis R, Adams D. Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation. J Gen Physiol. 2004;123:401-16 pubmed
  2. Bourdin B, Marger F, Wall Lacelle S, Schneider T, Klein H, Sauve R, et al. Molecular determinants of the CaVbeta-induced plasma membrane targeting of the CaV1.2 channel. J Biol Chem. 2010;285:22853-63 pubmed publisher
    ..2. Altogether, these data support a model where high affinity binding of Ca(V)beta to the I-II linker of Ca(V)alpha1 largely accounts for Ca(V)beta-induced plasma membrane targeting of Ca(V)1.2. ..
  3. Grueter C, Abiria S, Wu Y, Anderson M, Colbran R. Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits. Biochemistry. 2008;47:1760-7 pubmed publisher
    ..In combination, these data show that phosphorylation dynamically regulates the interactions of specific isoforms of the Ca2+ channel beta subunits with CaMKII. ..
  4. Beguin P, Nagashima K, Mahalakshmi R, Vigot R, Matsunaga A, Miki T, et al. BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis. J Cell Biol. 2014;205:233-49 pubmed publisher
    ..Thus, BARP can modulate the localization of Cav? and its association with the Cav?1 subunit to negatively regulate VGCC activity. ..
  5. Agrawal M, Kumar V, Singh A, Kashyap M, Khanna V, Siddiqui M, et al. trans-Resveratrol protects ischemic PC12 Cells by inhibiting the hypoxia associated transcription factors and increasing the levels of antioxidant defense enzymes. ACS Chem Neurosci. 2013;4:285-94 pubmed publisher
    ..Our data shows that the whole-treatment group of trans-resveratrol is most efficient in decreasing hypoxia induced cell death through its antioxidant properties. ..
  6. Kuhn S, Knirsch M, Ruttiger L, Kasperek S, Winter H, Freichel M, et al. Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4. Channels (Austin). 2009;3:366-76 pubmed
    ..These results indicate that neither Ca(V)beta3 nor Ca(V)beta4 are indispensable for hair cell Ca(2+) currents but contribute to the overall current properties. ..
  7. Badou A, Jha M, Matza D, Mehal W, Freichel M, Flockerzi V, et al. Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function. Proc Natl Acad Sci U S A. 2006;103:15529-34 pubmed
    ..These observations suggest that the Cav channels expressed by T cells have adopted novel regulation/gating mechanisms. ..
  8. Vendel A, Terry M, Striegel A, Iverson N, Leuranguer V, Rithner C, et al. Alternative splicing of the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell-specific expression in the cerebellar cortex. J Neurosci. 2006;26:2635-44 pubmed
    ..These results have strong bearing on our current understanding of the structure of alternatively spliced Ca2+ channel beta subunits and the cell-specific roles they play in the CNS. ..
  9. Morgan E, Mace O, Affleck J, Kellett G. Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption. J Physiol. 2007;580:593-604 pubmed
    ..The integration of glucose and Ca(2+) absorption represents a complex nutrient-sensing system, which allows both absorptive pathways to be regulated rapidly and precisely to match dietary intake. ..
  10. Catterall W. Voltage-gated calcium channels. Cold Spring Harb Perspect Biol. 2011;3:a003947 pubmed publisher
    ..This article presents the molecular relationships and physiological functions of these Ca(2+) channel proteins and provides information on their molecular, genetic, physiological, and pharmacological properties. ..
  11. Bourdin B, Shakeri B, Tétreault M, Sauvé R, Lesage S, Parent L. Functional characterization of CaVα2δ mutations associated with sudden cardiac death. J Biol Chem. 2015;290:2854-69 pubmed publisher
    ..Altogether, our results provide novel insight in the molecular mechanism underlying the modulation of CaV1.2 currents by CaVα2δ. ..
  12. Castellano A, Wei X, Birnbaumer L, Perez Reyes E. Cloning and expression of a neuronal calcium channel beta subunit. J Biol Chem. 1993;268:12359-66 pubmed
  13. Zhang Y, Yamada Y, Fan M, Bangaru S, Lin B, Yang J. The beta subunit of voltage-gated Ca2+ channels interacts with and regulates the activity of a novel isoform of Pax6. J Biol Chem. 2010;285:2527-36 pubmed publisher
    ..These results suggest that full-length Ca(v)beta may act directly as a transcription regulator independent of its role in regulating Ca(2+) channel activity. ..
  14. Gandini M, Henríquez D, Grimaldo L, Sandoval A, Altier C, Zamponi G, et al. CaV2.2 channel cell surface expression is regulated by the light chain 1 (LC1) of the microtubule-associated protein B (MAP1B) via UBE2L3-mediated ubiquitination and degradation. Pflugers Arch. 2014;466:2113-26 pubmed publisher
    ..Together these results revealed a novel functional coupling between LC1 and the N-type channels. ..
  15. Burgess D, Biddlecome G, McDonough S, Diaz M, Zilinski C, Bean B, et al. beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain. Mol Cell Neurosci. 1999;13:293-311 pubmed
    ..The existence of beta subunit reshuffling demonstrates that molecular plasticity of Ca2+ channel assembly, a normal feature of early brain development, is retained in the mature brain. ..