Gene Symbol: Cacnb1
Description: calcium voltage-gated channel auxiliary subunit beta 1
Alias: voltage-dependent L-type calcium channel subunit beta-1, CAB1, brain calcium channel beta 1 subunit, calcium channel beta 1 subunit, calcium channel voltage-dependent subunit beta 1, calcium channel, voltage-dependent, beta 1 subunit
Species: rat
Products:     Cacnb1

Top Publications

  1. Lautermilch N, Few A, Scheuer T, Catterall W. Modulation of CaV2.1 channels by the neuronal calcium-binding protein visinin-like protein-2. J Neurosci. 2005;25:7062-70 pubmed
    ..Differential regulation of CaV2.1 channels by CaM, VILIP-2, CaBP1, and other neurospecific Ca2+-binding proteins is a potentially important determinant of Ca2+ entry in neurotransmission. ..
  2. Mezler M, Barghorn S, Schoemaker H, Gross G, Nimmrich V. A ?-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes. Br J Pharmacol. 2012;165:1572-83 pubmed publisher
    ..Threshold reduction as well as an increase in current at synaptic terminals may facilitate vesicle release and could trigger excitotoxic events in the brains of patients with AD. ..
  3. Gui P, Wu X, Ling S, Stotz S, Winkfein R, Wilson E, et al. Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-Src and protein kinase A pathways. J Biol Chem. 2006;281:14015-25 pubmed
    ..These findings are consistent with the growing recognition of the importance of integrin-channel interactions in cellular responses to injury and the acute control of synaptic and blood vessel function. ..
  4. Beguin P, Nagashima K, Mahalakshmi R, Vigot R, Matsunaga A, Miki T, et al. BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis. J Cell Biol. 2014;205:233-49 pubmed publisher
    ..Thus, BARP can modulate the localization of Cav? and its association with the Cav?1 subunit to negatively regulate VGCC activity. ..
  5. Leroy J, Richards M, Richards M, Butcher A, Nieto Rostro M, Pratt W, et al. Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties. J Neurosci. 2005;25:6984-96 pubmed
  6. Perez Reyes E, Castellano A, Kim H, Bertrand P, Baggstrom E, Lacerda A, et al. Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel. J Biol Chem. 1992;267:1792-7 pubmed
    ..These results indicate that the cardiac L-type Ca2+ channel has a similar subunit structure as in skeletal muscle, and provides evidence for the modulatory role of the beta subunit. ..
  7. Pragnell M, Sakamoto J, Jay S, Campbell K. Cloning and tissue-specific expression of the brain calcium channel beta-subunit. FEBS Lett. 1991;291:253-8 pubmed
    ..Hence the encoded brain beta-subunit, which has a primary structure highly similar to its isoform in skeletal muscle, may have a comparable role as an integral regulatory component of a neuronal calcium channel. ..
  8. Tsunemi T, Saegusa H, Ishikawa K, Nagayama S, Murakoshi T, Mizusawa H, et al. Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current. J Biol Chem. 2002;277:7214-21 pubmed
    ..These results suggest that P-type-specific splice variants may exist but that post-translational processing or modification by uncharacterized interacting proteins is also required for generating the P-type current. ..
  9. Grueter C, Abiria S, Wu Y, Anderson M, Colbran R. Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits. Biochemistry. 2008;47:1760-7 pubmed publisher
    ..In combination, these data show that phosphorylation dynamically regulates the interactions of specific isoforms of the Ca2+ channel beta subunits with CaMKII. ..

More Information


  1. Catterall W. Voltage-gated calcium channels. Cold Spring Harb Perspect Biol. 2011;3:a003947 pubmed publisher
    ..This article presents the molecular relationships and physiological functions of these Ca(2+) channel proteins and provides information on their molecular, genetic, physiological, and pharmacological properties. ..
  2. Gregg R, Messing A, Strube C, Beurg M, Moss R, Behan M, et al. Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling. Proc Natl Acad Sci U S A. 1996;93:13961-6 pubmed
  3. Conklin M, Powers P, Gregg R, Coronado R. Ca2+ sparks in embryonic mouse skeletal muscle selectively deficient in dihydropyridine receptor alpha1S or beta1a subunits. Biophys J. 1999;76:657-69 pubmed
    ..However, excitation-contraction coupling is not essential for Ca2+ spark formation in these cells. ..
  4. Burgess D, Biddlecome G, McDonough S, Diaz M, Zilinski C, Bean B, et al. beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain. Mol Cell Neurosci. 1999;13:293-311 pubmed
    ..The existence of beta subunit reshuffling demonstrates that molecular plasticity of Ca2+ channel assembly, a normal feature of early brain development, is retained in the mature brain. ..
  5. Maltez J, Nunziato D, Kim J, Pitt G. Essential Ca(V)beta modulatory properties are AID-independent. Nat Struct Mol Biol. 2005;12:372-7 pubmed
  6. Gonzalez Gutierrez G, Miranda Laferte E, Nothmann D, Schmidt S, Neely A, Hidalgo P. The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating. Proc Natl Acad Sci U S A. 2008;105:14198-203 pubmed publisher
  7. Abiria S, Colbran R. CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation. J Neurochem. 2010;112:150-61 pubmed publisher
    ..2alpha(1) and beta subunits. These findings demonstrate a biochemical mechanism underlying LTCC facilitation by CaMKII. ..