Gene Symbol: Cacna1i
Description: calcium voltage-gated channel subunit alpha1 I
Alias: voltage-dependent T-type calcium channel subunit alpha-1I, caVT.3, calcium channel, voltage-dependent, T type, alpha 1I subunit, calcium channel, voltage-dependent, alpha 1I subunit, low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I), voltage-dependent calcium channel, voltage-gated calcium channel subunit alpha Cav3.3
Species: rat
Products:     Cacna1i

Top Publications

  1. Ma Y, Pan Z. Spontaneous regenerative activity in mammalian retinal bipolar cells: roles of multiple subtypes of voltage-dependent Ca2+ channels. Vis Neurosci. 2003;20:131-9 pubmed
    ..However, T-type Ca2+ channels appear to be essential for the initiation of the spontaneous activity in mammalian bipolar cells. ..
  2. Murbartián J, Arias J, Lee J, Gomora J, Perez Reyes E. Alternative splicing of the rat Ca(v)3.3 T-type calcium channel gene produces variants with distinct functional properties(1). FEBS Lett. 2002;528:272-8 pubmed
    ..The functional impact of splicing was inter-related, suggesting an interaction. We conclude that alternative splicing of the Ca(v)3.3 gene produces channels with distinct properties. ..
  3. Mozaffari M, Patel C, Schaffer S. Mechanisms underlying afterload-induced exacerbation of myocardial infarct size: role of T-type Ca2+ channel. Hypertension. 2006;47:912-9 pubmed
    ..The data also uncovered an important link between pressure-mediated exacerbation of infarct size and T-type Ca2+ channel activity. ..
  4. Molineux M, McRory J, McKay B, Hamid J, Mehaffey W, Rehak R, et al. Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons. Proc Natl Acad Sci U S A. 2006;103:5555-60 pubmed
    ..The Ca(v)3 class of LVA calcium channels is thus expressed in specific combinations in a wide range of cerebellar neurons but contributes to rebound burst discharge in only a select number of cell classes. ..
  5. Iftinca M, McKay B, Snutch T, McRory J, Turner R, Zamponi G. Temperature dependence of T-type calcium channel gating. Neuroscience. 2006;142:1031-42 pubmed
    ..3, but not rat Ca(v)3.3. The observed changes in the kinetics were significant but not identical for the three isoforms, showing that the ability of T-type channels to conduct calcium varies with both channel isoform and temperature. ..
  6. Catterall W. Voltage-gated calcium channels. Cold Spring Harb Perspect Biol. 2011;3:a003947 pubmed publisher
    ..This article presents the molecular relationships and physiological functions of these Ca(2+) channel proteins and provides information on their molecular, genetic, physiological, and pharmacological properties. ..
  7. Basson M, Zeng B, Downey C, Sirivelu M, Tepe J. Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-β. Mol Oncol. 2015;9:513-26 pubmed publisher
    ..Targeting this pathway may inhibit proliferation in large unresectable tumors. ..
  8. Kang H, Park J, Lee J. Distinct contributions of different structural regions to the current kinetics of the Cav3.3 T-type Ca2+ channel. Biochim Biophys Acta. 2008;1778:2740-8 pubmed publisher
    ..3 channel are differentially controlled by several structural regions, among which the III-IV loop and domain I are the most prominent in governing both activation and inactivation kinetics. ..
  9. Yue J, Liu L, Liu Z, Shu B, Zhang Y. Upregulation of T-type Ca2+ channels in primary sensory neurons in spinal nerve injury. Spine (Phila Pa 1976). 2013;38:463-70 pubmed publisher

More Information


  1. Lee J, Daud A, Cribbs L, Lacerda A, Pereverzev A, Klockner U, et al. Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family. J Neurosci. 1999;19:1912-21 pubmed
    ..Based on its brain distribution and novel gating properties, we suggest that alpha1I plays important roles in determining the electroresponsiveness of neurons, and hence, may be a novel drug target. ..
  2. McRory J, Santi C, Hamming K, Mezeyova J, Sutton K, Baillie D, et al. Molecular and functional characterization of a family of rat brain T-type calcium channels. J Biol Chem. 2001;276:3999-4011 pubmed
  3. Lee J, Kim E, Park B, Kim K, Cha S, Kong I, et al. Identification of T-type alpha1H Ca2+ channels (Ca(v)3.2) in major pelvic ganglion neurons. J Neurophysiol. 2002;87:2844-50 pubmed
    ..In conclusions, T-type Ca2+ currents in MPG neurons mainly arise from alpha1H among the three isoforms (alpha1G, alpha1H, and alpha1I) and may contribute to generation of low-threshold spikes in sympathetic MPG neurons...
  4. Astori S, Wimmer R, Prosser H, Corti C, Corsi M, Liaudet N, et al. The Ca(V)3.3 calcium channel is the major sleep spindle pacemaker in thalamus. Proc Natl Acad Sci U S A. 2011;108:13823-8 pubmed publisher
    ..Together, these data identify a central role for Ca(V)3.3 channels in the rhythmogenic properties of the sleep-spindle generator and provide a molecular target to elucidate the roles of sleep spindles for brain function and development. ..