Genomes and Genes
Gene Symbol: Cacna1i
Description: calcium voltage-gated channel subunit alpha1 I
Alias: voltage-dependent T-type calcium channel subunit alpha-1I, caVT.3, calcium channel, voltage-dependent, T type, alpha 1I subunit, calcium channel, voltage-dependent, alpha 1I subunit, low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I), voltage-dependent calcium channel, voltage-gated calcium channel subunit alpha Cav3.3
- Lee J, Daud A, Cribbs L, Lacerda A, Pereverzev A, Klockner U, et al. Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family. J Neurosci. 1999;19:1912-21 pubmed..Based on its brain distribution and novel gating properties, we suggest that alpha1I plays important roles in determining the electroresponsiveness of neurons, and hence, may be a novel drug target. ..
- McRory J, Santi C, Hamming K, Mezeyova J, Sutton K, Baillie D, et al. Molecular and functional characterization of a family of rat brain T-type calcium channels. J Biol Chem. 2001;276:3999-4011 pubmed
- Lee J, Kim E, Park B, Kim K, Cha S, Kong I, et al. Identification of T-type alpha1H Ca2+ channels (Ca(v)3.2) in major pelvic ganglion neurons. J Neurophysiol. 2002;87:2844-50 pubmed..In conclusions, T-type Ca2+ currents in MPG neurons mainly arise from alpha1H among the three isoforms (alpha1G, alpha1H, and alpha1I) and may contribute to generation of low-threshold spikes in sympathetic MPG neurons...
- Astori S, Wimmer R, Prosser H, Corti C, Corsi M, Liaudet N, et al. The Ca(V)3.3 calcium channel is the major sleep spindle pacemaker in thalamus. Proc Natl Acad Sci U S A. 2011;108:13823-8 pubmed publisher..Together, these data identify a central role for Ca(V)3.3 channels in the rhythmogenic properties of the sleep-spindle generator and provide a molecular target to elucidate the roles of sleep spindles for brain function and development. ..