Gene Symbol: C7
Description: complement C7
Alias: complement component C7, complement component 7
Sumitra M, Manikandan P, Nayeem M, Manohar B, Lokanadam B, Vairamuthu S, et al
. Time course studies on the initiation of complement activation in acute myocardial infarction induced by coronary artery ligation in rats. Mol Cell Biochem. 2005;268:149-58 pubmed
..Immunoexpression studies confirmed the initiation of the terminal C activation as shown by the expression of C5, C6, C7, C8, C9 and sC5b-9 complex at the 8th h of AMI...
Nauta A, Daha M, Tijsma O, van de Water B, Tedesco F, Roos A. The membrane attack complex of complement induces caspase activation and apoptosis. Eur J Immunol. 2002;32:783-92 pubmed
..Apoptosis as a consequence of complement-mediated cell damage may provide an explanation for the presence of apoptosis in inflammatory processes, for instance in hyperacute xenograft rejection. ..
Mason G, Murray R, Pappin D, Rivett A. Phosphorylation of ATPase subunits of the 26S proteasome. FEBS Lett. 1998;430:269-74 pubmed
..Some differences were observed in the 2D-PAGE pattern of proteasomes immunoprecipitated from cultured cells compared to purified rat liver 26S proteasomes suggesting possible differences in subunit compositions of 26S proteasomes. ..
Xiong Z, Qian W, Suzuki K, McNamara J. Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration. J Neurosci. 2003;23:955-60 pubmed
..Here we demonstrate that the sequential infusion of individual proteins of the membrane attack pathway (C5b6, C7, C8, and C9) into the hippocampus of awake, freely moving rats induced both behavioral and electrographic seizures ..
Ren G, Huynh C, Bijian K, Cybulsky A. Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury. Mol Immunol. 2008;45:2236-46 pubmed publisher
..e. when ASK1 is overexpressed, p38 activation is amplified, and C5b-9 assembly leads to GEC injury via ASK1 and p38. The present study thus defines a novel role for ASK1 as a mediator of C5b-9-dependent cell injury. ..
Hadders M, Bubeck D, Roversi P, Hakobyan S, Forneris F, Morgan B, et al
. Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9. Cell Rep. 2012;1:200-7 pubmed publisher
..components associate through sideways alignment of the central MAC-perforin (MACPF) domains, resulting in a C5b6-C7-C8Î²-C8Î±-C9 arc...
Adler S, Baker P, Pritzl P, Couser W. Detection of terminal complement components in experimental immune glomerular injury. Kidney Int. 1984;26:830-7 pubmed
..models of immunologic renal injury in the rat by immunofluorescence (IF) for terminal complement components C5, C6, C7, and C8 in glomeruli using antisera to human C5-8, which cross-react with the analogous rat complement components...
Okamoto K, Wang W, Rounds J, Chambers E, Jacobs D. Sublytic complement attack increases intracellular sodium in rat skeletal muscle. J Surg Res. 2000;90:174-82 pubmed
..10% human or rat serum under conditions of no complement activation, activation by zymosan, inactivation by heat, C7 or C9 deficiency, selective inhibition of complement pathway, and inhibition of Na(+)-K(+) ATPase by ouabain...
Soane L, Cho H, Niculescu F, Rus H, Shin M. C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway. J Immunol. 2001;167:2305-11 pubmed
..Sublytic assembly of membrane-inserted terminal complement complexes consisting of C5b, C6, C7, C8, and C9 proteins (C5b-9) inhibits caspase-3 activation and apoptotic death of oligodendrocytes...